Angioarchitecture of Brain AVMs and Bleeding Risk in Northeastern Malaysia
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Angioarchitecture of Brain Arteriovenous Malformations and the Risk of Bleeding: An Analysis of Patients in Northeastern Malaysia
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Shibani Kandai, Mohd Shafie Abdullah, Nyi Nyi Naing
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Angioarchitecture of Brain Arteriovenous Malformations and the Risk of Bleeding: An Analysis of Patients in Northeastern Malaysia
Year: 2010
Copyright (license): CC BY 4.0
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Summary of article contents:
Introduction
Brain arteriovenous malformation (BAVM) is a vascular malformation characterized by an intricate tangle of arteries and veins without an intervening capillary bed, predominantly affecting young males. Patients typically present with various clinical manifestations, including headaches, seizures, neurological deficits, and significant intracranial hemorrhage, particularly among those who experience acute bleeding. Understanding the angioarchitecture of BAVM is crucial for identifying risk factors associated with intracranial bleeding, which can lead to considerable morbidity and mortality. This study aims to examine these factors and explore the relationship between the volume of hematoma and the architectural features of BAVM.
Predictive Angioarchitectural Factors of Intracranial Bleeding
The study highlights the significance of specific angioarchitectural factors in predicting the risk of intracranial hemorrhage. Key findings indicated that smaller nidal sizes, deep-seated locations, and deep venous drainage were associated with an increased risk of bleeding, with small nidal size showing a remarkable correlation where it is 2.7 times more likely to result in hemorrhage compared to larger nidal sizes. Additionally, the presence of coexisting intranidal or prenidal aneurysms further elevated the hemorrhagic risk. The analysis revealed that 69% of the studied patients presented with intracranial hemorrhage, a substantial indication of the urgency in managing these patients.
Conclusion
The study underscores the crucial role of understanding the angioarchitecture of brain arteriovenous malformations in predicting intracranial bleeding risks. The findings affirm that specific characteristics—small nidal size, deep location, and deep venous drainage—serve as vital indicators for clinicians. Knowledge of these factors can inform timely and effective management strategies, emphasizing the need for a multidisciplinary approach involving neuroradiologists, neurosurgeons, and neurologists to optimize patient outcomes. The need for comprehensive evaluation and management plans for patients with BAVM, particularly those with high-risk angioarchitectural features, remains imperative.
FAQ section (important questions/answers):
What is a brain arteriovenous malformation (BAVM)?
A BAVM is a complex vascular malformation in the brain characterized by an entangled connection of arteries and veins, lacking an intervening capillary bed, and can cause serious neurological issues such as headaches, seizures, or intracranial hemorrhage.
What are the main risk factors for BAVM bleeding?
Significant risk factors include small nidal size, deep location, and deep venous drainage. Coexisting aneurysms also increase bleeding risks, especially in young males, highlighting the importance of early diagnosis and management.
What were the common clinical manifestations of BAVM in the study?
The study found that 69% of patients presented with intracranial hemorrhage, 19% with seizures, and 8.6% with headaches, indicating the serious nature of this condition and the urgency for medical intervention.
How does angioarchitecture relate to risk in BAVM?
Angioarchitectural factors such as small nidal size and deep location can predict intracranial bleeding risks. Recognizing these factors is crucial for timely referrals and effective multidisciplinary management of high-risk patients.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Angioarchitecture of Brain AVMs and Bleeding Risk in Northeastern Malaysia”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Bleeding:
Bleeding in the context of arteriovenous malformations (AVMs) refers to intracranial hemorrhage, which is a significant clinical presentation of brain AVMs. The study focuses on understanding the risk factors and angioarchitecture associated with such bleeding situations, emphasizing how specific features can influence the likelihood of hemorrhage in affected patients.
2) Study (Studying):
The study is a cross-sectional analysis aiming to uncover the association between the angioarchitecture of brain arteriovenous malformations and the risk of intracranial bleeding. By evaluating patient data over a seven-year period, the research contributes valuable insights into the natural history and management of BAVMs.
3) Male (Mālē):
The predominance of male patients in the study highlights a demographic aspect relevant to brain arteriovenous malformations, as young males are most commonly affected. Understanding the gender distribution aids in clinical awareness and may assist in identifying populations at higher risk for AVM-related complications.
4) Seat (Seated):
In this context, 'seated' refers to the location of the AVM within the brain, differentiating between superficial and deep-seated lesions. The angioarchitecture associated with the depth of the malformation is critical for predicting risks related to bleeding, highlighting the importance of precise anatomical descriptions in treatment planning.
5) Table:
The term 'table' likely pertains to the data presentations within the study, particularly regarding statistical analyses. Tables serve as a visual tool for summarizing complex data such as patient demographics, outcomes, and significant predictors of hemorrhage, thus facilitating better understanding and interpretation of the research findings.
6) Measurement:
Measurement refers to the assessment of variables like nidal size in brain arteriovenous malformations. Accurate measurement plays a crucial role in evaluating the angioarchitecture of AVMs, helping to establish correlations with clinical outcomes such as the occurrence of intracranial bleeding and informing potential treatment strategies.
7) Writing:
Writing, in the context of research, underscores the importance of clear communication in disseminating study findings. It involves documenting methodologies, results, and interpretations effectively, which is essential for contributing to the broader medical literature and ensuring knowledge transfer among clinicians, researchers, and healthcare providers.
8) Indian:
The mention of 'Indian' likely reflects the ethnic background of participants in the study, with demographic details providing insights into the population affected by brain AVMs. Recognizing the ethnic diversity among patients can enhance understanding of potential genetic or environmental factors contributing to the incidence and outcomes of AVMs.
9) Sahi:
Shahi likely refers to one of the authors or contributors of the study, emphasizing collaborative efforts in research. Author contributions are fundamental in providing expertise, validating findings, and enhancing the overall quality of the study, thereby influencing the advancement of knowledge in the field of neurosurgery and vascular malformations.
10) Genu (Geṇu):
Genu denotes a specific anatomical reference point used during measurement in the study, particularly relating to size estimation of AVMs. Accurate reference points, like the genu of the internal carotid artery, are pivotal for standardizing assessments, ensuring precision in defining the characteristics of arteriovenous malformations.
11) Khaw:
Khaw likely refers to a contributing author or researcher involved in the study. The acknowledgement of various contributors is vital in highlighting interdisciplinary collaboration that enhances study quality, broadens research perspectives, and assures credibility of findings related to brain arteriovenous malformations and associated hemorrhagic risks.
12) Mast:
Mast may refer to an author associated with relevant literature or research in the domain of brain AVMs. Acknowledging scholarly contributions reinforces the collective effort in advancing knowledge, establishing precedent studies, and guiding the interpretation of findings in the context of existing literature on arteriovenous malformations.
Other Health Sciences Concepts:
Discover the significance of concepts within the article: ‘Angioarchitecture of Brain AVMs and Bleeding Risk in Northeastern Malaysia’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:
Central nervous system, Statistical analysis, P Value, Clinical presentation, Cross-sectional study, Neurological Deficit, Clinical manifestation, Intracranial bleeding, Multidisciplinary approach, Intracranial haemorrhage, Magnetic resonance imaging, Angiography, Risk factor, Subarachnoid hemorrhage, Arteriovenous malformation, Emergency Department, Cerebral arteries, Multivariate model, Digital Subtraction Angiography, Subarachnoid haemorrhage, Patient interview, Neurologist, Neurosurgeon, Arterial feeders, Hospital Universiti Sains Malaysia, Cerebral angiogram, Central nervous system arteriovenous malformation, Brain arteriovenous malformation, Angiographic architecture, Haematoma volume, Deep venous drainage, Nidal size, Neurointerventional radiologists, Deep-seated BAVM, Coexisting aneurysms, Fisher score, Stroke and neurosciences, Multiple logistic regression, Venous drainage, Non-contrast computed tomography, Angioarchitecture of brain AVM, Haemodynamics, Deep location, Intranidal aneurysms, Computed tomography scanning, Focal and diffuse, McNemar's test, Angioarchitectural factors, Location of the lesion, Young male patients, Deep seated lesions, Radiosurgeons, Internal carotid artery, Intracranial bleed, Vascular malformation, Intraparenchymal haematoma, Angioarchitecture of brain, Small nidal size, Angioarchitecture, Intracranial haematoma, Cerebral catheterisation, Brain haemangiomas, Intranidal or prenidal, Diffuse type of, Cerebral veins, Intraparenchymal hematoma.