Clinical Profile and Management of Juvenile Nasopharyngeal Angiofibroma
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Appraisal of Clinical Profile and Management of Juvenile Nasopharyngeal Angiofibroma in Malaysia
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Original source:
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Shahid Hassan, Jafri Abdullah, Baharudin Abdullah, Shah Jihan WD, Hasnan Jaafar, Shafie Abdullah
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Appraisal of Clinical Profile and Management of Juvenile Nasopharyngeal Angiofibroma in Malaysia
Year: 2007
Copyright (license): CC BY 4.0
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Summary of article contents:
Introduction
Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign but locally invasive tumor predominantly affecting adolescent males, characterized by symptoms such as recurrent epistaxis and nasal blockage. The diagnosis is primarily based on clinical presentations and enhanced CT scan findings rather than tissue biopsy, with angiography serving as the gold standard for diagnosis. Pre-operative superselective embolization (SSE) and surgical excision are the preferred treatment modalities. A study conducted at the ORL-HNS hospital of University Science Malaysia included 25 male patients with JNA, predominantly aged 9–13, illustrating the clinical characteristics, diagnostic challenges, and surgical approaches utilized for management.
Surgical Approaches and Their Importance
One significant aspect of JNA management is the surgical approach, which varies based on tumor size, location, and extension. The study highlights various techniques, including transpalatal and maxillary swing approaches, with each having specific applications based on individual cases. The maxillary swing approach was notably employed in three cases of extensive tumor recurrences and found to provide adequate exposure, facilitating complete resection with acceptable morbidity. This technique stands out as particularly useful for advanced tumors with intracranial involvement, as it optimizes the surgical workflow and minimizes complications like persistent bleeding and difficulties in dissection. The study demonstrated that careful selection of surgical approaches greatly influences surgical outcomes and recurrence rates, underscoring the importance of tailored interventions based on tumor characteristics.
Conclusion
In conclusion, juvenile nasopharyngeal angiofibroma remains a complex clinical problem that requires a multifaceted diagnostic and therapeutic approach. The findings from the retrospective review at Universiti Sains Malaysia underscore the effectiveness of pre-operative embolization combined with surgical excision, including innovative techniques like the maxillary swing approach, in managing JNA cases. Early diagnosis and meticulous follow-up are crucial in preventing recurrences, as these tumors exhibit unpredictable behavior. The experiences shared in the study contribute valuable insights into the management of JNA, advocating for an individualized approach to treatment and the need for continued research into surgical methodologies to improve patient outcomes.
FAQ section (important questions/answers):
What are the common symptoms of juvenile nasopharyngeal angiofibroma?
Patients typically present with recurrent epistaxis, nasal blockage, headaches, and hyponasal voice. Advanced cases may show facial asymmetry, palatal bulge, proptosis, and blurred vision due to local and intracranial tumor extensions.
How is juvenile nasopharyngeal angiofibroma diagnosed?
Diagnosis relies primarily on clinical evaluation and typical CT scan findings. Angiography is the gold standard investigation, showing the typical tumour blush. A definitive tissue biopsy is generally avoided due to bleeding risks.
What treatment options are available for juvenile nasopharyngeal angiofibroma?
The treatment of choice involves pre-operative superselective embolisation (SSE) followed by surgical excision. Radiotherapy may be utilized for intracranial extensions or inoperable advanced cases. Regular follow-up is crucial for identifying recurrences.
What are the surgical approaches for treating juvenile nasopharyngeal angiofibroma?
Various surgical approaches include transpalatal, lateral rhinotomy, and maxillary swing techniques. Selection depends on tumor size, extension, and expertise available. Combined approaches may be used for intracranial extensions to ensure adequate exposure and dissection.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Clinical Profile and Management of Juvenile Nasopharyngeal Angiofibroma”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Incision:
An incision refers to the surgical cut made to access a tumor, such as juvenile nasopharyngeal angiofibroma (JNA). Different types of incisions are chosen based on tumor size and location. Appropriate incision techniques are critical for effective access and removal of the tumor while minimizing tissue damage and complications.
2) Radiotherapy:
Radiotherapy is a treatment utilizing ionizing radiation to control or kill malignant cells, often used for JNA cases with significant intracranial extensions. While surgery remains the primary treatment, radiotherapy serves as an alternative for inoperable or advanced tumors, highlighting its role in comprehensive oncological treatment plans.
3) Bleeding:
Bleeding is a significant concern during surgical procedures for JNA due to the rich vascular supply of the tumor. Preoperative embolization helps minimize intraoperative bleeding, facilitating safer dissection. Managing bleeding is essential to avoid complications such as hematoma and prolonged recovery after surgery, ensuring patient safety.
4) Table:
Tables in the text are utilized to organize data regarding patient demographics, clinical presentations, tumor staging, and surgical approaches. They provide visual clarity and facilitate quick reference, aiding clinicians and researchers in understanding patterns, outcomes, and the effectiveness of various treatment modalities in JNA cases.
5) Sign:
In the context of diagnosing JNA, 'signs' refer to observable indicators, such as specific features seen in imaging studies. Key signs identified in CT scans, like erosion of anatomical structures and tumor presence, are critical for accurate diagnosis, guiding treatment decisions and predicting patient outcomes.
6) Blood:
Blood loss during surgical interventions for JNA is a considerable risk due to the tumor's vascular nature. Understanding and managing blood loss is vital for surgical success, as excessive bleeding can lead to complications and necessitate blood transfusions, impacting the patient's overall recovery and health status.
7) Wall:
The term 'wall' often refers to the anatomical structures surrounding the tumor, such as the posterior antral wall which is visualized in imaging studies. Understanding these structures aids in surgical planning and can indicate the extent of tumor invasion, influencing surgical approach and management strategies.
8) Post:
Post usually signifies the time after surgical procedures, where follow-up care and monitoring occur. 'Post' refers to potential complications that must be managed after surgery, such as trismus or fistula, emphasizing the importance of postoperative evaluation to ensure successful recovery and detect any recurrence early.
9) Blindness:
Blindness is a severe potential complication associated with extensive JNA involvement near the orbit or after surgical complications. Awareness of this risk underlines the importance of careful surgical planning and technique, as preserving optic structures is vital during the excision of tumors with possible optic nerve involvement.
10) Swelling:
Swelling can occur due to various factors in JNA cases, including tumor mass effect, postoperative reactions, or complications. Recognizing and managing swelling is crucial for patient comfort and recovery, indicating potential complications that may require further intervention or surgical adjustment after initial treatment.
11) Disease:
Disease refers to the pathological condition represented by JNA, characterized by a benign but locally invasive tumor. The understanding of this disease guides clinical assessments, treatment options, and follow-up protocols, emphasizing the complexities involved in managing a condition typically seen in adolescent males.
12) Male (Mālē):
JNA predominantly affects males, with the majority of patients in the male demographic presenting around pre-pubertal age. This gender prevalence underscores the need for targeted clinical awareness and research on JNA in males, including risk factors and specific clinical management strategies tailored for this group.
13) Gold (Golden):
Gold, in this context, refers to the 'gold standard' diagnostic procedures, such as angiography, which are considered the most accurate methods for diagnosing JNA. Understanding what constitutes the gold standard helps clinicians develop effective diagnostic strategies, ensuring high fidelity in diagnosis and subsequent treatment planning.
14) Chemotherapy:
Chemotherapy is referenced as an alternative treatment modality for JNA with limited success, underscoring its impracticality in most cases. This highlights the continued preference for surgical intervention as the primary treatment, as chemotherapy's effectiveness on this benign tumor type remains minimal, warranting investigation into more focused therapies.
15) Vomiting:
Vomiting can be associated with JNA cases that have intracranial extensions, often indicating increased intracranial pressure or other complications. This symptom may necessitate further evaluation and management in a clinical setting, marking an important consideration in patient monitoring and symptomatic treatment strategies during case management.
16) Channel:
Channel refers to the vascular channels present in the tumor's histological structure. Recognizing the vascular nature of JNA is essential for surgical planning and understanding the tumor's behavior, as these channels can contribute to significant bleeding during interventions, highlighting the need for effective preoperative management.
17) Science (Scientific):
Science signifies the interdisciplinary approach combining clinical observation, imaging techniques, and innovative surgical methods in the management of JNA. The scientific inquiry into various treatment modalities and outcomes enhances the understanding of this tumor type, driving improvements in diagnostics, surgical techniques, and postoperative care.
18) Nausea:
Nausea is a potential symptom in JNA patients with intracranial extensions, often linked to increased intracranial pressure or related complications. Recognizing nausea in clinical presentations is vital for comprehensive patient management, serving as a signal for potential severe complications that may require prompt medical intervention.
19) Repair:
Repair refers to the surgical rectification of complications arising from JNA procedures, such as trismus or palatal fistulas. It underscores the importance of addressing postoperative issues through reconstructive techniques to restore functionality and quality of life, emphasizing the need for meticulous surgical approaches to minimize such complications.
20) Study (Studying):
Study denotes the retrospective analysis of JNA cases, assessing demographics, clinical presentations, treatment modalities, and outcomes. Systematic study of such cases contributes to the broader knowledge base regarding management strategies, recurrence rates, and the long-term impact of various surgical interventions on affected populations.
21) Pose:
Pose signifies the challenges faced in diagnosing and managing JNA due to its complex nature and symptoms that may overlap with other conditions. Understanding these challenges helps clinicians approach diagnosis and treatment with greater caution and discernment, ultimately leading to better outcomes for patients with this condition.
22) Rich (Ṛch):
Rich describes the abundant vascularity typical of JNA, which is critical in understanding its pathology and surgical risks. Recognizing the 'rich' vascular supply necessitates careful planning to minimize intraoperative bleeding and optimize surgical techniques, reflecting the delicate balance required in managing such highly vascular tumors.
Other Health Sciences Concepts:
Discover the significance of concepts within the article: ‘Clinical Profile and Management of Juvenile Nasopharyngeal Angiofibroma’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:
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