Soybean vs. Goat’s Milk: Effects on Tumor-Marker Enzymes in Rats
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Comparison between the Effect of Soybean and Goat’s Milk on Tumor-Marker Enzyme Activities During Hepatocarcinogenesis in Rats
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Asmah Rahmat, Chin Kam Seam, Susi Endrini, Siti Muskinah Hj. Mansor
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Comparison between the Effect of Soybean and Goat’s Milk on Tumor-Marker Enzyme Activities During Hepatocarcinogenesis in Rats
Year: 2001
Copyright (license): CC BY 4.0
Download the PDF file of the original publication
Summary of article contents:
Introduction
The study investigates the impact of soybean and goat's milk on hepatocarcinogenesis in rats, specifically focusing on the physiological response when subjected to carcinogens diethylnitrosamine (DEN) and acetylaminofluorene (AAF). Given that soybean is recognized for its strong antioxidant properties, which may play a role in inhibiting cancer development, and that goat's milk is a nutritious physiological fluid, the research aims to clarify their potential protective effects against liver cancer. The experimental design included feeding thirty-six Sprague-Dawley rats with the aforementioned carcinogens, followed by treatments with either soybean or goat's milk.
Effect of Soybean and Goat's Milk on Liver Enzymes
An important finding of this study centers on the effect of DEN/AAF administration on liver enzyme activities, particularly gamma-glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP). The administration of DEN/AAF significantly increased the levels of these enzymes, which are commonly associated with liver damage and carcinogenic processes, while also causing a notable decrease in the rats' body weight. The introduction of soybean and goat's milk into the diet applied after the carcinogenic treatment aimed to assess whether these substances could counteract the detrimental effects observed, thus highlighting their potential therapeutic roles.
Conclusion
The study underscores the significance of exploring dietary substances like soybean and goat's milk in cancer prevention and management strategies. While the administration of the carcinogens DEN and AAF resulted in adverse effects on liver function in the rats, further investigation is warranted to fully elucidate the protective mechanisms of soybean and goat's milk. The findings suggest a potential for these nutritional interventions to mitigate liver damage and alter the course of hepatocarcinogenesis, reinforcing the need for additional research in this domain to better understand their implications for cancer treatment and prevention.
FAQ section (important questions/answers):
What is the objective of the study involving soybean and goat's milk?
The study aimed to investigate the effects of soybean and goat's milk on hepatocarcinogenesis in rats, particularly focusing on changes in plasma gamma-glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP) levels after carcinogen treatment.
How were the rats divided for this experiment?
Thirty-six Sprague-Dawley rats were divided into six groups: control, DEN/AAF, soybean, DEN/AAF with soybean, goat's milk, and DEN/AAF with goat's milk treatment to evaluate the effects of each treatment.
What treatments were administered to the rats during the study?
The rats received treatments of soybean and goat's milk at a dosage of 5 ml per day for eight weeks, alongside their respective carcinogenic treatments of diethylnitrosamine (DEN) and acetylaminofluorene (AAF).
What were the observed effects of DEN/AAF treatment on rats?
Treatment with DEN/AAF resulted in significantly increased levels of alkaline phosphatase (ALP) and gamma-glutamyl transpeptidase (GGT), as well as a significant decrease in the rats' body weight.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Soybean vs. Goat’s Milk: Effects on Tumor-Marker Enzymes in Rats”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Milk:
Milk is a nutrient-rich physiological fluid that plays a crucial role in the study as it serves as a dietary component being analyzed for its potential protective effects against hepatocarcinogenesis. The inclusion of goat's milk in the experimental groups is designed to examine its effects on liver enzyme activities, relevant to cancer development.
2) Species:
The term 'species' refers to the specific group of organisms used in the research, in this case, Sprague-Dawley rats. Understanding the species is essential for interpreting the study’s results because physiological responses to dietary interventions might vary significantly among different species, impacting the generalizability of the findings to humans.
3) Blood:
Blood is a crucial biological fluid analyzed in the study to measure the activities of gamma-glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP). These enzyme levels in plasma provide insight into liver function and potential carcinogenic effects, thereby linking the study's dietary interventions to health outcomes focused on hepatocarcinogenesis.
4) Study (Studying):
The term 'study' refers to the systematic investigation described in the abstract that aims to explore the influence of soybean and goat's milk on hepatocarcinogenesis induced by specific carcinogens. It encapsulates the experimental design, objectives, and outcomes, providing a framework to understand the effects of dietary components on liver health.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Soybean vs. Goat’s Milk: Effects on Tumor-Marker Enzymes in Rats’. Further sources in the context of Science might help you critically compare this page with similair documents:
Goat milk, Dietary treatment, Control group, Nutritional value, Alkaline phosphatase, Carcinogenesis, High nutritional value, Gamma glutamyl transpeptidase, Soybean, Antioxidant characteristics.