HLA Types and Disease Expression in Malaysian Lupus Patients
Journal name: The Malaysian Journal of Medical Sciences
Original article title: Disease Expression and HLA Types in Early and Late Onset Disease of Malaysian Patients with Systemic Lupus Erythematosus
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Original source:
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Azizah Mohd Radzi, Kuak Soo Huan, Normaznah Yahaya, Ainol Shahera, Norella Kong, Rahim Mohd Noah
The Malaysian Journal of Medical Sciences:
(A peer-reviewed, open-access journal)
Full text available for: Disease Expression and HLA Types in Early and Late Onset Disease of Malaysian Patients with Systemic Lupus Erythematosus
Year: 2001
Copyright (license): CC BY 4.0
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Summary of article contents:
Introduction
The relationship between age and the expression of systemic lupus erythematosus (SLE) has garnered attention in recent research. This study aims to investigate potential differences in disease expression between patients with late-onset SLE (those aged 40 years and above) and early-onset SLE (those younger than 40 years). By examining a cohort of 13 late-onset and 90 early-onset patients, the study seeks to explore whether age at onset impacts the presentation and severity of SLE symptoms and whether genetic factors play a role in the age of disease onset.
Presentation Patterns in Late-Onset SLE
One significant finding from the study reveals that late-onset SLE patients exhibit distinct initial symptoms compared to their early-onset counterparts. Notably, 31% of late-onset patients presented with pericarditis, a sharp contrast to only 3% of early-onset patients displaying the same symptom. This disparity suggests that there may be different pathogenic mechanisms or genetic influences affecting how SLE manifests based on the age of onset, potentially indicating a need for tailored approaches in diagnosis and treatment.
Conclusion
The findings from this study highlight important age-related differences in the presentation of systemic lupus erythematosus, particularly the higher incidence of pericarditis in late-onset cases. Understanding how age and possibly genetics influence disease manifestation is crucial for improving the management and therapeutic strategies for SLE patients of varying ages. Further research is warranted to explore the underlying mechanisms and implications of these observed differences in disease expression.
FAQ section (important questions/answers):
What was the focus of the study on lupus patients?
The study aimed to explore age-related differences in lupus expression and the influence of genetic makeup on the age of disease onset.
How many patients were studied with late onset lupus?
Thirteen patients with late onset systemic lupus erythematosus, defined as having an onset age of 40 years and above, were included in the study.
What percentage of late onset patients presented with pericarditis?
The study found that 31% of late onset patients initially presented with pericarditis, compared to only 3% of early onset patients.
What were the two age groups analyzed in the study?
The study analyzed 13 late onset patients (40 years and older) and 90 early onset patients (under 40 years) to identify differences in disease expression.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “HLA Types and Disease Expression in Malaysian Lupus Patients”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Disease:
In this context, 'Disease' refers specifically to systemic lupus erythematosus (SLE), a chronic autoimmune condition with variable presentation and severity. The study aims to understand how the age of onset impacts the disease's manifestation and progression, highlighting the importance of both age and genetic factors in understanding SLE.
2) Study (Studying):
The term 'Study' denotes a systematic investigation involving a cohort of patients with systemic lupus erythematosus. It involves comparing late onset and early onset cases to identify differences in clinical presentation and potential genetic influences, thus contributing to a better understanding of the disease's mechanisms and facilitating tailored interventions.
Other Science Concepts:
Discover the significance of concepts within the article: ‘HLA Types and Disease Expression in Malaysian Lupus Patients’. Further sources in the context of Science might help you critically compare this page with similair documents:
Genetic make up, Patient population, Systemic lupus erythematosus, Pericarditis, Age-related difference, Early onset.