Physiological Permeability of Third Molar Dentine with/without Odontoblasts

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Journal name: The Malaysian Journal of Medical Sciences
Original article title: A Physiological Permeability Study of Third Molar Dentine with Odontoblasts Preserved and Odontoblasts Free Preparations
The Malaysian Journal of Medical Sciences (MJMS) is a peer-reviewed, open-access journal published online at least six times a year. It covers all aspects of medical sciences and prioritizes high-quality research.
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Original source:

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Author:

Farid Che Ghazali


The Malaysian Journal of Medical Sciences:

(A peer-reviewed, open-access journal)

Full text available for: A Physiological Permeability Study of Third Molar Dentine with Odontoblasts Preserved and Odontoblasts Free Preparations

Year: 2000

Copyright (license): CC BY 4.0


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Summary of article contents:

Introduction

Dentine is a vital biological tissue that forms an intricate relationship with odontoblasts, the cells responsible for its formation. In human adults, odontoblasts are fully differentiated and send their cytoplasmic processes into dentinal tubules. This study explores the permeability of dentine, particularly focusing on the hydrodynamic mechanism thought to regulate fluid movement in response to stimuli, thus affecting nerve endings. The primary aim of this pilot investigation is to enhance understanding of how odontoblasts influence the permeability of human dentine, particularly in terms of its role in fluid dynamics.

The Influence of Odontoblasts on Dentine Permeability

The research involves comparing fluid flow across dentine in human third molars under two conditions: with preserved odontoblasts and without. In the experiments, pulp tissues were removed from molars while leaving odontoblasts intact, and the specimens were treated either chemically or through alkali immersion to create odontoblast-free specimens. Observations indicated that fluid flow persisted in both conditions until equilibrium was reached, though the volume of water flow was significantly greater in the odontoblast-free specimens. This suggests that water movement in the absence of odontoblasts relies on capillary action alone, whereas preserved odontoblasts also facilitate water ingress through osmotic pressure, signifying their crucial role in maintaining dentine's barrier properties.

Conclusion

The findings of this study underscore the importance of odontoblasts in regulating the permeability of dentine and highlight their dual role in fluid dynamics. This investigation lays the groundwork for further studies aimed at understanding how variations in or loss of odontoblasts could affect dental health, particularly regarding the potential for fluid-induced sensitivity or pathology in dental tissues. Overall, the results emphasize the functional relevance of odontoblasts in preserving the integrity and barrier functions of the dentine, thereby contributing to the broader field of dental research and potential clinical implications in treating dental sensitivity and related conditions.

FAQ section (important questions/answers):

What is the purpose of the study on human dentine?

The study aims to understand the influence of odontoblasts on the permeability of human dentine, comparing fluid flow in preserved and free odontoblast preparations.

How were the dentine samples prepared for the study?

Dentine samples were prepared from human third molars, with pulp tissues removed. Some were chemically fixed to preserve odontoblasts, while others were treated with NaOH to create odontoblast-free specimens.

What did the results indicate regarding fluid flow in dentine?

The results showed that fluid flow was greater in odontoblast-free preparations than in preserved ones, suggesting that fluid movement is driven differently depending on the presence of odontoblasts.

What socio-demographic factors were assessed in the Baling, Kedah study?

The study assessed children's nutritional status and socio-demographic variables, including household income, education levels, and occupations of heads of households to evaluate the socio-economic conditions in the region.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Physiological Permeability of Third Molar Dentine with/without Odontoblasts”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Study (Studying):
Study refers to systematic investigation and analysis undertaken to acquire knowledge in a particular field, such as health or social sciences. In the provided text, several studies focus on dental health, nutritional status, and cardiovascular disease, highlighting the importance of empirical research in understanding health issues and guiding interventions.

2) Science (Scientific):
Science is a systematic enterprise that builds and organizes knowledge in the form of testable explanations and predictions about the universe. The articles incorporate scientific methodologies to explore various health-related subjects, applying quantitative and qualitative assessments to validate findings and enhance our overall understanding of human biology and health.

3) Education:
Education signifies the process of acquiring knowledge, skills, values, and habits. The investigations highlighted the importance of educational programs for mothers regarding nutrition, as enhancing nutritional knowledge can significantly improve children's health outcomes and prevent malnutrition. Educational interventions are essential for fostering informed communities and promoting better health practices.

4) Putra:
Putra refers to Universiti Putra Malaysia, an educational institution involved in research and studies on health and nutrition. It collaborates with various departments to analyze socio-demographic and nutritional aspects in rural populations, contributing valuable insights into public health and informing policies benefiting community health initiatives.

5) Water:
Water is a critical resource for human survival and health. The studies mentioned assess water access in rural communities, exploring its impact on nutritional status and overall health. Adequate water supply is foundational for promoting hygienic practices, efficient agricultural production, and ensuring children’s growth and well-being.

6) Knowledge:
Knowledge embodies the information and skills acquired through experience or education. The studies emphasize the significance of nutritional knowledge for caretakers and families, suggesting that increased awareness can lead to improved dietary behaviors and health outcomes, particularly in vulnerable populations such as young children.

7) Medicine:
Medicine refers to the science and practice of diagnosing, treating, and preventing diseases. The research articles explore various medical topics, including cardiovascular disease and dental health, illustrating the necessity of combining clinical knowledge with community health studies to address complex health issues facing populations.

8) Measurement:
Measurement relates to the process of obtaining the magnitude of a quantity. In the articles, accurate anthropometric measurements and biochemical assessments provide vital data necessary for evaluating health indicators, assessing nutritional status, and understanding disease risk factors, thus enabling informed decision-making in health interventions.

9) Disease:
Disease refers to pathological conditions that disrupt normal bodily functions. The studies address different diseases, including cardiovascular abnormalities and nutritional disorders, emphasizing the importance of studying their risk factors and impacts on communities to foster effective preventive measures and improve health outcomes.

10) Padi (Pāḍī, Paḍi):
Padi refers to rice cultivation, which is significant in Malaysian contexts, especially in rural areas. The studies highlight socio-demographic factors in padi farming communities, illustrating how lifestyle and economic changes impact household nutrition and the prevalence of malnutrition among children, reinforcing the need for targeted interventions.

11) Food:
Food is essential for growth, development, and overall health. The articles assess dietary intake among children, addressing the connection between food consumption patterns and nutritional status. They underline the importance of balanced diets in preventing malnutrition and supporting adequate physical and cognitive development in young populations.

12) Relative:
Relative in this context likely refers to comparative measures in the studies, such as the relative prevalence of nutritional deficiencies or the relative impact of education on health outcomes. Understanding relative differences helps identify priority areas for intervention and resource allocation in healthcare planning.

13) Village:
Village describes the rural communities studied in the research. The articles focus on socio-demographic profiles of villages, exploring their economic activities and health challenges. Such community-level analyses are critical for tailoring public health initiatives and support systems to the unique needs of these populations.

14) Family:
Family symbolizes the basic social unit that plays a vital role in shaping individual behaviors and health choices. The studies consider family dynamics and socio-demographic influences on children's nutritional status, highlighting the necessity of family-oriented health education and interventions for effective improvements.

15) Trader:
Trader refers to individuals engaged in commerce, primarily in rural areas. The articles mention occupation-related shifts within households, with trading activities representing an economic component that influences family income and overall nutrition. Economic stability contributes to dietary quality and access to healthcare resources.

16) Death:
Death signifies the end of life, an event closely monitored in public health contexts. The studies report on disease prevalence and mortality risks in rural communities, emphasizing the need for effective healthcare interventions to reduce mortality rates associated with chronic diseases, particularly among vulnerable populations.

17) Male (Mālē):
Male refers to one gender identified in the studies, often analyzed in relation to health outcomes and risk factors. The research includes gender comparisons to understand how males are affected by cardiovascular diseases, lifestyle habits, and nutritional deficiencies, providing insights for tailored healthcare strategies.

18) Kun (Kuṇ, Kūṇ, Kūṉ):
Koon references one of the authors associated with the studies, contributing to the body of research within the Malaysian context. The involvement of diverse researchers strengthens the validity and reliability of findings, reflecting a collaborative approach in addressing health challenges prevalent in the region.

19) Pharmacological:
Pharmacological relates to the branch of medicine concerned with the uses, effects, and modes of action of drugs. The studies touch upon the importance of understanding pharmacological impacts on health, highlighting the need for awareness of medication interactions with lifestyle factors, particularly in cardiovascular disease management.

20) Malnutrition:
Malnutrition signifies a condition resulting from inadequate or excessive nutrient intake, leading to health complications. The articles focus heavily on assessing malnutrition among children in rural Malaysia, aiming to highlight the causes, implications, and potential interventions necessary to alleviate this pervasive public health issue.

21) Accumulation (Accumulating, Accumulate):
Accumulated refers to the gradual gathering or increase of substances, such as nutrients or water. In the studies, the concept may pertain to volumes of water absorbed by dental tissues or cumulative health impacts of dietary practices, emphasizing the importance of monitoring long-term health trajectories.

22) Machang:
Machang refers to another geographical location in Malaysia relevant to the studies. Similar to Baling, it represents an area where data was gathered to analyze socio-demographic and health trends, providing insights into rural health dynamics and supporting regional comparative research efforts.

23) Nature:
Nature encompasses both the intrinsic qualities of organisms and the external environment. In this context, it refers to the biological and socio-economic characteristics of populations studied. Understanding the nature of the communities allows researchers to develop culturally appropriate health interventions and educational programs.

24) Sugar:
Sugar refers to simple carbohydrates relevant to dietary assessments discussed in the studies. The articles emphasize dietary sugar intake as a factor influencing overall health, particularly related to obesity and cardiovascular disease, underscoring the need for public awareness and improved dietary guidelines in communities.

25) Raja (Rāja, Rājā):
Raja may refer to a cultural or traditional aspect within the Malaysian context, potentially reflecting the heritage and social structures of the study populations. Understanding cultural background contributes to the design of health programs that respect community values and practices, facilitating better outcomes.

26) Muda (Mudā, Muḍa):
Muda typically signifies 'young' or 'new' in Malay. It may reference the youthful demographic groups being studied, particularly children in rural areas. Recognizing the needs and health trends among younger populations is crucial for developing effective health policies and educational outreach programs.

27) Diet:
Diet refers to the usual food and drink consumed, which is central to studies analyzing nutritional intake among children. The articles highlight the importance of diverse and balanced diets in combating malnutrition and ensuring optimal health outcomes, reinforcing the need for continuous dietary education.

28) Wall:
Wall can symbolize the structural components of physiological or environmental boundaries, such as dentin walls in dental studies. Understanding these boundaries is critical for evaluating procedural impacts, barriers in health uptake, and the relationship between structure and function in biological research.

29) Milk:
Milk is a vital source of nutrition, particularly for children. The articles note its consumption as a primary food item, contributing positively to dietary intake but also reflecting on the need for a balanced diet. Educational efforts should address milk's role in overall nutrition and health.

30) Salt (Salty):
Salt is an essential nutrient that, in excessive amounts, can lead to health issues like hypertension. The studies address dietary salt intake, emphasizing its role in cardiovascular health and the necessity for public health initiatives that promote awareness of balanced salt consumption to prevent disease.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Physiological Permeability of Third Molar Dentine with/without Odontoblasts’. Further sources in the context of Science might help you critically compare this page with similair documents:

Malnutrition, Agricultural activities, Obesity, Blood-pressure, Cholesterol, Nutritional status, Study population, Dietary Intake, LDL cholesterol, HDL cholesterol, Socioeconomic factors, Total cholesterol, Cardiovascular disease, Visual acuity, Physical Inactivity, Malnourished children, Coronary heart disease, Smoking habit, Lipid metabolism, Impaired glucose tolerance, Caloric intake, Anthropometric measurement, Risk factor, Triglyceride, Refractive error, Dietary Assessment, CVD Risk Factors, Body posture, Glucose Tolerance, Socio-demographic data, Acute coronary syndrome, Study area, Socio Demographic Profile, Education Level, Young adult, Lipoprotein A, Serum sample, Low income group, Dietary fat, Functional group, Nutrition education, Household income, Intervention Study, CVD risk, Serum lipid, Socio-demographic characteristic.

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