Bartonella henselae and Bartonella quintana seroprevalence in HIV-positive,...

[Full title: Bartonella henselae and Bartonella quintana seroprevalence in HIV-positive, HIV-negative and clinically healthy volunteers in Gauteng, South Africa]

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[Find the meaning and references behind the names: Anastasia, John, Allan, Jennifer, Hani, Chris]

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Poster doi:10.4102/ojvr.v 79 i 2.479 http://www.ojvr.org Bartonella henselae and Bartonella quintana seroprevalence in HIV-positive, HIV-negative and clinically healthy volunteers in Gauteng, South Africa Authors: Anastasia N. Trataris 1,2 Lorraine Arntzen 1 Jennifer Rossouw 1 John Frean 1,2 Allan Karstaedt 3 Affiliations: 1 National Institute for Communicable Diseases, National Health Laboratory Service, South Africa 2 University of the Witwatersrand, South Africa 3 Chris Hani Baragwanth Hospital, Bertsham, South Africa Correspondence to: Anastasia Trataris Email: anastasian@nicd.ac.za Postal address: Centre for Emergingand Zoonotic Diseases Special Bacterial Pathogens Reference Laboratory How to cite this poster: Trataris, A.N., Arntzen, L., Rossouw, J., Frean, J. & Karstaedt, A., 2012, ‘ Bartonella henselae and Bartonella quintana seroprevalence in HIVpositive, HIV-negative and clinically healthy volunteers in Gauteng, South Africa’, Onderstepoort Journal of Veterinary Research 79(2), Art. #479, 1 page. http:// dx.doi.org/10.4102/ojvr. v 79 i 2.479 Note: Proceedings of the Conference of the Southern African Centre for Infectious Disease Surveillance ‘One Health’ held at the National Institute for Communicable Diseases, Johannesburg, July 2011 © 2012. The Authors Licensee: AOSIS OpenJournals. This work is licensed under the Creative Commons Attribution License Bartonella is a genus of opportunistic, Gram-negative bacilli transmitted from animals to human hosts. Bartonellae are newly emerging pathogens that can cause a variety of clinical manifestations in both immunocompromised and healthy persons The aims were to determine the IgG and IgM seroprevalences of Bartonella henselae and Bartonella quintana in immunocompromised and immunocompetent individuals using an immunofluorescence assay (IFA) A total of 382 HIV-positive outpatients of the Chris Hani Baragwanth HIV-clinic, 382 retrospective residual samples from HIV-negative antenatal patients, and 42 clinically healthy volunteers were tested using a commercially available IFA kit to determine the prevalence of IgG and IgM antibodies to B. henselae and B. quintana The IgM and IgG seroprevalences for the HIV-positive patients were 14 % (53/382) and 32 % (121/382), respectively, compared to 18 % for both IgM (62/342) and IgG (63/342) in the HIVnegative antenatal patients. Similarly, the prevalence for IgM was 17 % (7/42) and IgG was 19 % (8/42) for the clinically healthy volunteers. HIV-positivity appears to be a significant risk factor for Bartonella infection, compared with healthy subjects. Although IFAs have a high sensitivity for Bartonella antibody detection, they have various limitations including cross-reactivity with other closely-related human pathogens . Page 1 of 1

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Seroprevalence, Cross-reactivity, Antenatal patients, HIV positive patient, Antibody detection, HIV Negative, IgG and IgM, HIV-positive, Emerging pathogen, Significant Risk Factor, Gauteng, South Africa.