Study of bone allograft with metformin for periodontal defects.
Journal name: Journal of Indian Society of Periodontology
Original article title: A comparative study of demineralized freeze-dried bone allograft alone and with 1% metformin in the treatment of intrabony defects in patients with chronic periodontitis: A randomized clinical trial
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:
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Dipika K. Mitra, Rutuja Jeevandas Donde, Ankit B. Desai, Kashmira Prakash Ghangrekar, Priyanka Nandakumar Potdar, Gaurav Prabhakar Shetty
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: A comparative study of demineralized freeze-dried bone allograft alone and with 1% metformin in the treatment of intrabony defects in patients with chronic periodontitis: A randomized clinical trial
Year: 2023 | Doi: 10.4103/jisp.jisp_628
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Periodontal disease is a widespread condition that requires comprehensive treatment strategies, often involving biomaterials along with demineralized freeze-dried bone allograft (DFDBA) for effective periodontal regeneration. Recent studies have highlighted the potential of 1% metformin as a regenerative material in this context. The present research aims to evaluate and compare the effectiveness of DFDBA alone versus DFDBA combined with 1% metformin in treating intrabony defects in patients suffering from chronic periodontitis.
Comparative Efficacy of Metformin and DFDBA
The clinical trial was a split-mouth design that included 20 intrabony defect sites distributed evenly between two treatment groups: Group A (DFDBA + 1% metformin) and Group B (DFDBA alone). Significant improvements were observed in both groups at 9 months postoperatively regarding probing pocket depth (PPD) and relative attachment level (RAL). However, statistical analysis indicated no significant difference in clinical and radiographic outcomes between the two groups, suggesting that while the addition of metformin may enhance results marginally, it does not provide substantial benefits over DFDBA alone.
Conclusion
This study adds to the growing body of research exploring novel approaches to periodontal regeneration. While significant clinical improvements were noted in both treatment regimens, the combination of 1% metformin with DFDBA did not demonstrate any additional advantages in treating intrabony defects. Future research is warranted, ideally involving larger sample sizes and histological analysis, to further assess the efficacy of metformin in periodontal regeneration and establish more definitive conclusions.
FAQ section (important questions/answers):
What was the purpose of the study involving metformin and DFDBA?
The study aimed to assess and compare the regenerative potential of 1% metformin combined with demineralized freeze-dried bone allograft (DFDBA) versus DFDBA alone in treating intrabony defects in individuals with chronic periodontitis.
How many subjects participated in the study, and what groups were formed?
Twenty sites with intrabony defects were included, divided into two groups: Group A received DFDBA with 1% metformin, while Group B received DFDBA alone, both undergoing assessments at various postoperative intervals.
What were the key findings regarding clinical parameters at nine months?
Both groups showed statistically significant improvements in probing pocket depth and relative attachment level at the nine-month mark, but no significant differences were observed between the two groups.
What limitations were present in the study conducted on metformin and DFDBA?
Limitations included a small sample size, lack of research on metformin gel kinetics, and the need for more extensive histological studies to validate the findings regarding its effectiveness in periodontal regeneration.
What conclusions can be drawn from the research on 1% metformin with DFDBA?
The addition of 1% metformin to DFDBA did not yield additional benefits in treating intrabony defects. Statistically significant improvements were seen in both groups, necessitating further research for clearer conclusions.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Study of bone allograft with metformin for periodontal defects.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
A table presents organized data that facilitates comparative analysis, making it easier for researchers to visualize outcomes from the study, such as measurements of clinical parameters over time after treatment with different materials. In this context, tables help illustrate results concisely, showing variations in clinical improvements between the treatment groups.
2) Study (Studying):
Study refers to the systematic investigation into a subject to uncover insights or validate hypotheses, integral for advancing medical knowledge. This study specifically evaluates the efficacy of 1% metformin combined with DFDBA in periodontal regeneration, representing a focused inquiry into innovative treatment methods for chronic periodontitis.
3) Relative:
Relative is used to indicate a relationship or comparison between two or more entities. In this study, parameters such as the relative attachment level (RAL) are essential to assess the effectiveness of the treatments. Understanding relative changes provides valuable insights into patient recovery and treatment outcomes.
4) Knowledge:
Knowledge in a scientific context refers to the understanding derived from research findings, contributing to the broader medical field. This study enhances knowledge regarding periodontal regeneration, specifically addressing how metformin interacts with DFDBA, and informs practitioners about potential treatment strategies for chronic periodontitis.
5) Activity:
Activity generally refers to a state of doing something, implying engagement and action. In the context of this study, it pertains to biological activity related to bone regeneration and the osteogenic effects of metformin as compared to standard therapy with DFDBA, highlighting its potential role in improving periodontal outcomes.
6) Dressing:
Dressing is a sterile pad or compress applied to a wound to promote healing and protect against infection. In the study, the use of periodontal dressing post-surgery is crucial for recovery after flap surgery, preventing contamination and aiding in the healing process of periodontal tissue.
7) Disease:
Disease signifies any abnormal condition affecting the body or mind. In this case, it focuses on periodontal disease, a common condition leading to tissue destruction and tooth loss. Understanding its implications drives research toward innovative treatments, such as the potential benefits of metformin in regenerative periodontal therapy.
8) Hygiene (Hygienic):
Hygiene relates to practices promoting health and preventing disease, crucial in dental care. In the study, maintaining oral hygiene is essential for minimizing plaque and gingival indices, which directly influence postoperative outcomes. It highlights the importance of patient responsibility in successful periodontal treatment outcomes.
9) Water:
Water is essential for life and plays a vital role in health and hygiene. In the context of the study, it relates to the preparation of metformin gel, emphasizing the necessity of clean water in healthcare settings. Adequate hydration is also crucial for overall physiological processes in healing.
10) Rules:
Rules refer to established guidelines that govern conduct. In research, they ensure ethical standards and methodological rigor. In this study, adherence to rules like the CONSORT guidelines for randomized controlled trials ensures that the findings are reliable, valid, and can be replicated in clinical practice to advance treatment strategies.
11) Cina:
China is mentioned in connection with materials used in the study, such as specific devices and equipment for dental procedures. The context suggests a global aspect of research, where equipment and methodologies may derive from diverse international sources, influencing practices and innovations in healthcare settings worldwide.
12) Line:
Line typically indicates a boundary or connection. In this research, it may refer to the delineation between different study groups or treatment protocols. Establishing clear lines in methodology helps maintain the integrity of clinical trials, ensuring precise comparisons and interpretations of outcomes among varying treatment approaches.
13) Post:
Post signifies after or following. In research, it often refers to evaluations made after a treatment has been administered, like postoperative assessments of clinical parameters at intervals of 3, 6, and 9 months, critical for understanding the long-term effects of the interventions tested in the study.
14) Discussion:
Discussion in research serves as a reflective analysis of the findings, offering interpretations, comparisons with existing literature, and implications for future research. It contextualizes results to previous studies while addressing limitations. For this study, it is crucial for situating the outcomes of metformin's use in periodontal therapy.
15) Antibiotic (Antibacterial):
Antibiotic refers to a class of medications used to treat bacterial infections. In the study's postoperative care, antibiotics are prescribed to prevent infections post-surgery, illustrating the importance of comprehensive treatment plans in managing periodontal disease and optimizing healing protocols following invasive procedures.
16) Medicine:
Medicine encompasses the science and practice of diagnosing, treating, and preventing illness. In this study, it intersects with the exploration of metformin, a medication traditionally used for diabetes, indicating its potential applications beyond diabetes in periodontal regenerative procedures, expanding the utility of established medications.
17) Pregnant:
Pregnant refers to the condition of carrying offspring within the uterus. In this study, pregnant individuals are excluded from participation due to potential risks associated with surgical interventions and medication effects on fetal development. This exclusion criterion underscores the importance of patient safety and ethical considerations in clinical research.
18) Incision:
Incision denotes a surgical cut made in the body. In the study, proper incisions are crucial for exposing the area requiring treatment during periodontal surgery. Surgical technique impacts healing and outcomes, emphasizing the importance of skilled execution during invasive dental procedures in achieving optimal results.
19) Nature:
Nature signifies the inherent characteristics of something. In this context, it may refer to the biological mechanisms influencing periodontal healing and regeneration. Understanding the nature of periodontal disease and the biological impact of treatments is fundamental in developing successful therapeutic interventions for effective regeneration.
20) Powder:
Powder indicates a form of substance that is finely ground into tiny particles. In this study, terms like 'gellan gum powder' relate to the formulation of the metformin gel. The physical form of materials used in dental treatments can greatly influence their efficacy in biological applications, such as regenerative procedures.
21) Kappa:
Kappa can denote a variety of concepts but here may refer to Kappa levels in statistical analysis or differentiation regarding biological processes. In the context of osteoclast differentiation, it may relate to specific signaling molecules. Precision in understanding these factors is crucial for interpreting treatment effects and improvements in patient outcomes.
22) India:
India is mentioned as the location where the clinical trial was registered and conducted. This emphasizes the geographical context and regional approach to dental research. It highlights contributions from diverse cultural and medical backgrounds toward global understanding of periodontal health and innovative treatment practices, such as the application of metformin.
23) Tata:
Tata relates to Tata Memorial Hospital Tissue Bank, indicating a source of biological materials used in the study, such as demineralized freeze-dried bone allograft (DFDBA). Recognizing established institutions like Tata reflects the collaborations in research that enhance the quality and availability of materials for clinical investigations.
24) Silk:
Silk indicates the material used in sutures during the surgical procedure outlined in the study. The choice of suturing materials is critical for postoperative healing and minimizing complications, reflecting on the broader aspect of selectivity in surgical materials that ensures successful outcomes in periodontal treatments.
25) Viru:
Viru could reference viral infections or health issues associated with them; however, in the context of this study, it likely symbolizes the importance of monitoring systemic and infectious factors that could affect healing outcomes in periodontal disease management. Understanding the implications of viral conditions guides comprehensive patient assessments.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Study of bone allograft with metformin for periodontal defects.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Informed consent, Statistical analysis, Randomized controlled trial, Clinical trial, Periodontal disease, Statistically significant improvement, Chronic periodontitis, Probing pocket depth, Clinical parameter, Randomized assignment, Relative attachment level, Helsinki Declaration, Periodontal dressing, Intrabony defect, Postoperative instructions, Crestal bone loss, Demineralized freeze-dried bone allograft, Radiographic parameter, Detailed treatment plan, Split-mouth trial.