Gingival hyperplasia: An initial oral manifestation of acute myeloid leukemia
Journal name: Journal of Indian Society of Periodontology
Original article title: Gingival hyperplasia: An initial oral manifestation of acute myeloid leukemia
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:
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Jitendra Sharan, Sonali Mohapatra, Gaurav Chhabra, Somanath Padhi, Sandhya Biswal, Uday Hemant Barhate, Ashok Kumar Jena
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Gingival hyperplasia: An initial oral manifestation of acute myeloid leukemia
Year: 2023 | Doi: 10.4103/jisp.jisp_54
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
This case report emphasizes the critical role of oral health-care professionals in recognizing early signs of systemic diseases, particularly acute leukemia. A young female patient, aged 11, presented with notable oral symptoms including gingival overgrowth, bleeding, and systemic signs such as fatigue and weight loss. Upon detailed examination and diagnostic workup, including a complete blood count and bone marrow analysis, a diagnosis of acute myeloid leukemia (AML) was established. The report illustrates the importance of early detection of systemic diseases through oral manifestations, highlighting how these symptoms can precede more prominent systemic indicators.
Importance of Early Diagnosis of Oral Manifestations
One of the key takeaways from this case is the significant correlation between oral symptoms and systemic diseases, notably in pediatric patients with leukemia. Gingival overgrowth and bleeding can be indicative of underlying hematologic disorders, such as leukemia. The patient in this report exhibited rapid gingival enlargement, prompting an investigation that confirmed the presence of leukemic infiltration. This emphasizes how oral signs, such as unexplained gingival bleeding or enlargement without associated poor oral hygiene, can be initial indicators of serious systemic conditions. Oral health-care professionals play a pivotal role in recognizing these potential warning signs, allowing for timely referrals and management of underlying diseases.
Conclusion
This case serves as a reminder to healthcare providers of the importance of being vigilant about oral manifestations as potential indicators of systemic illnesses. The findings underscore the necessity for interdisciplinary approaches in patient care, especially when oral symptoms are the primary presenting factors. Effective management of conditions such as gingival enlargement secondary to leukemia can be achieved through proper chemotherapy protocols. Overall, this report underlines the need for oral health-care professionals to conduct preliminary diagnostic investigations, facilitating early diagnosis and intervention to enhance patient outcomes.
FAQ section (important questions/answers):
What are the early oral manifestations of systemic diseases?
Systemic diseases can often present with early oral symptoms like gingival overgrowth, bleeding, and other changes, which can be crucial for early diagnosis and treatment planning.
What was the main complaint of the 11-year-old patient?
The 11-year-old girl presented with generalized gingival enlargement, bleeding, weakness, and recent weight loss, indicating an underlying systemic issue, confirmed later as acute myeloid leukemia.
How is acute myeloid leukemia confirmed as a diagnosis?
Acute myeloid leukemia is diagnosed through a combination of blood tests, bone marrow examinations, flow cytometry immunophenotyping, cytogenetics, and molecular studies.
What treatment did the patient receive for her leukemia?
The patient was treated with induction chemotherapy according to established protocols, which included medications like cytarabine and daunorubicin.
Why is it important for dental professionals to recognize systemic diseases?
Dental professionals should recognize signs of systemic diseases, as oral symptoms can be the initial manifestation, allowing for early diagnosis and better patient outcomes.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Gingival hyperplasia: An initial oral manifestation of acute myeloid leukemia”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
Table refers to a structured arrangement of data, typically used to summarize information for easy reference. In the context of medical articles, tables present key findings readily, such as laboratory results or patient demographics, facilitating the comparison and analysis of clinical data crucial to making informed decisions in healthcare.
2) Blood:
Blood is a vital fluid in the human body responsible for transporting oxygen, nutrients, hormones, and waste products. In the context of leukemia, blood tests reveal critical information about blood cell counts and the presence of abnormal cells, helping in the diagnosis and monitoring of hematological conditions.
3) Chemotherapy:
Chemotherapy is a treatment method that utilizes powerful drugs to kill rapidly dividing cancer cells. In acute leukemia cases, it serves as the primary treatment approach, aiming to induce remission. Understanding chemotherapy's effects and management of side effects, such as immunosuppression and infections, is essential for patient care.
4) Disease:
A disease is a pathological condition characterized by a set of signs and symptoms affecting the body's normal functioning. Recognizing disease early, particularly systemic diseases like leukemia through oral manifestations, enhances the chance of effective treatment and improved patient outcomes.
5) Bleeding:
Bleeding in medical terms refers to the loss of blood, which can be internal or external. In hematological disorders like leukemia, bleeding is a significant clinical symptom due to thrombocytopenia, necessitating urgent medical evaluation and intervention to prevent life-threatening complications.
6) Rules:
Rules establish systematic protocols or guidelines that ensure consistency and safety in clinical practice. In hematology, following established rules regarding diagnostics and treatment regimens helps clinicians provide standardized care, reducing variability and improving patient outcomes in complicated conditions like leukemia.
7) Sign:
A sign is a clinical indicator observable by a clinician, which may suggest a medical condition. In acute leukemia cases, signs include oral manifestations, such as gingival bleeding or hyperplasia, which can lead healthcare professionals to initiate further diagnostic investigations for systemic diseases.
8) Accumulation (Accumulating, Accumulate):
Accumulation in medicine refers to the buildup of substances, such as abnormal cells in the bone marrow. In leukemia, there is an accumulation of leukemic blasts, leading to decreased normal blood cell production, resulting in significant clinical complications such as anemia, bleeding, and susceptibility to infections.
9) Observation:
Observation is a critical component in clinical practice where clinicians assess and monitor patients. Accurate observation of symptoms, such as gingival overgrowth in leukemia cases, is vital for early diagnosis and timely initiation of appropriate treatments, contributing to better patient management.
10) Antibiotic (Antibacterial):
Antibiotics are medications used to treat bacterial infections. In patients undergoing chemotherapy, such as those with leukemia experiencing febrile neutropenia, prophylactic or therapeutic antibiotics are crucial to prevent or treat infections that arise due to compromised immune systems following treatment.
11) Knowledge:
Knowledge refers to the understanding and awareness of medical principles and practices. For healthcare professionals, having extensive knowledge of systemic diseases, such as recognizing oral manifestations of underlying conditions, is pivotal in early diagnosis and coordination of multidisciplinary care.
12) Arrow:
Arrow is commonly used to refer to graphical representations or indicators in medical literature, often symbolizing direction or progression, such as in flow diagrams illustrating disease pathways or treatment protocols. Accurate representation aids in better understanding clinical processes, enhancing the decision-making framework in healthcare.
13) Thalassemia:
Thalassemia is a hereditary blood disorder characterized by abnormal hemoglobin production, leading to anemia. It is significant in oncohematological contexts, as healthcare providers should differentiate between various hematological diseases, including thalassemia and leukemia, to establish accurate diagnoses and optimal treatment plans.
14) Discussion:
Discussion in medical articles provides analysis and interpretation of findings. This section critically examines results, contextualizes them within existing literature, and suggests implications for practice, enhancing the understanding of clinical phenomena and guiding future research.
15) Evolution:
Evolution in a medical context refers to the progression or development of a disease over time. Understanding the evolution of systemic diseases helps healthcare providers anticipate complications, optimize treatment strategies, and improve patient prognosis through timely interventions.
16) Stripling:
Stripling refers to a young person or adolescent. In medical literature, it highlights the importance of recognizing clinical conditions specific to pediatric populations, such as the unique presentations of diseases like leukemia in younger patients, emphasizing tailored approaches to diagnosis and treatment.
17) Relative:
Relative pertains to relationships between variables in a medical context, such as the relative risk of complications associated with a condition. Understanding relative factors assists healthcare professionals in evaluating the likelihood of disease development or treatment response in patients and guiding clinical decisions.
18) Account:
Account refers to detailed reporting or explanation of a patient's medical history or clinical findings. In healthcare, providing an accurate account of symptoms and treatments is essential for effective patient management and ensuring continuity of care within multidisciplinary teams.
19) Hygiene (Hygienic):
Hygiene encompasses practices that promote health through cleanliness and infection prevention. In dentistry, maintaining good oral hygiene is essential, especially for patients with systemic diseases, as poor hygiene can exacerbate conditions like gingival hyperplasia, complicating treatment outcomes.
20) Wisdom:
Wisdom in medical practice refers to the ability to make sound decisions based on knowledge and experience. For healthcare professionals, exercising wisdom in diagnosing complex conditions and understanding the interplay between oral and systemic health can significantly impact patient outcomes.
21) Cancer:
Cancer is a broad term for diseases characterized by uncontrolled cell growth. Understanding the types of cancer, especially hematological malignancies like leukemia, is crucial for healthcare professionals in diagnosis and implementing appropriate treatment measures, which can include chemotherapy, aimed at inducing remission.
22) Reason:
Reason in a clinical context refers to the rationale behind medical decisions. Understanding the reasons for particular therapeutic approaches ensures that healthcare providers remain informed and responsive to the evolving needs of patients, particularly in complex cases involving systemic diseases.
23) Fever:
Fever is an elevated body temperature often indicative of infection or other inflammatory processes. In oncology, the presence of fever in patients undergoing chemotherapy, such as those with leukemia, necessitates careful monitoring and management to mitigate risks associated with febrile neutropenia.
24) Death:
Death signifies the cessation of biological functions in a living organism. In clinical settings, understanding the risk of death related to untreated conditions like acute leukemia underlines the critical importance of early diagnosis and appropriate intervention to improve survival rates.
25) Study (Studying):
A study refers to research conducted to explore a specific hypothesis or question in medicine. Research studies are vital in understanding disease mechanisms, evaluating treatment efficacy, and informing clinical practice based on evidence, ultimately leading to improved patient care.
26) Post:
Post refers to the period after a procedure or treatment. Monitoring patients post-chemotherapy, particularly regarding recovery and potential complications, is crucial for ensuring successful outcomes and guiding ongoing care in conditions like leukemia.
27) Drug:
Drug refers to a chemical substance used for medical treatment. In oncology, drugs are critical in chemotherapy regimens to target cancerous cells, and understanding their mechanisms, side effects, and interactions is vital for optimizing therapeutic strategies and patient safety.
28) Pur:
Poor describes inadequate conditions or circumstances, such as poor oral hygiene, which can adversely affect health outcomes. Recognizing poor health behaviors, especially in patients with systemic diseases like leukemia, enables healthcare providers to implement strategies for improvement.
29) Life:
Life signifies the state of being alive and is of utmost value in healthcare. Enhancing the quality of life for patients with cancer and systemic diseases is a primary objective for healthcare professionals, encompassing effective diagnosis, treatment, and supportive care to promote well-being.
Other Health Sciences Concepts:
Discover the significance of concepts within the article: ‘Gingival hyperplasia: An initial oral manifestation of acute myeloid leukemia’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:
Anemia, Peripheral Blood Smear, World Health Organization, Complete blood count, Thrombocytopenia, Gingival hyperplasia, Febrile neutropenia, Acute myeloid leukemia, Bone marrow examination, Hematological Disorder, Induction chemotherapy, Oral Health Care Professionals, Gingival overgrowth, Acute leukemia, Oral manifestation, French-American-British classification, Chemotherapy protocol.