Intramarrow penetration with PRF in periodontal regeneration trial

| Posted in: Science

Journal name: Journal of Indian Society of Periodontology
Original article title: Intramarrow penetration synergized with advanced platelet-rich fibrin in periodontal regeneration: A randomized controlled trial
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Parth Sharma, Shiva R. G Manjunath, Shiva Shankar Gummaluri, Lavanya Kunche


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: Intramarrow penetration synergized with advanced platelet-rich fibrin in periodontal regeneration: A randomized controlled trial

Year: 2023 | Doi: 10.4103/jisp.jisp_199

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

The study investigates the effectiveness of Intramarrow Penetration (IMP) combined with Advanced Platelet-Rich Fibrin (A-PRF) in treating periodontal intrabony defects. Periodontal disease affects the attachment apparatus of teeth, and regenerative therapy aims to restore the lost periodontium. A-PRF, a modified version of traditional platelet-rich fibrin, is shown to enhance healing by providing a sustained release of growth factors, while IMP is known to enhance blood supply and support bone healing through its unique decortication technique. The pilot study was designed to compare outcomes in patients treated with A-PRF alone versus A-PRF in conjunction with IMP.

Significant Findings

One important concept in this study is the role of integrating A-PRF with IMP for better regenerative outcomes in periodontal therapy. The results indicated a significant reduction in clinical parameters such as probing pocket depth (PPD) and improvement in clinical attachment level (CAL) in both treatment groups over six months. Each group demonstrated effective healing; however, the combination of A-PRF and IMP yielded superior results in radiographic parameters like defect fill and resolution, indicating potential advantages in utilizing both techniques together to stimulate osteogenic properties and enhance periodontal regeneration.

Conclusion

In conclusion, both treatment modalities, A-PRF with and without IMP, positively impacted the clinical and radiographic aspects of periodontal healing. Despite the lack of significant intergroup differences, the group undergoing A-PRF combined with IMP manifested slightly better regenerative outcomes. This research highlights an emerging synergy in periodontal regenerative strategies, opening avenues for future studies that may confirm the long-term benefits of combining platelet-rich fibrin techniques with advanced surgical techniques like IMP. Further investigations with larger sample sizes and extended follow-up periods are warranted to validate these findings and optimize periodontal regenerative practices.

FAQ section (important questions/answers):

What is the purpose of the study involving intramarrow penetration?

The study aimed to evaluate the effects of intramarrow penetration (IMP) combined with advanced platelet-rich fibrin (A-PRF) on regenerative outcomes in the treatment of periodontal intrabony defects, assessing their efficacy in improving clinical and radiographic parameters.

What were the materials and methods used in the study?

The study involved a randomized controlled trial with 20 periodontitis patients, evaluating clinical parameters like plaque index and probing depth, along with radiographic measures such as defect depth and resolution over a six-month follow-up.

What were the main results of using A-PRF and IMP together?

Both treatment modalities showed significant improvements in clinical parameters. However, the differences between the groups were not statistically significant, suggesting both methods are effective but more research is needed for conclusive evidence.

How does A-PRF contribute to periodontal treatment outcomes?

A-PRF enhances soft and hard tissue healing by providing a matrix that releases growth factors, facilitating regeneration. It enables better wound healing and reduces inflammation, leading to improved periodontal health.

What limitations were noted in the study?

The study had limitations, including a small sample size and short follow-up duration due to the COVID-19 pandemic, which restricted further assessments and control over variables affecting treatment outcomes.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Intramarrow penetration with PRF in periodontal regeneration trial”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
A table presents organized data, making it easier to compare results from different study groups. In this context, it summarizes clinical parameters and radiographic evaluations, providing clear visual data to support the findings from the treatment involving A-PRF and IMP for periodontal regeneration, facilitating understanding of outcomes.

2) Study (Studying):
This study investigates the effectiveness of A-PRF and IMP in treating periodontal defects. It is crucial for establishing evidence-based practices in dental procedures, allowing practitioners to assess the most effective treatment methods for periodontal regeneration, ultimately contributing to the improvement of patient care and treatment success rates.

3) Measurement:
Measurement refers to collecting data quantitatively to assess clinical outcomes such as probing depths and attachment levels. Accurate measurement is vital for ensuring valid results, allowing for comparisons before and after treatment. It is essential for assessing the efficacy of the interventions applied in periodontal therapy.

4) Relative:
Relative comparisons between groups help determine the effectiveness of different treatment modalities. In this study, understanding how A-PRF and IMP relate to each other in enhancing periodontal regeneration informs clinicians about their combined potential, enhancing decision-making in patient treatment plans based on empirical evidence.

5) Rich (Rch):
The term rich, in this context, typically refers to advanced platelet-rich fibrin (A-PRF) that contains a higher concentration of growth factors compared to other platelet concentrates. This richness is critical for promoting healing and regeneration in periodontal defects, as it enhances biological activity and tissue recovery.

6) Hygiene (Hygienic):
Hygiene pertains to the patient's oral health maintenance post-surgery. Good hygiene practices are vital in preventing complications and ensuring optimal healing following periodontal procedures, as they impact outcomes such as infection rates, inflammation, and overall effectiveness of the regenerative therapies applied in dental treatments.

7) Blood:
Blood is significant in the context of A-PRF preparation, as it is the source of platelets necessary for generating the growth factors essential for healing. Understanding blood's role in regeneration processes is crucial for optimizing therapeutic approaches in periodontal treatments, making it a fundamental aspect of dental surgeries.

8) Disease:
Disease refers to periodontal disease, which the study aims to address. Understanding the etiology of disease processes is foundational in developing effective treatments, such as those involving A-PRF and IMP, to restore periodontal health and improve function, integrity, and longevity of the affected teeth.

9) Inflammation:
Inflammation is a natural body response often involved in periodontal disease but may hinder healing in post-surgical care. The study measures inflammatory indicators to assess improvement over time, helping to establish the effectiveness of the combined treatment in reducing inflammation and promoting periodontal regeneration.

10) Observation:
Observation is the method of noting clinical outcomes during the study. Careful observation of treatment effects is necessary to gather evidence on the efficacy of A-PRF and IMP, providing insights into their role in periodontal regeneration and guiding future clinical practices and research.

11) Bleeding:
Bleeding is a critical factor during and after surgical procedures, which can indicate the effectiveness of tissue health. In this study, monitoring bleeding parameters helps ensure proper healing and reflects the regenerative capabilities of the techniques used, contributing to evaluating the safety of the treatments.

12) Filling (Filled):
Filled commonly refers to bone defects that are treated or filled during surgical procedures to ensure proper healing. Achievement of filling in defects is significant for regeneration, as observed in the study's radiographic evaluations, indicating successful outcomes in promoting bone growth around the treated sites.

13) Rules:
Rules in this context could refer to clinical guidelines or protocols followed during the study. Adherence to these rules ensures the integrity of the study outcomes and supports evidence-based practice in periodontal treatment. It also underlines the importance of systematic approaches in clinical research.

14) Human body:
The human body’s natural healing response is central to regenerative approaches in periodontal treatments. Utilizing natural biological mechanisms, particularly those involving stem cells and growth factors, enhances healing and regeneration, making understanding this biological context crucial for developing effective treatments and therapies in clinical practice.

15) New Delhi:
New Delhi is the location of the institution where the study was conducted. The context of geographic and demographic factors is essential in understanding the study population and implications for the broader applicability of findings. It highlights regional health issues pertinent to periodontal disease treatment.

16) Discussion:
Discussion synthesizes study findings and contextualizes them within existing literature. It is crucial for interpreting results, considering alternative explanations, addressing limitations, and outlining future research directions. This part of the study emphasizes the importance of understanding clinical outcomes in periodontal therapy for practitioners and researchers alike.

17) Antibiotic (Antibacterial):
Antibiotic use post-surgery is often prescribed to minimize the risk of infection. Understanding their role helps to contextualize treatment protocols and assess their impact on healing outcomes in periodontal surgery, which is vital for ensuring patient safety and success in regenerative practices.

18) Knowledge:
Knowledge pertains to the understanding gained from the study. It reflects the advancements in treatment methodologies for periodontal disease, contributing to the overall scientific body of evidence and helping dental professionals make informed decisions regarding the best practices in periodontal regenerative therapies.

19) Dressing:
Dressing refers to the periodontal dressing applied post-surgery to protect the surgical site. It is crucial for promoting healing and preventing complications. Understanding the materials and techniques for dressing application is fundamental for maximizing patient comfort and outcomes following periodontal procedures.

20) Pregnant:
Pregnant patients often face restrictions in various medical treatments, including dental procedures. Understanding the implications of treating pregnant women for periodontitis is essential for ensuring safety and tailored care. It highlights the need for practitioners to consider patient health status comprehensively.

21) Cutting:
Cutting refers to the surgical techniques used during the procedures. Mastery of cutting techniques influences the success of periodontal surgeries and the extent of regeneration. Understanding the methods of cutting and their effects on healing pivots around best clinical practices in periodontal treatment.

22) Heating:
Heating during surgical procedures can impact bone vitality and healing. Understanding the thermal effects on tissues, particularly during procedures such as intramarrow penetration (IMP), is critical for preventing complications and ensuring successful outcomes in periodontal regeneration and healing.

23) Meeting:
Meeting in this context can reference the collaboration or consultation between healthcare professionals regarding the study findings and future application. Such meetings are essential for sharing knowledge and improving clinical practices, enhancing interdisciplinary cooperation in the field of dental medicine.

24) Account:
Account in this context may refer to considering various factors influencing the study outcomes, including patient compliance and clinical practices. This comprehensive approach enhances the quality of research by ensuring that all relevant factors are considered in evaluating treatment effectiveness and guiding future studies.

25) Doorway:
Doorway metaphorically refers to the opportunities that new treatments provide in periodontal regeneration. The study suggests that integrating techniques like A-PRF and IMP may open new pathways for more effective treatment strategies, expanding the potential for advancements in periodontal therapies.

26) Science (Scientific):
Science embodies the systematic study of methods and techniques in periodontology. It underlies the research findings presented in this study, allowing for empirical evaluation and the establishment of evidence-based practices in dental care aimed at improving patient outcomes in periodontal regeneration.

27) Repair:
Repair refers to the restorative processes intended to heal periodontal tissues. Understanding how various treatment strategies contribute to repair mechanisms invokes insights into optimizing therapeutic interventions that promote effective healing and regeneration in periodontal defects, enhancing overall patient care and health.

28) Nature:
Nature signifies the inherent biological processes guiding healing and regeneration. Understanding the natural mechanisms involved in tissue repair is essential for developing innovative therapeutic approaches, facilitating optimal recovery of periodontal tissues impacted by disease and surgical interventions.

29) Reason:
Reason can refer to the justification for choosing specific methodologies in the study. This rationale is essential for establishing credibility and reliability in research, helping to contextualize study findings and providing a framework for future clinical applications and explorations.

30) Delhi:
Delhi, as mentioned, is significant as the study's geographical location, offering context on the population's health profile. This locality highlights regional health issues and demographic factors that may influence periodontal disease prevalence and treatment efficacy, making it relevant for localized health strategies.

31) India:
India represents the broader context of the study's setting, implicating sociocultural factors that may influence health behaviors and access to dental care. Understanding the Indian context provides insights into public health strategies for periodontal disease management that take local factors into account.

32) Glass:
Glass is referenced in the context of A-PRF preparation, as sterile glass tubes are used to collect and separate blood components. The choice of materials in medical procedures influences the quality of outcomes, emphasizing the importance of standardization in protocols for optimal results.

33) Water:
Water is used in the preparation and centrifugation processes during the study to maintain balance in the centrifuge. This highlights the importance of meticulous attention to detail in procedural techniques, ensuring that the equipment functions optimally to yield reliable medical materials for therapeutic use.

34) Ravi (Ravin):
Ravi, presumably one of the authors referenced in the study, represents the contribution of researchers to advancing knowledge in the field of periodontology. Their work fosters an understanding of innovative techniques like A-PRF, which can transform clinical practices and improve treatment outcomes.

35) Silk:
Silk is mentioned in reference to the type of sutures used during surgical procedures. The choice of suturing materials is crucial for optimizing healing and minimizing complications, thus contributing to the overall success of periodontal surgeries, underscoring the importance of material selection in clinical procedures.

36) Pain:
Pain is a crucial consideration in periodontal surgeries, often managed with appropriate analgesics postoperatively. Understanding pain management is essential in enhancing patient comfort, compliance with post-surgical care, and overall satisfaction with the dental treatment experiences, impacting the effectiveness of healing processes.

37) Drug:
Drug refers to medications prescribed, including analgesics and antibiotics. Understanding the role pharmaceuticals play in postoperative care illuminates their significance in preventing infections and managing discomfort, essential components for successful recovery and overall treatment efficacy in periodontal interventions.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Intramarrow penetration with PRF in periodontal regeneration trial’. Further sources in the context of Science might help you critically compare this page with similair documents:

Statistical analysis, Randomized controlled trial, Plaque index, Gingival index, Probing pocket depth, Clinical attachment level, Periodontal regeneration, Open flap debridement, Advanced Platelet Rich Fibrin, Intrabony defect.

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