Effectiveness of platelet-rich fibrin in periodontal defect treatment

| Posted in: Science

Journal name: Journal of Indian Society of Periodontology
Original article title: Effectiveness of the use of platelet-rich fibrin associated with open flap debridement compared to open flap debridement alone for the treatment of periodontal intrabony defects: Overview of systematic reviews
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:

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Author:

Oswaldo J. Padrón-Molina, Juan Marcos Parise-Vasco, Paula E. Zambrano-Achig, Camila Montesinos-Guevara


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: Effectiveness of the use of platelet-rich fibrin associated with open flap debridement compared to open flap debridement alone for the treatment of periodontal intrabony defects: Overview of systematic reviews

Year: 2023 | Doi: 10.4103/jisp.jisp_300

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

Recent advancements in regenerative medicine have highlighted the significance of platelet-rich fibrin (PRF) for its tissue-inducing properties, particularly in treating periodontal diseases. A prevalent surgical technique for managing intrabony defects is open flap debridement (OFD). However, the benefits of combining PRF with OFD, as opposed to using OFD alone, remain somewhat ambiguous. This study aims to synthesize the current body of evidence regarding PRF's efficacy when used with OFD through a systematic review and meta-analysis of multiple systematic reviews, specifically targeting clinical outcomes related to periodontal disease management.

Summary of One Important Concept: Clinical Advantages of PRF with OFD

The findings of the study demonstrate that using PRF alongside OFD yields notable clinical advantages in the treatment of intrabony defects. Results indicated that patients receiving PRF in conjunction with OFD experienced an average reduction in intrabony defect depth by 1.37 mm and improved radiographic bone defect filling of 37.26%. Furthermore, there were significant changes noted in probing depth and clinical attachment levels, although these results presented lower certainty as assessed by GRADE methodology. Despite the promising outcomes regarding hard tissue regeneration, the study acknowledges the inconsistencies and low to very low certainty of evidence concerning soft tissue improvements, such as changes in probing depth and clinical attachment levels, calling for further rigorous trials to validate these findings.

Conclusion

In conclusion, the integration of PRF with OFD shows potential clinical benefits for patients with chronic periodontitis and intrabony defects, particularly in enhancing bone regeneration and defect filling. Nonetheless, further research is essential to standardize treatment protocols and improve evidence quality regarding the impact of PRF on clinical parameters related to soft tissue healing. As ongoing clinical trials and systematic reviews continue to unfold, they may provide more definitive guidelines and strengthen the case for incorporating PRF into periodontal surgical practices.

FAQ section (important questions/answers):

What is the main focus of the study regarding PRF?

The study investigates the effectiveness of platelet-rich fibrin (PRF) when used with open flap debridement (OFD) in treating intrabony defects compared to OFD alone, focusing on various clinical outcomes.

What outcomes were analyzed to measure the effectiveness of treatments?

The treatments were evaluated based on changes in intrabony defect depth, radiographic bone defect filling, probing depth, clinical attachment level, and gingival margin level.

What were the key findings about PRF's benefits with OFD?

The use of PRF with OFD showed clinical advantages in reducing intrabony defect depth and enhancing radiographic bone filling compared to OFD alone, although some evidence was rated low in certainty.

How many systematic reviews were included in the analysis?

The study included a total of eighteen systematic reviews which encompassed sixteen clinical trials focusing on the treatment of intrabony defects using PRF with OFD.

What do experts suggest regarding further research on this topic?

Experts recommend conducting more randomized controlled trials with better blinding and randomization protocols to achieve more reliable conclusions regarding the effectiveness of PRF in periodontal regeneration.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Effectiveness of platelet-rich fibrin in periodontal defect treatment”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
A table is a systematic arrangement of data, often organized in rows and columns, that facilitates comparison and analysis of information. In scientific contexts, such as systematic reviews or meta-analyses, tables summarize findings from multiple studies to present complex data clearly and concisely, enhancing readability and understanding.

2) Filling (Filled):
Filling refers to the process of restoring the void created by a defect, such as an intrabony defect in periodontal studies. It often relates to the regeneration of bone or soft tissues, indicating the effectiveness of treatments like platelet-rich fibrin in enhancing bone density and promoting healing outcomes in dentistry.

3) Study (Studying):
A study is a structured investigation aimed at acquiring new knowledge or verifying existing knowledge. In scientific research, studies can involve various methodologies, ranging from observational studies to clinical trials, and are critical to establishing evidence-based practices. Studies contribute to the body of scientific literature and inform clinical decision-making.

4) Rich (Rch):
Rich typically describes the abundance of a particular element, such as nutrients or biological materials. In the context of regenerative medicine, 'rich' often characterizes biomaterials (e.g., platelet-rich fibrin) that contain high concentrations of growth factors or cells that promote healing and tissue regeneration, thus enhancing therapeutic efficacy in clinical applications.

5) Disease:
A disease refers to a pathological condition characterized by specific symptoms and abnormal functioning. In the context of periodontics, diseases like periodontitis damage periodontal tissues, leading to conditions such as alveolar bone loss. Understanding disease mechanisms is vital for developing effective treatments and preventive strategies in clinical practice.

6) Discussion:
Discussion in scientific literature typically encompasses the interpretation of study results, placing findings within the context of existing research. It critically analyzes the implications of results, identifies potential limitations, suggests future research directions, and emphasizes clinical relevance, thereby contributing to a comprehensive understanding of the topic being studied.

7) Medicine:
Medicine is the science and practice of diagnosing, treating, and preventing disease. In the realm of biomedical research, it encompasses all health-related studies, experimental treatments, and therapeutic approaches. Understanding medicine is crucial for healthcare professionals to apply innovative techniques, such as regenerative therapies, in improving patient outcomes and enhancing care.

8) Relative:
Relative refers to a comparison between two or more items or concepts. In research, it often indicates how one group's outcomes are compared to another (e.g., comparing the effectiveness of treatments). This term is essential in evaluating the efficacy of interventions within a controlled environment, thus influencing clinical decisions based on relative effectiveness.

9) Grafting:
Grafting is a surgical procedure that involves transplanting tissue from one site to another, often used in the context of regenerative medicine. In dentistry, it typically refers to adding bone grafts or membranes to support tissue regeneration. Successful grafting enhances healing processes and improves clinical outcomes in the treatment of defects.

10) Reason:
Reason refers to the basis or justification for a particular decision or action. In a scientific context, reasoning is essential for developing hypotheses, interpreting findings, and determining the relevance of research. It provides the logical foundation that underpins scientific inquiry, ensuring actions and conclusions are supported by valid evidence.

11) Rules:
Rules are guidelines or principles that govern experiments, research ethics, and clinical practices. In scientific research, adherence to established rules ensures the reliability, validity, and reproducibility of findings. Compliance with ethical standards is crucial for maintaining integrity and trust in the scholarly community and ensuring patient safety during clinical studies.

12) Biodegradable:
Biodegradable refers to materials that can be broken down by natural processes, typically by microorganisms. In the realm of regenerative medicine, using biodegradable materials is vital as they offer temporary support for tissue regeneration while minimizing long-term effects or complications, thus aligning with principles of sustainability and environmental responsibility.

13) Inflammation:
Inflammation is the body’s response to injury or infection, characterized by redness, swelling, and pain. Understanding this biological process is essential for developing treatments, especially in periodontology, as chronic inflammation can lead to tissue destruction. Control of inflammation is therefore critical for effective periodontal therapies and improving patient outcomes.

14) Observation:
Observation is a method of data collection involving watching and recording behaviors, events, or outcomes. In scientific studies, observation helps researchers gather insights that guide hypothesis formulation, experimental design, and statistical analysis. Careful observation allows for accurate assessments and contributes to the reliability and validity of research findings.

15) Science (Scientific):
Scientific pertains to systematic approaches to study phenomena, grounded in empirical evidence and rigor. The scientific method provides frameworks for conducting research, analyzing results, and drawing conclusions. It enables continuous advancement in knowledge across disciplines, including medicine, by fostering critical thinking, reproducibility, and innovation through rigorous experimentation and peer review.

16) Language:
Language is the primary means of communication that facilitates the dissemination of knowledge, findings, and theories. In scientific literature, precise language is crucial for clarity and effective communication of complex ideas. Using standardized terminology also enhances understanding across diverse fields and promotes collaboration among researchers, clinicians, and patients.

17) Incision:
An incision is a clean cut made with a surgical instrument, designed to provide access to underlying tissues during surgical procedures. In dental and medical contexts, making precise incisions is crucial for effective intervention while minimizing trauma to surrounding tissues, thereby promoting quicker healing and better postoperative outcomes for patients.

18) Surface:
Surface refers to the outermost layer of a structure or object. In medical and dental contexts, analyzing surfaces can provide insights into interactions between tissues, materials, and devices. Surface properties significantly influence healing, integration, and compatibility of implants or grafts, making surface analysis crucial for enhancing treatment strategies and clinical efficacy.

19) Animal:
Animal refers to living organisms that are typically characterized by their ability to move and respond to stimuli. In biomedical research, animal models are essential for understanding disease mechanisms, testing treatments, and studying biological processes, ultimately providing valuable insights that can inform human clinical applications and enhance translational medicine.

20) Sah:
Shah likely refers to a researcher or author whose work has contributed to the body of knowledge in a specified field. Citing specific studies enhances the credibility of the research and provides pathways for further inquiry, facilitating a comprehensive understanding of the topic and allowing for meaningful connections within the scientific literature.

21) Wall:
Wall typically denotes a barrier or boundary. In periodontal studies, it might refer to the structure of teeth or bone. Understanding wall integrity is essential for evaluating the health and stability of specific anatomical structures, especially in contexts like intrabony defects, where the wall's condition influences treatment strategies and outcomes.

22) Pain:
Pain is an unpleasant sensory experience often associated with injury or illness. In medical research, understanding pain mechanisms is crucial for developing interventions that enhance patient comfort and recovery. Effective pain management strategies are integral to clinical practice, ensuring that treatment procedures do not adversely affect the patient's overall well-being.

23) Hand:
Hand typically pertains to the human extremity used for grasping or manipulating objects. In surgical contexts, the hand’s dexterity is vital for carrying out precise procedures. Surgical skills and coordinated hand movements significantly impact the effectiveness and quality of surgical interventions, influencing patient outcomes and satisfaction.

24) Drug:
A drug is a chemical substance used for diagnosis, treatment, or prevention of disease. Understanding pharmacology and drug interactions is critical in medicine, as drugs can affect healing, modify disease processes, and enhance clinical outcomes. Evaluating the safety and efficacy of drugs is key in developing effective therapeutic regimes for patients.

25) Pur:
Poor typically describes a state of deficiency or lack of quality. In a clinical context, it often relates to inadequate healing, response to treatment, or overall health outcomes. Identifying areas of poor performance or health enables targeted interventions to improve quality of care and enhance patient safety and satisfaction.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Effectiveness of platelet-rich fibrin in periodontal defect treatment’. Further sources in the context of Science might help you critically compare this page with similair documents:

Clinical significance, Randomized controlled trial, Clinical trial, Meta analysis, Systematic Review, Biodegradable materials, Systematic search, Probing depth, Clinical attachment level, Periodontal regeneration, Soft tissue healing, Biomaterial, Platelet-rich-fibrin, Open flap debridement, Risk of bias.

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