Efficacy of amniotic vs. collagen membrane in treating periodontal defects
Journal name: Journal of Indian Society of Periodontology
Original article title: Comparative evaluation of the efficacy of amniotic membrane with collagen membrane along with demineralized freeze-dried bone allograft in the treatment of periodontal intrabony defects – A clinico-radiographic study
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:
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Eiti Agrawal, Rahul Chopra, Swyeta Jain Gupta, Nikhil Sharma, Farheen Khan, Neetika Gupta
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Comparative evaluation of the efficacy of amniotic membrane with collagen membrane along with demineralized freeze-dried bone allograft in the treatment of periodontal intrabony defects – A clinico-radiographic study
Year: 2022 | Doi: 10.4103/jisp.jisp_305
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
The study investigates the efficacy of human-derived amniotic membrane (AM) in conjunction with demineralized freeze-dried bone allograft (DFDBA) for the treatment of periodontal intrabony defects in chronic periodontitis patients. The randomized controlled clinical trial lasted six months, comparing outcomes from AM versus collagen membrane (CM) alongside open flap debridement (OFD) combined with DFDBA, a well-established grafting material. The key parameters evaluated included clinical indices such as plaque index (PI), gingival index (GI), pocket probing depth (PPD), and relative attachment level (RAL), as well as radiographic measures of defect resolution.
Comparative Effectiveness of Amniotic Membrane
The results indicated that both treatments showed statistically significant improvements within each group for clinical parameters and relative intrabony defect component levels over time. Although the findings demonstrated significant reductions in PI, GI, and PPD from baseline to the six-month follow-up, there was no significant difference observed between the two groups when compared to each other. This suggests that AM can serve as a viable alternative to CM in regenerative procedures without compromising patient outcomes. The biological properties of AM, which includes growth factors that can potentially enhance healing and regeneration, were highlighted as a promising aspect of its application in periodontal treatment.
Conclusion
In conclusion, the study supports the notion that AM is a suitable allograft option for regenerative procedures in periodontal therapy, demonstrating comparable effectiveness to CM. While both membranes yielded positive clinical and radiographic outcomes, future research with a longer follow-up period and larger sample sizes is needed to further explore the healing patterns and long-term benefits associated with AM. The potential advantages of AM, such as its enhanced biological activity and diverse characteristics, suggest it could play a significant role in advancing periodontal regenerative therapies.
FAQ section (important questions/answers):
What was the objective of the research study?
The study aimed to evaluate and compare the clinical effectiveness of amniotic membrane (AM) and collagen membrane (CM) when used with open flap debridement (OFD) and demineralized freeze-dried bone allograft (DFDBA) in treating periodontal intrabony defects.
What clinical parameters were measured during the study?
The clinical parameters included plaque index (PI), gingival index (GI), pocket probing depth (PPD), and relative attachment level (RAL), which were evaluated at baseline, 3 months, and 6 months post-treatment.
What were the significant findings of the study?
Both treatment groups showed significant improvements in clinical parameters from baseline to 6 months. However, there were no statistically significant differences between the groups concerning any clinical or radiographic outcomes.
What are the implications of using amniotic membrane?
Amniotic membrane can be considered a promising alternative to collagen membranes for regenerative procedures in periodontal treatment, due to its biologically active properties and potential benefits for healing.
What limitations were noted in the study?
Limitations included a short follow-up period, the absence of histological analysis, and the lack of advanced radiographic techniques like cone-beam computed tomography (CBCT) for assessing regeneration.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Efficacy of amniotic vs. collagen membrane in treating periodontal defects”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
The term 'Table' in a scientific context often refers to a structured presentation of data, including statistics and findings from a study. It facilitates easy comparison and interpretation of results, allowing researchers to communicate their findings succinctly and effectively, often outlining key parameters like age, clinical scores, and treatment results clearly for readers to assess experimental outcomes at a glance.
2) Study (Studying):
The word 'Study' refers to a systematic investigation designed to contribute to knowledge in a particular subject area. In this context, it denotes the research investigating the efficacy of amniotic membranes in treating periodontal defects, highlighting the methodology, clinical comparisons, and statistical analyses employed to draw conclusions from observed data and results.
3) Relative:
In research, 'Relative' often pertains to comparisons between two or more groups concerning certain parameters or outcomes. The term signifies how one variable or measurement stands in relation to another, crucial for assessing treatment effectiveness, such as comparing clinical improvements or bone fill levels between two groups treated with different membrane types.
4) India:
The term 'India' denotes the geographical context of the study, influencing aspects like patient demographics and local medical practices. Its inclusion highlights where the research was conducted, emphasizing the cultural, social, and health system characteristics that may affect patient responses, treatment accessibility, and the relevance of findings within a specific healthcare setting.
5) Measurement:
Measurement entails quantifying specific parameters to obtain reliable, verifiable data in research. This may include clinical measurements like probing depth or relative attachment level, crucial for assessing the efficacy of treatments in the study. Accurate measurements ensure reproducibility and allow for clear comparisons between baseline and post-treatment outcomes.
6) Hygiene (Hygienic):
The concept of hygiene in this study relates to oral health practices. Maintaining good oral hygiene is essential for preventing periodontal disease and ensuring the success of surgical interventions. Monitoring hygiene levels through metrics such as plaque index allows researchers to analyze the correlation between oral cleanliness and treatment outcomes after regenerative procedures.
7) Surface:
The term 'Surface' is often used in relation to dental surfaces during surgical procedures. In this context, it refers to the tooth root and surrounding areas involved in the periodontal treatments. Understanding the biological and physical interactions at the surface level is vital for effective healing and regeneration in periodontal surgeries.
8) Filling (Filled):
In this context, 'Filled' pertains to the process of placing biomaterials, like DFDBA, into periodontal defects. This action is crucial for the regenerative therapy discussed in the study. Monitoring how effectively the defect is filled following surgery demonstrates the treatment's success in promoting bone regeneration and periodontal health.
9) Rules:
The word 'Rules' suggests the guidelines and protocols followed during the study to ensure accuracy and integrity. This entails adherence to ethical standards, patient consent requirements, and methodological principles that govern clinical trials, ensuring that the findings are credible and reproducible under controlled conditions.
10) Shali (Sali):
The term 'Sali' likely refers to a researcher or author relevant to the study. Mentioning Sali connects the present work to broader scientific discussions or previously published research, contributing to a cumulative knowledge base. This citation allows for cross-comparison between findings and validation of methodologies used in related studies.
11) Biodegradable:
Biodegradable refers to materials like collagen membranes designed to break down naturally in the body over time. This property is beneficial in medical applications, reducing the need for additional surgical interventions to remove non-resorbable implants. The term emphasizes the advantages of using such membranes in regenerative procedures for enhancing healing processes.
12) Disease:
The term 'Disease' in this context pertains to periodontal disease, a significant focus of the study. It underscores the medical condition being treated, characterized by inflammatory destruction of periodontal tissue. Understanding the pathology of the disease is crucial for evaluating the effectiveness of the regenerative therapies being investigated.
13) Activity:
The term 'Activity' can relate to the biological functions occurring during the study, such as cellular responses to regenerative treatments. In the study, it may refer to the activity of growth factors in amniotic membranes or the cellular responses in periodontal tissues during healing, crucial for assessing treatment efficacy.
14) Dressing:
The term 'Dressing' refers to the protective covering applied post-surgery to aid healing and prevent infection. In this study, it underscores the importance of wound protection after periodontal surgery. Proper dressing techniques contribute to successful healing outcomes by providing both physical barriers and environmental stability during recovery.
15) Kumar:
Kumar might refer to another researcher or author, connecting the current study with past research efforts. Citing Kumar allows for the contextualization of the findings, enriching the study's validity by aligning it with previously established research, expanding the knowledge base, and providing additional insights regarding the treatment approaches discussed.
16) Tata:
The term 'Tata' likely denotes Tata Memorial Hospital in Mumbai, indicating the source of the materials (e.g., amniotic membranes) used in the study. This institution’s name adds credibility, highlighting a collaboration with a reputable healthcare provider known for its contributions to medical research and patient care in India.
17) Silk:
Silk, in the context of this study, likely refers to the type of sutures used in periodontal surgery. The use of silk sutures provides durability and ease of handling, ensuring proper closure during healing. The choice of sutures can influence postoperative outcomes, doing so in alignment with effective surgical methodology.
18) Human body:
The phrase 'Human body' contextualizes the study within biological systems, highlighting that the effects of the regenerative procedures are being examined in human patients. This serves to establish the relevance of the study's findings to real-world clinical applications and the physiological processes underlying healing and recovery following surgical interventions.
19) Antibiotic (Antibacterial):
The term 'Anti-bacterial' pertains to properties that inhibit bacterial growth, which is critical in postoperative healing scenarios. The study explores membranes' characteristics, such as amniotic membranes' potential anti-bacterial properties, which may reduce infection risks post-surgery, significantly influencing treatment success and patient recovery outcomes.
20) Repopulation:
The term 'Repopulation' refers to the process of stem and progenitor cells migrating to the treatment site and proliferating to facilitate tissue regeneration. In regenerative periodontal treatments, effective repopulation plays a vital role in restoring healthy periodontal structures, highlighting the regenerative capabilities of the membranes used in the study.
21) Inflammation:
The word 'Inflammation' relates to the body's response to injury or infection, often detrimental in periodontal disease. The study investigates the roles of various treatments in managing inflammation to promote healing. Reducing inflammation is crucial for enhancing outcomes in periodontal regenerative therapies, ensuring favorable recovery and tissue regeneration.
22) Transformation (Transform, Transforming):
The term 'Transforming' in this context likely refers to the transforming growth factor-beta (TGF-β), a key cytokine involved in cellular growth and differentiation. Understanding how TGF-β influences healing and tissue regeneration underscores its importance in the study, particularly regarding its role in modulating immune responses and promoting bone healing.
23) Discussion:
The 'Discussion' section of a study reflects on the results, comparing findings with existing literature. It interprets the implications of the research, addressing how the findings contribute to the field of periodontal regeneration and sheds light on the limitations of the study, guiding future research directions.
24) Tamilnadu (Tamil-nadu):
Tamil Nadu is a state in India that signifies the regional context of the study, which may influence healthcare practices and patient demographics. The cultural and environmental factors associated with Tamil Nadu may additionally affect treatment responses, providing insights into the regional healthcare landscape related to periodontal diseases.
25) Incision:
The term 'Incision' refers to surgical cuts made to access underlying tissues during periodontal procedures. The precision of incisions is critical for optimal healing and recovery, and understanding the surgical technique is fundamental to the study's aims, emphasizing the importance of careful implementation to achieve favorable outcomes.
26) Grafting:
The term 'Grafting' describes the surgical technique of transplanting tissue to another site, which is essential in regenerative procedures. The study evaluates different grafting materials and techniques used in periodontal interventions, underscoring their significance in promoting healing and bone regeneration within the context of treating periodontal defects.
27) Science (Scientific):
The term 'Science' denotes the systematic enterprise that builds and organizes knowledge through observation and experimentation. In this context, the study represents a scientific investigation into periodontal regenerative practices aimed at improving patient outcomes, illustrating the application of scientific methodologies and principles in clinical research.
28) Nature:
In this context, 'Nature' refers to the inherent characteristics of biological materials, indicating how natural substances like amniotic membranes play a critical role in regenerative processes. Studying the natural properties of these membranes aids in understanding their effectiveness in stimulating healing and their biological compatibility with human tissues.
29) Tamil:
Tamil, a Dravidian language, refers to the cultural and linguistic heritage of the state of Tamil Nadu, emphasizing the importance of local context in understanding patient demographics and healthcare practices. The cultural identity can influence the study's application and relevance within specific communities in the region.
30) Nadu:
The word 'Nadu' means 'land' or 'country' in Tamil, often used when referring to Tamil Nadu. Its inclusion underscores the regional aspect and highlights the specific geographical context of the research, which may have implications on healthcare practices, cultural influences, and patient responses in periodontal treatments.
31) Beta:
The term 'Beta' often relates to the transforming growth factor-beta (TGF-β), a significant cytokine involved in cellular processes. In this study, understanding the role of TGF-β helps highlight its impact on healing and tissue regeneration, vital for assessing the effectiveness of regenerative strategies employed in periodontal therapy.
32) Drug:
The word 'Drug' encompasses pharmacological substances that can influence biological processes; in this context, it may refer to medications impacting periodontal health. Understanding how various drugs can affect inflammation, healing, and overall treatment outcomes is essential for optimizing patient care regimens in periodontal interventions.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Efficacy of amniotic vs. collagen membrane in treating periodontal defects’. Further sources in the context of Science might help you critically compare this page with similair documents:
Statistical analysis, Statistically Significant, Randomized controlled clinical trial, Chronic periodontitis, Oral hygiene instruction, Clinical parameter, Collagen membrane, Open flap debridement, Amniotic membrane, Periodontal dressing, Guided tissue regeneration, Intrabony defect, Bioresorbable membrane, Demineralized freeze-dried bone allograft, Nonresorbable membranes, Relative intrabony defect component level, Millimeter X-ray grid.