Efficacy of Co-enzyme Q10 in treating periodontal diseases.

| Posted in: Science

Journal name: Journal of Indian Society of Periodontology
Original article title: Comparative evaluation of efficacy of topical and intra-sulcular application of Co-enzyme Q10 in the non-surgical treatment of periodontal diseases
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:

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Author:

Parveen Dahiya, Asheema Malhotra, Anushika Pajnoo, Rajan Gupta, Reet Kamal


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: Comparative evaluation of efficacy of topical and intra-sulcular application of Co-enzyme Q10 in the non-surgical treatment of periodontal diseases

Year: 2022 | Doi: 10.4103/jisp.jisp_542

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

Periodontitis is a chronic inflammatory condition affecting the supporting structures of teeth, which can lead to tooth loss and contribute to systemic inflammation. The disease involves the generation of reactive oxygen species (ROS), leading to increased oxidative stress within the periodontal tissues. To counteract oxidative stress, antioxidants such as coenzyme Q10 (CoQ10) have been explored for their potential therapeutic benefits in the management of periodontal disease. The objective of this systematic review was to evaluate the efficacy of topical and intrasulcular applications of CoQ10 as an adjunct to nonsurgical periodontal therapy, based on studies published between 2000 and 2020.

Efficacy of Coenzyme Q10 in Periodontal Therapy

The review included a total of 11 randomized controlled trials that evaluated the use of CoQ10 in patients with periodontal diseases. Results indicated that CoQ10 therapy, when used as an adjunct to scaling and root planing (SRP), demonstrated significant improvements in clinical parameters, including plaque index, gingival index, bleeding on probing, and clinical attachment loss compared to SRP alone. In particular, intrasulcular application of the gel exhibited superior retention and effectiveness in managing the underlying inflammation. This highlights the potential of CoQ10 not only for enhancing the outcomes of traditional periodontal treatments but also for its role as a therapeutic antioxidant in supporting overall periodontal health.

Conclusion

Overall, the findings of this systematic review suggest that adjunctive therapy with CoQ10 offers promising long-lasting therapeutic effects when used in conjunction with SRP, effectively addressing the oxidative stress associated with periodontal disease. The possibility of employing CoQ10 gel as a standalone treatment to complement standard periodontitis management protocols is also indicated. However, further long-term clinical studies are warranted to better understand the optimal dosing and duration of CoQ10 therapy, as well as its comparative effects against other antioxidant agents. Future research should also consider the incorporation of biochemical and microbial analyses for a comprehensive evaluation of the treatment's efficacy.

FAQ section (important questions/answers):

What is the aim of the systematic review on coenzyme Q10?

The systematic review aims to investigate the efficacy of topical and intrasulcular application of coenzyme Q10 as an adjunct to nonsurgical treatment of periodontal disease.

What materials and methods were used in the study?

The review included clinical studies following PRISMA guidelines, focusing on randomized control trials in humans published between 2000 and 2020 that compared coenzyme Q10 with nonsurgical periodontal therapy.

What were the main results of using coenzyme Q10?

The use of coenzyme Q10 as an adjunct to scaling and root planing showed significant improvement in clinical parameters compared to scaling and root planing alone.

What conclusions were drawn regarding coenzyme Q10 treatment?

Adjunctive therapy with coenzyme Q10 provides longer-lasting therapeutic effects and better results, suggesting its potential as a sole agent in standard treatment procedures for periodontitis.

What limitations were noted in the systematic review?

The review acknowledged high risk of bias in some included studies due to selective reporting and incomplete outcome data.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Efficacy of Co-enzyme Q10 in treating periodontal diseases.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
A table is an organized arrangement of data in rows and columns, commonly used in academic research to present findings clearly and efficiently. In this context, tables summarize clinical parameters, treatment outcomes, and participant data, facilitating easy comparison and analysis of results across different studies involving coenzyme Q10 and periodontal disease.

2) Study (Studying):
A study refers to a systematic investigation aimed at acquiring knowledge about a particular subject or phenomenon. In this abstract, studies are essential for validating the efficacy of coenzyme Q10 in periodontal treatment, guiding clinical practice, and informing future research directions by comparing various parameters and results across multiple trials.

3) Disease:
Disease denotes a pathological condition that significantly impairs normal functioning. In the context of the review, periodontitis is discussed as a chronic inflammatory disease affecting oral health, leading to tooth loss and systemic issues. Understanding disease mechanisms allows for developing targeted treatments and interventions to improve patient outcomes.

4) Bleeding:
Bleeding is an important clinical parameter often assessed in periodontal studies to evaluate gum health. The presence of bleeding on probing (BOP) indicates inflammation and disease progression in the context of periodontitis. Monitoring bleeding helps gauge the effectiveness of interventions, such as coenzyme Q10 applications, in vulnerable populations.

5) Sharman (Sarma, Sharma, Sarman):
Sharma refers to one of the researchers whose studies contribute to the body of knowledge regarding coenzyme Q10 and periodontal disease. Their work is acknowledged in the review, emphasizing the significance of their findings and methodologies in understanding the impacts of antioxidant therapies in treating gingivitis and periodontitis.

6) Rules:
Rules are guiding principles or guidelines that govern research conduct. In this study, adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) rules ensures transparency, reliability, and reproducibility, which are crucial for assessing the quality and validity of the systematic review's findings regarding coenzyme Q10.

7) Rupa:
Roopa signifies another contributor to the research landscape on coenzyme Q10. As an author of several relevant studies, the findings from Roopa's research provide insights into the clinical effects of coenzyme Q10 in periodontal therapy, underscoring the collaborative nature of scientific research in expanding therapeutic knowledge.

8) Inflammation:
Inflammation is a biological response of tissues to harmful stimuli, crucial in periodontal disease development. In the context of this research, inflammation drives periodontal tissue destruction, and understanding its role allows for the potential of using coenzyme Q10 as a therapeutic antioxidant to mitigate inflammatory responses during treatment.

9) Species:
Species in the review context refers to various cellular or molecular forms involved in periodontal disease. The term encompasses microorganisms such as bacteria that drive disease processes and reactive oxygen species (ROS) which contribute to inflammation and tissue damage, signifying the complexity of periodontal pathologies and treatment strategies.

10) Tree:
Tree, although generally associated with a plant structure, metaphorically highlights the branching paths of scientific inquiry in periodontal treatment. Each branch (study or therapeutic approach) contributes to the collective understanding of disease management, emphasizing the need for diverse research paths to cover various aspects of periodontal health.

11) Human body:
The human body serves as the fundamental biological context wherein periodontal diseases manifest. Understanding the physiological processes occurring within the human body, including the role of antioxidants like coenzyme Q10, is essential for developing effective interventions that restore health and prevent disease progression in periodontal tissues.

12) Accumulation (Accumulating, Accumulate):
Accumulation indicates the buildup of substances or phenomena, often detrimental in diseases. In periodontitis, the accumulation of plaque and inflammatory mediators exacerbates tissue damage. Recognizing how accumulation contributes to disease severity is vital in designing effective treatment regimens that utilize coenzyme Q10 to counteract such effects and promote healing.

13) Measurement:
Measurement involves quantifying clinical parameters essential for evaluating the effectiveness of treatments in studies. Accurate measurement of indicators like probing depth, plaque, and gingival index provides the data needed to assess the impact of interventions like coenzyme Q10, ensuring that clinical decisions are informed by empirical evidence and statistics.

14) Discussion:
Discussion is a vital component of research that interprets findings, contextualizes results, and addresses implications. In this review, the discussion section analyzes the impacts of coenzyme Q10 in periodontal therapy, allowing authors to articulate conclusions drawn from the studies and indicate future directions for research in dental medicine.

15) Substance:
Substance refers to a physical entity with specific properties and behaviors. In the context of the review, coenzyme Q10 as a substance plays a critical role in oxidative stress management and inflammation. Understanding the biochemical nature of substances allows researchers to explore therapeutic potentials and application methods in clinical practices.

16) Suffering:
Suffering relates to the physical or psychological distress experienced by individuals due to ailments, including periodontal disease. Understanding the suffering linked to periodontal conditions emphasizes the need for effective treatments and therapies, including coenzyme Q10, aiming to alleviate discomfort and improve patients' overall quality of life in dental health contexts.

17) Activity:
Activity denotes any biological process, movement, or function occurring within the body. In periodontal disease, inflammatory activity from immune responses can lead to tissue damage. Understanding activity patterns helps researchers develop therapies targeting specific processes, including the use of coenzyme Q10 to modulate such activities beneficially during treatment.

18) Relative:
Relative pertains to the comparative measure of characteristics or outcomes. In the review, relative comparisons of clinical parameters before and after treatment with coenzyme Q10 give insights into its efficacy versus control groups. Establishing relative differences is essential for determining how well a treatment works in practice, fostering informed clinical choices.

19) Quality:
Quality refers to the standard or grade of treatment, findings, or research. In this systematic review, quality assessment of included studies is crucial to determine the reliability of conclusions drawn regarding coenzyme Q10's effectiveness in periodontal disease. High-quality research ensures that findings are credible and generalizable in clinical settings.

20) Science (Scientific):
Science is a systematic enterprise that builds and organizes knowledge through observation and experimentation. The review exemplifies scientific inquiry by analyzing data from multiple studies, exploring the role of coenzyme Q10 in periodontal therapy, and contributing to ongoing dialog in the scientific community regarding effective treatment strategies for chronic conditions.

21) Nature:
Nature represents the intrinsic characteristics and phenomena of the physical world. In dental research, understanding the nature of bacteria, inflammation, and healing processes is vital for developing effective therapies. The review reflects on natural processes regarding coenzyme Q10's antioxidant properties and how they interact within biological systems during periodontal treatments.

22) Visit:
Visit refers to the patient encounters with healthcare providers, pertinent to monitoring progress during treatment. In longitudinal studies, scheduled visits are critical for evaluating the effectiveness of therapies, such as coenzyme Q10, by assessing clinical parameters over time and making necessary adjustments in treatment strategies to improve patient outcomes.

23) Wall:
Wall metaphorically describes the barriers formed by accumulated tissue damage or chronic inflammation in chronic periodontal disease. Addressing the 'walls' that obstruct effective healing is crucial in therapy, where interventions like coenzyme Q10 aim to restore structural integrity and promote recovery, emphasizing comprehensive approaches to periodontal health.

24) Hand:
Hand symbolizes the manual skills required in dental practices, especially in delivering treatments and conducting procedures. It also represents the hands-on nature of periodontal therapy, where dentists administer interventions such as coenzyme Q10 applications. Effective use of hands in treatment correlates with improved patient care and procedural success.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Efficacy of Co-enzyme Q10 in treating periodontal diseases.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Topical application, Oxidative stress, Plaque index, Gingival index, Systematic Review, Randomized control trial, Gingivitis, Periodontitis, Chronic periodontitis, Antioxidant therapy, Scaling and root planing, Tumor necrosis factor-alpha, Clinical attachment level, Adjunctive therapy, Free Radical, Coenzyme Q10, Clinical parameter, Bleeding On Probing, Preferred Reporting Items for Systematic Reviews and Meta-Analyses.

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