NAFLD and inflammatory periodontal disease: A case-control study
Journal name: Journal of Indian Society of Periodontology
Original article title: Association between nonalcoholic fatty liver disease and inflammatory periodontal disease: A case‑control study
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Ajay Duseja, Gurparkash Singh Chahal, Ashish Jain, Manu Mehta, Aditya Ranjan, Vishakha Grover
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Association between nonalcoholic fatty liver disease and inflammatory periodontal disease: A case‑control study
Year: 2021 | Doi: 10.4103/jisp.jisp_45
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Periodontal disease is an immune-mediated inflammatory condition resulting from microbial infection, leading to the destruction of gingival tissue and supporting tooth structures. Recent epidemiological studies have highlighted associations between periodontal disease and various systemic health conditions, including cardiovascular disease and diabetes. This study investigates the potential link between nonalcoholic fatty liver disease (NAFLD) and inflammatory periodontal disease within a north Indian population, given the rising prevalence of NAFLD and its severity-related complications in the region.
Association Between NAFLD and Periodontal Disease
The study enrolled 40 patients diagnosed with NAFLD and 40 healthy volunteers to compare their periodontal statuses over eight months. Results demonstrated a prevalence of periodontitis in 20% of NAFLD patients compared to 11.9% of healthy controls. Though no statistically significant relationship was found between NAFLD severity and periodontal disease indicators, certain clinical parameters such as the number of missing teeth and bleeding on probing showed higher odds ratios in hepatic disease patients. Additionally, Spearman correlation analysis indicated a significant positive relationship between tumor necrosis factor-alpha (TNF-α) and bleeding on probing in hepatic disease cases, suggesting that systemic inflammatory markers may play a role in the connection between periodontal health and liver disease.
Conclusion
Findings suggest that patients with hepatic disease exhibit a higher prevalence of periodontal disease, with worse oral hygiene compared to healthy individuals. Although the data did not reach statistical significance when comparing NASH and non-NASH individuals, the study indicates a possible association between NAFLD and inflammatory periodontal diseases that warrants further multi-centric research. These insights underscore the need for interdisciplinary approaches to investigate the complex relationship between oral and systemic health, particularly in populations affected by NAFLD.
FAQ section (important questions/answers):
What was the aim of the study?
The study aimed to evaluate the possible association between nonalcoholic fatty liver disease (NAFLD) and inflammatory periodontal disease among a population in North India.
What were the inclusion criteria for NAFLD patients?
Inclusion criteria included patients showing hepatic steatosis on ultrasound, elevated liver enzymes for over three months, and absence of viral hepatitis or autoimmune markers.
What were the findings regarding periodontal disease prevalence?
The study found that 20% of NAFLD patients had periodontitis compared to 11.9% in healthy controls, indicating a higher prevalence of periodontal disease in hepatic disease patients.
Which statistical methods were used in the study?
Statistical analyses included paired t-tests and multivariate logistic regression using IBM SPSS STATISTICS to evaluate the associations between periodontal and hepatic health indicators.
What conclusion did the study reach regarding periodontal health?
The study concluded that hepatic disease patients exhibited poorer oral hygiene and periodontal health compared to healthy individuals, suggesting an association between periodontal disease and NAFLD.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “NAFLD and inflammatory periodontal disease: A case-control study”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
Table is a structured arrangement of data in rows and columns, commonly used in scientific literature to present findings in an organized manner. In this article, tables summarize demographic data, clinical parameters, and significant outcomes from the study, facilitating quick reference for readers and aiding comparison between study groups.
2) Disease:
Disease refers to a pathological condition affecting the body or mind, often characterized by specific symptoms and signs. In this context, the study investigates the association between nonalcoholic fatty liver disease (NAFLD) and inflammatory periodontal disease, highlighting the health implications of these conditions on affected populations.
3) Study (Studying):
Studying entails systematic examination and analysis aimed at understanding complex themes and issues. The researchers engaged in studying the relationship between NAFLD and periodontal disease, highlighting the significance of interdisciplinary approaches in health research and the potential ramifications of their findings on clinical practices.
4) Bleeding:
Bleeding, particularly in a medical context, signifies the loss of blood from the circulatory system. In periodontal disease, bleeding on probing (BOP) is an indicator of gum inflammation and is assessed during examinations to evaluate gingival health. Elevated BOP can reflect the severity of periodontal conditions and its potential systemic implications.
5) Inflammation:
Inflammation is the body's immune response to injury, infection, or harmful stimuli, often presenting with redness, heat, swelling, and pain. This study emphasizes the role of inflammation in chronic diseases, particularly exploring how inflammatory markers like TNF-α relate to periodontal health and systemic conditions like NAFLD.
6) Measurement:
Measurement refers to the quantitative assessment of a parameter or characteristic. In the mentioned study, various health indicators such as liver enzymes, probing depths, and body mass index were measured to evaluate the relationships between hepatic conditions and periodontal health, providing essential data for analysis and conclusions.
7) Rules:
Rules in a research context often relate to guidelines or standards that govern methodology and analysis. This study likely adhered to ethical rules regarding participant consent and data collection, ensuring the validity and reliability of findings whilst adhering to protocols established by institutional review boards.
8) Hygiene (Hygienic):
Hygiene encompasses practices that maintain health and prevent disease, particularly through cleanliness. In the context of this study, oral hygiene practices can significantly impact periodontal health, with poor hygiene potentially exacerbating systemic diseases like NAFLD, indicating the intricate link between dental care and overall health.
9) Suffering:
Suffering reflects the experience of physical or mental distress often associated with health conditions. This article discusses patients suffering from hepatic diseases and periodontal conditions, accentuating the need for awareness and intervention to alleviate their suffering, thus emphasizing the importance of interconnected health management.
10) Relative:
Relative describes the relationship or comparison between entities. In this research, relative prevalence rates of periodontal disease between NAFLD patients and healthy controls illustrate the impact of systemic health on oral conditions, guiding further inquiries into the significance of these relationships within health care strategies.
11) Science (Scientific):
Science is a systematic pursuit of knowledge that builds on measurable evidence and critical analysis. This study embodies the scientific method by investigating the link between diseases and evaluating clinical health parameters, contributing to the broader understanding of the relationship between oral health and systemic diseases.
12) Indian:
Indian refers to something related to India, including its culture, people, and medical context. In this study, the focus on the Indian population highlights regional health issues concerning NAFLD and periodontal disease, providing unique insights that may differ from findings in Western populations, addressing local health needs.
13) Stiffness:
Stiffness indicates resistance to deformation or movement, often measured in clinical assessments to evaluate conditions like liver disease. In this study, liver stiffness measurement (LSM) is significant in assessing the severity of hepatic conditions like NAFLD, guiding diagnostics and treatment strategies for patients exhibiting disease progression.
14) Male:
Male refers to the biological sex that typically produces small, mobile gametes (sperms). In this study, the inclusion of both males and females allows for a comprehensive understanding of gender differences in the prevalence of NAFLD and periodontal disease, shedding light on potential disparities in health outcomes.
15) Observation:
Observation involves carefully monitoring and recording phenomena to gather empirical data. This study utilizes observation to analyze health indicators and clinical parameters in patients, thereby drawing correlations between NAFLD and periodontal conditions, ultimately contributing to evidence-based conclusions regarding their interrelation.
16) India:
India is a South Asian country with a diverse population and significant health challenges. The study's focus on the Indian population provides crucial insights into the prevalence of NAFLD and periodontal disease within this context, highlighting the need for targeted healthcare approaches tailored to specific regional health trends.
17) Drug:
Drug refers to any substance that causes a physiological change in the body, often used for diagnosis, treatment, or prevention of disease. The study acknowledges drug history in participants, given that certain medications can influence liver health or exacerbate NAFLD and assess potential confounding variables.
18) Rheumatoid arthritis:
Rheumatoid arthritis is an autoimmune condition characterized by chronic inflammation of the joints. The mention within the discussion likely draws parallels with the systemic nature of periodontal disease, emphasizing the importance of holistic approaches to treatment concerning autoimmune and inflammatory diseases and their connections to oral health.
19) Discussion:
Discussion is a critical component of research articles that interprets findings, explores implications, and proposes areas for further research. This section reflects on the study's results, considers the context of previous research, and theorizes the potential mechanisms linking periodontal disease and hepatic health.
20) Activity:
Activity refers to a range of physiological functions or behaviors. In the context of this study, it may relate to liver activity or the biological processes associated with periodontal health, influencing inflammation and systemic disease interactions and emphasizing the need for integrated medical assessments for affected individuals.
21) Account:
Account refers to a narration or explanation of specific events or findings. In the context of this study, authors provide an account of their observations and analyses, presenting data on the health status of individuals with NAFLD and their periodontal health, thereby contributing to the scientific literature on these conditions.
22) Punjab:
Punjab is a region in Northern India known for its rich culture and history. Mentioning Punjab in the study emphasizes the geographical focus, indicating that the findings may reflect unique regional health trends in NAFLD and periodontal disease that could vary from other parts of India and beyond.
23) Family:
Family refers to a group of individuals related by blood, marriage, or adoption. In health studies, family history is relevant as it can influence disease risk and genetic predisposition. The study may consider familial relationships in evaluating predispositions to conditions like NAFLD and periodontal disease, enhancing risk assessment.
24) Sharman (Sarma, Sharma, Sarman):
Sharma may refer to a common surname in India, representing cultural or familial identity within the study's context. It underscores the need for representation of diverse backgrounds in research, reflecting the population under investigation and potentially influencing health outcomes based on socio-economic and cultural factors.
25) Blood:
Blood is the bodily fluid that delivers necessary substances like nutrients and oxygen to cells, while also transporting waste products. In this study, blood parameters like liver enzymes are crucial in assessing the hepatic health of patients with NAFLD, highlighting the integral role of blood analysis in disease evaluation.
26) Sign:
Sign refers to observable indicators of a condition or disease. In this study, signs such as clinical parameters of periodontal health provide evidence for diagnosing and understanding the relationship between NAFLD and oral health, helping to inform comprehensive healthcare approaches for affected individuals.
27) Pose:
Pose signifies the act of presenting or creating a situation, particularly regarding challenges or questions. In the study, it may refer to the challenges posed by chronic diseases like NAFLD on periodontal health, underlining the importance of understanding these relationships for effective health management strategies.
28) Viru:
Viru likely refers to viral infections or markers, often significant in studying hepatic conditions. While not primarily the focus, discussing viral components acknowledges their potential impact on liver disease, accentuating the necessity of holistic evaluations in patients with complex health profiles like NAFLD.
Other Science Concepts:
Discover the significance of concepts within the article: ‘NAFLD and inflammatory periodontal disease: A case-control study’. Further sources in the context of Science might help you critically compare this page with similair documents:
Metabolic syndrome, Systemic disease, C-Reactive Protein, Healthy volunteers, Oral health status, Interleukin-6, Nonalcoholic fatty liver disease, Biochemical evaluation, Hepatocellular Carcinoma, Aspirate transaminase, Significant positive correlation, Multivariate logistic regression analysis, Clinical parameter, Oral bacteria, Chronic periodontal disease, Nonalcoholic steatohepatitis.