Nanocomposite bone graft for periodontal regeneration: A RCT evaluation

| Posted in: Science

Journal name: Journal of Indian Society of Periodontology
Original article title: Extracellular matrix containing nanocomposite bone graft in periodontal regeneration – A randomized controlled clinical and radiographic evaluation
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Abhinav Prakash Deshpande, Mala Dixit Baburaj, Lashika Vasant Tambe, Upendra Prasad


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: Extracellular matrix containing nanocomposite bone graft in periodontal regeneration – A randomized controlled clinical and radiographic evaluation

Year: 2021 | Doi: 10.4103/jisp.jisp_440

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

This study focuses on evaluating the effectiveness of incorporating an extracellular matrix (ECM) component, specifically natural collagen, into nanocrystalline hydroxyapatite (nHA) bone grafts for treating intrabony defects in patients with chronic periodontitis. With a sample of 40 patients, the research compares two surgical interventions: one group received nHA combined with collagen, while the other received nHA alone. Assessment parameters included plaque index, gingival index, probing pocket depth (PPD), clinical attachment level (CAL), and radiographic defect depth (RDD) measured at baseline, 3 months, and 6 months post-surgery.

Importance of Collagen in Bone Grafts

The study demonstrates the significant role of collagen in enhancing clinical outcomes during the early healing phase. Results indicated that patients in the group that received nHA with collagen experienced a more considerable reduction in PPD and improvement in CAL at the 3-month follow-up compared to the control group. This finding suggests that the presence of collagen provides essential ECM support vital for tissue regeneration and healing processes, leading to improved clinical parameters soon after the procedure. While both graft materials yielded satisfactory results, the initial benefits observed with the collagen-containing graft seem to stem from its ability to accelerate healing, potentially resulting in better integration of the graft with surrounding tissues.

Conclusion

In conclusion, both nHA and nHA-collagen grafts demonstrated satisfactory clinical and radiographic improvements, suggesting their compatibility and effectiveness in periodontal regenerative therapy. The study highlights that while the addition of collagen to nHA enhances initial healing parameters, the long-term results (after 6 months) between both groups were comparable. This underscores the potential of collagen-enhanced nHA grafts for improving initial clinical outcomes, but emphasizes the necessity for extended follow-up to fully assess the long-term sustainability of these improvements in periodontal treatment. Future research with a larger sample size and longer observation periods is recommended to validate and expand upon these findings.

FAQ section (important questions/answers):

What is the aim of the study involving collagen and nHA?

The study aims to evaluate the effect of adding natural collagen, an extracellular matrix (ECM) component, to nanocrystalline hydroxyapatite (nHA) bone graft for treating intrabony defects in patients with chronic periodontitis.

What methods were used to evaluate treatment outcomes in the study?

Treatment outcomes included measuring plaque index, gingival index, probing pocket depth (PPD), clinical attachment level (CAL), and radiographic defect depth (RDD) at baseline, 3 months, and 6 months postsurgery.

How did the two groups compare in terms of periodontitis treatment?

Group A, which received nHA with collagen, showed a statistically significant reduction in PPD and CAL after 3 months compared to Group B, which only received nHA, though both showed comparable results after 6 months.

What were the conclusions regarding the effectiveness of nHA composite?

The conclusions indicated that adding collagen to nHA enhanced early clinical parameters, yielding satisfactory clinical and radiographic outcomes, but results were similar for both groups after 6 months.

What limitations were acknowledged in the study and future recommendations?

The study recommended larger sample sizes, longer follow-up durations, paired/split-mouth designs, and the use of cone-beam computed tomography for further assessments.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Nanocomposite bone graft for periodontal regeneration: A RCT evaluation”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
Table refers to a structured format used to present data clearly and concisely. In this context, tables are used to display clinical parameters, results, and comparative analyses in the study, helping to visualize significant improvements or differences between treatment groups. They facilitate easier interpretation of complex information.

2) Study (Studying):
Study refers to a systematic investigation into various factors related to chronic periodontitis and treatment efficacy. This clinical study specifically evaluates the effects of two types of bone grafts on periodontal regeneration, contributing valuable data to enhance understanding and therapeutic approaches in periodontal disease management.

3) Rules:
Rules pertain to the guidelines and protocols established for conducting research, ensuring ethical compliance, and maintaining methodological rigor. In the context of this study, rules guided patient selection, treatment procedures, and ethical considerations per clinical standards, significantly affecting the reliability and validity of the study's outcomes.

4) India:
India is relevant as the geographical context where the study was conducted. The cultural and health care environment in India shapes patient recruitment, treatment methods, and access to medical technologies, making it significant in understanding results and applicability to Indian populations suffering from dental conditions.

5) Relative:
Relative refers to the relationships or comparisons made within the study. It is significant in assessing the results of treatment interventions relative to standard practices. Understanding relative effects enables practitioners to evaluate the effectiveness of novel therapies like collagen-enhanced grafts against conventional methods in treating periodontal disease.

6) Chennai:
Chennai is the location of the pharmaceutical company Eucare Pharmaceuticals, which provides the materials used in the study. The city's healthcare infrastructure, including hospitals and research facilities, supports clinical research like this study. Chennai's significance lies in facilitating advancements in dental treatment protocols and materials.

7) Composite:
Composite typically refers to a material made from two or more constituent materials with different physical or chemical properties. In this study, the term highlights the combination of nanocrystalline hydroxyapatite with collagen, resulting in improved properties for bone grafting, which mimics natural bone healing properties and enhances regeneration.

8) Line:
Line relates to the methodology used in scientific research that delineates protocols and processes for conducting experiments. This structured line of research ensures consistency in treatments and assessments, facilitating the reliability of results. It also refers to guidelines for data interpretation and clinical evaluation.

9) Hygiene (Hygienic):
Hygiene is critical in periodontal care, referring to practices that promote oral health and prevent disease progression. The study emphasizes the role of oral hygiene maintenance in ensuring successful treatment outcomes. Good hygiene practices can decrease plaque accumulation and improve clinical parameters in patients undergoing periodontal therapy.

10) Measurement:
Measurement pertains to the process of quantitatively assessing clinical parameters such as probing pocket depth and clinical attachment level. Accurate measurement is vital for evaluating the success of periodontal treatments and determining improvements in oral health. Standardized measurements ensure comparability and reproducibility of results across different studies.

11) Dressing:
Dressing refers to the material used to protect surgical sites post-operation. In periodontal surgeries, proper dressing influences healing and minimizes complications. The study incorporates the use of a specific dressing for optimal healing after graft placement, demonstrating its importance in post-surgical care and patient recovery.

12) Mineral:
Mineral refers to naturally occurring inorganic substances that are pivotal in biological processes and structural components. In the context of this study, hydroxyapatite (a mineral) plays a critical role in bone regeneration. The study explores how composite materials can facilitate the mineralization process essential for effective bone healing.

13) Animal:
Animal refers to the use of animal models in prior research that may have informed this study's methodologies or outcomes. Relevant animal studies help translate findings to human applications, securing essential biological insights into graft behavior and regeneration processes, thus establishing groundwork for subsequent clinical investigations.

14) Visit:
Visit refers to scheduled follow-ups post-treatment enabling practitioners to monitor patient outcomes and recovery. In this study, recall visits are vital for assessing clinical parameters over time and ensuring patients maintain oral hygiene. These visits inform long-term effectiveness and provide insights into treatment sustainability.

15) Fish:
Fish is relevant because the collagen used in the composite graft material originates from fish. Marine collagen is noted for its biocompatibility and safety. This component may enhance graft performance, which is primary to the study, showcasing the utilization of alternative sources for regenerative medicine in periodontal therapy.

16) Wall:
Wall refers to the boundary structures in tissues, particularly the periodontal pocket walls. In surgical contexts, the health and integrity of these walls influence treatment success. The study evaluates how interventions impact the dimensional changes of these walls, showcasing the relationship between surgery and periodontal regeneration.

17) Accumulation (Accumulating, Accumulate):
Accumulation signifies the build-up of materials, like bacteria or biofilm in periodontal contexts. Monitoring accumulation helps determine the effectiveness of treatments and the importance of hygiene. The study potentially examines the effects of different grafts on controlling microbial accumulation and promoting healthy periodontal environments.

18) Inflammation:
Inflammation refers to the body's response to injury or infection, often seen in periodontal disease. The study addresses how effective treatment can reduce inflammation, leading to improved clinical outcomes. Understanding the role of inflammation is crucial for developing interventions that enhance healing and regeneration in periodontal therapy.

19) Discussion:
Discussion refers to the section of the study where findings are interpreted within the context of existing literature. This analysis links results to broader implications for clinical practice and enhances understanding of the observed outcomes. The discussion highlights the significance of collagen augmentation in improving graft efficacy.

20) Antibiotic (Antibacterial):
Antibiotic refers to the systemic medications administered post-surgery to prevent infection. In periodontal therapies, antibiotics are critical in managing postoperative complications. The study outlines the antibiotic regimen provided to patients, emphasizing its role in promoting healing and supporting successful treatment outcomes in conjunction with grafting procedures.

21) Similarity:
Similarity in research refers to the comparative aspects of treatment interventions and their outcomes within the study. Understanding similarities helps clinicians evaluate the effectiveness of different approaches in periodontal regeneration. The study aims to delineate the similarities and differences between the two types of bone grafts in effectiveness.

22) Education:
Education signifies the knowledge-sharing aspect pertaining to patient care. In periodontal practice, educating patients about gum health and proper hygiene is essential. This study contributes to the educational framework for clinicians, enhancing understanding of treatment options and empowering patients through knowledge for better health practices.

23) Incision:
Incision refers to the surgical cut made during periodontal procedures. Proper incision techniques are paramount for achieving optimal surgical outcomes. This study analyzes how incision strategies affect healing and tissue response, underscoring the importance of surgical precision in regenerative periodontal therapies.

24) Cutting:
Cutting relates to surgical techniques employed to access periodontal tissues for treatment. This includes the methods used to detach the gum tissue and insert grafts. Effective cutting techniques are vital for minimizing tissue trauma and maximizing regenerative success in the context of periodontal therapy.

25) Disease:
Disease signifies the underlying pathogenic conditions being studied, specifically chronic periodontitis. Understanding the intricacies of disease allows for improved therapeutic strategies. The study focuses on how graft materials can effectively manage periodontal disease, contributing to the broader understanding of disease treatment and management.

26) Surface:
Surface pertains to the property of materials, including the wettability and bioactivity of the grafts. The surface characteristics of bone graft materials play a crucial role in cellular attachment and tissue integration. This aspect is significant for evaluating the efficacy of the graft materials in periodontal regeneration.

27) Nashik:
Nashik is a city in Maharashtra, India, and contextually significant for the study. While the research is conducted in Chennai, Nashik may represent a demographic or logistical aspect, emphasizing the broader Indian landscape where similar studies can be replicated, reflecting the regional healthcare dynamics.

28) Reason:
Reason underlines the justification for conducting the study, such as the necessity of comparing different grafts. Identifying reasons for the study supports its relevance, enhancing its ability to address gaps in current knowledge regarding effective treatment interventions for periodontal disease.

29) Water:
Water in this context likely symbolizes an essential component in maintaining health and facilitating biological processes. The role of hydration in cellular function and healing post-surgery might be emphasized, showcasing the importance of adequate postoperative care for successful recovery in periodontal treatments.

30) Silk:
Silk typically refers to the material of sutures used in surgical procedures. The study notes the use of silk sutures for closing surgical sites. The choice of suture material affects healing and the overall success of the procedure, emphasizing the interplay between materials and pathways of recovery.

31) Post:
Post signifies the period following surgery where healing is evaluated. Postoperative assessments are crucial for determining the effectiveness of treatments and adjustments needed. The study outlines how parameters are monitored and analyzed after the grafting procedures to ensure optimum recovery and treatment success.

32) Male:
Male pertains to the gender distribution among study participants. Recognizing demographics like gender is essential in understanding the impact of treatments across populations, allowing researchers to generalize findings or tailor interventions based on gender-specific responses to periodontal treatment outcomes.

33) Dish (Dis):
Dish refers to the sterile dappen dish used to prepare graft materials before surgical procedures. Proper preparation ensures the integrity and effectiveness of the materials utilized in surgical contexts. The use of a specific dish underscores the importance of sterility and precision in periodontal surgeries.

Other Science Concepts:

[back to top]

Discover the significance of concepts within the article: ‘Nanocomposite bone graft for periodontal regeneration: A RCT evaluation’. Further sources in the context of Science might help you critically compare this page with similair documents:

Ethics committee, Randomized controlled clinical trial, Extracellular matrix, Oral hygiene maintenance, Probing pocket depth, Clinical attachment level, Tissue regeneration, Clinical parameter, Open flap debridement, Periodontal dressing, Intrabony defect, Chronic periodontitis patients, Systemic antibiotic, Power of the study.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Consider supporting this website: