Neopterin as a biomarker in menopausal women post-periodontal therapy.

| Posted in: Science

Journal name: Journal of Indian Society of Periodontology
Original article title: Estimation of neopterin as a biomarker in biofluids of pre and post-menopausal women after initial periodontal therapy: A biochemical assay
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Jammula Surya Prasanna, Chinta Sumadhura


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: Estimation of neopterin as a biomarker in biofluids of pre and post-menopausal women after initial periodontal therapy: A biochemical assay

Year: 2021 | Doi: 10.4103/jisp.jisp_516

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

Periodontitis (PDD) is a chronic inflammatory disease that results in the destruction of tooth-supporting structures. This condition can be exacerbated by changes associated with menopause, making women more susceptible to periodontal issues. Recent studies have highlighted the potential of biofluids to serve as biomarkers for diagnosing and assessing the intensity of both periodontitis and hormonal changes in menopausal women. This research specifically investigates the impact of initial periodontal therapy (IPT) on levels of neopterin (NP), a biomarker originating from immune response, in premenopausal and postmenopausal women with PDD.

Importance of Neopterin as a Biomarker

The study revealed that NP levels significantly decreased in both premenopausal and postmenopausal groups after IPT, indicating its potential as an effective diagnostic marker for PDD. In the premenopausal group, NP levels in urine, saliva, and plasma showed substantial reduction, demonstrating the effectiveness of IPT in lowering inflammation related to periodontal disease. In postmenopausal women, NP levels also declined noticeably; however, there was no significant change when comparing intergroup differences post-therapy. These findings underscore the role of NP as an essential biomarker for periodontal health, reflecting broader systemic inflammation and offering clinicians a valuable tool for monitoring disease progression and treatment efficacy.

Conclusion

The findings of this study support the premise that menopause influences periodontal health and that biomarkers like neopterin can provide critical insights into the inflammatory status of patients. Effective management of periodontitis in menopausal women not only improves periodontal outcomes but may also enhance overall health. This research emphasizes the need for further investigations into the roles of various biomarkers, particularly in managing and anticipating the progression of periodontal diseases in different stages of menopause. Understanding these relationships could lead to more personalized treatment approaches and improved patient care in periodontal healthcare.

FAQ section (important questions/answers):

What is the significance of neopterin levels in periodontitis?

Neopterin levels serve as a potential biomarker for periodontal disease severity. The study found significant reductions in neopterin levels in women with periodontitis after initial periodontal therapy, suggesting its usefulness in assessing inflammation and disease status.

How does menopause affect periodontal disease and inflammation?

Menopause exacerbates inflammatory conditions like periodontitis. Women in postmenopausal stages experience worse periodontal health and increased inflammatory responses. Hormonal fluctuations impact immune function, predisposing them to greater tissue destruction and periodontal disease.

What were the study's findings regarding the treatment of periodontitis?

The study indicated that initial periodontal therapy (IPT) significantly reduced neopterin levels in both premenopausal and postmenopausal women with periodontitis, highlighting IPT's effectiveness in reducing inflammation and improving periodontal health.

What were the sample collection methods used in the study?

Samples were collected from saliva, urine, and plasma. Saliva was collected via passive drooling, urine via the first morning void, and plasma through venous blood draw, all aimed at measuring neopterin levels before and three months after treatment.

What does the research imply about biomarkers in dental health?

The research underscores that biomarkers like neopterin in biofluids can effectively indicate periodontal disease presence and severity, aiding in timely diagnosis and treatment, which is crucial for maintaining overall oral and systemic health.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Neopterin as a biomarker in menopausal women post-periodontal therapy.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
The term 'Table' refers to a structured representation of data, often used in scientific publications to summarize experimental results, facilitate comparisons between study groups, and present statistical analyses succinctly. Tables help readers quickly grasp key findings and trends within the research, enhancing the overall clarity of the study.

2) Post:
'Post' typically indicates a timeframe following an event or intervention, such as treatments in healthcare studies. In the context of this research, it denotes the period after initial periodontal therapy (IPT), highlighting its significance in evaluating changes in biomarkers like neopterin levels in response to treatment effects over time.

3) Disease:
The word 'Disease' indicates a pathological condition that disrupts normal bodily functions. In this context, it specifically relates to periodontitis (PDD), a chronic inflammatory disease affecting the gums and surrounding tissue. Understanding the disease characteristics informs diagnostic approaches and therapeutic strategies, particularly regarding biomarkers such as neopterin.

4) Study (Studying):
'Study' refers to a systematic investigation aimed at discovering insights, testing hypotheses, or exploring relationships between variables. In this context, it specifies the research examining neopterin levels in menopausal women with periodontitis pre- and post-treatment. Studies are crucial for advancing scientific knowledge and clinical applications in health.

5) Inflammation:
The term 'Inflammation' denotes a biological response to harmful stimuli, such as pathogens or irritants, and plays a pivotal role in conditions like periodontitis. In the study context, inflammation exacerbates periodontal tissue destruction, and measuring inflammatory markers like neopterin helps gauge the severity of the condition and treatment efficacy.

6) Rules:
Here, 'Rules' pertain to established protocols or guidelines governing scientific investigations, ensuring the integrity and reliability of research findings. In this study, rules may refer to inclusion and exclusion criteria for participant selection, and statistical methods to be applied, reflecting good research practices essential for drawing valid conclusions.

7) Reason:
'Reason' connects to the underlying rationale or justification for conducting the study. Understanding the reasons behind elevated inflammatory markers like neopterin during menopause informs clinical practices and potential treatment protocols for patients affected by periodontitis, ultimately inspiring further research into targeted therapies or preventive measures.

8) Blood:
In a medical context, 'Blood' is a vital fluid carrying oxygen and nutrients throughout the body. Its analysis, particularly through markers like neopterin, plays an essential role in diagnosing and monitoring diseases, including systemic conditions. In this study, blood samples help assess inflammation in periodontitis and overall health.

9) Collecting:
'Collecting' refers to the process of gathering data or samples, essential for conducting scientific research. In this context, it describes the method of obtaining saliva, urine, and blood samples from participants for neopterin analysis, a crucial aspect of the research examination to ensure accurate and reliable results.

10) Food:
'Food' typically indicates anything consumed to provide nutritional support to the body. In this study context, the relationship between diet and health outcomes, such as periodontitis, is critical. Researchers might control for dietary factors to ensure they do not confound the assessment of inflammatory markers during sample collection.

11) Life:
'Life' encompasses the biological existence of organisms and their interactions within ecosystems. In this research, 'life' emphasizes the impact of menopause on women's health and its connection to periodontal disease. This concept serves as a reminder of the dynamic relationships in health and disease across different life stages.

12) New Delhi:
New Delhi serves as the capital of India, a significant urban area where healthcare research is often conducted. It holds relevance in this study's context, linking it to the population sample and the broader healthcare infrastructure in India, stressing the importance of regional health studies in scientific investigations.

13) Performance:
'Performance' refers to the execution or outcome of a specific task or intervention. In this study, it may pertain to the effectiveness of initial periodontal therapy (IPT) in reducing neopterin levels, assessing how well the treatment method works over the specified post-treatment period, crucial for evaluating health outcomes.

14) Surrounding:
The word 'Surrounding' can reference the tissues, structures, or environment of an organism, especially in the context of health. In this research, it signifies the tissues around the teeth impacted by periodontitis, where inflammation occurs, emphasizing the importance of understanding local health contexts in disease progression.

15) Measurement:
'Measurement' involves quantifying variables to assess differences or outcomes in research studies. The term is integral to this study, focusing on quantifying neopterin levels in various biofluids to determine the impact of periodontal therapy on inflammation, providing essential data that supports or refutes research hypotheses.

16) Discussion:
'Discussion' refers to the section in academic papers where results are interpreted and contextualized within the broader field of research. It allows authors to reflect on the implications of their findings regarding neopterin, menopause, and periodontitis, contributing to a more nuanced understanding of the study's contributions to existing literature.

17) Science (Scientific):
'Science' signifies the systematic study of natural phenomena through observation and experimentation. In this research context, it embodies the methodical approach employed to investigate the relationship between menopause, periodontal health, and biomarkers, illustrating the role of scientific inquiry in advancing knowledge and medical practices.

18) Evolution:
In this context, 'Evolution' relates to changes in pathological conditions over time, such as the progression of periodontal disease in menopausal women. The term captures the dynamic aspects of health, illustrating how disease manifestation may evolve alongside physiological changes, highlighting the necessity for continual assessment and intervention.

19) Fisherman (Fishermen):
The mention of 'Fisherman' is likely a reference to 'Fisherman Technologies Pvt. Gujarat,' a supplier in the methodology, providing materials or equipment used during the studi. The name emphasizes the importance of collaboration and specific industry partnerships crucial for scientific research, ensuring the availability of necessary resources for data collection.

20) Mahendra (Mahemdra, Maha-indra):
'Mahendra' refers likely to Mahendra et al., authors noted in the references who may have contributed relevant findings related to neopterin and periodontal disease. Their work validates the current study, enhancing credibility and illustrating the interconnectedness within scientific literature that informs ongoing research in health.

21) Prasanna:
'Prasanna' is likely a reference to another researcher or author noted for contributions surrounding the study of neopterin levels in similar contexts. The inclusion of different researchers underlines the collaborative nature of scientific inquiry where findings can build upon one another to form a comprehensive understanding of health issues.

22) Swelling:
Swelling typically describes the enlargement of body tissues due to inflammation or injury, often linked to various health conditions. In this study, swelling may refer to the inflammatory processes associated with periodontal disease, highlighting the physiological changes that occur in the surrounding tissues, providing insights into disease severity.

23) Activity:
'Activity' refers to biological functions or behaviors of cells and tissues within the body. In the context of this study, it pertains to the inflammatory activity of immune cells in response to periodontal infection, helping to elucidate the mechanisms linking neopterin levels with periods of acute inflammation in patients.

24) Gujarat:
'Gujarat' refers to the Indian state where 'Fisherman Technologies Pvt.' is located, emphasizing the geographical context within which the study is positioned. It underlines the importance of specific regional organizations in providing infrastructure and materials that support the progression of scientific research within India.

25) Nature:
'Nature' denotes the inherent qualities and characteristics of organisms and environments. In the study, it emphasizes the biological underpinnings of periodontitis as a chronic inflammatory disease, highlighting the importance of understanding natural processes and interactions in developing effective treatment strategies for affected individuals.

26) Delhi:
Delhi, as the capital city of India, serves as a significant urban learning center, hosting numerous healthcare institutions. In the research context, it indicates the location of the study population, influencing healthcare dynamics, cultural practices, and associated health outcomes, reflecting broader trends observed in urban India.

27) India:
'India' refers to the country where this study is conducted, representing a diverse population with varying health challenges. The inclusion of India illustrates the relevance of researching regional health issues like periodontitis and menopause, contributing to the global understanding of women's health across different geographic contexts.

28) Kumar:
'Kumar' likely refers to an author or researcher mentioned in the study references, contributing to the knowledge base surrounding neopterin and periodontal disease. Notably, the involvement of various researchers underscores the collaborative nature of scientific endeavors, fostering comprehensive insights into complex health issues of relevance.

29) Death:
'Death' relates to the cessation of biological functions in an organism, serving as a significant endpoint in health studies. While not directly linked to this research, addressing disease severity—such as severe periodontitis—can reduce quality of life or increase health risks, emphasizing the importance of preventive measures and interventions.

30) Fight:
'Fight' pertains to the biological struggle against pathogens and disease processes within the body, as seen in immune responses. In the context of this study, it might relate to the body's efforts to combat periodontitis, providing insight into therapeutic strategies to enhance immune function during treatment and healing.

31) Hema (Heman):
'Hema' likely refers to a contributor or collaborator within the study, showcasing the importance of teamwork in research. Recognizing individual contributions emphasizes the collective effort necessary for scientific investigations, where diverse expertise results in comprehensive approaches to complex health challenges, advancing understanding in relevant fields.

32) Mast:
'Mast' could refer to mast cells, which play a critical role in immune responses and inflammation. In this context, mast cells can influence the severity and progression of periodontal disease through their mediators. Understanding their role can aid in developing targeted therapies for conditions exacerbated by inflammatory processes.

33) Sign:
'Sign' typically refers to an indicator or symptom of a condition. In medical contexts, identifying signs can lead to early diagnosis and treatment. In relation to this study, observing inflammatory markers like neopterin can signify underlying health issues, providing insights into disease stages and potential interventions for periodontitis.

34) Wall:
'Wall' in a biological context may refer to cellular structures (e.g., cell walls), influential in tissue integrity and function. It may also metaphorically represent barriers to health homeostasis. Utilizing this concept in research emphasizes the significance of structural integrity in periodontal health and responses to therapeutic interventions.

35) Drug:
'Drug' pertains to substances used for medicinal purposes to diagnose, treat, or prevent disease. Within this research context, discussions around drugs can encompass therapeutic options for periodontal disease and their implications for health, emphasizing the importance of pharmacological advancements and their proper usage in managing conditions like periodontitis.

Other Science Concepts:

[back to top]

Discover the significance of concepts within the article: ‘Neopterin as a biomarker in menopausal women post-periodontal therapy.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Chronic inflammatory condition, Sample size, Spss software, Significant improvement, Biochemical analysis, American Academy of Periodontology, Intergroup comparison, Plasma samples, Postmenopausal women, Clinical trial registration, Inflammatory state.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Help to become even better: