Turmeric extract vs. chlorhexidine in chronic periodontitis treatment.

| Posted in: Science Health Sciences Journals

Journal name: Journal of Indian Society of Periodontology
Original article title: Comparative evaluation of 2% turmeric extract with nanocarrier and 1% chlorhexidine gel as an adjunct to scaling and root planing in patients with chronic periodontitis: A pilot randomized controlled clinical trial
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Sanjeela Rakshith Guru, K Adithya Reddy, Ravi J. Rao, Shyam Padmanabhan, Rakshith Guru, TS Srinivasa


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: Comparative evaluation of 2% turmeric extract with nanocarrier and 1% chlorhexidine gel as an adjunct to scaling and root planing in patients with chronic periodontitis: A pilot randomized controlled clinical trial

Year: 2020 | Doi: 10.4103/jisp.jisp_207

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

Periodontal disease is a complex condition primarily caused by the invasion of pathogenic microorganisms in the subgingival biofilm, often requiring mechanical treatment combined with chemotherapeutic agents to enhance antibacterial effects. The present study aimed to investigate the efficacy of 2% curcumin delivered through a nanocarrier system compared to 1% chlorhexidine gel as adjuncts to scaling and root planing (SRP) in chronic periodontitis patients. The focus was on improving clinical outcomes and reducing microbial load in periodontal pockets, targeting specific pathogens known to exacerbate the disease.

The Role of Nanotechnology in Periodontal Therapy

The incorporation of nanoparticles in drug delivery systems represents a significant advancement in periodontal therapy. Nanocarriers enhance the bioavailability and stability of therapeutic agents, allowing for more effective localized treatment of periodontal pockets. Pluronic F127, a hydrophilic surfactant known for its thermoreversible gelation properties, was utilized to formulate the curcumin nanogel in this study. The results indicated that both the 2% curcumin nanogel and 1% chlorhexidine gel effectively reduced clinical parameters such as the gingival index, plaque index, probing pocket depth, and clinical attachment level. Moreover, microbiological assessments showed significant reductions in levels of periodontal pathogens like Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythia, reinforcing the potential of nanotechnology in local drug delivery systems for periodontal treatments.

Conclusion

The findings from the study demonstrated that both local drug delivery agents—2% curcumin with a nanocarrier and 1% chlorhexidine gel—exhibited comparable antibacterial effects and improved clinical and microbiological parameters in patients with chronic periodontitis. The comparable efficacy of curcumin when delivered as a nanogel highlights its promising application in periodontal therapy, alongside the more traditional chlorhexidine. Future studies with larger sample sizes and longer follow-up periods are recommended to further evaluate the clinical utility and benefits of curcumin as a local drug delivery system in the treatment of periodontal diseases.

FAQ section (important questions/answers):

What was the focus of the study regarding periodontal treatment?

The study aimed to evaluate the efficacy of 2% curcumin with nanocarrier versus 1% chlorhexidine gel as local drug delivery agents in treating periodontal pockets in patients with chronic periodontitis.

How were the patients selected for the study?

Forty-five chronic periodontitis patients aged 25–50 years with probing pocket depths of 5–7 mm were selected. Patients with recent periodontal treatment or specific conditions were excluded.

What were the main findings regarding clinical parameters?

Both treatment agents led to significant improvements in clinical parameters, including plaque index, gingival index, probing pocket depth, and clinical attachment level. However, no significant differences were observed between treatments.

Which bacterial levels were analyzed in the study?

The study focused on three periodontopathic bacteria: Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and Tannerella forsythia (Tf), with significant reductions noted in both treatment groups.

What does the conclusion suggest about curcumin and chlorhexidine?

The study concludes that both 2% curcumin with a nanocarrier and 1% chlorhexidine gel demonstrate comparable antibacterial effects, supporting their use in local drug delivery for periodontal treatment.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Turmeric extract vs. chlorhexidine in chronic periodontitis treatment.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
In research, a table is a systematic arrangement of data, often used to present results in a structured manner to facilitate comparison and interpretation. Tables are essential in academic papers, particularly in scientific studies, as they summarize experimental data, making it easier for readers to grasp complex information quickly.

2) Study (Studying):
A study involves systematic investigation and analysis aimed at understanding a specific phenomenon. In the medical context, studies assess treatments, drugs, or conclusions drawn from clinical research. They are fundamental in advancing knowledge, improving health outcomes, and informing practice through empirical evidence gathered from observations or experiments.

3) Drug:
A drug is a substance used to diagnose, cure, treat, or prevent disease. Drugs can have therapeutic effects or, in some cases, adverse effects. The development and evaluation of drugs are crucial in the medical field to ensure safety, efficacy, and appropriate application in treating various conditions.

4) India:
India is a country in South Asia known for its diverse cultures and languages. It has a significant role in global healthcare and pharmaceutical industries, contributing to medical research and public health initiatives. India is a key player in the development and distribution of herbal products, including turmeric as a remedy.

5) Turmeric:
Turmeric is a spice derived from the Curcuma longa plant, widely recognized for its anti-inflammatory and antioxidant properties. It contains curcumin, which has potential health benefits, particularly in treating inflammatory diseases. Its usage in various traditional medicine practices reflects its significance in contemporary wellness approaches and research.

6) Disease:
A disease is an abnormal condition affecting the body or mind, often characterized by specific symptoms and signs. Understanding diseases is critical for developing effective treatments and prevention strategies, particularly in fields like immunology, epidemiology, and public health to enhance quality of life and overall population well-being.

7) Rules:
Rules are established guidelines or principles that govern behavior or processes, ensuring order and consistency. In scientific research, rules are applied to maintain rigor in methodology, ethical considerations, and data interpretation. Following these rules enhances the credibility and replicability of studies, crucial for advancing knowledge.

8) Antibiotic (Antibacterial):
An antibiotic is a type of antibacterial drug specifically designed to combat bacterial infections by either inhibiting bacterial growth or destroying bacteria. The development and use of antibiotics have revolutionized medicine; however, issues like antibiotic resistance pose challenges, necessitating responsible prescribing practices and ongoing research.

9) Karnataka:
Karnataka is a state in India known for its rich cultural heritage and advanced healthcare sector. It plays a vital role in pharmaceutical research and education. The state's institutions contribute significantly to medical advancements and public health through innovative research and clinical trials, fostering a robust healthcare environment.

10) Activity:
Activity, in a biological context, refers to the function or behavior of a molecule, cell, or organism, often measured during experiments. Understanding the activity levels of drugs, such as curcumin in fighting pathogens, informs treatment efficacy and guides therapeutic applications in clinical practices.

11) Surface:
Surface refers to the outer or topmost layer of an object or substance. In medical studies involving drug delivery, the surface properties of materials can influence interactions with biological tissues, affecting drug absorption and therapeutic outcomes. Understanding surface characteristics is crucial in developing effective drug delivery systems.

12) Hygiene (Hygienic):
Hygiene refers to practices and conditions conducive to maintaining health and preventing disease. Good oral hygiene is essential in dentistry to prevent conditions like periodontal disease. Research indicates that effective hygiene regimens can significantly reduce microbial load and improve overall health outcomes, underscoring its importance in healthcare.

13) Water:
Water is essential for all forms of life, serving as a solvent for chemicals and biological reactions. In medical studies, water’s role in drug formulation or delivery systems, as well as hydration's impact on health, is often assessed. Understanding water's properties aids in developing effective medicinal formulations and treatments.

14) Inflammation:
Inflammation is the body's response to injury or infection, characterized by redness, swelling, heat, and pain. Chronic inflammation can contribute to various diseases, making it a critical target for treatment. Understanding inflammatory pathways informs therapeutic approaches, particularly in conditions like periodontitis, where inflammation plays a central role.

15) Measurement:
Measurement in research refers to the process of quantifying variables or outcomes to obtain data. Accurate measurement is crucial for reliability and validity in studies. In clinical research, measuring parameters like probing pocket depth or plaque index value informs treatment efficacy and helps gauge health outcomes scientifically.

16) Powder:
Powder refers to a solid material composed of fine particles. In pharmaceuticals, powders are often used as formulations for drugs, including curcumin. Understanding the properties of powders, such as solubility and stability, is vital in developing effective delivery systems and ensuring appropriate therapeutic effects.

17) Post:
Post refers to the period following an event or treatment. In research, post-treatment assessments are crucial for understanding the effectiveness and impact of interventions. Evaluating outcomes after treatment helps determine long-term benefits, recurrence, or side effects, guiding further clinical practices and studies.

18) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra is a state in western India known for its economic significance and healthcare infrastructure. It hosts numerous medical institutions and research centers. The state's contributions to pharmaceutical developments and research in alternative medicine highlight its importance in advancing healthcare and promoting traditional remedies like turmeric.

19) Calculation:
Calculation refers to the mathematical process of determining values or quantities, essential in research for statistical analyses. Accurately calculating means, variances, or treatment effects informs conclusions and supports evidence-based practice in medicine. Calculations guide researchers in interpreting data and ensuring the statistical reliability of findings.

20) Pomegranate:
Pomegranate is a fruit known for its nutritional benefits and antioxidant properties. In traditional medicine, it has been used for its potential health benefits, including its anti-inflammatory effects. Its inclusion in research reflects an interest in natural remedies and dietary components in managing health conditions.

21) Discussion:
Discussion in research involves analyzing results, drawing conclusions, and relating findings to existing literature. This section is critical for contextualizing research outcomes and explaining their significance. It allows researchers to explore implications, acknowledge limitations, and suggest future directions for research and clinical practices based on findings.

22) Developing:
Developing refers to the process of creating or improving something, such as new drugs or technologies. In health science, developing innovative treatments or delivery systems is essential for advancing therapeutic options. This process often involves extensive research to ensure efficacy, safety, and applicability in clinical settings.

23) Container:
A container is a physical receptacle used to hold substances. In pharmaceutical applications, containers are critical for storing drugs, ensuring stability and preventing contamination. The choice of container type can affect the drug formulation's integrity and efficacy, making it an important consideration in medicinal product design.

24) Toxicity:
Toxicity refers to the degree to which a substance can cause harm to organisms. In pharmacology, assessing the toxicity of drugs is crucial to ensure safety and avoid adverse effects. Understanding toxicity informs dosage decisions and helps establish safety profiles for new medications prior to clinical use.

25) Medicine:
Medicine refers to the field focused on diagnosing, treating, and preventing disease. It encompasses various practices, including pharmacology, surgery, and therapy. The continuous advancement of medicine relies on research and empirical evidence, aiming to improve health outcomes and increase the quality of life through innovative solutions.

26) Pregnant:
Pregnant refers to a state in which a female carries a developing fetus. Treatments involving pregnant individuals require careful consideration of safety and effects on both the mother and the fetus. Medical studies aim to address the potential risks and ethical issues associated with exposing pregnant individuals to new medications.

27) Quality:
Quality refers to the standard of something, often related to its ability to meet specified requirements or expectations. In research and healthcare, maintaining high quality in studies, treatments, and products is crucial for positive outcomes. Ensuring quality influences efficacy, safety, and overall patient satisfaction.

28) Allergy:
Allergy is a hypersensitivity reaction by the immune system to certain substances, leading to various clinical symptoms. Understanding allergies is essential in medicine, particularly in pharmacology, to avoid adverse drug reactions. Identifying potential allergens informs safe prescribing practices and helps mitigate risks in patient care.

29) Science (Scientific):
Science is the systematic study of the natural world through observation and experimentation. It provides the foundation for understanding health topics, enabling advancements in various fields, including medicine and pharmacology. Scientific research produces evidence-based practices essential for improving healthcare outcomes and informing clinical guidelines.

30) Samtosha (Samtosa, Santosa, Santosha, Santosh):
Santosh refers to Dr. C Santosh Kumar, a consultant biostatistician involved in supporting the statistical aspects of the research study mentioned. His expertise is essential for ensuring accurate data analysis and interpretation, contributing to the overall credibility and validity of the study's conclusions and findings.

31) Tulasi:
Tulasi, also known as holy basil, is an aromatic herb with medicinal properties, commonly used in traditional medicine. It is believed to have various health benefits, such as anti-inflammatory effects and promoting overall well-being. Its use in research reflects an interest in natural remedies and holistic health practices.

32) Family:
Family refers to a group of related plants, animals, or humans. In scientific classifications, it categorizes similar organisms based on shared characteristics. In medicine, understanding family relationships among pathogens can help determine treatment strategies and the potential for cross-reactivity among agents within the same category.

33) Purity:
Purity refers to the absence of contaminants or impurities in a substance. In pharmaceuticals, the purity of drug compounds is critical for ensuring safety and efficacy. Evaluating purity helps confirm that formulations are suitable for clinical use, directly impacting health outcomes and regulatory compliance.

34) Medium:
Medium refers to a substance through which other substances are transmitted or contained. In microbiological studies, medium often refers to the nutrient solution used to grow bacteria for analysis. Understanding different media types is vital for isolating and identifying pathogenic organisms in clinical and research laboratories.

35) Delhi:
Delhi is the capital territory of India, known for its political, economic, and cultural significance. It has a robust healthcare system and numerous research institutions contributing to medical advancements. The city plays a vital role in public health initiatives and the regulation of pharmaceuticals in India.

36) Kumar:
Kumar may refer to Dr. C Santosh Kumar, a significant contributor to the statistical analysis of the study mentioned. His role is crucial for validating the research findings, ensuring that the statistical methods used are appropriate and accurately reflect the collected data, thus enhancing the study's integrity.

37) Field:
Field refers to a particular area of study or professional practice. In the context of research, it encompasses various disciplines and specialties, such as medicine, pharmacology, or biology. Focusing on specific fields allows for targeted research and the development of specialized knowledge to improve practices and innovations.

38) Visit:
A visit refers to the act of going to see someone or something for a purpose. In medical research, it can refer to scheduled appointments for patient evaluations, data collection, and follow-up assessments. Visits are essential for monitoring treatment progress and ensuring patient adherence to study protocols.

39) Blood:
Blood is a vital fluid in the body responsible for transporting oxygen, nutrients, and waste products. It plays a crucial role in immune responses and overall health. In medical research, blood analysis can provide valuable insights into health conditions, disease prevalence, and treatment efficacy.

40) Miti:
Miti does not have a conventional definition in a scientific context and may refer to a less commonly known term in specific cultural or regional usage. Clarifying its meaning can be essential to understand its relevance in an academic or medicinal context.

41) Line:
Line refers to an arrangement or a series of items in a sequential manner. In research, line can signify the pathway or process that connects understanding various phenomena. It can also relate to treatment lines, which outline the sequence of therapies used in managing patient care.

42) Salt (Salty):
Salt, particularly sodium chloride, is essential for various biological functions, including fluid balance and nerve transmission. In medicine, salts are often used in drug formulations, both as active and inactive components. Understanding the role of salt in therapeutics informs drug design and formulation strategies.

43) Pur:
Poor refers to a condition of low quality, insufficient quantity, or inadequate status. In healthcare, it often describes health disparities or limited access to medical services. Addressing poverty in healthcare is crucial for promoting equity and improving health outcomes in underprivileged populations.

44) Male:
Male refers to the sex of organisms that produce small, mobile gametes known as sperm. In research, gender differences are often significant in studying health conditions and treatments. Understanding male-specific health issues can guide tailored strategies in medical practice and improve overall health management.

Other Health Sciences Concepts:

[back to top]

Discover the significance of concepts within the article: ‘Turmeric extract vs. chlorhexidine in chronic periodontitis treatment.’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:

Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Chronic periodontitis, Scaling and root planing, Microbiological analysis, Clinical trials registry – India, Gel electrophoresis, Pluronic F127, Local Drug Delivery, Multiplex polymerase chain reaction, Clinical parameter, Tannerella forsythia, Subgingival plaque sample.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Help to become even better: