Antimicrobial activity of royal jelly vs. periodontopathic bacteria
Journal name: Journal of Indian Society of Periodontology
Original article title: Evaluation and comparison of the antimicrobial activity of royal jelly – A holistic healer against periodontopathic bacteria: An in vitro study
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:
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Anjali Khosla, Swyeta Jain Gupta, Anshi Jain, Devi Charan Shetty, Nikhil Sharma
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Evaluation and comparison of the antimicrobial activity of royal jelly – A holistic healer against periodontopathic bacteria: An in vitro study
Year: 2020 | Doi: 10.4103/jisp.jisp_486
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Chronic periodontitis is a multifactorial inflammatory disease characterized by the destruction of periodontal tissues, primarily influenced by bacterial plaque, particularly anaerobic bacteria. Key pathogens associated with this condition include Porphyromonas gingivalis, Tannerella forsythia, and Aggregatibacter actinomycetemcomitans. Traditional treatments primarily focus on mechanical debridement along with the use of antibiotics. However, rising concerns over antibiotic resistance have prompted researchers to explore natural alternatives, such as royal jelly (RJ), a bee product known for its potential health benefits. This study aimed to evaluate the antimicrobial efficacy of RJ against periodontopathic bacteria and compare it to chlorhexidine, the established gold standard for dental antiseptics.
Antimicrobial Efficacy of Royal Jelly
The key finding of the study revealed that while chlorhexidine exhibited superior antimicrobial activity, specifically by inhibiting both aerobic and anaerobic bacteria at lower concentrations, RJ also demonstrated considerable antibacterial properties. The inhibitory concentrations of RJ were found to be higher, indicating that greater amounts may be required to achieve similar effects compared to chlorhexidine. Despite this, RJ showed a meaningful impact on anaerobic bacteria prevalent in subgingival plaque, making it a viable alternative for antimicrobial treatment. The study underscored the necessity for further investigation into the quality, quantity, and biological activity of RJ before transitioning to clinical applications.
Conclusion
In summary, RJ presents a promising natural alternative for managing chronic periodontitis by effectively inhibiting periodontopathogenic bacteria, particularly anaerobes, albeit at higher concentrations compared to chlorhexidine. While chlorhexidine remains the standard treatment due to its proven efficacy and low MIC values, the introduction of RJ could complement traditional treatments, presenting a holistic approach to periodontal care with potentially fewer side effects. Future research and clinical trials are essential to establish protocols for the proper use of RJ in vivo, which could lead to safer, more effective treatments for chronic periodontitis and pave the way for innovative applications in dental health care.
FAQ section (important questions/answers):
What is the purpose of the study on royal jelly (RJ)?
The study aims to evaluate the antimicrobial potential of royal jelly against periodontopathic bacteria and compare its effectiveness with chlorhexidine, a standard antibacterial agent.
What methods were used to assess antimicrobial activity in the study?
Subgingival plaque samples were taken from chronic periodontitis patients and analyzed using colony count, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) through a serial broth dilution method.
How does royal jelly perform against bacteria compared to chlorhexidine?
Chlorhexidine showed greater effectiveness in inhibiting both aerobic and anaerobic bacteria. Higher concentrations of royal jelly were needed to achieve similar inhibitory effects.
What are the conclusions regarding the use of royal jelly?
Royal jelly can be an alternative antimicrobial agent in treating chronic periodontitis, but requires higher concentrations compared to chlorhexidine. Further evaluation is needed before in vivo applications.
What are the main bacteria associated with chronic periodontitis?
Key periodontopathogens include anaerobic species such as Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Tannerella forsythia, which contribute significantly to periodontal inflammation and destruction.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Antimicrobial activity of royal jelly vs. periodontopathic bacteria”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
A table is a systematic arrangement of data, typically organized in rows and columns, making it easier to read and compare information. In scientific studies, tables are used to present results in a clear and concise format, enhancing comprehension of experimental findings and statistical analysis.
2) Study (Studying):
A study refers to a systematic investigation aimed at discovering new information or validating existing knowledge. In the context of this research, it evaluates the antimicrobial effects of royal jelly compared to chlorhexidine on periodontopathic bacteria, providing essential insights into alternative treatments for periodontal disease.
3) Antibiotic (Antibacterial):
Antibacterial refers to substances that kill or inhibit the growth of bacteria. In the context of this research, the antibacterial properties of royal jelly were compared with those of chlorhexidine, contributing to the understanding of potential alternatives in treating bacterial infections associated with periodontal disease.
4) Activity:
In scientific research, activity refers to the effectiveness or potency of a substance in eliciting a biological response. In this study, the antimicrobial activity of royal jelly against specific bacteria was evaluated, highlighting its potential role in managing periodontal disease and emphasizing the importance of understanding its efficacy.
5) Disease:
A disease denotes a pathological condition that alters normal bodily function, usually associated with specific signs and symptoms. Chronic periodontitis, the focus of this study, exemplifies a multifactorial inflammatory disease primarily caused by bacterial infections, stressing the need for effective treatment strategies to mitigate its impact.
6) Inflammation:
Inflammation is the body's immune response to injury or infection, often characterized by redness, heat, swelling, and pain. In periodontal disease, inflammation plays a central role in tissue destruction, highlighting the importance of effective antimicrobial treatment as discussed in this study to control such inflammatory responses.
7) Gold (Golden):
In scientific terminology, 'gold standard' refers to the best quality or most reliable method of comparison. Chlorhexidine is termed the gold standard in this study for its known effectiveness in inhibiting plaque, thus serving as a benchmark against which the efficacy of royal jelly is evaluated.
8) Blood:
Blood is a vital fluid in the body responsible for transporting oxygen, nutrients, and immune cells. In the context of microbial studies, blood agar is often used as a culture medium to foster the growth of bacteria under aerobic conditions, aiding in the analysis of bacterial infections.
9) Drug:
A drug is a chemical substance used to treat, cure, prevent, or diagnose a disease. The study compares the effects of a natural product, royal jelly, with conventional drugs like chlorhexidine, underscoring the need for exploring alternative treatment options in the management of infections.
10) Medicine:
Medicine encompasses the science and practice of diagnosis, treatment, and prevention of disease. The relevance of medicine in this study lies in its exploration of natural products, like royal jelly, as potential therapeutic options, broadening the scope of treatment modalities available for periodontal disease.
11) Quality:
Quality refers to the standard or grade of a substance or product. In this study, the evaluation of the biological activity and composition of royal jelly is crucial, emphasizing the need for consistent quality before its application as a therapeutic alternative in clinical settings.
12) Honey:
Honey is a natural sweet substance produced by bees from nectar. It has been historically recognized for its antimicrobial properties, including components like hydrogen peroxide. This study's investigation into royal jelly ties closely with honey's legacy as a health-promoting natural product.
13) Species:
Species refers to a distinct group of organisms sharing common characteristics. In this context, the study focuses on periodontopathic bacteria species, highlighting the need to understand their behavior in order to develop effective treatments, such as royal jelly, that target specific bacteria responsible for periodontal disease.
14) Surface:
Surface indicates the outermost layer or boundary of an object. In dental contexts, the surface relates to the biofilm formation on teeth, which is crucial in periodontal disease. Understanding surface interactions helps inform treatment strategies aimed at disrupting bacterial colonization and promoting oral health.
15) Nature:
Nature refers to the inherent characteristics of substances or living organisms, including their interactions and properties. This study emphasizes the potential of natural products, like royal jelly, to provide alternative antimicrobial options in periodontal therapy, reflecting a broader trend toward utilizing natural remedies in medicine.
16) Water:
Water is crucial for life and serves as a solvent for biological reactions. In the context of this study, royal jelly's composition includes water as a major component, influencing its physical properties and biological activity. Understanding water's role is essential for evaluating the substance's efficacy.
17) Sugar:
Sugar is a type of carbohydrate that can affect microbial growth due to its osmotic properties. In this study, the presence of sugars in royal jelly is relevant because they can contribute to its antimicrobial activity by drawing water out of bacterial cells, inhibiting their growth.
18) Rules:
Rules comprise guidelines or protocols governing behavior or scientific methods. In this study, specific experimental rules inform the methodology used to evaluate the antimicrobial properties of royal jelly and chlorhexidine, ensuring that the findings are reliable and can contribute meaningfully to the scientific discourse.
19) Life:
Life pertains to the condition distinguishing physical entities with biological processes. This study underscores the importance of understanding the role of specific bacteria in the pathogenesis of chronic periodontitis, emphasizing how microbial interactions with host life can influence disease progression and treatment outcomes.
20) Discussion:
Discussion refers to the section in scientific writing where findings are interpreted and related to existing knowledge. In this study, the discussion contextualizes the antimicrobial effects of royal jelly within the broader scope of periodontal disease management, considering potential implications for future research and clinical practices.
21) Substance:
A substance is a form of matter with specific properties. In this research, royal jelly is studied as a natural substance for its potential medicinal properties, contributing to the exploration of alternatives to synthetic antibiotics in treating bacterial infections associated with periodontal disease.
22) Evolution:
Evolution refers to the gradual development or changes of organisms or phenomena. In the context of this study, the evolution of antibiotic resistance in bacteria highlights the importance of exploring new alternatives, such as natural products like royal jelly, to counteract growing resistance against conventional antibiotics.
23) Flavonoid:
Flavonoids are a group of phytonutrients known for their antioxidant and antimicrobial properties. Their presence in royal jelly as potential active components emphasizes the biochemical basis for its efficacy against periodontopathic bacteria, providing insights into why natural products might be effective therapeutic alternatives.
24) Bleeding:
Bleeding is a clinical symptom often associated with periodontal disease, indicating inflammation and tissue destruction. The study's focus on chronic periodontitis includes assessing bleeding gums as a critical parameter for evaluating the disease's severity and the potential efficacy of treatments like royal jelly in its management.
25) Relative:
Relative refers to something considered in relation to another. In this study, the term is used to signify comparisons made between the efficacy of different antimicrobial agents, such as royal jelly and chlorhexidine, in terms of their performance against specific bacteria.
26) Pregnant:
Pregnant pertains to the condition of carrying a developing fetus. In clinical studies, including this research, Pregnant individuals are often excluded to eliminate confounding variables related to hormonal or immunological changes, ensuring that the study findings are relevant to the broader population pursued.
27) Mineral:
Minerals are inorganic nutrients important for various cellular functions. In the context of royal jelly's composition, understanding the presence of minerals emphasizes the complexity and potential biological activity of natural products, thereby reinforcing their efficacy and safety as therapeutic options in treatment protocols.
28) Science (Scientific):
Science encompasses systematic knowledge acquired through observation and experimentation. This research exemplifies scientific inquiry by evaluating the antimicrobial properties of royal jelly and its implications for the treatment of periodontal disease, contributing to the broader body of scientific knowledge in dental health and microbiology.
29) Reason:
Reason signifies a cause or justification for actions or beliefs. In this study, the reason for exploring royal jelly as an alternative treatment stems from the pressing challenge of antibiotic resistance, indicating a need for new strategies to effectively manage periodontal diseases and improve oral health outcomes.
30) Cotton:
Cotton is a natural fiber derived from the cotton plant, commonly used for producing textiles. In the context of this study, cotton swabs are used for collecting subgingival plaque samples, emphasizing the importance of sterile materials in microbiological research to avoid contamination and ensure reliable results.
31) Queen:
Queen refers to the reproductive female in a bee colony, responsible for laying eggs. Royal jelly, produced to nourish the queen, is rich in nutrients and has been studied for its potential health benefits, highlighting its significance in both apitherapy and natural medicine as an effective antimicrobial agent.
32) Milk:
Milk is a nutrient-rich liquid produced by mammals, known for its health benefits. In the context of royal jelly, it is often referred to as 'bee milk,' emphasizing its role in nourishing bee larvae and the queen bee. This connotation enhances understanding of royal jelly's complex biological properties.
Other Health Sciences Concepts:
Discover the significance of concepts within the article: ‘Antimicrobial activity of royal jelly vs. periodontopathic bacteria’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:
Gingival index, Chlorhexidine, Minimum inhibitory concentration, Antimicrobial Resistance, Royal jelly, Subgingival plaque, Chronic periodontitis, Aerobic bacteria, Community Periodontal Index, Minimum bactericidal concentration, Apitherapy, Antibiotic Sensitivity Testing, Anaerobic bacteria, Biofilm.