Deoxypyridinoline as a biomarker for alveolar bone loss in periodontitis.
Journal name: Journal of Indian Society of Periodontology
Original article title: Evaluation of deoxypyridinoline levels in gingival crevicular fluid and serum as alveolar bone loss biomarker in patients with periodontitis
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:
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Suhail Syed, Vinathi Reddy Kankara, Krishnanjeya Reddy Pathakota, Preethi Krishnan, Ashank Mishra
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Evaluation of deoxypyridinoline levels in gingival crevicular fluid and serum as alveolar bone loss biomarker in patients with periodontitis
Year: 2020 | Doi: 10.4103/jisp.jisp_256
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Periodontitis is a chronic inflammatory disease that adversely affects the supporting tissues of teeth, primarily due to microbial infections and the resulting host immune response. This disease leads to progressive bone destruction, tooth mobility, and potential tooth loss when untreated. The research highlights the role of gingival crevicular fluid (GCF) as a non-invasive medium that contains various biomarkers indicating periodontal disease activity, with a focus on deoxypyridinoline (DPD) as a potential indicator of osteoclast-mediated bone turnover. The study aims to assess the reliability of DPD levels in GCF as a biomarker for chronic periodontitis compared to clinically healthy individuals.
Increased DPD Levels in Chronic Periodontitis Patients
The findings of the study reveal that GCF DPD levels were significantly elevated in chronic periodontitis patients—11.5 nmol/L compared to 4.71 nmol/L in healthy individuals—suggesting that DPD serves as a sensitive indicator of ongoing periodontal destruction. However, the study found no significant correlation between the severity of periodontal disease, as measured by probing pocket depth (PPD) and clinical attachment loss (CAL), and DPD levels in both GCF and serum. This challenges the traditional understanding that increased disease severity corresponds to higher biomarker levels, indicating that the assessment of DPD may require a nuanced interpretation that considers the site-specific nature of GCF and the dynamic processes involved in periodontal disease.
Conclusion
The research concludes that while GCF DPD levels are elevated in chronic periodontitis patients and can indicate active periodontal destruction, they do not correlate with disease severity as traditionally expected. This calls for further studies with larger sample sizes and varying stages of periodontal disease to evaluate DPD's utility as a biomarker more accurately. Enhanced understanding of the role of biomarkers like DPD could improve early diagnosis and the monitoring of periodontal disease progression, paving the way for targeted interventions.
FAQ section (important questions/answers):
What is the significance of deoxypyridinoline (DPD) in periodontitis?
DPD is a biomarker indicating osteoclast-mediated bone turnover, reflecting bone destruction and active phases of periodontal disease, which may help predict disease status.
How were study participants selected for the research?
The study involved 15 periodontally healthy individuals and 15 chronic periodontitis patients, matched by age and gender, excluded any with systemic diseases or recent infections.
What were the main findings regarding GCF DPD levels?
GCF DPD levels were significantly higher in chronic periodontitis patients compared to healthy individuals, indicating potential as a biomarker for periodontal disease activity.
Did the study find any correlation between DPD levels and age?
No significant correlation was found between DPD levels and increasing age in either group, suggesting that other factors may influence DPD concentration.
What conclusion did the study reach regarding periodontal disease severity?
The study concluded that increased periodontal disease severity did not correlate significantly with GCF or serum DPD levels in chronic periodontitis patients.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Deoxypyridinoline as a biomarker for alveolar bone loss in periodontitis.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
In scientific research, a table organizes and presents data in rows and columns to facilitate comparison and interpretation of findings. It enhances the clarity and understanding of numerical results, making it easier for readers to draw conclusions and identify trends in the data collected during the study.
2) Disease:
A disease refers to an abnormal condition affecting the body or mind, characterized by specific symptoms and signs. In the context of this text, periodontal disease includes chronic inflammatory conditions affecting the gums and supporting structures of teeth, highlighting its importance in dental and medical research.
3) Study (Studying):
A study involves systematic investigation and analysis aimed at understanding specific phenomena or testing hypotheses. In this context, the study focuses on the evaluation of deoxypyridinoline (DPD) levels in gingival crevicular fluid (GCF) and their correlation with periodontal disease, contributing valuable insights to dental science.
4) Blood:
Blood is a vital bodily fluid that circulates throughout the body, delivering nutrients and oxygen while removing waste products. In the context of this research, blood samples are collected to assess serum deoxypyridinoline levels, offering insight into systemic bone metabolism and its relation to periodontal health.
5) Activity:
Activity refers to the state of being active or engaging in specific processes. In this text, it primarily relates to the biochemical activity associated with bone turnover and inflammation in periodontal disease, emphasizing the importance of understanding biological markers for disease progression and treatment effectiveness.
6) Rules:
Rules are prescribed guidelines or principles governing behavior, procedures, or processes. In research, adherence to methodological rules ensures the validity and reliability of results. In the context of this study, applying strict rules during sample collection and analysis is crucial for obtaining accurate data on DPD levels.
7) Bleeding:
Bleeding, in medical terms, refers to the loss of blood from the circulatory system. In dental research, bleeding during periodontal examination is assessed as a significant clinical parameter, indicating the presence of inflammation and tissue destruction, thus serving as an essential component in evaluating periodontal disease severity.
8) Reason:
Reason refers to a cause, explanation, or justification for a particular phenomenon. In the study context, the reasoning behind investigating DPD levels in GCF and serum relates to the need for reliable biomarkers that can indicate periodontal disease activity and predict potential complications in patients with chronic periodontitis.
9) Male:
Male refers to the gender associated with biological sex, characterized by specific physiological and genetic traits typically exemplified by XY chromosomes. In this study, the demographic data include male participants, indicating gender distribution and allowing for analysis of potential differences in periodontal disease manifestations and biomarkers compared to females.
10) Observation:
Observation is the act of noticing or perceiving something, often used to gather data and insights in research. In the study, clinical observation of periodontal conditions is critical for assessing disease severity and for drawing connections between clinical parameters and the biological markers under investigation.
11) Life:
Life refers to the condition of being alive, characterized by growth, reproduction, and response to stimuli. In the context of this research, understanding the biological processes of life at the cellular level, especially in bone and immune responses, is essential for evaluating the mechanisms underlying periodontal disease.
12) Rheumatoid arthritis:
Rheumatoid arthritis is a chronic inflammatory autoimmune disorder that primarily affects joints, leading to pain, swelling, and potential joint destruction. Mentioning it in the study highlights the relevance of systemic inflammatory conditions in dental health and their potential interactions with periodontal disease, enriching the understanding of shared pathophysiological mechanisms.
13) Inflammation:
Inflammation is the body's physiological response to injury or infection, characterized by redness, swelling, heat, and pain. In periodontal disease, inflammation plays a crucial role in tissue destruction and disease progression. Understanding the inflammatory processes involved helps researchers identify effective therapeutic targets for managing periodontal conditions.
14) Surrounding:
Surrounding refers to the area or environment encircling an entity. In this text, it relates to the context of the study, particularly focusing on the local effects of periodontal disease on structures surrounding the teeth, such as gums and bone, emphasizing the need for localized biomarkers like DPD in GCF.
15) Discussion:
Discussion refers to the section of research where findings are interpreted, contextualized, and explored in relation to existing knowledge. It allows researchers to analyze their results, draw conclusions, and suggest future research directions, fostering a comprehensive understanding of the implications of DPD levels on periodontal disease management.
16) Antibiotic (Antibacterial):
Antibiotics are medications used to treat bacterial infections by inhibiting the growth or kill bacteria. In periodontal health, antibiotics may be prescribed to address infections associated with periodontal disease, underscoring the importance of understanding microbial influences on periodontal health and the role of systemic treatment strategies.
17) Knowledge:
Knowledge refers to the awareness or understanding gained through experience or education. In the research context, knowledge about periodontal disease and its biomarkers guides scientific inquiry, informs clinical practice, and ultimately enhances patient care in the management and treatment of periodontal conditions.
18) Science (Scientific):
Science is the systematic study of the natural world through observation and experimentation. In this text, the scientific approach underlies the research's methodology, providing a structured framework for investigating the relationships between DPD levels, periodontal disease, and the broader biological processes involved in health and disease.
19) Company:
Company generally refers to a business entity or organization involved in commercial activities. While not explicitly discussed in the study, companies may play a role in developing diagnostic tools and assays used in research, demonstrating the interconnections between scientific inquiry and commercial applications in healthcare and disease management.
20) Nature:
Nature refers to the inherent characteristics of entities, including biological processes and ecosystems. In this context, recognizing the nature of periodontal disease helps researchers understand the multifaceted interactions between microbial agents, host responses, and the underlying biological markers, guiding efforts to improve diagnosis and treatment outcomes.
21) Cotton:
Cotton is a natural fiber commonly used in medical and dental settings for various purposes, including isolation during procedures. In the context of gingival crevicular fluid collection, cotton rolls are used to maintain a dry area during sample collection, underscoring the importance of maintaining sample integrity during research.
22) Kappa:
Kappa, in scientific contexts, often refers to a coefficient that measures inter-rater reliability or agreement among observers. It can be significant in research to ensure consistency in clinical assessments, providing an indication of the reliability of measurements taken during evaluations in the study of periodontal health.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Deoxypyridinoline as a biomarker for alveolar bone loss in periodontitis.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Cross-sectional study, Plaque index, Bleeding index, Systemic health, Probing pocket depth, Gingival crevicular fluid, Clinical parameter, Clinical attachment loss, Bone turnover, Modified gingival index, Chronic periodontitis patients, Deoxypyridinoline levels, Biologic plausibility, Metallophosphoesterase, Oral fluids, Double-antibody sandwich enzyme-linked immunosorbent assay, Non-invasive oral fluids, Institutional ethical committee clearance.