Evaluation of debridement vs. debridement with bone matrix in defects.
Journal name: Journal of Indian Society of Periodontology
Original article title: Comparative evaluation of open flap debridement alone and in combination with anorganic bone matrix/cell-binding peptide in the treatment of human infrabony defects: A randomized clinical trial
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Pratima Ram Niwas Mishra, Abhay Pandurang Kolte, Rajashri Abhay Kolte, Natasha Gev Pajnigara, Kanan Ketan Shah
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Comparative evaluation of open flap debridement alone and in combination with anorganic bone matrix/cell-binding peptide in the treatment of human infrabony defects: A randomized clinical trial
Year: 2019 | Doi: 10.4103/jisp.jisp_339
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Periodontal diseases, characterized by chronic inflammatory conditions leading to alveolar bone loss, require effective treatment strategies aimed at regenerating the lost periodontal structure. Among these treatments, regenerative periodontal therapy is integral to restoring the health and function of the periodontium. Recent advancements include the use of synthetic materials such as anorganic bone matrix combined with cell-binding peptides, specifically ABM/P-15, which have shown promise in enhancing fibroblast migration and bone regeneration. The present study evaluates the efficacy of combining open flap debridement (OFD) with ABM/P-15 in treating human infrabony periodontal defects compared to OFD alone.
Enhanced Regenerative Capacity with ABM/P-15
The study involved 20 patients with chronic periodontitis, who were randomly assigned to receive either OFD alone (Control group) or OFD with ABM/P-15 (Test group). Clinical parameters such as probing pocket depth (PPD), clinical attachment level (CAL), and radiographic defect depth (RDD) were recorded at baseline and after six months. Results indicated that patients in the Test group experienced a statistically significant reduction in PPD and a greater gain in CAL compared to the Control group. Specifically, the Test group exhibited a mean PPD reduction of 4.15 mm and CAL gain of 3.10 mm, alongside a highly significant reduction in RDD. These improvements demonstrate that ABM/P-15 effectively enhances periodontal regeneration when used in conjunction with traditional surgical methods.
Conclusion
The findings of this study highlight the effectiveness of ABM/P-15 as a promising material for periodontal regeneration, particularly in infrabony defects. By enhancing cellular attachment and migration, ABM/P-15 not only facilitates better clinical outcomes but also promotes significant defect fill, as evidenced by radiographic assessments. This combination therapy demonstrates considerable potential for improving the regenerative success of periodontal treatments, indicating that ABM/P-15 could establish new standards in periodontal and implant dentistry. Further studies, ideally incorporating varied defect morphologies and advanced imaging techniques, are recommended to solidify these preliminary findings and expand upon the implications of ABM/P-15 in clinical practice.
FAQ section (important questions/answers):
What is the purpose of the study involving ABM/P-15?
The study aims to evaluate the effectiveness of open flap debridement with and without ABM/P-15 in treating human infrabony periodontal defects, focusing on clinical and radiographic improvements in patients with chronic periodontitis.
What are the key findings regarding probing pocket depth (PPD)?
The Test group showed a significant mean PPD reduction of 4.15 ± 1.04 mm at 6 months compared to the Control group, indicating that ABM/P-15 enhances periodontal regeneration.
How does ABM/P-15 contribute to periodontal regeneration?
ABM/P-15 combines an inorganic bone matrix and a cell-binding peptide, enhancing fibroblast migration and attachment to the graft material, thus promoting better healing and tissue regeneration.
What secondary outcomes did the study measure?
In addition to PPD, the study evaluated changes in clinical attachment level (CAL) and radiographic defect depth, finding significant improvements in the Test group compared to the Control group.
What were the overall conclusions of the study?
The use of ABM/P-15 in periodontal treatment showed promising results, improving clinical and radiographic outcomes, suggesting its potential as an effective bone augmentation material in periodontal and implant dentistry.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Evaluation of debridement vs. debridement with bone matrix in defects.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
In the context of scientific studies, a table organizes data clearly, enabling easy comparison and interpretation of results. Tables present statistical findings, measurements, and observations in a structured format, allowing researchers to communicate complex information effectively, making it easier for readers to grasp essential trends and outcomes in the study.
2) Study (Studying):
A study refers to a systematic investigation conducted to explore a specific hypothesis or research question. In clinical research, like examining periodontal effects, a study design outlines methods and analyses employed to gather data, assess clinical efficacy, and generate conclusions that advance knowledge and improve patient care practices.
3) Measurement:
Measurement in scientific research is the quantitative assessment of variables. Accurate measuring ensures the validity and reliability of data collected, such as probing pocket depth or clinical attachment levels in periodontal studies. Proper measurement techniques are crucial for evaluating treatment outcomes, guide clinical decisions, and contribute to evidence-based practices.
4) Relative:
Relative comparison in research contexts helps establish associations or differences between variables or treatment groups. By evaluating relative changes, such as clinical parameters or healing outcomes between test and control groups, researchers can determine the effectiveness of interventions, providing insights into which treatment options yield better results.
5) Wall:
In periodontal studies, 'wall' commonly refers to the bony structures surrounding alveolar defects. The morphology and number of bony walls play critical roles in determining the regenerative potential of periodontal treatments, as more walls typically indicate better healing prospects. Understanding wall configurations aids in treatment planning and predicting outcomes.
6) Repair:
Repair in the context of periodontal therapy describes the biological process of healing damaged periodontal tissues. This may involve the formation of a long junctional epithelium or the restoration of lost bone. Effective repair is vital for re-establishing periodontal health, influencing patient outcomes and overall oral functionality.
7) Observation:
Observation is a key component of clinical trials, requiring systematic and careful recording of physical signs, behaviors, or responses to treatments. Observational data provide critical insights into the efficacy and safety of interventions. Accurate observations contribute to the reliability of findings and inform adjustments in treatment protocols.
8) Activity:
Activity in a research context often refers to biological or cellular processes, such as osteoblastic activity in bone regeneration. Understanding the mechanisms behind activity levels helps researchers assess the efficacy of materials used in treatments, guiding improvements in therapeutic strategies for better healing and periodontal regeneration outcomes.
9) Disease:
Disease, particularly in the context of periodontitis, denotes a pathological condition affecting periodontal tissues, characterized by inflammation and potential tooth loss. Understanding the etiology, progression, and treatment of periodontal disease is essential for developing effective therapies and improving patient outcomes in clinical dental practice.
10) Filling (Filled):
Filled pertains to the successful restoration of tissue volume or structure, particularly in bone grafting procedures for periodontal defects. Effective filling enhances healing and regeneration of lost periodontal components. Measuring the extent of filling is crucial for evaluating the success of regenerative treatments and providing insight into therapeutic efficacy.
11) Hygiene (Hygienic):
Hygiene practices are crucial for maintaining oral health and preventing periodontal diseases. Patients' adherence to oral hygiene protocols influences treatment outcomes in periodontal therapies. Effective hygiene measures contribute to the long-term success of periodontal regeneration and require education on proper techniques for maintaining optimal oral conditions.
12) Reason:
Reason encompasses the rationale behind conducting a particular study or implementing specific treatment strategies. In research, articulating a reason aids in justifying the methodology and assumptions, ultimately enhancing the relevance and credibility of the findings. A clear reason helps align research objectives with clinical practices, serving patient needs.
13) Sign:
Sign refers to any observable indicator of health status or treatment outcomes in clinical practice. Recognizing signs of periodontal healing or disease is crucial for diagnosis and monitoring treatment efficacy. Accurate identification allows for timely intervention, potentially influencing overall patient prognosis and long-term dental health.
14) Discussion:
Discussion in scientific papers provides a critical analysis of study results, allowing researchers to interpret findings and contextualize them within existing literature. It offers insights into the implications of the results for practice, highlights limitations, and suggests future research directions. It is essential for advancing knowledge in the field.
15) Antibiotic (Antibacterial):
Antibiotics are medications used to treat bacterial infections, and in periodontal therapy, they may be employed to manage infections associated with periodontal diseases. Understanding the role of antibiotics in conjunction with surgical procedures helps optimize patient outcomes and minimize complications, making their appropriate use critical for effective treatment strategies.
16) Dressing:
A dressing applied post-surgical procedures serves as a protective barrier over treated tissues, promoting healing and preventing contamination. Its selection and application are crucial for protecting surgical sites, reducing trauma, and facilitating proper tissue regeneration. Adequate dressing use contributes to better recovery outcomes and overall treatment success.
17) Pregnant:
Pregnant individuals require careful consideration regarding periodontal treatment, as hormonal changes can influence disease progression and treatment responses. It is essential to evaluate risks and benefits, ensuring treatments are safe for both mother and fetus. Clinicians should tailor approaches to address unique challenges faced during pregnancy concerning oral health.
18) Grafting:
Grafting refers to the surgical technique of transplanting tissue or bone to restore lost structures, commonly used in periodontal therapy to fill defects or enhance regeneration. The selection of appropriate graft materials is crucial for successful outcomes, impacting the healing process and re-establishment of periodontal integrity.
19) Science (Scientific):
Science underpins the methodology and validation of research findings. In the context of periodontal studies, applying scientific principles ensures the rigor and reproducibility of results, advancing our understanding of disease mechanisms and treatment effects. It drives innovation and informs best practices in clinical care and research.
20) Surface:
Surface characteristics of biomaterials, such as ABM/P-15, influence their interaction with biological tissues, affecting cell adhesion, proliferation, and overall healing outcomes. Understanding the surface properties of graft materials is essential for optimizing their use in periodontal treatments to enhance regeneration and achieve desired clinical results.
21) Nature:
Nature refers to the inherent characteristics of biological materials or processes. In periodontal therapy, recognizing the nature of tissues and their healing capabilities is essential for developing effective treatments. Insights into the nature of healing processes guide the selection of appropriate interventions for optimal periodontal regeneration.
22) Animal:
Animal models are essential in biomedical research for transitioning knowledge from laboratory settings to human applications. They provide insights into biological responses to treatments, including periodontal therapies. Understanding results from animal studies helps researchers hypothesize potential human outcomes, guiding clinical innovations and improvements in periodontal care.
23) Pandita (Pandit):
Pandit refers to a specific author or researcher contributing to periodontal literature. Their findings could provide insights or evidence supporting treatment methodologies. Analyzing the works of individuals like Pandit can inform current practices and explore the effectiveness of regenerative approaches in managing periodontal defects.
24) Beta:
Beta likely refers to a statistical term or might denote a variable used within studies. In research, 'beta' can also indicate the effect size or risk factors associated with particular outcomes. Understanding relationships and effects analyzed through beta values is integral to interpreting study results.
25) Amde (Ande):
Ande may reference a specific section or data presented in a study, denoting associations or findings attributed to a contributor. If related to periodontal research, identifying such attributions aids in validating knowledge and understanding treatment implications for clinical practice based on aforementioned author's research.
26) Kher:
Kher indicates a researcher or author known for their contributions to the field, perhaps discussing advancements in clinical practices or treatment methodologies. Studies associated with Kher could inform current research, guiding effective techniques and strategies in periodontal therapies and improving patient management practices.
27) Drug:
Drugs in periodontal research may refer to pharmacological agents used alongside surgical treatments to enhance healing or control infections. Understanding the role of drugs is crucial for optimizing patient outcomes post-surgery and providing evidence-based recommendations for concurrent therapies integrated into periodontal care protocols.
28) Dish (Dis):
Dish refers to the equipment used in laboratory settings for preparing or culturing materials, especially in cellular studies. In gum treatments or regenerative procedures, appropriate conditions and mediums, often facilitated by a dish, ensure effective manipulation of biological samples, influencing outcomes in periodontal research.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Evaluation of debridement vs. debridement with bone matrix in defects.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Statistical analysis, Patients consent, American Academy of Periodontology, Probing pocket depth, Clinical attachment level, Clinical outcome, Power Analysis, Periodontal regeneration, Clinical parameter, Open flap debridement, Guided tissue regeneration, Chronic periodontitis patients, Osteoblastic cells.