Antioxidant therapy in periodontal disease: A promising approach.
Journal name: Journal of Indian Society of Periodontology
Original article title: Antioxidant therapy (lycopene and green tea extract) in periodontal disease: A promising paradigm
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Pragya Tripathi, Vikram Blaggana, Preeti Upadhyay, Manika Jindal, Shweta Gupta, Sadaf Nishat
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Antioxidant therapy (lycopene and green tea extract) in periodontal disease: A promising paradigm
Year: 2019 | Doi: 10.4103/jisp.jisp_277
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Periodontal disease, characterized by inflammation of the periodontal attachment apparatus, leads to conditions like gingivitis, the mildest form of periodontal disease. While periodontal pathogens are the primary cause, oxidative stress also significantly contributes to its pathogenesis, impacting the body's antioxidant defenses. Uric acid (UA), a natural antioxidant found in saliva, plays a critical role in assessing the total antioxidant capacity of the body. This study aimed to examine the effects of oral supplementation with antioxidants such as lycopene and green tea extract on clinical periodontal parameters and salivary UA levels in patients with gingivitis, in conjunction with scaling and root planing (SRP).
The Role of Antioxidants in Periodontal Health
The research demonstrated that both lycopene and green tea possess potent antioxidant properties that can mitigate oxidative stress associated with gingivitis. In the study, 30 systemically healthy participants suffering from generalized gingivitis were divided into two groups: a test group receiving antioxidant supplementation (lycopene and green tea extract) and a control group receiving standard oral prophylaxis. Clinical assessments, including the plaque index (PI) and sulcular bleeding index (SBI), were conducted, along with the measurement of salivary UA levels at baseline and after 45 days. The results revealed a significant improvement in both PI and SBI in the test group, compared to the control group, indicating that the antioxidants contributed positively to periodontal health. Furthermore, salivary UA levels increased significantly in the test group, supporting the idea that antioxidant supplementation can enhance the total antioxidant capacity of saliva.
Conclusion
This study concludes that oral supplementation of lycopene and green tea extract positively influences periodontal health by improving clinical parameters and elevating salivary UA levels in gingivitis patients. Although the findings highlight the therapeutic potential of these antioxidants as adjuncts to traditional treatments such as SRP, further research is necessary. Larger-scale, longitudinal studies that evaluate the long-term impact of antioxidant supplementation on periodontal diseases are needed to fully understand its role and efficacy in managing gingivitis and periodontitis. The research underscores the importance of incorporating nutritional supplementation into periodontal therapy to enhance patient outcomes.
FAQ section (important questions/answers):
What is the purpose of this study on antioxidants?
The study aimed to investigate the effect of lycopene and green tea extract on periodontal health and salivary uric acid levels in patients with gingivitis undergoing scaling and root planing.
How were participants selected for the antioxidant study?
Thirty systemically healthy participants aged 18-40 with generalized gingivitis were randomly assigned into two groups, ensuring exclusion of those with systemic illness or recent antibiotic use.
What were the key findings from the antioxidant treatment?
Both treatment groups showed significant reductions in plaque and sulcular bleeding index, but the test group exhibited a notable increase in salivary uric acid levels compared to the control group.
How does lycopene and green tea affect periodontal health?
Lycopene and green tea extract are powerful antioxidants that may reduce oxidative stress, improve antioxidant capacity, and enhance periodontal health when used in conjunction with traditional dental cleaning methods.
What recommendations were made for future research on this topic?
Further studies with larger sample sizes and additional inflammatory markers are recommended to establish the effectiveness of antioxidant therapy in managing periodontal diseases more comprehensively.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Antioxidant therapy in periodontal disease: A promising approach.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
In research, a 'Table' is a structured arrangement of data, often used to summarize findings for clarity and ease of understanding. In this study, tables present the results of clinical evaluations, comparisons of parameters like plaque and bleeding indexes, and salivary uric acid levels before and after treatment, making the information accessible and interpretable for readers.
2) Study (Studying):
The term 'Study' refers to a systematic investigation aimed at discovering or confirming facts. In this context, it highlights the research’s intent to assess the impact of antioxidants on periodontal health. Such studies are crucial in scientific inquiry, contributing to evidence-based practices in dental health, particularly concerning gingivitis treatment.
3) Disease:
'Disease' refers to a pathological condition that alters bodily functions and structures. The text specifically addresses periodontal disease, emphasizing the inflammatory processes that can lead to gingivitis and, subsequently, more severe conditions. Understanding the mechanisms of disease is fundamental for developing effective treatments and improving patient outcomes in dentistry.
4) Inflammation:
'Inflammation' is a biological response to harmful stimuli, often characterized by redness, swelling, and pain. In this research, inflammation is a key concept, as periodontal disease stems from inflammatory processes. The study measures the effects of antioxidant therapies on inflammation, which could lead to improved treatment strategies for gingivitis.
5) Bleeding:
'Bleeding' in this context refers to the condition often observed during periodontal examinations, specifically noted through the Sulcular Bleeding Index (SBI). Increased bleeding can indicate inflammation and disease severity in gingivitis patients. Monitoring bleeding is critical for evaluating treatment efficacy and periodontal health status in clinical settings.
6) Activity:
'Activity' often signifies the effectiveness or engagement of a specific process. In this research, it pertains to the antioxidant activity of compounds like lycopene and green tea extract. This activity is associated with their potential benefits for reducing oxidative stress in periodontal disease, impacting clinical outcomes and contributing to understanding therapeutic mechanisms.
7) Relative:
'Relative' relates to comparisons and can refer to the assessment of changes concerning a baseline condition. In the study, the relative improvement of clinical measures, like plaque and bleeding indexes post-treatment, is significant for establishing the efficacy of adjunctive therapies alongside standard periodontal treatment.
8) Death:
'Death' signifies the ultimate outcome of severe diseases, including untreated periodontal disease, which can lead to tooth loss. While not directly a focus of this study, understanding the implications of periodontal conditions highlights the importance of timely interventions, such as antioxidant supplementation, to prevent progression to more serious health issues.
9) Beta:
'Beta' often relates to a class of carotenoids, which are pigments and antioxidants. In the context of this research, it may refer to beta-carotene, another antioxidant whose effects have been studied. Understanding various types of antioxidants helps evaluate their roles in managing oxidative stress related to periodontal tissue health.
10) Discussion:
'Discussion' is a crucial section in research where findings are interpreted in the context of existing literature. This part of the article evaluates the significance of observed results regarding periodontal health improvement due to antioxidants. Discussion helps to relate findings to broader implications for future research and clinical practices.
11) Collecting:
'Collecting' refers to the process of gathering samples or data for analysis. In this study, saliva collection is essential for evaluating uric acid levels in participants. The methodology for collecting samples affects the reliability of results, reinforcing the importance of careful practices in scientific research.
12) Science (Scientific):
'Scientific' pertains to the methods and practices of inquiry that are based on empirical evidence. The study employs scientific approaches to investigate the impact of antioxidant supplementation, aiming to provide reliable data that contribute to advancements in dental treatments. Scientific rigor is fundamental for establishing credible conclusions and recommendations.
13) Antibiotic (Antibacterial):
'Antibiotic' refers to a class of drugs used to treat bacterial infections. While the study focuses on antioxidants for periodontal therapy, understanding antibiotic effects is vital as some participants may have been excluded if they had received antibiotics recently. This highlights the importance of managing various treatment modalities in patient care.
14) Container:
'Container' indicates a vessel used for holding samples, such as saliva in this study. Appropriate containers are crucial for maintaining the integrity of biological samples during collection and storage. Ensuring proper handling supports the reliability of results and accuracy in evaluating therapeutic impacts in research.
15) Medicine:
'Medicine' encompasses the field that focuses on health, prevention, and treatment of disease. The mention of medicine in this study underscores the role of pharmaceutical adjuncts, like antioxidants, in treating periodontal disease within the broader scope of dental healthcare, highlighting the interplay between different therapeutic approaches.
16) Species:
'Species' refers to distinct biological classifications within the study. While not explicitly mentioned in the study's context, understanding various bacterial species in periodontal disease is essential for grasping inflammatory responses and treatment dynamics. Knowledge of species involved aids in developing targeted therapies for periodontal conditions.
17) Hygiene (Hygienic):
'Hygiene' relates to practices that maintain health and prevent disease. In dental health, oral hygiene is crucial for preventing conditions like gingivitis. The study indirectly emphasizes the importance of hygiene through oral prophylaxis and how adjunct therapies complement routine practices for effective periodontal disease management.
18) Cancer:
'Cancer' denotes a serious disease characterized by uncontrolled cell growth. While not a direct focus of this study, the connection to oxidative stress and the role of antioxidants in disease prevention may suggest the relevance of dietary antioxidants in reducing cancer risks as well, underlining the multifaceted benefits of such supplements.
19) Animal:
'Animal' often pertains to studies involving living organisms for biomedical research. While this study focuses on human participants, previous animal studies on antioxidants can provide foundational knowledge for understanding the therapeutic benefits and biological mechanisms, which often inform human clinical trials in medical and dental research.
20) Drug:
'Drug' indicates a chemical used for diagnosis, treatment, or prevention of disease. In this context, the study explores antioxidants as therapeutic agents. Understanding the pharmacological properties of these compounds is essential for evaluating their efficacy and safety in treating conditions like gingivitis, thereby enhancing patient care strategies.
21) Male:
'Male' pertains to the gender aspect often relevant in clinical trials. The study mentions the exclusion of females at specific physiological stages, indicating the importance of controlling biological variables to ensure the validity of research outcomes. Gender considerations are vital for interpreting results and generalizing findings.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Antioxidant therapy in periodontal disease: A promising approach.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Oxidative stress, Reactive oxygen species, Periodontal disease, Periodontal pathogens, Chronic periodontitis, Antioxidant therapy, Scaling and root planing, Matrix metalloproteinase.