Micronutrient profile in serum: Type II diabetes vs. healthy with periodontitis.
Journal name: Journal of Indian Society of Periodontology
Original article title: A comparative evaluation of the micronutrient profile in the serum of diabetes mellitus Type II patients and healthy individuals with periodontitis
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:
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Biju Thomas, Ballamajalu Rajendra Prasad, Nallilu Suchetha Kumari, Vishakh Radhakrishna, Amitha Ramesh
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: A comparative evaluation of the micronutrient profile in the serum of diabetes mellitus Type II patients and healthy individuals with periodontitis
Year: 2019 | Doi: 10.4103/jisp.jisp_398
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Periodontal disease is an immunoinflammatory condition that arises from the interaction between microbial plaque biofilm and the host's immune response, eventually causing destruction to the periodontal tissues. Recent evidence suggests that periodontitis is not just a localized oral disease but can have systemic health implications, particularly in relation to diabetes mellitus (DM). These diseases exhibit a bidirectional relationship, with periodontitis recognized as a significant complication of DM. This study aims to evaluate the role of essential micronutrients—zinc, copper, selenium, and iron—in the serum of patients with chronic periodontitis, both with and without Type II DM, to understand their potential as biomarkers of the disease and assess any systemic effects.
Importance of Micronutrients
The research highlights the critical role of micronutrients in maintaining oral and overall health. Essential micronutrients like zinc, copper, selenium, and iron are vital for various biochemical processes, including immune function and tissue repair. In the study, it was observed that serum zinc levels were significantly lower in both periodontitis groups compared to healthy controls, indicating its potential role as a biomarker for chronic periodontitis. Conversely, serum copper levels were elevated in patients with periodontitis and diabetes, suggesting an inflammatory response. The findings indicate that disrupted micronutrient levels may contribute to the pathogenesis of periodontal disease, emphasizing the integral relationship between nutrition and oral health.
Conclusion
The results of the study conclude that altered serum levels of zinc, copper, selenium, and iron are associated with chronic periodontitis, particularly in patients with DM Type II. The decrease in zinc and selenium levels alongside the increase in copper levels points towards their potential as biomarkers for chronic periodontitis and underscores the systemic implications of periodontal health. Given these findings, there is a need for further research into the role of micronutrients in periodontal disease and their potential impact on other inflammatory systemic conditions. This study paves the way for future investigations integrating micronutrient assessments in managing patients with periodontal complications.
FAQ section (important questions/answers):
What micronutrients are essential for periodontal health?
Essential micronutrients for periodontal health include zinc, copper, selenium, and iron. These play a vital role in metabolism, immune function, and cellular proliferation, which are crucial for maintaining the integrity of periodontal tissues.
How does diabetes mellitus relate to periodontal disease?
Diabetes mellitus is recognized as a major complication of periodontal disease, indicating a bidirectional relationship. Both conditions can exacerbate each other, leading to increased severity of periodontal infections and diabetic complications.
What were the findings regarding serum zinc levels in the study?
The study found that serum zinc levels were significantly lower in chronic periodontitis patients compared to healthy individuals, indicating zinc's potential role as a biomarker for periodontal disease.
What statistical methods were used in this study?
Statistical analysis was performed using Student's t-test, analysis of variance (ANOVA), Tukey's honestly significant difference test, and Pearson’s correlation to evaluate differences among groups and relationships between variables.
What are the implications of this study for future research?
Future research should explore the serum levels of micronutrients in other inflammatory diseases and consider analyzing multiple biological samples to understand the systemic and local impacts of chronic periodontal disease.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Micronutrient profile in serum: Type II diabetes vs. healthy with periodontitis.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Study (Studying):
The term 'Study' refers to a systematic investigation designed to develop or contribute to knowledge in a specific domain. In the context of medical and scientific research, studies often aim to discover associations, effects, or underlying mechanisms related to health conditions, treatments, or biological interactions.
2) Table:
In research, 'Table' is a structured format used to organize data clearly and concisely. Tables present findings, such as experimental results, in a way that allows for quick comparison. They are essential for summarizing complex information, making it easier for readers to grasp key findings and trends.
3) Disease:
'Disease' denotes a pathological condition characterized by specific signs and symptoms. In medical research, understanding diseases—including their etiology, progression, and effects—is crucial for developing effective treatments. Chronic diseases like diabetes and periodontitis illustrate how two health conditions can influence each other and overall health.
4) Inflammation:
'Inflammation' is a biological response to harmful stimuli, such as pathogens, damaged cells, or irritants. It plays a vital role in the immune response but can become chronic, contributing to various diseases. In the context of periodontal disease, inflammation is a critical factor that affects tissue health and integrity.
5) Blood:
'Blood' is a vital fluid that circulates in the body, transporting oxygen, nutrients, and immune cells to tissues while removing waste products. In health studies, blood analysis can reveal biochemical markers indicative of underlying conditions, such as nutrient deficiencies associated with diseases like periodontitis and diabetes.
6) Activity:
'Activity' refers to the state of being active, particularly in biological or physiological contexts. In health studies, assessing cellular or metabolic activity is essential for understanding disease mechanisms, responses to treatments, and the overall functionality of organs or tissues, particularly in relation to nutrient levels.
7) Hygiene (Hygienic):
'Hygiene' involves practices that promote health and prevent disease, particularly through cleanliness. In relation to periodontal health, maintaining good oral hygiene is crucial for preventing diseases such as periodontitis. Research highlights how hygiene practices can directly influence oral microbiomes and overall health.
8) Sugar:
'Sugar' often refers to glucose or other simple carbohydrates that supply energy to the body. However, excessive sugar consumption is linked to various health issues, including insulin resistance and diabetes, both of which can exacerbate periodontal disease. Understanding sugar's role is vital for health outcomes.
9) Male:
'Male' denotes the sex characterized by specific biological differences, including hormone levels and reproductive anatomy. Studies often assess gender differences in disease prevalence and response to treatment, as conditions like periodontal disease may show variances in incidence and severity between males and females.
10) Human body:
'Human body' refers to the living organism composed of various systems, organs, and tissues working together to sustain life. In health research, understanding how different components of the human body interact is essential for examining the effects of diseases, treatments, and the role of micronutrients.
11) Accumulation (Accumulating, Accumulate):
'Accumulation' refers to the gradual increase or gathering of substances over time. In medical contexts, the accumulation of certain micronutrients or cellular waste can impact health. Research often investigates how accumulated substances influence diseases, organ function, and systemic responses in conditions such as diabetes and periodontitis.
12) Discussion:
'Discussion' in academic research is a section where findings are interpreted in context. It allows researchers to explore implications, compare results with prior studies, and propose future research directions. It provides an opportunity for critical thinking regarding the data collected and its relevance to existing knowledge.
13) Developing:
'Developing' refers to the process of growth, progress, or evolution. In scientific research, understanding the developing stages of diseases or interventions is essential for identifying effective treatment strategies. This term often appears in the context of developing better health guidelines or therapies for chronic conditions.
14) Alcoholism:
'Alcoholism' is a chronic condition marked by uncontrolled drinking and a preoccupation with alcohol. It poses significant health risks, influencing numerous physiological processes and associations with other diseases. Research explores its impact on conditions such as periodontal health, highlighting its relevance in overall health assessments.
15) Antibiotic (Antibacterial):
'Antibiotic' pertains to substances used to inhibit bacterial growth. In clinical contexts, antibiotics treat infections but can also disrupt normal microbiota. Understanding their role is critical in studies of periodontal disease, given that antibiotic treatments may influence the balance of oral bacterial populations.
16) Suffering:
'Suffering' denotes the experience of pain or distress, often associated with chronic conditions. In medical research, understanding the suffering caused by diseases like diabetes or periodontal disease is vital for developing effective interventions and improving patients' quality of life and mental well-being.
17) Pregnant:
'Pregnant' refers to the condition of carrying a developing fetus. Pregnancy poses unique health challenges, influencing various conditions. Research may explore the effects of pregnancy on periodontal health or the implications of micronutrient levels, particularly since pregnancy can alter immune responses and nutritional needs.
18) Quality:
'Quality' represents the standard of something, particularly in terms of health or experience. In health research, assessing the quality of life and health outcomes of individuals with chronic conditions informs better care strategies. Quality of life assessments account for the impact of diseases on personal and social well-being.
19) Species:
'Species' denotes a group of organisms that can interbreed and produce fertile offspring. Understanding species diversity is vital in ecological and medical contexts, where various species can influence disease transmission, treatment responses, and host-pathogen interactions, particularly in studies examining periodontal disease in different populations.
20) Mineral:
'Mineral' refers to inorganic substances crucial for various bodily functions. In health studies, essential minerals (like zinc and iron) play roles in metabolic pathways and immune responses. Their levels can affect disease susceptibility and progression, particularly in conditions like periodontal disease and diabetes.
21) Science (Scientific):
'Science' is the systematic study of the structure and behavior of the physical and natural world through observation and experimentation. It provides a framework for understanding health, diseases, and treatments, and is foundational in research that explores the links between micronutrients and diseases such as periodontitis.
22) Thomas:
'Thomas' may refer to a specific supporter or contributor to research findings or medical discussions. Names in academic texts often reference researchers who have conducted relevant studies. In this context, citing Thomas might connect the discussion to established research in the fields of micronutrient deficiencies and health.
23) Family:
'Family' can denote a group of related individuals or organisms. In epidemiological studies, family history plays a critical role in assessing genetic predispositions to diseases. Noting family health trends may inform understanding of chronic diseases such as diabetes and their interrelation with periodontal health.
24) Repair:
'Repair' refers to the process of restoring health or normal functionality after injury or disease. In the context of periodontal health, the ability to repair damaged tissues can be influenced by nutrient levels and overall health, emphasizing the need for adequate micronutrients for effective tissue regeneration.
25) Nature:
'Nature' pertains to the physical world and everything in it, including plants, animals, and ecosystems. Understanding the nature of biological interactions, such as those between nutrients, pathogens, and host responses, is essential in developing effective medical treatments and insights into disease processes.
26) Medium:
'Medium' can refer to a substance that provides a suitable environment for growth or interaction. In microbiology, the culture medium supports the growth of microorganisms. In the study context, medium can also refer to blood or serum in which nutrients are analyzed for health research.
27) Animal:
'Animal' pertains to living organisms that are members of the kingdom Animalia. In medical research, animal studies contribute to understanding biological processes and disease mechanisms relevant to human health. They can offer insights into the effects of treatments and nutritional intake on health outcomes.
28) Field:
'Field' refers to a specific area of study or professional practice. In health research, various fields such as nutrition, epidemiology, and microbiology intersect to provide comprehensive insights into the relationships between diet, diseases, and overall health, contributing to advancements in medical science.
29) Birth:
'Birth' relates to the process of being born and can signify the beginning of life. In health discussions, maternal health and conditions affecting birth outcomes are critical. The relationship between micronutrient status during pregnancy and health implications for both mother and child is a vital area of research.
30) Sign:
'Sign' signifies an indication or evidence of a condition. In medical contexts, signs are vital for diagnosing diseases, and significant findings in research may indicate underlying health issues. Recognizing signs of nutrient deficiencies or disease can lead to early intervention and improved health outcomes.
31) Post:
'Post' refers to something that occurs after a specific point in time. In research reports, follow-up studies or post-treatment assessments are crucial for determining the long-term effects of interventions. Understanding post-intervention health changes informs practitioners about the effectiveness of treatments.
32) Drug:
'Drug' refers to a substance used to diagnose, treat, or prevent health conditions. In health studies, investigating the effects of drugs on diseases like periodontitis or diabetes is vital for developing effective treatment plans and understanding potential interactions with other health factors.
33) Pur:
'Poor' denotes an inadequate state, often referring to health or nutritional status. In nutritional studies, identifying populations with poor micronutrient levels is crucial for addressing health disparities. Poor nutritional intake can significantly influence disease susceptibility and overall health in various populations.
34) Life:
'Life' signifies the condition that distinguishes living organisms from inorganic matter. In health contexts, quality of life assessments aim to gauge the impact of diseases on daily living. Understanding how chronic diseases afflict individuals is essential for enhancing health outcomes and overall well-being.
Other Health Sciences Concepts:
Discover the significance of concepts within the article: ‘Micronutrient profile in serum: Type II diabetes vs. healthy with periodontitis.’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:
Diabetes mellitus, Body mass index, Periodontal health, Cross-sectional study, Chronic periodontitis, Bidirectional relationship, Serum level, Nutritional factor, Systemic effect, Micronutrients role, Oxidative defense, Tukey test.