Herbal antioxidant's effect on procalcitonin in smokers with periodontitis
Journal name: Journal of Indian Society of Periodontology
Original article title: Efficacy of an herbal antioxidant as an adjunct to nonsurgical periodontal therapy on procalcitonin levels in smokers with chronic periodontitis
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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M. V. N Sravya, Rekha Rani Koduganti, Veerendranath Reddy Panthula, Prasanna Jammula Surya, Himabindu Gireddy, Rajashree Dasari, Manasa Ambati
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Efficacy of an herbal antioxidant as an adjunct to nonsurgical periodontal therapy on procalcitonin levels in smokers with chronic periodontitis
Year: 2019 | Doi: 10.4103/jisp.jisp_742
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Periodontitis is a chronic inflammatory disease primarily caused by bacterial plaque, with smoking recognized as a significant environmental risk factor that exacerbates tissue damage. This condition is characterized by an imbalance in the host's immune response, leading to increased susceptibility to infections. Procalcitonin (ProCT), a marker for systemic inflammation, is often elevated in smokers due to oxidative stress caused by tobacco use. This study aimed to investigate the effects of a herbal antioxidant, Oxitard™, administered post-scaling and root planing (SRP) on serum ProCT levels in smokers diagnosed with chronic periodontitis (CP).
The Role of Oxitard™ in Reducing Procalcitonin Levels
The study involved forty smokers aged between 35 and 60 years, randomized into two groups: one receiving Oxitard alongside SRP and the other undergoing SRP alone. Results indicated a significant reduction in serum ProCT levels after three months in Group A, with levels decreasing from 2.61 ng/ml to 0.77 ng/ml. In contrast, Group B's ProCT levels dropped from 2.53 ng/ml to 1.74 ng/ml. Additionally, clinical parameters such as the Gingival Index (GI), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL) showed more substantial improvements in Group A compared to Group B. This highlights the potential beneficial effects of Oxitard as an adjunct treatment in managing chronic periodontitis in smokers by ameliorating oxidative stress and inflammation.
Conclusion
This study concludes that systemic administration of Oxitard after SRP significantly improves both biochemical and clinical outcomes in smokers with chronic periodontitis. Enhanced reduction in ProCT levels and improved periodontal indices suggest that herbal antioxidants can be safely integrated into treatment regimens for smokers. Future research is recommended to explore the long-term effects of Oxitard and its potential use in non-smokers or those who quit smoking, to further validate its efficacy as an adjunct treatment in periodontal therapy.
FAQ section (important questions/answers):
What is the relationship between smoking and periodontitis risk?
Smokers are four times more prone to developing periodontitis compared to nonsmokers. The compromised immune response and toxic elements in cigarettes increase susceptibility to this gum disease.
What was the aim of the study regarding Oxitard?
The study aimed to evaluate the benefits of Oxitard, an herbal antioxidant, when administered after scaling and root planing (SRP) on serum procalcitonin levels in smokers with chronic periodontitis.
What were the study's main findings about Oxitard's effects?
Results showed that administering Oxitard significantly improved both clinical and biochemical parameters in smokers with chronic periodontitis compared to those receiving SRP alone.
What is procalcitonin and its significance in the study?
Procalcitonin (ProCT) is a marker for inflammation. Its levels were measured to assess the inflammatory response in smokers with chronic periodontitis during the study.
How was the study conducted with regard to participants?
The study involved forty smokers aged 35 to 60 years, divided into two groups. One received SRP plus Oxitard, while the other received only SRP.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Herbal antioxidant's effect on procalcitonin in smokers with periodontitis”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
Table refers to a systematic arrangement of data or information, often used in academic and research contexts to present findings, comparisons, or statistical analyses clearly. In the context of studies, tables help summarize results, making it easier for readers to understand key outcomes, parameters, and statistical significance of findings.
2) Study (Studying):
Study signifies the systematic investigation of a particular subject, often aimed at discovering or confirming facts, theories, or principles. In scientific contexts, studies help build knowledge through data collection and analysis. The reliability and validity of a study are crucial for its acceptance in the scientific community.
3) Disease:
Disease denotes a pathological condition of a bodily part, an organism, or system resulting from various causes, such as infection, genetic defect, or environmental factors. In the study of chronic periodontitis among smokers, understanding diseases is critical to identify risk factors, develop treatments, and improve patient outcomes.
4) Relative:
Relative often describes a comparison or relationship between two or more entities. In the context of studies, it may refer to comparing the effects of treatments or interventions relative to control groups. It emphasizes understanding how one factor impacts another within the researched population.
5) Blood:
Blood is the fluid that circulates through the cardiovascular system, carrying oxygen and nutrients to cells while removing waste products. In medical studies, blood samples are vital for biochemical analyses, helping researchers understand physiological states, disease markers, and the overall health of study participants.
6) Rules:
Rules are established principles or regulations governing a particular activity or conduct. In a research context, rules may pertain to ethical standards, participant recruitment, data collection methods, and statistical analyses, ensuring that studies are conducted reliably, ethically, and in accordance with best practices in research.
7) Himalaya (Hima-alaya):
Himalaya, in this context, refers to the Himalaya Drug Company, which is known for producing herbal medicinal products. Their involvement in studies often underscores the significance of herbal and ayurvedic treatments in contemporary healthcare, as seen in the use of Oxitard in addressing periodontitis in smokers.
8) Bleeding:
Bleeding refers to the loss of blood from the circulatory system, which can be a critical sign in assessing health conditions, particularly in periodontal disease. Monitoring bleeding on probing (BOP) is crucial in dental evaluations; it reflects tissue health and inflammation, aiding in the assessment of treatment effects.
9) Species:
Species denotes a group of organisms that can interbreed and produce fertile offspring. In studies involving microbiology or chronic periodontitis, recognizing different bacterial species is crucial, as periodontitis is a polymicrobial disease where various microbial species interact and contribute to the disease process.
10) Company:
Company refers to a business entity or organization. In research, companies often sponsor studies or supply products, signifying the intersection of commercial interests and scientific inquiry. Their involvement can shape research agendas, particularly in exploring the efficacy of proprietary treatments or interventions.
11) Powder:
Powder typically refers to finely ground solids often used in medicinal formulations. In the context of herbal products like Oxitard, powdered ingredients from plants are combined to harness their therapeutic properties, thereby contributing to treatments for conditions like chronic periodontitis, especially in smokers.
12) Pain:
Pain is an unpleasant sensory and emotional experience associated with real or potential tissue damage. Understanding pain is crucial in clinical studies as it guides treatment decisions, measures treatment efficacy, and helps researchers assess patients' quality of life and overall wellbeing following interventions.
13) Drug:
Drug refers to a substance used as a medication to diagnose, cure, treat, or prevent illness. Pharmaceutical companies develop drugs based on rigorous research. In clinical studies, effective drugs, including herbal options like Oxitard, are evaluated for their safety and efficacy in treating specific health conditions.
14) Pur:
Poor often describes a suboptimal condition or quality. In medical research, it can refer to inadequate treatment responses, health practices, or socioeconomic conditions. Discussing 'poor' outcomes among smokers in treatment studies underscores challenges in managing diseases like periodontitis and highlights the need for targeted interventions.
15) Male:
Male refers to the sex of individuals characterized by specific reproductive anatomy and genetic traits. In health studies, including those on periodontitis, gender may influence disease prevalence, treatment response, and overall health outcomes, making it a vital demographic variable in research design and analysis.
16) Emblica officinalis:
Emblica officinalis, also known as Amla, is a plant recognized for its rich vitamin C content and antioxidant properties. In traditional medicine, it’s valued for its health benefits. Its inclusion in herbal formulations signifies the importance of such plants in promoting oral health and combating oxidative stress.
17) Glycyrrhiza glabra:
Glycyrrhiza glabra, commonly known as Licorice, is utilized in traditional medicine for its anti-inflammatory and soothing effects. Its role in formulations like Oxitard highlights the significance of herbal components in promoting recovery from diseases, particularly in conditions influenced by oxidative stress and inflammation.
18) Withania somnifera:
Withania somnifera, or Ashwagandha, is an adaptogenic herb known for reducing stress and enhancing overall health. In studies concerning chronic periodontitis, its incorporation into treatments like Oxitard demonstrates the focus on holistic approaches that address both physical and psychological factors in health management among smokers.
19) Mangifera indica:
Mangifera indica, or Mango, is a fruit-bearing tree with numerous health benefits attributed to its rich nutritional profile. Its inclusion in herbal medications emphasizes the practice of leveraging natural products to boost health, particularly in addressing conditions that have complex underlying biological mechanisms, such as periodontitis.
20) Vitis vinifera:
Vitis vinifera, known as Grape or grapevine, is recognized for its antioxidant properties and health benefits. It is often included in health products due to its polyphenol content. In studies, its presence in products like Oxitard reflects the trend of integrating traditional knowledge and modern medicinal practices.
21) Yashtimadhu (Yastimadhu, Yashti-madhu):
Yashtimadhu, or Licorice root, is valued in traditional medicine for its soothing properties and ability to manage inflammation. Its inclusion in herbal formulations highlights the significance of natural ingredients in combating oxidative stress and promoting healing processes, particularly in the context of dental health.
22) Ashvagandha (Asvagandha, Ashwagandha, Ashvagamdha, Ashva-gandha):
Ashwagandha is an adaptogen known for its ability to reduce stress and anxiety. Its role in medicinal formulations underscores a holistic approach to health, where managing psychological stress might enhance treatment outcomes for diseases such as periodontitis, especially in individuals with concurrent smoking habits.
23) Discussion:
Discussion in research refers to the section where findings are interpreted and contextualized within existing literature. It's a critical component of scientific papers, serving to explore implications, address limitations, and propose future research directions. This section provides insight into the importance of results and their impact on the field.
24) Antibiotic (Antibacterial):
Antibiotics are substances that inhibit the growth of or destroy microorganisms. They are crucial in treating bacterial infections but must be used judiciously to prevent resistance. In periodontal studies, evaluating the effectiveness of antibiotics is vital in understanding the best treatment protocols, especially for disease exacerbated by smoking.
25) Karnataka:
Karnataka is a state in India known for its diverse flora and fauna, including many medicinal plants. The region's rich tradition of Ayurvedic medicine influences research involving botanical compounds. The state's relevance extends to studies on health interventions, particularly those exploring plant-based treatments like Oxitard.
26) Activity:
Activity in a scientific context refers to the measure of how a substance affects biological systems. For example, the antioxidant activity of herbal products in combating oxidative stress plays a crucial role in evaluating their efficacy in treating conditions like chronic periodontitis, helping to inform clinical practices.
27) Amalaki:
Amalaki, or Indian Gooseberry, is known for its high vitamin C content and antioxidant properties. It is widely used in traditional medicine to promote health and immunity. Its inclusion in herbal formulations emphasizes the relevance of natural antioxidants in managing inflammation and supporting overall health.
28) Draksha (Draksa):
Draksha, or Grapes, are valued for their nutritional benefits and antioxidants. In health formulations, they contribute to combating oxidative stress and improving overall well-being. Their use in product formulations like Oxitard underscores the importance of leveraging natural ingredients to support treatment outcomes in periodontal care.
29) Godhuma (Go-dhuma):
Godhuma, or wheat, is a staple grain known for its nutritional components. In Ayurveda, it is valued for various health benefits. Incorporating wheat or its by-products into therapeutic products reflects traditional practices that recognize the importance of nutritional support in health interventions, particularly in chronic diseases.
30) Yashada (Yasada):
Yashada, or Zinc, is essential for various metabolic processes and immune function. In Ayurveda, its therapeutic properties are acknowledged. Its inclusion in herbal formulations signifies the importance of trace elements in enhancing health outcomes, particularly in inflammatory conditions like chronic periodontitis, where immune function plays a critical role.
31) Lavanga (Lavamga):
Lavanga, or Cloves, are highly regarded in traditional medicine for their analgesic and anti-inflammatory properties. Their inclusion in health products is significant as they may enhance treatment efficacy, particularly in managing conditions with inflammatory components, such as periodontitis, thereby contributing to overall oral health.
32) Surface:
Surface refers to the outermost layer of an organism or object. In terms of periodontal disease, the tooth surface is critical, serving as a habitat for plaque and bacteria. Understanding surface interactions is essential in designing effective treatments that target disease-causing microorganisms effectively.
33) India:
India is known for its rich heritage in Ayurvedic medicine and diverse botanical resources. The country's traditional practices significantly influence the development of herbal treatments like Oxitard. Research conducted in India often incorporates these elements, contributing to global discussions on integrating traditional and modern medicinal practices.
34) Viti:
Viti is a genus of flowering plants that includes grapevines. These plants are valued for their health benefits, primarily attributed to their antioxidant content. Their inclusion in medicinal formulations highlights the importance of natural compounds in treating chronic conditions, especially within the context of oral health.
35) Amra:
Amra, or Mango, is recognized for its health benefits due to its vitamin-rich profile. Its incorporation into herbal formulations reflects the therapeutic potential of popular fruits in traditional medicine, emphasizing the integration of culturally significant plants in modern health interventions targeting diseases like periodontitis.
36) Gold (Golden):
Gold often symbolizes value and efficacy in traditional medicine, particularly in Ayurveda where it is sometimes used in formulations for its purported health benefits. Discussing 'gold standard’ methods in clinical research emphasizes the importance of rigorous methodologies to achieve reliable health outcomes in treatments being studied.
37) Life:
Life encompasses the condition that distinguishes animals and plants from inorganic matter, characterized by growth, reproduction, and response to stimuli. In health and medical research, understanding the quality of life associated with health interventions is crucial; it aids in measuring the effectiveness of treatments on patients' wellbeing.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Herbal antioxidant's effect on procalcitonin in smokers with periodontitis’. Further sources in the context of Science might help you critically compare this page with similair documents:
Reactive oxygen species, Institutional Ethical Committee, Systemic administration, Chronic periodontitis, Written informed consent, Antioxidant therapy, Scaling and root planing.