Omega-3 supplementation and scaling effects on salivary IL-1β in periodontitis.
Journal name: Journal of Indian Society of Periodontology
Original article title: Evaluation of dietary supplementation of omega-3 polyunsaturated fatty acids as an adjunct to scaling and root planing on salivary interleukin-1β levels in patients with chronic periodontitis: A clinico-immunological study
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Vanali Vinodbhai Umrania, Pawar Chandrashekara Rao Deepika, Madhuri Kulkarni
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Evaluation of dietary supplementation of omega-3 polyunsaturated fatty acids as an adjunct to scaling and root planing on salivary interleukin-1β levels in patients with chronic periodontitis: A clinico-immunological study
Year: 2017 | Doi: 10.4103/jisp.jisp_16
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Chronic periodontitis is a significant oral health issue characterized by prolonged inflammation due to specific pathogenic bacteria present in biofilms. This condition results in tissue destruction primarily driven by the host's inflammatory response rather than the bacteria themselves. The study explores the potential of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) as a host-modulating agent to reduce inflammation and enhance recovery when combined with traditional scaling and root planing (SRP) treatment in patients suffering from chronic periodontitis.
Impact of Omega-3 Fatty Acids on Inflammation
The study's primary focus was on assessing clinical parameters and the levels of interleukin-1 beta (IL-1β) in saliva among chronic periodontitis patients who received dietary ω-3 PUFA supplementation alongside SRP compared to those who underwent SRP alone. The results showed improvements in clinical outcomes, particularly regarding the Bleeding Index and reductions in IL-1β levels, demonstrating the potential of ω-3 PUFAs to modulate cytokine profiles and promote the resolution of inflammation. However, clinical improvements in other parameters did not achieve statistical significance, suggesting that while ω-3 PUFAs may positively affect inflammatory markers, their influence on clinical outcomes remains uncertain and potentially controversial.
Conclusion
Omega-3 PUFA supplementation appears to offer anti-inflammatory benefits and may serve as an adjunctive management strategy for chronic periodontitis by modulating cytokine levels. While the study highlighted potential benefits in terms of inflammation reduction, further multicentric and controlled clinical trials are necessary to validate these findings fully and address aspects such as safety, dosage, and long-term efficacy. Thus, while ω-3 PUFAs may hold promise, their clinical effects warrant more in-depth investigation to determine their overall utility in periodontal therapy.
FAQ section (important questions/answers):
What was the aim of the study on omega-3 PUFAs?
The study aimed to evaluate clinical parameters and salivary levels of interleukin-1 beta (IL-1β) in chronic periodontitis patients after scaling and root planing, comparing results with and without dietary supplementation of omega-3 polyunsaturated fatty acids.
How were participants selected for the omega-3 PUFA study?
Participants were selected based on having severe chronic generalized periodontitis, being nonsmokers, and not having undergone any periodontal treatments in the last six months. A total of 40 patients participated after excluding those who were ineligible.
What were the main findings regarding interleukin-1 beta levels?
The study found a statistically significant reduction in salivary levels of interleukin-1 beta (IL-1β) in the test group with omega-3 PUFA supplementation compared to the control group after three months of treatment.
What conclusion was drawn about omega-3 PUFA supplementation?
The study concluded that omega-3 PUFA supplementation could modulate cytokine levels, reducing inflammation in chronic periodontitis, but its impact on clinical outcomes was not statistically significant.
What clinical parameters were assessed in the study?
Clinical parameters assessed included plaque index, gingival index, bleeding index, probing depth, and clinical attachment level at baseline, 1 month, and 3 months after treatment to evaluate the effectiveness of interventions.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Omega-3 supplementation and scaling effects on salivary IL-1β in periodontitis.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Study (Studying):
The study is a systematic investigation into the effects of omega-3 polyunsaturated fatty acids on chronic periodontitis. It evaluates clinical parameters and cytokine levels, aiming to provide insights into how dietary supplements can enhance traditional treatments. This research contributes to understanding adjunctive therapies in periodontal care and their implications for patient management.
2) Table:
In the context of the research, a table is utilized to present data clearly and concisely, summarizing clinical parameters and salivary interleukin-1 beta levels over time. Tables are essential for comparing results between groups, aiding in the visualization of findings, and enhancing the understanding of the study’s outcomes.
3) Inflammation:
Inflammation is a biological response that occurs when the body’s immune system reacts to harmful stimuli, including bacteria in periodontitis. In the study, inflammation is a critical focus, as reducing inflammatory cytokines like IL-1β is paramount for effectively managing periodontal disease and improving clinical outcomes after treatment.
4) Bleeding:
Bleeding, specifically the gingival bleeding index, is measured within the study to assess the condition of periodontal tissues. It serves as an important clinical parameter reflecting inflammation and tissue health. A significant reduction in bleeding indicates improvements in periodontal status, demonstrating the efficacy of treatments applied in the study.
5) Fish:
Fish is a rich source of omega-3 polyunsaturated fatty acids, which are the subject of the study. Consuming fish or fish oil supplementation can influence inflammatory processes in the body, particularly in chronic conditions like periodontitis. The relevance of fish ties into dietary recommendations for managing inflammation.
6) Hygiene (Hygienic):
Hygiene, particularly oral hygiene, is crucial in the management of periodontal diseases. Proper hygiene practices help reduce plaque buildup and bacterial colonization, which are necessary for preventing inflammation and periodontal tissue damage. The study emphasizes the role of hygiene alongside nutritional supplementation in achieving better clinical outcomes.
7) Beta:
Beta refers to interleukin-1 beta (IL-1β), a pro-inflammatory cytokine measured in the study. Levels of IL-1β are indicative of the inflammatory state in periodontal disease. Understanding and modulating these levels can help in managing chronic periodontitis, making IL-1β a key biomarker in this research.
8) Fish oil:
Fish oil is a supplement rich in omega-3 fatty acids, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Its role in the study is to evaluate the potential anti-inflammatory effects on periodontal disease when combined with conventional treatments like scaling and root planing, aiming for enhanced therapeutic outcomes.
9) Disease:
Disease, particularly chronic periodontitis, is the focus of the study. Understanding the mechanisms of this multifactorial disease, which involves both microbial factors and host responses, is critical. The investigation explores adjunctive therapies that may improve management and patient outcomes in this prevalent oral health condition.
10) Species:
Species refers to the different types of bacteria that can reside in the oral cavity and contribute to periodontal diseases. The presence of numerous pathogenic species triggers inflammatory responses, necessitating effective treatments to manage microbial challenges in periodontal therapy, which is a central topic of the study.
11) Drug:
Drugs explored in the context of the study include omega-3 polyunsaturated fatty acids, which serve as host modulation agents. Understanding their effects is crucial in investigating new therapeutic options for chronic conditions like periodontitis, showcasing the importance of pharmacological interventions in dental care.
12) Science (Scientific):
Science underpins the research, employing rigorous methodologies to understand the relationship between dietary supplementation and periodontal health. It embodies the pursuit of knowledge through experiments, hypotheses, and results that can guide future clinical practices in managing chronic periodontitis and inflammation in the oral cavity.
13) India:
India, where the study is conducted, faces a significant prevalence of chronic periodontitis. Understanding local health issues and cultural dietary practices is essential for addressing public health concerns. The study’s findings have implications for dental care strategies specific to Indian populations and their healthcare needs.
14) Visit:
Visit refers to patient follow-up appointments in the study. Regular monitoring allows for assessment of treatment efficacy and adjustments to care plans as necessary. These visits are crucial for ensuring compliance, reinforcing oral hygiene, and evaluating clinical outcomes in managing chronic periodontitis.
15) Diet:
Diet plays a crucial role in overall health, particularly in managing chronic inflammatory conditions like periodontitis. The study emphasizes the importance of omega-3 fatty acids in dietary supplementation, exploring how nutritional interventions can complement traditional dental treatments for improved periodontal health.
16) Male:
Male refers to the gender distribution of participants in the study. Understanding demographic variables, such as gender, is vital as they can influence disease prevalence, response to treatment, and clinical parameters in periodontal disease research, ensuring findings are generalizable and applicable across populations.
17) Human body:
The human body is the biological context in which the study operates, focusing on how dietary supplements can influence inflammatory processes and periodontal health. Understanding systemic responses aids in developing effective treatment protocols that acknowledge the interconnectedness of various bodily systems in disease management.
18) Maharashtra (Maharastra, Maha-rashtra):
Maharashtra, a state in India where the study is conducted, reflects regional health demographics and concerns. The findings have localized implications, addressing the prevalence of chronic periodontitis in the state and contributing to broader discussions on public health strategies regionally and nationally.
19) Discussion:
Discussion sections in research papers provide critical analysis of findings, contextualize results within existing literature, and explore implications for practice and future research. In this study, the discussion evaluates the impact of omega-3 PUFAs supplementation in periodontal health, highlighting its role in inflammatory modulation and clinical outcomes.
20) Substance:
In this research, the term substance refers to omega-3 polyunsaturated fatty acids as a therapeutic agent. Exploring its biochemical properties and health effects aids in understanding its potential role in managing chronic periodontitis. The study addresses how substances like these can influence inflammatory responses and healing processes.
21) Pregnant:
Pregnant individuals are excluded from the study to minimize complications associated with dietary supplements and pharmacologic interventions. Pregnancy may alter physiological responses, and focusing on a specific demographic enhances the reliability of results in understanding the effects of omega-3 PUFAs on chronic periodontitis management.
22) Reason:
Reason pertains to the rationale behind using omega-3 fatty acids as adjunctive therapy in managing chronic periodontitis. The study investigates the underlying biological mechanisms by which dietary supplementation may reduce inflammation, thereby illuminating the therapeutic potential and justifying further research in this domain.
23) House:
House, in this context, may refer to the institution where the study is conducted. The institutional environment is crucial for research integrity, ethics approval, and maintaining quality standards in participant care and data collection processes, ensuring scientifically valid and ethically sound results.
24) Pose:
Pose refers to the potential risks associated with dietary supplementation, particularly concerning long-term health implications. The study addresses these risks, emphasizing the need for careful consideration in administering supplements like omega-3 PUFAs, especially among certain populations who may have unique health profiles.
25) Road:
Road symbolizes the pathway or journey of research leading to a better understanding of periodontal disease management. It underscores the continuous need for exploration, evidence-based practice, and the evolution of treatment strategies in addressing chronic conditions like periodontitis effectively.
26) Pur:
Poor oral hygiene is a significant factor contributing to periodontal disease. Addressing the impact of hygiene practices is crucial in the study, as improving hygiene is fundamental in conjunction with dietary and adjunctive therapies to better manage and prevent the progression of chronic periodontitis.
Other Health Sciences Concepts:
Discover the significance of concepts within the article: ‘Omega-3 supplementation and scaling effects on salivary IL-1β in periodontitis.’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:
Control group, Test group, Chronic periodontitis, Inflammatory cytokines, Scaling and root planing, Interleukin-1 beta, Systemic circulation, Dietary Supplementation, Clinical outcome, Long-chain polyunsaturated fatty acids, Clinical parameter, Dental Treatment, Omega-3 polyunsaturated fatty acids, Salivary levels.