RANKL's link to clinical attachment in waterpipe smokers
Journal name: Journal of Indian Society of Periodontology
Original article title: The association between receptor activator of nuclear factor kappa-β ligand and clinical attachment level among waterpipe smoker
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:
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Saif Muhammed Taher Al-Mufti, Saif Sehaam Saliem, Hayder Raad Abdulbaqi
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: The association between receptor activator of nuclear factor kappa-β ligand and clinical attachment level among waterpipe smoker
Year: 2017 | Doi: 10.4103/jisp.jisp_124
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
This study investigates the salivary levels of receptor activator of nuclear factor kappa-β ligand (RANKL) among waterpipe smokers and explores the potential correlation between RANKL levels and clinical periodontal parameters. Previous research indicates that higher levels of RANKL are present in periodontitis patients compared to healthy individuals. Given the significance of smoking as a risk factor for periodontal diseases, this cross-sectional study aims to quantify RANKL levels in the saliva of 49 waterpipe smokers and 40 nonsmokers and assess their association with various clinical periodontal parameters such as clinical attachment level (CAL) and periodontal pocket depth (PPD).
Positive Correlation Between RANKL and Clinical Attachment Level
The results demonstrated a statistically significant difference in RANKL, PPD, and CAL between waterpipe smokers and nonsmokers. Notably, the study found that salivary RANKL levels were positively correlated with CAL; approximately 62.8% of the variation in CAL could be explained by RANKL levels, with the regression equation indicating a modest increase in CAL with RANKL levels. This highlights the potential for RANKL as a biomarker in identifying periodontal disease severity, suggesting that elevated salivary RANKL may contribute to attachment loss observed in waterpipe smokers.
Conclusion
The findings underscore the relationship between elevated salivary RANKL levels and increased periodontal attachment loss among waterpipe smokers, suggesting that waterpipe smoking adversely affects periodontal health. The positive correlation discovered emphasizes the potential of using salivary RANKL as a noninvasive diagnostic marker for evaluating the extent of periodontal disease. This study serves as an insightful exploration into the harmful effects of waterpipe smoking on periodontal health, warranting further research to expand understanding and improve preventive measures against periodontal diseases in smokers.
FAQ section (important questions/answers):
What was the aim of the study on RANKL levels?
The study aimed to measure salivary RANKL levels among waterpipe smokers and determine any correlation with clinical periodontal parameters.
How was the RANKL measured in participants' saliva?
Saliva samples were collected and analyzed using a human RANKL enzyme-linked immunosorbent assay kit to determine the RANKL concentration.
What main difference was found between smokers and nonsmokers?
The study found that waterpipe smokers had significantly higher levels of RANKL, periodontal pocket depth, and clinical attachment loss compared to nonsmokers.
How does RANKL relate to clinical attachment levels?
RANKL levels were positively associated with clinical attachment loss, explaining approximately 62.8% of loss in the examined sample.
What are the implications of this study's findings?
These findings suggest that elevated RANKL levels due to waterpipe smoking could negatively affect periodontal health and may serve as a diagnostic marker.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “RANKL's link to clinical attachment in waterpipe smokers”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
The term 'Table' refers to a systematic arrangement of data, often used in academic studies to present results clearly. In the context of the study, tables provide statistical comparisons and important descriptive information regarding study participants and findings, allowing for quick reference and analysis of correlations related to periodontal parameters.
2) Study (Studying):
The word 'Study' refers to a systematic investigation of a particular subject or phenomenon, often aimed at discovering new information or insights. In this context, the study focuses on the relationship between salivary RANKL levels and periodontal health among waterpipe smokers, contributing valuable data to the field of dental research.
3) Disease:
The term 'Disease' indicates a pathological condition that affects bodily function. In this research, periodontal disease is the focal point, examining how lifestyle factors like waterpipe smoking exacerbate the condition. Understanding the impacts of various diseases helps guide treatment and management, especially for those affected by gum health issues.
4) Kappa:
In this context, 'Kappa' refers to the statistical measure of inter-rater agreement used in the study. A kappa value greater than 0.7 signifies strong agreement among examiners, providing confidence in the reliability of the clinical measurements utilized for assessing periodontal health in participants, especially among smokers and nonsmokers.
5) Water:
The term 'Water' is significant in relation to the waterpipe smoking method being studied. Water is used as part of the smoking process in waterpipes, ostensibly reducing the temperature and harshness of smoke. However, its presence does not diminish the harmful effects associated with inhaling toxic substances found in waterpipe smoke.
6) Bleeding:
The term 'Bleeding' relates to the clinical parameter measured during periodontal assessments. Specifically, 'Bleeding on probing' indicates inflammation within the gums. This metric aids in evaluating periodontal health, as increased bleeding can signify deeper periodontal issues, essential for correlating salivary RANKL levels and clinical outcomes in the study.
7) Line:
In the context of the study, 'Line' refers to the standardized methodology used for measuring clinical parameters such as periodontal pocket depth and clinical attachment level. Precise measurements along specific lines of the teeth are crucial for inconclusive comparisons and to maintain consistency among examiners evaluating periodontal health.
8) Measurement:
The term 'Measurement' indicates the quantitative assessment of clinical parameters in the research. Accurate measurements of parameters such as clinical attachment level (CAL) and periodontal pocket depth (PPD) are vital for interpreting the relationship between salivary RANKL levels and periodontal disease severity among the study participants.
9) Surface:
The term 'Surface' signifies the specific area of teeth where clinical measurements are taken. Different tooth surfaces (mesial, distal, buccal/labial, and lingual/palatal) are assessed to provide a comprehensive understanding of periodontal health. This thorough examination aids in evaluating overall periodontal status in both smokers and nonsmokers.
10) Pir:
In this context, 'Peer' refers to healthy individuals with whom the study subjects' outcomes are compared. Understanding how different groups, specifically waterpipe smokers and their nonsmoking counterparts, exhibit variations in periodontal parameters provides diagnostic insight and contributes to the data on the harmful effects of smoking on oral health.
11) Accumulation (Accumulating, Accumulate):
The term 'Accumulation' relates to the build-up of dental plaque and its association with periodontal disease. This study highlights how plaque accumulation can influence the severity of periodontal disease among different smokers, emphasizing the need for effective oral hygiene practices to minimize risks associated with smoking-related dental issues.
12) Performance:
The term 'Performance' refers to the participants' ability to maintain proper oral hygiene. Variability in mechanical plaque control performance among smokers and nonsmokers is crucial to understanding how these individuals manage their periodontal health, further emphasizing the discussion on the negative impacts of waterpipe smoking.
13) Discussion:
The 'Discussion' section summarizes the interpretations of study results, including comparisons with previous research findings. It is essential for contextualizing the study's implications on periodontal health among waterpipe smokers and encouraging further investigation into non-invasive diagnostic tools for predicting disease based on salivary biomarkers.
14) Activity:
The term 'Activity' denotes the state of disease progression and how clinical parameters are monitored. Understanding the activity of periodontal disease is crucial for effective treatment plans. This term encompasses the overall engagement of the disease process, including how factors like smoking influence periodontal health.
15) Teaching:
In the context of the study, 'Teaching' refers to educational programs on oral health and smoking cessation aimed at patients and dental professionals. Enhancing awareness of the effects of waterpipe smoking on periodontal health is vital for improving patient outcomes through better education and proactive dental care strategies.
16) Hygiene (Hygienic):
The term 'Hygiene' highlights the importance of maintaining oral cleanliness in preventing periodontal disease. This study underscores how effective oral hygiene can mitigate the effects of smoking on periodontal health, suggesting a need for educational approaches to promote better habits among waterpipe smokers.
17) Science (Scientific):
The term 'Science' reflects the systematic study of the natural world through observation and experimentation. This research contributes to dental science by exploring the interactions between lifestyle choices like waterpipe smoking and biochemical markers in saliva, enriching the understanding of periodontal disease mechanisms.
18) Company:
In this context, 'Company' refers to entities engaged in scientific research or the manufacturing of biomedical products or kits used in such studies. Collaboration with a reputable company, such as the one providing the RANKL enzyme-linked immunosorbent assay kit used in this research, ensures accurate and reliable outcomes.
19) Family:
In this context, 'Family' represents the broader classification of organisms, specifically related to cytokines, such as the TNF (tumor necrosis factor) family to which RANKL belongs. Understanding these classifications is critical in immunology and pathology, yielding insights into the role of cytokines in inflammation and bone resorption.
20) Blood:
The term 'Blood' is significant concerning the systemic effects of smoking on health, particularly regarding the level of nicotine in blood correlating with smoking frequency. Elevated blood nicotine levels in waterpipe smokers, similar to those who smoke multiple cigarettes, suggest comparable health risks affecting oral health parameters.
21) Cina:
In this context, 'China' refers to the nationality of the company that manufactured the RANKL enzyme-linked immunosorbent assay kit used in the study. Understanding the global collaboration in scientific research enhances appreciation for international standards and quality in biomedical tools required for accurate health assessments.
22) Hand:
The term 'Hand' often relates to manual skills or actions performed in clinical settings. While not directly discussed in this study, the concept of 'hand' is integral to the tactile proficiency required by examiners for effectively performing clinical examinations and measurements during periodontal assessments.
23) Male:
The term 'Male' is relevant as the study specifically recruited male participants aged 30-40 years with a history of waterpipe smoking. Focusing on a specific demographic allows for a clearer understanding of the disease's impact within gender and age groups, contributing to the development of targeted interventions.
Other Science Concepts:
Discover the significance of concepts within the article: ‘RANKL's link to clinical attachment in waterpipe smokers’. Further sources in the context of Science might help you critically compare this page with similair documents:
Pilot study, Cross-sectional study, Correlation coefficient, Clinical attachment level, Toxic heavy metal, Quantitative determination, Regression equation, Bleeding On Probing, Salivary level of RANKL, Waterpipe smokers, Periodontal disease severity, Periodontal clinical parameters, Periodontal pocket depth, Nicotine blood level, Lack of systemic disease, Oral hygiene control performance, Glossary of periodontal terms.