Serum and saliva oxidative metabolites and cortisol in periodontitis

| Posted in: Science Health Sciences

Journal name: Journal of Indian Society of Periodontology
Original article title: Indagation of serum and salivary reactive oxygen metabolite and cortisol levels in chronic periodontitis and stress-induced chronic periodontitis patients
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Uma Sudhakar, Ramakrishnan Thyagarajan, Bhagyameena Jeyapal, Sushuruthi Jagadeesh, Parvathee Jayakumar


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: Indagation of serum and salivary reactive oxygen metabolite and cortisol levels in chronic periodontitis and stress-induced chronic periodontitis patients

Year: 2017 | Doi: 10.4103/jisp.jisp_6

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

Periodontal disease is characterized as a chronic inflammatory condition that emerges not solely from bacterial infection but as a response of the immune system to specific microorganisms, particularly in genetically susceptible individuals. Recent studies have highlighted the role of psychological stress in the etiology and progression of periodontal disease, indicating that chronic stress can lead to dysregulation of immune responses, thus exacerbating the destruction of periodontal tissues. This study specifically aims to assess the relationship between cortisol and reactive oxygen metabolites (ROM) concentrations in serum while examining their association with periodontal health and disease.

Cortisol and Reactive Oxygen Metabolites: A Critical Link

The study involved thirty patients divided into two groups: one group suffering from chronic periodontitis and the other from stress-induced chronic periodontitis. Both serum and salivary samples were analyzed to evaluate the correlation between cortisol levels and ROM. Results indicated that patients in the stress-induced group exhibited significantly higher mean levels of ROM compared to the non-stressed group. This suggests a substantial link between elevated cortisol levels, indicative of stress, and the progression of periodontal disease. The findings underscore that psychological stress may play a critical role in enhancing the vulnerability to periodontal disease through increased levels of inflammatory biomarkers, thereby accelerating tissue destruction.

Conclusion

This study provides conclusive evidence that heightened cortisol levels due to psychological stress positively correlate with increased reactive oxygen metabolite levels, further advancing the understanding of stress as a potential risk factor for periodontal disease. The established link suggests that interventions addressing psychosocial stress could be beneficial adjuncts in the management of periodontal disease. Future research involving larger sample sizes is essential for validating these findings and exploring the mechanisms by which stress may influence periodontal health. The implications of such studies could lead to innovative treatment approaches that integrate psychological well-being into periodontal care.

FAQ section (important questions/answers):

What is the primary aim of the study on chronic periodontitis?

The study aims to evaluate cortisol and reactive oxygen metabolites (ROM) concentrations in serum, examining their association with periodontal health and disease among patients with chronic periodontitis.

How were patients grouped in the periodontal disease study?

Thirty patients were divided into two groups: Group I consisted of chronic periodontitis patients, while Group II included stress-induced chronic periodontitis patients, with evaluations being performed on both groups.

What significant results were found regarding ROM levels in groups?

The study found that the mean ROM levels in Group II (stress-induced chronic periodontitis) were significantly higher than in Group I, suggesting stress's role in the progression of periodontal disease.

What correlation was observed in the study between cortisol and ROM levels?

A significant positive correlation was found between serum and salivary cortisol levels with serum and salivary ROM levels in both groups, indicating a relationship between stress and periodontal disease progression.

What did the study conclude about stress related to periodontal disease?

The study concluded that stress may contribute to the progression of periodontal disease by increasing cortisol and reactive oxygen metabolite levels, pointing to potential psychosocial interventions in treatment.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Serum and saliva oxidative metabolites and cortisol in periodontitis”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
In the context of the research presented, 'Table' refers to organized data that summarizes the findings on cortisol and reactive oxygen metabolite levels. It aids in visualizing comparative results between groups, emphasizing statistical significance and correlations that support conclusions drawn from the study, making complex data more comprehensible.

2) Study (Studying):
The term 'Study' denotes the systematic investigation conducted to explore the relationship between stress and periodontal disease. It outlines a methodology for gathering data on serum and salivary biomarkers, emphasizing the objective to identify correlations and provide insights into how psychological factors can influence oral health outcomes.

3) Disease:
In this document, 'Disease' refers to periodontal disease, a chronic inflammatory condition affecting the supporting structures of the teeth. Understanding its mechanisms—including the role of stress and cortisol levels—highlights its complexity beyond traditional bacterial infections, emphasizing the need for a multidisciplinary approach to treatment and management.

4) Depression:
'Depression' is referenced as a psychological factor contributing to the progression of periodontal disease. It suggests that individuals experiencing depression have altered physiological responses that may undermine immune function, thus increasing susceptibility to periodontal issues, illustrating the interconnectedness of mental and oral health.

5) Blood:
'Blood' indicates the biological medium utilized in the study to analyze cortisol and reactive oxygen metabolite levels. Blood samples provide essential biomarkers for understanding systemic responses to stress, illustrating the physiological link between emotional states and physical health, particularly in periodontal disease contexts.

6) Measurement:
The word 'Measurement' pertains to the quantification of cortisol and reactive oxygen metabolite levels in serum and saliva, which is crucial in understanding their roles in periodontal health. Accurate measurement techniques underpin the reliability of study findings and influence conclusions drawn regarding stress and oral health.

7) Relative:
'Relative' is utilized in comparing the significance of findings between different study groups. It emphasizes understanding how various levels of biomarkers relate to one another, providing insights into the differential impact of stress-induced conditions on periodontal disease progression, thereby illustrating the complexity of these relationships.

8) Redistribution:
'Redistribution' here refers to the movement of immune cells in response to stress, suggesting that psychological states can alter immune responses. This concept is vital for understanding how stress influences systemic health, affecting the body’s inflammatory processes and its implications for periodontal disease development.

9) Inflammation:
'Inflammation' denotes a biological response crucial to the progression of periodontal disease. The study highlights how stress can exacerbate inflammatory pathways, contributing to tissue destruction and disease progression, thus underlining the need to manage stress as part of comprehensive oral health care.

10) Observation:
'Observation' highlights the importance of empirical evidence gathered during the study. It reflects the researchers' systematic approach to note correlations and causal links between psychological factors and periodontal disease, reinforcing the study's credibility and providing a foundation for further scientific inquiry.

11) Discussion:
'Discussion' refers to the section where findings are interpreted and contextualized within existing literature. It allows researchers to speculate on implications, limitations, and future directions, bridging the gap between empirical evidence and practical applications in both clinical and psychological settings.

12) Accumulation (Accumulating, Accumulate):
'Accumulate' pertains to the process of collecting saliva for analysis, emphasizing the study's methodology in ensuring accurate biochemical assessment. It highlights the importance of effective sample collection in correlating stress levels with physiological changes related to periodontal health.

13) Science (Scientific):
The term 'Scientific' reflects the rigorous methodology underpinning the study's design and analysis. It reinforces the need for empirical evidence and systematic approaches in exploring the complex relationships between mental health factors and oral diseases, ensuring reliability and validity in the findings.

14) Antibiotic (Antibacterial):
'Antibiotic' is mentioned in the context of exclusion criteria for the study participants, highlighting the importance of controlling confounding factors. By excluding those on antibiotics, the study ensures that results are not influenced by external treatments that could impact biomarkers relevant to periodontal disease.

15) Knowledge:
'Knowledge' points to the growing understanding of the association between systemic health and periodontal disease, advocating for an integrative approach to treatment. This term underscores the importance of continued research in expanding our understanding of how stress and emotional states impact oral health.

16) Bleeding:
'Bleeding' refers to clinical manifestations observed in chronic periodontitis. It signifies the presence of inflammation and tissue breakdown, acting as a key indicator of periodontal disease severity. Its relevance lies in its association with immune response mechanisms influenced by stress and cortisol levels.

17) Quality:
'Quality' emphasizes the importance of high standards in research design, methodology, and data interpretation. In the context of this study, quality data enhances the reliability of findings, informing clinical practices and advancing our understanding of complex interplays between stress, health behaviors, and periodontal outcomes.

18) Species:
'Species' refers to the variety of microorganisms present in the oral microbiome, relevant to periodontal health. The influence of stress on bacterial populations and their pathogenic potential underscores the biological complexity of periodontal disease, illustrating how external factors may alter immune responses to these species.

19) Hygiene (Hygienic):
'Hygiene' is critical to maintaining oral health and preventing periodontal disease. The study alludes to the role of psychosocial stress in influencing personal hygiene behaviors, implying that stress management could improve oral hygiene practices and mitigate periodontal disease progression, linking mental well-being with physical health outcomes.

20) Reason:
'Reason' encapsulates the explanations provided for observed associations or findings in the study. It addresses the underlying mechanisms linking stress and periodontal disease, thereby providing insights into how psychological factors may lead to changes in immune responses, ultimately contributing to disease prevalence.

21) Pur:
'Poor' is used to describe certain lifestyle factors, including hygiene and nutrition, which may be exacerbated by stress leading to enhanced susceptibility to periodontal disease. It underscores the need for comprehensive care that addresses both psychological and physical health to improve outcomes.

Other Health Sciences Concepts:

[back to top]

Discover the significance of concepts within the article: ‘Serum and saliva oxidative metabolites and cortisol in periodontitis’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:

Immune system, Statistical analysis, Psychological stress, Hamilton Rating Scale, Oxidative stress, Periodontal disease, Chronic periodontitis, Cortisol level, Clinical attachment level, Hypothalamic-pituitary-adrenal axis, Study Limitation, Neuroendocrine interaction, Participants' Characteristics, Salivary cortisol, Reactive oxygen metabolite.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Help to become even better: