Fibrin network changes in PRF: young vs. old age groups.
Journal name: Journal of Indian Society of Periodontology
Original article title: Fibrin network pattern changes of platelet-rich fibrin in young versus old age group of individuals: A cell block cytology study
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Shravanthi Raghav Yajamanya, Anirban Chatterjee, Chaitanya Nischay Babu, Deepika Karunanithi
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Fibrin network pattern changes of platelet-rich fibrin in young versus old age group of individuals: A cell block cytology study
Year: 2016 | Doi: 10.4103/0972-124X.176390
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
The study addresses the variations in fibrin network patterns within platelet-rich fibrin (PRF) across different age groups. It focuses on how age influences the density and arrangement of fibrin networks, as well as the entrapment of platelets and white blood cells (WBCs) within these networks. By evaluating samples from 95 patients categorized into three age groups (20–39 years, 40–59 years, and 60 years and above), the research aims to provide insights into the age-related changes in PRF that may impact its efficacy in periodontal regeneration.
The Impact of Age on Fibrin Network Patterns
The results reveal significant differences in fibrin network configurations related to the age of the individuals. Younger patients predominantly exhibited dense fibrin networks and higher platelets and WBCs entrapment within the fibrin matrix. As age increased, the study noted a trend toward looser fibrin structures, marked decreases in platelet and WBC entrapment, and varying distributions of these cells. Notably, in older age groups, the arrangement tended to become more irregular, indicating that age plays a crucial role in influencing the quality of PRF. This highlights the interdependence of fibrin networks and platelets, which collectively enhance the wound healing process.
Conclusion
The findings of this research underscore the importance of considering patient age when evaluating the effectiveness of PRF in clinical settings, particularly in periodontal treatment. The study concludes that the age of a patient significantly impacts the fibrin network structure and the associated capacity to trap essential cells involved in healing. This emphasizes the potential for tailoring periodontal regenerative treatments based on patient demographics, which could ultimately improve health outcomes. Further research into other factors such as nutrition and gender is recommended to expand understanding in this area.
FAQ section (important questions/answers):
What was the purpose of the study on platelet-rich fibrin (PRF)?
The study aimed to evaluate how fibrin network patterns in PRF vary among different age groups, particularly focusing on the relationship between age and the density of these networks.
How were the patients divided for the PRF study?
Ninety-five patients were divided into three age groups: 20–39 years, 40–59 years, and 60 years and above, to compare fibrin network characteristics across these age ranges.
What significant findings were observed regarding fibrin network density?
The study found that as patients' ages increased, there was a noticeable decrease in dense fibrin network patterns and an increase in loose fibrin arrangements, affecting platelet and white blood cell entrapment.
What methods were used to evaluate the PRF samples?
PRF was prepared from blood samples and analyzed using cell block cytology methods to assess age-related changes in fibrin density and the presence of platelets and white blood cells.
Can age influence the quality of PRF obtained?
Yes, the study concluded that age significantly affects the quality of PRF in terms of fibrin network patterns and the entrapment of platelets and white blood cells, impacting regenerative outcomes.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Fibrin network changes in PRF: young vs. old age groups.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Blood:
Blood is a vital biological fluid that functions as a transport medium for nutrients, gases, hormones, and waste products within the body. In this context, it is particularly relevant for the preparation of platelet-rich fibrin (PRF), which is derived from blood and crucial for promoting healing and regeneration in periodontal treatment.
2) Study (Studying):
The term study refers to the systematic investigation into a particular subject, which in this case focuses on the variations in fibrin network patterns of PRF across different age groups. This study aims to reveal significant insights into how age impacts the quality and functionality of PRF in clinical applications.
3) Arrangement:
Arrangement pertains to the organization or structural formation of elements within a system. In the context of this study, it describes the way fibrin networks are arranged in PRF clots, affecting their stability and efficacy. Understanding these arrangements is key to optimizing PRF's role in tissue regeneration.
4) Table:
Tables serve as structured data presentations for summarizing and organizing information, often facilitating comparison. In this study, tables are likely used to present demographic and age-related distributions of participants, which aids in understanding the study's findings regarding the variations in PRF characteristics among different age groups.
5) Rich (Rch):
Rich often refers to a high concentration or abundance of a particular substance. In this study, platelet-rich fibrin (PRF) indicates an elevated concentration of platelets essential for promoting healing. Richness in platelets enhances the regenerative properties of PRF, making it a valuable tool in periodontal therapy.
6) Container:
A container is an object that holds or stores items. In medical studies, containers are pivotal for specimen collection, such as blood samples. Here, it refers to the vacuum test tubes used during blood collection to obtain samples for PRF preparation, ensuring aseptic conditions for accurate results.
7) Quality:
Quality signifies the standard or degree of excellence of a substance. In this context, it relates to the characteristics of PRF, particularly its fibrin network density and the capacity to entrap platelets and white blood cells. Variations in quality across age groups can influence treatment efficacy.
8) Disease:
Disease represents a pathological condition affecting bodily function. Within this study, periodontitis is addressed as a significant disease that leads to loss of tooth attachment. Understanding the role of PRF in regenerating periodontal tissues is essential for managing diseases related to gum health.
9) Nature:
Nature refers to the inherent or essential qualities of something. In the context of this study, it indicates the biological properties of PRF, which play a crucial role in inflammation and healing processes. Understanding these natural characteristics aids in optimizing PRF's clinical applications.
10) Activity:
Activity pertains to the engagement in biological processes. In this context, it often describes platelet function in wound healing and PRF efficacy. Understanding the activity of platelets within the PRF over different age groups highlights essential variations in healing potential and regenerative capability.
11) Surface:
Surface refers to the outer layer of a substance. In the context of PRF, surface interactions are crucial for platelet activation and fibrin network formation. Analyzing surface characteristics helps in comprehending how platelets and white blood cells interact within the PRF matrix for effective healing.
12) Medium:
Medium refers to an intermediate substance through which processes occur. Here, it can describe the environment in which blood samples are processed for PRF preparation. Additionally, the term reflects the use of various media in laboratory procedures that aid in maintaining sample integrity during analysis.
13) Inflammation:
Inflammation is a biological response to harmful stimuli, promoting healing. In the context of this study, inflammation is significant for understanding tissue responses post-injury. Examining the role of PRF in regulating inflammation can elucidate its effectiveness in tissue regeneration and healing during periodontal treatment.
14) Discussion:
Discussion refers to the analytical examination and interpretation of study results. In this study, it involves evaluating how age affects fibrin network patterns and the implications for clinical applications. Engaging in discussion helps researchers to convey the importance of findings and avenues for future research.
15) Accumulation (Accumulating, Accumulate):
Accumulate means to gather or collect over time. In this study, it describes how platelets and white blood cells accumulate within the fibrin network of PRF. Understanding these accumulation patterns is vital as they play a crucial role in the healing processes and PRF's regenerative capabilities.
16) Knowledge:
Knowledge signifies the understanding gained through study or experience. In the context of this study, increasing knowledge about the interaction between platelets and fibrin networks across different age groups can lead to improved clinical strategies in periodontal treatment and enhanced patient outcomes in regenerative therapies.
17) Evolution:
Evolution signifies the gradual development or change of species or systems over time. Within this study, it reflects the advancements in platelet concentrates, leading to improved biomaterials like PRF. Recognizing the evolution of these therapeutic aids assists in understanding their growing importance in regenerative dentistry.
18) Pregnant:
Pregnant refers to the condition of carrying a developing embryo or fetus. Within the context of this study, exclusion criteria include pregnant individuals, emphasizing the importance of ensuring patient safety and considering potential complications in medical research involving blood-derived products like PRF.
19) Cutting:
Cutting refers to the act of severing or dividing something. In this study, it relates to the procedures involved in preparing PRF slides for analysis. Understanding cutting techniques can impact the quality of histological samples and the accuracy of assessing fibrin network patterns.
20) Heating:
Heating refers to the application of heat to a substance. In the context of PRF preparation, heating processes may be applied during slide preparation to facilitate staining and enhance visibility of fibrin network patterns. Proper heating techniques are essential for effective histological analysis.
21) Account:
Account refers to a report or explanation of events or findings. In this study, accounts of patient demographics and fibrin network observations are crucial for understanding the results. Accurate accounts enhance the reliability and validity of conclusions drawn from the study's findings.
22) Repair:
Repair refers to the process of restoring function or structure. In the realm of this study, repair pertains to tissue healing influenced by the properties of PRF. Understanding how different fibrin network arrangements affect repair can guide clinical practice in regenerative therapies.
23) Patel:
Patel is a surname likely referring to one of the researchers or authors involved in the study. Acknowledging researchers like Patel adds credibility to the findings and allows for tracing the contributions of specific individuals in advancing knowledge concerning PRF and its applications.
24) Water:
Water is a vital component in biological systems. While not explicitly emphasized in the study, its presence in the blood and during PRF preparation is crucial for maintaining physiological conditions. Understanding its role can elucidate fluid dynamics in blood and affect the quality of PRF.
25) Hand:
Hand may represent a metaphorical or literal tool in clinical procedures. In research contexts, it reflects the necessity of skilled manipulation of biological samples, like PRF. Skilled hands in laboratory settings ensure proper handling and preparation, impacting study outcomes and treatment applications.
26) Life:
Life signifies living organisms characterized by biological processes. In this study, the relevance of life is intertwined with understanding healing and regeneration processes influenced by the characteristics of PRF. The study ultimately focuses on enhancing life quality through improved regenerative therapies.