Ethical guidelines and animal models in periodontal research.

| Posted in: Science

Journal name: Journal of Indian Society of Periodontology
Original article title: Ethical guidelines, animal profile, various animal models used in periodontal research with alternatives and future perspectives
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:

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Author:

Mohan Kumar Pasupuleti, Subramanya Shetty Molahally, Supraja Salwaji


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: Ethical guidelines, animal profile, various animal models used in periodontal research with alternatives and future perspectives

Year: 2016 | Doi: 10.4103/0972-124X.186931

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

Laboratory animal models play a vital role in the investigation of periodontal disease, allowing researchers to evaluate the disease's etiopathogenesis, test the efficacy of therapeutic techniques, and assess novel treatments before human application. This review focuses on the various animal models used in dental research, particularly in periodontics, along with the ethical guidelines governing their use. A systematic search through the MEDLINE/PubMed database was conducted to gather relevant publications from 2009 to May 2013, highlighting the need for refinement, replacement, and reduction in the number of experimental animal models utilized in research.

Ethical Considerations in Animal Research

One of the significant concepts outlined in the review is the ethical guidelines for using animals in research. These guidelines emphasize the importance of minimizing animal usage while ensuring the welfare of the subjects involved. Researchers are urged to select the least sentient animals necessary for experiments, avoid unnecessary pain, and provide proper care and housing for the animals. The reviewed literature also outlines the principles of the "Three Rs" (Replacement, Reduction, and Refinement), as well as the additional "Fourth R" (Rehabilitation) established by regulatory bodies like CPCSEA in India. Implementing these ethical considerations is essential to advance dental research while addressing moral concerns regarding animal welfare.

Conclusion

In conclusion, this review underscores the significance of adhering to ethical guidelines when utilizing animal models in dental research. It highlights the diversity of animal choices available and the importance of choosing appropriate models that reflect human anatomical characteristics. Furthermore, the review emphasizes the necessity of developing innovative alternatives, such as ex vivo models, to minimize the use of live animals. By applying these principles, researchers can contribute to scientific advancement while maintaining high ethical standards in animal research.

FAQ section (important questions/answers):

What is the purpose of using animal models in dental research?

Animal models help investigate the causes and effects of periodontal diseases, test surgical techniques, and evaluate new therapies before they are applied to humans, ensuring safety and efficacy in dental treatments.

What ethical guidelines should be followed for animal research?

Researchers must ensure minimal use of animals, provide proper care, utilize anesthesia for painful procedures, and aim to reduce animal suffering. An ethical committee should oversee all animal research activities.

What alternatives to animal models are available in research?

Alternatives include in vitro methods, computer models, and using alternative organisms like lower vertebrates and microorganisms. These methods help reduce the number of animals needed while still providing valuable research insights.

What advancements have been made in animal research models?

Recent developments include ex vivo models, which replicate human biological environments more accurately. These models can minimize animal usage while enhancing the understanding of disease mechanisms and potential treatments.

Why is it essential to refine animal model usage in research?

Refining animal model usage addresses ethical concerns, reduces the number of animals needed, minimizes suffering, and promotes the development of alternative methods, all of which contribute to more humane and effective research practices.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Ethical guidelines and animal models in periodontal research.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Animal:
Animal models are crucial in scientific research, specifically in studying human diseases and testing therapies. They provide insights into biological processes, allowing researchers to explore the physiological interactions in vivo. The use of animals helps refine treatments and interventions before human applications, addressing ethical considerations in research.

2) Disease:
The term disease refers to pathological conditions that affect the body's normal functions. In dental research, understanding diseases like periodontal disease is vital for developing effective treatments. Research helps unveil the underlying causes of diseases, their progression, and interactions with other biological systems, promoting advancements in medical science.

3) Table:
In academic research, tables are used to organize and present data systematically. They facilitate easy comparison and interpretation of information, such as the profile of various animal models used in studies. Tables can summarize outcomes, participant characteristics, or experimental results, enhancing the clarity of research findings.

4) Study (Studying):
Studying involves actively engaging with material to acquire knowledge and understanding through observation, analysis, and reflection. In research, studying encompasses designing and conducting experiments, reviewing literature, and analyzing data. The study process is critical for generating reliable information and validating scientific hypotheses.

5) Life:
Life encompasses biological organisms' existence, their physiological functions, and interactions. In research, understanding life at various levels (cellular, organismal) is essential for addressing health-related issues. The study of life sciences helps inform treatments and preventative measures, shedding light on the underlying biological mechanisms of diseases.

6) Pulse:
Pulse refers to the rhythmic expansion and contraction of arteries resulting from heartbeats. It is a critical indicator of circulatory health and is often measured in studies assessing animal welfare during experiments. Monitoring pulse can provide insights into stress responses and physiological changes in research subjects.

7) Drug:
A drug is a substance used to diagnose, treat, or prevent diseases. In research, drugs are tested on animal models to evaluate their efficacy and safety before human trials. Understanding the interactions between drugs and biological systems is vital for developing effective therapies and improving patient outcomes.

8) Science (Scientific):
Science is the pursuit of knowledge through systematic study and experimentation. It encompasses various disciplines, including biology, chemistry, and physics. Scientific inquiry leads to discoveries that can improve understanding of the natural world, inform public policy, and enhance health through innovations and evidence-based practices.

9) Knowledge:
Knowledge represents the understanding and awareness gained through experience or education. In research, acquiring knowledge is fundamental for developing hypotheses and theories. Knowledge informs practices, guides experiments, and contributes to the body of scientific literature, fostering innovation and progress in understanding complex phenomena.

10) Training:
Training in a research context involves educating individuals in methodologies, ethical practices, and procedural skills necessary for conducting experiments. Proper training ensures researchers develop competency, replicate studies effectively, and adhere to ethical standards, ultimately contributing to the reliability and integrity of scientific outcomes.

11) Cancer:
Cancer refers to a group of diseases characterized by uncontrolled cell growth and spread to other parts of the body. Research on cancer often involves animal models to understand tumor biology and evaluate new treatments. Studying cancer pathology helps identify genetic and environmental risk factors.

12) Pain:
Pain signifies an unpleasant sensory and emotional experience often associated with actual or potential tissue damage. In research involving animal models, understanding pain responses is crucial to ensure ethical treatment and minimize suffering. Effective pain management strategies are essential when conducting experiments involving surgical or invasive procedures.

13) Writing:
Writing is an essential skill in scientific communication, enabling researchers to share findings, describe methodologies, and discuss implications. Clear and concise writing enhances the dissemination of knowledge, facilitates collaboration, and aids in the peer review process, making it easier for others to build upon existing research.

14) India:
In the context of research, India is notable for its growing contributions to science and technology. Ethical guidelines established in India govern animal research, reflecting a commitment to animal welfare and responsible scientific practices. The country's policies continue to evolve to balance research needs with ethical considerations.

15) Death:
Death is the cessation of biological functions that sustain life. In research, understanding the factors leading to death in experimental models provides insights into disease pathology and treatment efficacy. Ethical considerations regarding the humane treatment of animals, especially concerning euthanasia after studies, are critical.

16) Hand:
Hand refers to the manual dexterity used in conducting various research procedures and experiments. The skillful use of hands is often necessary for surgeries, handling specimens, and maintaining laboratory equipment. Proper training in manual skills enhances research quality and fosters safety in experimental settings.

17) Educational institution:
Educational institutions are places where knowledge is imparted, and research is conducted. They play a vital role in training future scientists and researchers, establishing ethical standards, and promoting scientific literacy. Institutions also foster collaboration, enabling interdisciplinary research approaches that advance scientific inquiry.

18) Inflammation:
Inflammation is a biological response to harmful stimuli, such as pathogens or irritants. It plays a crucial role in periodontal disease pathology and is extensively studied in dental research. Understanding inflammation mechanisms assists in developing targeted therapies aimed at reducing adverse health effects and promoting healing.

19) Antibiotic (Antibacterial):
Antibiotics are substances used to treat bacterial infections. Research on antibiotics often involves studying their efficacy using animal models to understand pharmacodynamics and resistance mechanisms. Continuous research and development of antibiotics are essential to combat emerging bacterial strains and ensure effective treatment options.

20) Suffering:
Suffering refers to the distress experienced by living beings, often due to pain or emotional upset. In research, minimizing suffering is a fundamental ethical concern. Researchers must ensure humane treatment of animal subjects by employing adequate pain relief measures and adhering to ethical guidelines governing animal welfare.

21) Toxicity:
Toxicity indicates the degree to which a substance can harm organisms. Assessing toxicity is crucial in drug development and environmental studies. Toxicity tests often utilize animal models to determine safe dosage levels and identify potential adverse effects, influencing regulations and safety standards in pharmaceutical applications.

22) Activity:
Activity in a research context can refer to various forms of biological or behavioral responses measured during experiments. Activity levels can provide insights into health status, treatment efficacy, and the overall welfare of animal models during studies, impacting how research outcomes are interpreted and applied.

23) Language:
Language facilitates communication of scientific ideas, findings, and methodologies. In research, the clarity of language in writing and speaking is essential for effectively sharing knowledge with peers, stakeholders, and the public. It fosters understanding and collaboration across various disciplines and cultural backgrounds.

24) Teaching:
Teaching is the process of imparting knowledge or skills. In research settings, it involves training students and researchers in methodologies, ethical practices, and scientific reasoning. Effective teaching strategies enhance learning experiences and equip individuals to contribute meaningfully to scientific inquiry and discovery.

25) Kindness:
Kindness refers to the compassionate treatment of all living beings, particularly when conducting research involving animals. Adopting a perspective of kindness fosters ethical research practices, ensures well-being, and promotes humane treatment, contributing to a positive research environment and improved outcomes.

26) Species:
Species refers to distinct groups of organisms that share similar characteristics. Research often involves specific animal species chosen for their biological relevance to human conditions. Understanding species differences helps researchers tailor experimental approaches, ensuring that findings are applicable to human health and disease.

27) Repair:
Repair refers to the restoration of tissue or function following damage or injury. In dental research, understanding biological repair mechanisms is essential for developing effective treatments for periodontal diseases. Investigating repair processes informs the design of therapies that enhance healing and recovery.

28) Medium:
Medium in research refers to the environments or substances used to culture cells or tissues. Selecting the appropriate medium is crucial for optimizing conditions for growth and experimentation. Medium composition can significantly impact biological responses and outcomes in experimental studies.

29) Indian:
Indian pertains to originating from India, a country with a rich tradition in scientific research and progress. The Indian context influences ethical guidelines for animal testing, emphasizing the importance of responsible practices and respect for animal welfare in the scientific community.

30) Killing (Killed):
Killed refers to the humane euthanasia of experimental animals at the end of studies when necessary. Ethical guidelines dictate that animals that cannot be rehabilitated should be euthanized painlessly. This practice ensures compliance with animal welfare standards and responsible research conduct.

31) Doubt:
Doubt signifies uncertainty or skepticism regarding claims, methodologies, or results in research. Addressing doubt through rigorous validation and peer review processes is essential for establishing the credibility of scientific findings, fostering a culture of critical thinking and continuous improvement in research practices.

32) Field:
Field in research refers to a specific area of study or discipline, such as dentistry or pharmacology. Each field employs specialized methods and knowledge bases. Research within a field advances understanding, informs practice, and contributes to the broader scientific community.

33) Tree:
Tree can metaphorically relate to the classifications and relationships among various species, akin to branches in a phylogenetic tree representing evolutionary relationships. Understanding these connections is critical in biological research, informing studies on genetic similarities and differences that may affect disease susceptibility or treatment efficacy.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Ethical guidelines and animal models in periodontal research.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Three R's, Inclusion criteria, Exclusion criteria, Clinical trial, Experimental model, Periodontal disease, Regulatory bodies, Biological processes, Outcome Measures, Animal profile, Four 'R's, Ex-vivo model, Ethical guideline, Clinical characteristic.

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