Herbal gel caused contact stomatitis and desquamative gingivitis.

| Posted in: Science

Journal name: Journal of Indian Society of Periodontology
Original article title: Herbal oral gel induced contact stomatitis along with desquamative gingivitis due to a coloring agent
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:

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Author:

Baljeet Singh, Alka Sharma, Avnika Garg


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: Herbal oral gel induced contact stomatitis along with desquamative gingivitis due to a coloring agent

Year: 2015 | Doi: 10.4103/0972-124X.167165

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

The case report details a rare instance of contact stomatitis in a 32-year-old female patient who developed painful ulcers and desquamative gingivitis following the use of a curcumin-based oral gel. Upon investigation, it was determined that the allergic reaction was not due to curcumin itself but rather the coloring agent erythrosine contained in the gel. The significance of understanding allergic reactions to topical agents in oral healthcare is highlighted, as many practitioners remain unaware of the potential adverse effects from various substances, including herbal preparations and coloring agents in medications.

The Role of Coloring Agents in Allergic Reactions

Erythrosine, a common food and cosmetic color additive, has been implicated in allergic reactions and contact stomatitis. This case emphasizes the often-overlooked potential for such additives to cause severe mucosal reactions, especially in individuals who may sensitively react to these agents without prior exposure. Previous documented cases have noted similar reactions to erythrosine in denture materials, but the current report expands the awareness of this risk to over-the-counter topical treatments. It underscores the necessity for thorough allergy testing and consideration of all ingredients in medical formulations, particularly for those with a history of sensitivity or allergic reactions.

Conclusion

The occurrence of contact stomatitis in the presented case serves as a reminder of the importance of vigilance regarding potential allergens in topical agents used for oral care. It is crucial for healthcare professionals to consider contact reactions in their differential diagnosis of oral lesions and to communicate the implications of using topical treatments containing various additives to patients. There is a pressing need for increased awareness and regulation of allergenic substances in common medical formulations, so that patients can be informed and protected from unexpected adverse reactions.

FAQ section (important questions/answers):

What is contact stomatitis and how does it manifest?

Contact stomatitis is an inflammation of the oral mucosa caused by irritants, presenting as irregular erosions, ulcers, and desquamative gingivitis, typically seen after exposure to allergens or irritants, such as certain oral gels or coloring agents.

What was unique about the patient case reported?

The case involved a 32-year-old healthy female who developed contact stomatitis after using a curcumin-based oral gel, which was traced back to an allergy to the coloring agent erythrosine present in the gel.

What treatment was administered to the patient?

The patient was advised to stop using the oral gel, and treatment included cleaning the lesions, systemic antihistamines, nonsteroidal anti-inflammatory drugs, and topical steroids, leading to improvement within a week.

What allergens were confirmed in the allergy tests?

Allergy tests confirmed sensitivities to the curcumin-based oral gel and specifically to erythrosine, indicating the potential adverse reactions to coloring agents commonly used in topical medicinal products.

What precautions should be taken regarding topical oral products?

It's essential to be cautious with topical oral products containing coloring agents or other additives, as they may cause allergic reactions, and patients should be informed of any potential side effects.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Herbal gel caused contact stomatitis and desquamative gingivitis.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Allergy:
Allergy refers to a hypersensitive reaction of the immune system to substances that are generally harmless. In the context of the case report, the patient developed allergic contact stomatitis due to exposure to curcumin and the coloring agent erythrosine. This emphasizes the importance of considering allergies during clinical evaluations and treatments.

2) Ulcer:
An ulcer is a sore on the skin or mucous membrane characterized by the loss of tissue. In this case, the patient exhibited multiple oral ulcers caused by contact stomatitis. The ulcers formed after using the curcumin gel reflect the inflammatory response to the allergic reaction affecting the oral mucosa.

3) Table:
While the term 'table' isn't explicitly mentioned in the provided text, it could refer to data presentation in clinical studies. In medical literature, tables often summarize findings, data, or statistical analyses that provide clarity and context to research results, facilitating easier understanding of complex information for readers.

4) Colouring (Coloring):
Coloring agents like erythrosine are added to various products for aesthetic appeal, but they can also provoke allergic reactions. In this case report, the presence of erythrosine in the curcumin gel led to an adverse reaction in the patient, highlighting the need for awareness regarding potential allergens in topical agents.

5) Relative:
The word 'relative' may imply the relationship or comparison made in the context of diagnosing conditions. In medical case reports, relative incidences of certain conditions, such as allergic reactions, can guide clinicians in understanding how common or rare an issue is, assisting in differential diagnosis and treatment planning.

6) Substance:
Substance refers to any form of matter, especially in the context of potential allergens or irritants. Many substances, including medications, foods, and topical agents, can induce reactions within the body. Identifying the specific substance responsible for allergies or irritations is crucial for effective treatment and patient safety.

7) Study (Studying):
Study in the medical context typically refers to research designed to gather data, analyze results, and draw conclusions concerning health conditions. The provided text discusses a case report, which contributes to medical literature by documenting an unusual allergic reaction, further informing clinical practice and expanding the understanding of contact stomatitis.

8) Drug:
Drugs are compounds used for treating diseases, alleviating symptoms, or modifying physiological conditions. In this case, curcumin gel, a topical preparation, served as a therapeutic agent that inadvertently caused an allergic reaction in the patient, underscoring the complexity of drug interactions and the necessity for careful ingredient scrutiny.

9) Medicine:
Medicine encompasses a broad field involving the diagnosis, treatment, and prevention of illness. The case report highlights how non-prescription medicines, like the curcumin-based gel, can lead to adverse effects, emphasizing the responsibility of healthcare providers to educate patients on possible side effects of topical treatments.

10) Disease:
A disease denotes a pathological condition of a bodily part, an animal, or a plant resulting from various causes. Here, allergic contact stomatitis represents a distinct disease that arises from immune system reactions to specific substances. The recognition of such conditions is critical for targeted treatment and management.

11) Food:
Food refers to any nutritious substance consumed to maintain life and health. In this context, specific food additives, including coloring agents like erythrosine, act as potential allergens that can result in oral reactions. Understanding the interactions between food components and individual sensitivities is essential for preventing allergic reactions.

12) Swelling:
Swelling is the enlargement of a body part due to inflammation or accumulation of fluids. The patient exhibited swelling in her lips due to the allergic reaction from the curcumin gel. It serves as a visible indicator of inflammation, prompting further investigation into underlying causes and appropriate management strategies.

13) Water:
Water is essential for life and is commonly used as a solvent in medications. In the case report, sterile water was introduced during patch tests to prepare allergenic agents for allergy testing. Its role underscores the importance of proper handling and preparation in medical testing and treatments.

14) Pain:
Pain is a significant symptom indicating tissue damage or inflammation within the body. The patient experienced pain and sensitivity in the gums and lips due to the allergic reaction. Understanding pain mechanisms is integral in guiding treatment decisions and enhancing patient comfort during recovery from oral lesions.

15) Inflammation:
Inflammation is the body’s response to injury or infection, often leading to redness, heat, swelling, and pain. The details of the case report describe inflammatory changes in the oral mucosa, showcasing how inflammation can manifest in noticeable symptoms following allergen exposure, and the clinical importance of managing such reactions.

16) Discussion:
Discussion refers to the section in medical literature where findings, implications, and relations to existing studies are analyzed. In this case report, the discussion contextualizes the importance of recognizing contact stomatitis among differential diagnoses for oral ulcers, contributing to the broader topic of allergic reactions in dental practice.

17) Irritation:
Irritation describes a state of discomfort or inflammation resulting from exposure to harmful stimuli. This case illustrates irritation of oral tissues due to local application of curcumin gel, demonstrating how certain cosmetic and therapeutic products can lead to adverse effects, thus necessitating careful ingredient review in dental products.

18) Antibiotic (Antibacterial):
Antibiotics are medical agents used to treat bacterial infections. Although not the focus of this case, antibiotics are commonly prescribed in dental practices. Understanding the potential interactions between antibiotics and allergic reactions is key to ensuring effective treatment decisions while minimizing risks of adverse events in patients.

19) Cinnamon:
Cinnamon is a common spice that can act as an allergen in some individuals. Mentioned in the report as a potential irritant, it highlights how ingredients in everyday products, including oral care items, can lead to allergic reactions, emphasizing the need for vigilance in ingredient awareness among clinicians.

20) Pregnant:
Pregnant refers to a condition where a woman carries developing offspring. The case report included references to a study involving pregnant rats studying erythrosine effects. This serves to illustrate the potential impact of food dyes on biological systems, revealing insights important for prenatal care and maternal health considerations.

21) Account:
In medical literature, accounting refers to recognizing and considering specific factors during diagnosis. The report suggests that clinicians should account for possible contact stomatitis when evaluating oral lesions, promoting comprehensive assessments that include potential allergic reactions as part of standard diagnosis and management workflows.

22) Hygiene (Hygienic):
Hygiene involves practices associated with cleanliness and health maintenance. Although the case mainly addresses allergic reactions, promoting good oral hygiene is vital for overall health. Clinicians should emphasize the importance of hygiene in preventing oral conditions that may exacerbate allergic reactions or contribute to inflammation and discomfort.

23) Candy:
Candy represents sweet confections commonly consumed but may contain allergens such as artificial coloring agents. In the case report context, it illustrates how food items can become sources of allergic reactions due to their components, stressing the importance of ingredient awareness in dietary habits and consumer product safety.

24) Visit:
Visit refers to a patient's consultation with healthcare professionals for diagnosis and treatment. The patient visited a dental clinic, which emphasizes the role of healthcare facilities in evaluating oral conditions. Regular visits allow for timely detection and management of complications such as allergic reactions and contact stomatitis.

25) Mast:
Mast cells are immune system cells involved in allergic responses. The report referenced studies on erythrosine, indicating its effects on mast cells, suggesting that certain components could trigger mast cell degranulation. Understanding mast cell function is crucial in exploring mechanisms of allergy development and potential therapeutic interventions.

26) Salt (Salty):
Salt, while not a direct focus in this case, is vital in numerous biological functions and can influence bodily responses. In allergy testing, saline solutions are often utilized as controls. This highlights the fundamental role of basic substances like sodium chloride in medical practices including allergy assessment and management.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Herbal gel caused contact stomatitis and desquamative gingivitis.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Differential diagnosis, Oral mucosa, Oral mucosal reactions, Oral Ulcer, Coloring agent, Denture Stomatitis, Oral hygiene product, Dental materials, Oral lesion.

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