Antimicrobial evaluation of bioactive glass in periodontal therapy.
Journal name: Journal of Indian Society of Periodontology
Original article title: Evaluation of antimicrobial properties of bioactive glass used in regenerative periodontal therapy
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:
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Ram Sabarish Chandrasekar, Vamsi Lavu, Kennedy Kumar, Suresh Ranga Rao
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Evaluation of antimicrobial properties of bioactive glass used in regenerative periodontal therapy
Year: 2015 | Doi: 10.4103/0972-124X.167166
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
The oral cavity serves as a complex ecosystem that facilitates the colonization of various microorganisms, which can provoke inflammatory responses in periodontal tissues, leading to bone defects. In treating periodontal disease, effective regeneration of the lost bone and tissue apparatus is crucial for improved tooth support. Bone grafting materials, particularly alloplasts like the bioactive glass (BAG) Perioglas™, play an essential role in this regenerative effort. Recent studies indicate that materials with inherent antibacterial properties could significantly enhance outcomes by preventing bacterial colonization at the surgical site.
Antibacterial Effect of Perioglas™
In an observational study, the antibacterial properties of Perioglas™ were evaluated against the early oral colonizer, Streptococcus salivarius. The results demonstrated that the antibacterial activity of BAG is concentration-dependent, with a notable effect observed at a concentration of 50 mg/mL. The study employed various methodologies, including smear examinations and culture growth analysis, to assess the reduction in viable bacterial colonies. findings showed that BAG significantly reduced the presence of S. salivarius in both culture media and smears, indicating its potential utility as a bone grafting material with therapeutic benefits in periodontal surgeries.
Conclusion
The findings suggest that Perioglas™ exhibits considerable antibacterial effects, which may improve the predictability of regenerative periodontal therapies by mitigating bacterial recolonization post-surgery. While the study supports the potential of incorporating BAG into periodontal treatments, it also highlights the need for further research, particularly regarding its efficacy against Gram-negative anaerobic organisms and in conditions that more closely mimic the physiological environment of the human body. Enhanced understanding of such materials could lead to advancements in antibacterial surface coatings for implantable devices and improve therapeutic strategies in periodontal regeneration.
FAQ section (important questions/answers):
What is the purpose of the study involving Perioglas™?
The study aims to analyze the antibacterial properties of Perioglas™ against the oral commensal Streptococcus salivarius, which is an early colonizer in the dental plaque formation.
How was the antibacterial activity of Perioglas™ assessed?
Antibacterial activity was evaluated by measuring the reduction in colony-forming units of Streptococcus salivarius after incubating various concentrations of Perioglas™ for 24 hours.
What were the key findings of the research?
The results indicated that Perioglas™ displayed a significant antibacterial effect against Streptococcus salivarius, with the efficacy increasing proportionally to its concentration.
What significance does bioactive glass have in periodontal therapy?
Bioactive glass, such as Perioglas™, demonstrates inherent antibacterial properties that may enhance the predictability of regenerative periodontal therapy by controlling bacterial colonization.
What are the limitations mentioned in the study?
The study's limitations include not using simulated body fluids and not testing the efficacy of bioactive glass against Gram-negative anaerobic organisms.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Antimicrobial evaluation of bioactive glass in periodontal therapy.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
The term 'Table' refers to a structured collection of data or information presented in rows and columns for easy reference and comparison. In the context of research papers, tables are often used to summarize findings, show experimental results, or present comparative data across different studies or conditions, facilitating quick understanding and analysis for readers.
2) Antibiotic (Antibacterial):
The keyword 'Antibacterial' indicates substances that inhibit bacterial growth or kill bacteria. In medical and dental research, specifically, antibacterial agents are crucial as they help manage infections, promoting healing processes, especially in surgical fields like periodontal therapy where preventing microbial colonization can enhance treatment outcomes.
3) Study (Studying):
The term 'Study' implies a systematic investigation or research to gather knowledge about a specific subject. In scientific research, studies are foundational as they provide empirical evidence through experiments or observational analysis, making them vital for understanding phenomena, validating hypotheses, or advancing medical practices and innovations.
4) Activity:
The keyword 'Activity' refers to the behavior, process, or function of a biological or chemical agent. In the context of antibacterial studies, it often describes the effectiveness of certain substances in inhibiting or killing bacteria, critically impacting the development and application of treatments in diverse medical fields.
5) Glass:
In this context, 'Glass' relates to bioactive glass, a synthetic material used in medical applications, especially in bone regeneration. It has unique properties that promote healing and tissue integration. The term signifies advancements in biomedical materials that significantly enhance therapeutic options for conditions like periodontal disease.
6) Surface:
'Surface' indicates the outermost layer of a material or biological structure. In biomedical contexts, surface characteristics of materials, such as bioactive glass, are critical if they interact effectively with biological tissues. Surfaces influence cellular responses, adhesion, and overall material function in regenerative procedures, marking their relevance in therapeutic efficacy.
7) Blood:
The term 'Blood' denotes the vital fluid in the human body transporting nutrients, gases, and waste. In studies focusing on periodontal healing, blood plays a significant role in wound healing and infection control. Its ionic composition can affect microbial dynamics and the regenerative capability of materials like bioactive glass.
8) Observation:
'Observation' refers to the act of monitoring or noting phenomena during a study. It's essential in scientific research where careful documentation of events, reactions, and outcomes is crucial for validating results, drawing conclusions, and informing future research directions, enhancing the overall scientific understanding of biological processes.
9) Relative:
'Relative' implies a connection or comparison to something else, essential for contextualizing findings in scientific studies. Understanding relative effects, concentrations, or comparisons between different treatments, such as varying concentrations of bioactive glass, helps researchers evaluate efficacy and make informed decisions about therapeutic applications in clinical settings.
10) Grafting:
'Grafting' denotes the process of transplanting tissue or material to repair or replace damaged anatomical structures. In periodontal regenerative therapy, grafting is a critical procedure to restore lost bone and tissue. The effectiveness of different graft materials can significantly influence long-term patient outcomes and healing rates.
11) Species:
The term 'Species' is used to categorize living organisms sharing common characteristics. In microbiology and medicine, identifying specific bacterial species, such as 'Streptococcus salivarius,' is crucial for understanding infections, developing targeted treatments, and conducting research to uncover the interactions between bacteria and human health in various conditions.
12) Nature:
The term 'Nature' encompasses the inherent characteristics, properties, and essential qualities of substances or phenomena. Understanding the nature of materials, like bioactive glass used in grafting, is vital for evaluating their biological compatibility, functionality, and overall impact on healing processes in fields like regenerative medicine.
13) Human body:
'Human body' refers to the complex biological structure comprising various systems that interact and function in harmony. Understanding its dynamics, responses, and health conditions is foundational in medical research, particularly in developing effective treatments and interventions that align with biological processes for improved patient care.
14) Inflammation:
'Inflammation' is a biological response of tissues to harmful stimuli, such as pathogens or injury. It plays a dual role in healing and disease. Understanding inflammation's management is crucial in regenerative medicine, as it can affect healing processes, therapeutic outcomes, and the effectiveness of materials used in treatments.
15) Discussion:
'Discussion' involves interpreting research findings, relating them to existing knowledge, and providing insights into implications and future research directions. It is a critical section in scientific papers, allowing authors to contextualize their results, address limitations, and discuss potential real-world implications, ultimately contributing to the advancement of medical knowledge.
16) Accumulation (Accumulating, Accumulate):
'Accumulate' describes the gradual collection or buildup of substances or effects over time. In microbiology, it often refers to the increase of bacteria in a given environment. Understanding how bacteria accumulate is essential for developing strategies to manage infections, particularly in open systems like the oral cavity, which significantly impact health outcomes.
17) Bleeding:
'Bleeding' refers to the loss of blood from the circulatory system, often due to injury or surgical intervention. In periodontal therapy, understanding bleeding dynamics is critical for managing patients' healing processes and ensuring effective treatment outcomes. Accurate management of bleeding during procedures is vital to minimize complications and enhance recovery.
18) Habitat:
'Habitat' denotes the natural environment where organisms live, grow, and thrive. In microbiology contexts, understanding the oral cavity as a habitat for bacteria is fundamental for studying microbial interactions, disease processes, and the impact of materials used in dental treatments, emphasizing the importance of environmental factors on health.
19) Disease:
'Disease' refers to a pathological condition affecting the body or its systems, characterized by specific signs and symptoms. In dental contexts, understanding diseases like periodontal disease is essential for developing effective treatment strategies. Research into materials and methods for combating diseases leads to advancements in health care practices and improved patient outcomes.
20) Repair:
'Repair' describes the process of restoring damaged tissues or structures to their original state or function. In regenerative medicine, repair mechanisms are essential for healing wounds and restoring periodontal tissues. Effectively harnessing materials, such as bioactive glass, enhances repair processes, enabling more predictable and successful outcomes in therapeutic interventions.
21) Water:
'Water' is a vital biological solvent involved in numerous physiological processes. In the context of studies involving bioactive materials, the role of water as a solvent influences how materials like bioactive glass interact with biological systems. Its presence affects dissolution rates and the release of therapeutic ions, making it critical for evaluating efficacy.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Antimicrobial evaluation of bioactive glass in periodontal therapy.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Observational study, In vitro, Anti-microbial activity, Anti-plaque effect, Antibacterial agent, Colony forming unit, Gram staining, Culture plates, Periodontal regeneration, Streptococcus salivarius, Bone grafting material.