Evaluation of freeze-dried bone allograft in Grade II furcation defects

| Posted in: Science

Journal name: Journal of Indian Society of Periodontology
Original article title: A comparative evaluation of freeze-dried bone allograft with and without bioabsorbable guided tissue regeneration membrane Healiguide® in the treatment of Grade II furcation defects: A clinical study
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:

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Author:

Deept Jain, Dhruvakumar Deepa


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: A comparative evaluation of freeze-dried bone allograft with and without bioabsorbable guided tissue regeneration membrane Healiguide® in the treatment of Grade II furcation defects: A clinical study

Year: 2015 | Doi: 10.4103/0972-124X.162198

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

Periodontal diseases are prevalent globally and significantly contribute to tooth loss through attachment and bone loss around the furcal surfaces of molars, leading to furcation involvement. The primary aim of treating furcation defects is to maintain the affected tooth and restore anatomical integrity, allowing for better long-term outcomes and increased retention. In recent years, methods such as guided tissue regeneration (GTR) and bone grafting have gained traction, with particular attention to the effectiveness of freeze-dried bone allografts (FDBA) alongside bioabsorbable membranes. This study aimed to compare the success of FDBA in treating Grade II furcation defects with and without the use of a bioabsorbable GTR membrane.

Efficacy of Freeze-Dried Bone Allograft

The research included ten patients with bilateral Grade II furcation defects, treated using a split-mouth design to compare two groups: one treated with FDBA alone (control) and the other with FDBA in conjunction with a bioabsorbable GTR membrane (test). Clinical assessments revealed significant improvements in probing depths and relative attachment levels (RAL) in both arms at six months post-surgery. However, intergroup comparisons showed no statistically significant differences between the two treatment modalities. The findings highlight the therapeutic value of FDBA in enhancing periodontal regeneration while suggesting that the additional use of a GTR membrane may not offer significant advantages over FDBA alone in the context of Grade II furcation defects.

Conclusion

In conclusion, this study demonstrated that both treatment approaches led to notable clinical improvements in managing Grade II furcation defects. While FDBA, with or without GTR, provided effective results in reducing probing depth and enhancing attachment levels, there was no statistically significant difference in outcomes between the two methods. The study underlines the need for further research with larger sample sizes and advanced radiographic assessments to explore the long-term efficacy of these treatment strategies in periodontal therapy.

FAQ section (important questions/answers):

What was the purpose of the study on FDBA?

The study aimed to evaluate the effectiveness of freeze-dried bone allograft (FDBA) with and without bioabsorbable guided tissue regeneration (GTR) membrane Healiguide® in treating Grade II furcation defects in patients.

How was the study conducted regarding patient selection?

Ten patients aged 30-55 with bilateral Grade II furcation defects were selected after phase I therapy, then divided into two groups for treatment using a split-mouth design.

What were the main findings regarding clinical parameters at 6 months?

Both treatment groups showed significant improvements in probing depth, horizontal furcation depth, and relative attachment level at 6 months post-surgery, although no significant differences were found between the two groups.

What were the inclusion criteria for the study participants?

Participants had to be diagnosed with Grade II furcation defects, with probing depths of ≥4 mm and gingival margins at or coronal to the furcation roof, ensuring adequate conditions for study inclusion.

What were the conclusions drawn from the study?

The study concluded that both treatment modalities significantly improved clinical parameters. However, there was no statistically significant difference between FDBA alone and FDBA with a GTR membrane, indicating a need for further research.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Evaluation of freeze-dried bone allograft in Grade II furcation defects”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Table:
In the context of clinical studies, a table is a structured representation of data that displays results from various parameters measured during the research, such as probing depth, gingival index, and bleeding scores. Tables facilitate easy comparison and analysis, helping to summarize complex data visually for better understanding and interpretation of therapeutic efficacy.

2) Study (Studying):
A study refers to a systematic investigation aimed at discovering or verifying facts, theories, or practical applications. In the given text, the study evaluates the efficacy of specific treatment modalities for Grade II furcation defects in periodontal therapy. It encompasses methodology, results, and conclusions drawn from clinical evidence collected during research.

3) India:
India serves as the geographical context of the research study discussed in the text. It highlights the location of the institutions involved, particularly the Subharti Dental College and Hospital in Meerut, Uttar Pradesh. The cultural and medical practices in India may influence patient demographics and treatment responses in periodontal disease management.

4) Post:
The prefix 'post' indicates the timeframe after a surgical procedure, commonly referring to postoperative assessments or follow-up visits. In the context of the study, 'post' signifies the measurements taken at specific intervals (3 months and 6 months) after treatment, aiming to evaluate the progress and effectiveness of the interventions used.

5) Dressing:
Dressing refers to the protective covering applied to surgical sites to promote healing and prevent infection. In the study, periodontal dressing is mentioned as part of postoperative care, facilitating recovery and protecting grafted areas after surgical interventions for furcation defects. Proper dressing application is crucial in maintaining site hygiene and supporting tissue regeneration.

6) Relative:
Relative often describes the relationship between measured variables in the study. For instance, 'relative attachment level' (RAL) assesses the distance from the base of a periodontal defect to a reference point, thereby providing a metric for evaluating periodontal regeneration. Understanding relative changes aids in comparing treatment outcomes effectively and assessing therapeutic efficacy over time.

7) Disease:
The term 'disease' denotes a pathological condition impacting bodily function. In the context of the study, periodontal disease, characterized by inflammation and loss of connective tissue, serves as the primary condition under investigation. Understanding the disease's mechanisms allows for better treatment strategies, contributing to the study's focus on improving patient outcomes in periodontal therapy.

8) Hygiene (Hygienic):
Hygiene refers to practices aimed at maintaining health and preventing disease, particularly in the context of oral health. The study emphasizes oral hygiene instructions to patients as crucial during the intervention period. Good hygiene practices prevent plaque accumulation, which is essential for successful treatment outcomes and long-term maintenance of periodontal health.

9) Calculation:
Calculation pertains to determining numerical values based on data collected during the study. Sample size calculations are fundamental to ensure sufficient power for statistical analysis. In this study, methodologies and calculations related to clinical measurements (like probing depths) play a vital role in validating the efficacy of the treatments assessed.

10) Grafting:
Grafting involves transplanting tissue or bone to facilitate regeneration, which is key in periodontal treatment. The study evaluates the use of freeze-dried bone allograft (FDBA), a type of graft, in treating Grade II furcation defects. Grafting is crucial for promoting new bone formation and re-establishing periodontal attachment.

11) Chennai:
Chennai is mentioned as the location where the bioabsorbable guided tissue regeneration membrane, Healiguide®, was developed. The location underlines the origin of the materials used in the study, providing context about the resources available in India for periodontal therapy. It highlights the local advancements in dental material science relevant to the research.

12) Hand:
Hand relates to the manual instruments and techniques employed in the periodontal surgical procedures described in the study. Specific hand instruments, such as scalers and curettes, are crucial in the mechanical removal of plaque and calculus during phase I therapy. Technique and skill with hand instruments significantly impact the outcomes of periodontal interventions.

13) Inflammation:
Inflammation is a biological response to injury or infection, plays a critical role in periodontal disease. The study's focus on treating Grade II furcation defects underscores the importance of managing inflammation to achieve better healing outcomes. Understanding the inflammatory process can aid practitioners in formulating effective treatment strategies for periodontal diseases.

14) Measurement:
Measurement refers to quantifying clinical parameters to evaluate treatment efficacy. In this study, various indicators such as probing depth, gingival index, and relative attachment levels are systematically assessed before and after surgery. Accurate measurement ensures reliable data, contributing to evidence-based conclusions on the treatments' effectiveness for furcation defects.

15) Discussion:
Discussion encompasses the interpretation and analysis of study findings in the larger context of existing literature. In this text, the discussion part highlights the researchers' insights on treatment results, comparing their findings with prior studies. It is essential for contextualizing data, drawing conclusions, and providing recommendations for future research and practice.

16) Knowledge:
Knowledge refers to the accumulated understanding and insights gained from research and clinical practice. The study aims to contribute to the existing body of knowledge regarding periodontal therapies, particularly in effectively managing Grade II furcation defects. Advancing knowledge in this field can drive improvements in clinical practices and patient outcomes.

17) Swelling:
Swelling denotes an increase in size or volume, often associated with inflammation after surgical procedures. In this study context, monitoring for swelling in postoperative patients is crucial, as it can reveal complications or healing issues. Lack of reported swelling indicates successful recovery and effective management of surgical sites.

18) Bleeding:
Bleeding is a clinical concern during and after surgical interventions. Monitoring bleeding is essential for assessing complications and ensuring patient safety. The study's findings highlighted no significant bleeding issues, which suggests successful surgical techniques and adequate postoperative management, contributing to better overall outcomes and reduced risks for patients.

19) Incision:
Incision refers to the surgical cut made to facilitate access to underlying tissues for treatment. The study involves making precise incisions for flap surgeries in treating furcation defects. The skill in making incisions impacts surgical outcomes, healing time, and the effectiveness of subsequent treatments in periodontal therapy.

20) Quality:
Quality in this context relates to the standards of clinical outcomes achieved through the treatment modalities explored in the study. High-quality results, such as significant improvements in probing depths and attachment levels, demonstrate the efficacy of the interventions. Ensuring quality in treatment is essential for long-term success in periodontal therapy.

21) Surface:
Surface generally refers to the anatomical area that is treated or affected during periodontal therapy. The study emphasizes the importance of the root surface and furcation areas in managing periodontal defects. Addressing the surface-related issues is fundamental to achieving successful regeneration and improving periodontal health.

22) Animal:
Animal refers to studies often used in preclinical research to evaluate the effectiveness of treatments before human trials. Understanding animal models provides insights into biological mechanisms and potential outcomes for similar procedures in humans. The text discusses prior research involving animal studies that have shaped knowledge about periodontal regeneration.

23) Water:
Water is crucial in biological contexts, particularly concerning tissue hydration and cellular functions. In the study, water is mentioned regarding the preparation of freeze-dried bone allografts, emphasizing that removing excessive water enhances the allograft's structural integrity and biological properties. This process is vital for optimizing bone graft effectiveness in regeneration.

24) Visit:
Visit pertains to the follow-up appointments scheduled post-treatment for monitoring patient recovery and treatment outcomes. The study outlines multiple recall visits at 1 month, 3 months, and 6 months to evaluate clinical parameters. These visits are essential for ensuring proper healing and long-term success of periodontal interventions.

25) Tata:
Tata is recognized in the text as the source of the freeze-dried bone allograft used in the study. The mention highlights the collaboration with the Tata Memorial Hospital's tissue bank in Mumbai, reflecting the institutional support and availability of quality materials for conducting research aimed at improving periodontal treatment outcomes.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Evaluation of freeze-dried bone allograft in Grade II furcation defects’. Further sources in the context of Science might help you critically compare this page with similair documents:

Treatment modalities, Statistical analysis, Inclusion criteria, Exclusion criteria, Patient Monitoring, Plaque index, Gingival index, Clinical improvement, Sample size calculation, Probing depth, Statistically significant difference, Statistical method, Oral hygiene instruction, Clinical parameter, Relative attachment level, Periodontal dressing, Bone grafting material, Guided tissue regeneration.

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