Minocycline adjunct therapy for recurrent gingival hyperplasia.

| Posted in: Science

Journal name: Journal of Indian Society of Periodontology
Original article title: Systemic antimicrobial therapy (minocycline) as an adjunct to non-surgical approach to recurrent chronic generalized gingival hyperplasia
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:

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Author:

Parag M. Khatri, Shraddanand Bacha


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: Systemic antimicrobial therapy (minocycline) as an adjunct to non-surgical approach to recurrent chronic generalized gingival hyperplasia

Year: 2014 | Doi: 10.4103/0972-124X.131345

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

Periodontal disease is a multifactorial condition marked by the formation of periodontal pockets, loss of clinical attachment, and alveolar bone resorption. The interplay between bacterial factors, host response, and various genetic and environmental elements significantly contributes to tissue destruction in periodontitis. Recognizing periodontitis as an infectious disease prompts the use of systemic antibiotics, particularly when conventional mechanical therapies are ineffective. Various antibiotics, including minocycline, are increasingly used to enhance treatment outcomes in patients with refractory periodontal disease.

The Role of Systemic Minocycline Therapy in Periodontal Treatment

A case study presents a 28-year-old female patient with recurrent chronic generalized periodontitis characterized by gingival enlargement, despite undergoing multiple surgical interventions. The treatment plan involved a combination of conventional mechanical debridement and systemic antimicrobial therapy with minocycline. Following the administration of minocycline, significant clinical improvements were observed, including reduced pocket depth and enhanced attachment levels. The case underscores the effectiveness of systemic minocycline as an adjunct to mechanical therapy, demonstrating a positive clinical response by reducing inflammation and promoting periodontal health.

Conclusion

The findings from this case illustrate the potential benefits of incorporating systemic antimicrobial therapy, specifically minocycline, into the management of recurrent periodontal disease. While recurrence of periodontal disease remains unpredictable, the psychological and functional benefits derived from improved oral health significantly outweigh the risks. Ongoing oral hygiene and maintenance play a critical role in the long-term success of periodontal therapy, necessitating further follow-up to assess the durability and predictability of treatment outcomes.

FAQ section (important questions/answers):

What is the role of systemic antibiotics in periodontal disease management?

Systemic antibiotics serve as an effective adjunct to mechanical debridement in treating periodontal diseases, helping to address specific pathogens and improve clinical outcomes for certain patients.

What case is discussed in the report regarding minocycline treatment?

The report details a 28-year-old female patient with recurrent chronic generalized periodontitis and gingival enlargement, who was treated successfully with systemic minocycline combined with conventional non-surgical therapy.

What improvements were observed after treatment with minocycline?

Post-treatment assessments showed significant reductions in pocket depth, improved attachment levels, and noticeable improvements in gingival inflammation and overall health.

Why are systemic drugs like minocycline used in periodontal therapy?

Systemic drugs like minocycline are utilized due to their antimicrobial properties, which enhance the effectiveness of scaling and root planning, especially in non-responsive or recurrent cases.

What factors contribute to the success of periodontal therapy?

Successful periodontal therapy is influenced by effective oral hygiene maintenance, the removal of bacterial biofilm, and management of plaque accumulation to prevent recurrence.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Minocycline adjunct therapy for recurrent gingival hyperplasia.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Disease:
Disease refers to a pathological condition that disrupts normal bodily functions. In the context of the text, periodontal disease is highlighted as a multifactorial condition characterized by inflammation of the gums, leading to tissue destruction and potential systemic health implications. Understanding the disease process is crucial for effective management and treatment strategies.

2) Table:
In clinical and research settings, a table usually presents structured data for easy reference. It could include patient demographics, treatment plans, clinical results, and outcome measures. Tables help compare data systematically, allowing clinicians and researchers to analyze relationships and trends, aiding in understanding treatment efficacy and patient responses.

3) Bleeding:
Bleeding is a clinical sign indicative of inflammation or tissue trauma. In periodontal disease, bleeding often occurs at the gingival margin due to the inflammatory response to plaque accumulation. Monitoring bleeding on probing is a critical part of periodontal assessments, indicating disease severity and treatment responses.

4) Inflammation:
Inflammation is the body's natural response to injury or infection, characterized by redness, swelling, and pain. In the context of periodontal disease, inflammation occurs around the gums due to bacterial infection, leading to attachment loss and bone resorption. Management focuses on reducing inflammation to halt disease progression.

5) Antibiotic (Antibacterial):
Antibacterial agents specifically target bacterial organisms, which is relevant in managing infections. In the context of periodontal disease, using antibacterial agents can help reduce microbial load, complementing mechanical debridement strategies. Understanding their specific roles enhances treatment protocols aimed at improving clinical outcomes in periodontal therapy.

6) Post:
Post refers to events following a specific occurrence, such as a treatment or surgical intervention. In the context of the text, post-operative assessments involve evaluating clinical parameters after treatment, which is crucial for determining the effectiveness of interventions and the progression of periodontal health in the patient.

7) Relative:
Relative often describes relationships within data or between entities. In medical literature, it may denote comparisons between treatment groups or conditions. For example, assessing the relative risk of disease recurrence following different therapeutic protocols helps establish effective treatment plans and enhances understanding of patient outcomes based on various factors.

8) Activity:
Activity in a clinical context often pertains to disease processes, such as pathogenic activity in periodontal disease. Assessing the microbial activity level helps determine the extent of infection and guides treatment decisions. Tracking activity, particularly pre and post-treatment, can indicate the effectiveness of therapeutic interventions.

9) Drug:
A drug is a substance used to diagnose, cure, treat, or prevent disease. In the context of periodontal disease, drugs such as minocycline play a crucial role in therapeutic strategies. Understanding the pharmacological properties and mechanisms of action is essential for optimizing treatment outcomes and minimizing side effects.

10) Accumulation (Accumulating, Accumulate):
To accumulate means to gather or collect over time. In periodontal disease, the accumulation of plaque and pathogenic bacteria leads to inflammation and tissue breakdown. Understanding the dynamics of accumulation helps in devising effective prevention and treatment strategies to improve oral health outcomes.

11) Hygiene (Hygienic):
Hygiene refers to practices that maintain health and prevent disease, particularly oral hygiene in this context. Effective hygiene routines are essential in preventing periodontal diseases by minimizing plaque accumulation. Educating patients about proper hygiene techniques can significantly influence treatment outcomes and overall periodontal health.

12) Visit:
Visit refers to appointments patients have with healthcare providers. Routine visits in periodontal therapy are crucial for monitoring disease progression, assessing treatment effectiveness, and reinforcing oral hygiene practices. Increased patient engagement during visits enhances collaborative care, ultimately improving health outcomes in periodontal management.

13) Study (Studying):
A study in a clinical context typically refers to systematic investigations aimed at understanding disease mechanisms, treatment efficacy, and patient outcomes. Research findings contribute to the development of evidence-based practices in periodontal therapy, informing clinicians about the best strategies for managing recurrent or refractory cases.

14) Rheumatoid arthritis:
Rheumatoid arthritis is an autoimmune disease characterized by chronic inflammation primarily affecting joints. In periodontal health, its presence can complicate management due to shared susceptibility to inflammatory processes. Understanding its interplay with periodontal disease is essential for comprehensive patient care and tailored treatment plans.

15) Chemotherapy:
Chemotherapy traditionally refers to drug treatment targeting cancer; however, in the context of this text, it implies the strategic use of drugs like antibiotics to address infections. This broader definition highlights how pharmacotherapy can be used effectively to manage periodontal disease and reduce bacterial challenges.

16) Discussion:
Discussion refers to the critical analysis of findings within a study or treatment context. In the provided text, discussion sections analyze treatment outcomes and compare them with existing literature, providing insights into the effectiveness of therapeutic approaches and guiding future research directions and clinical practices.

17) Inference:
Inference involves drawing conclusions based on data or observations. In the clinical setting, clinicians infer treatment effectiveness and disease progression by analyzing clinical data pre- and post-treatment. Inferences help guide ongoing management strategies and inform the adaptation of treatment plans to enhance patient outcomes.

18) Killing (Killed):
Killing refers to the eradication of bacteria, especially in the context of infections. In periodontal therapy, antimicrobial agents aim to kill or inhibit pathogenic bacteria contributing to disease. Understanding the mechanisms of action of these agents is key to optimizing periodontal treatment and improving patient health.

19) Family:
Family refers to the immediate relatives encompassing genetic predispositions and lifestyle factors impacting health. In a medical context, understanding family health histories can guide risk assessments and tailor preventive strategies for conditions like periodontal disease, which may exhibit familial patterns of susceptibility and severity.

20) Blood:
Blood is a vital fluid that circulates nutrients, waste products, and immune cells throughout the body. In periodontal disease, analyzing blood parameters can help assess systemic health and potential links between periodontal inflammation and systemic conditions. Understanding these connections aids in comprehensive patient management.

21) Coral:
Coral, in this context, likely refers to the color depicting healthy gingival tissue. Coral pink gums are a sign of good periodontal health. Maintaining such coloration can indicate effective disease management and reflects the overall health of the gingival tissues following appropriate treatment interventions.

22) Mast:
Mast cells are immune cells involved in inflammatory responses, including those seen in periodontal disease. Their role in mediating immune responses to pathogenic bacteria is essential in understanding tissue inflammation and healing dynamics in periodontitis, making them relevant to treatment strategies aimed at reducing inflammation.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Minocycline adjunct therapy for recurrent gingival hyperplasia.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Periodontal disease, Long-term follow-up, Systemic administration, Scaling and root planning, Oral hygiene maintenance, Probing depth, Gingival hyperplasia, Tetracycline, Clinical parameter, Gingival enlargement, Chronic generalized periodontitis, Subgingival calculus.

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