Amlodipine-induced gingival overgrowth in Loni's rural population
Journal name: Journal of Indian Society of Periodontology
Original article title: Incidence of amlodipine-induced gingival overgrowth in the rural population of Loni
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:
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Avneesh Tejnani, Ameet Mani, Neha Kaur Sodhi, Alok Mehta, Sonal Gourkhede, Vinayak Thorat, Pramod Marawar
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Incidence of amlodipine-induced gingival overgrowth in the rural population of Loni
Year: 2014 | Doi: 10.4103/0972-124X.131332
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Amlodipine, a widely used calcium channel blocker for managing hypertension and angina, has been associated with the side effect of gingival overgrowth, yet the incidence and mechanisms behind this phenomenon remain inadequately defined. This study was designed to determine the incidence of amlodipine-induced gingival hyperplasia among dental patients who have been on the medication for a minimum of three months. Previous reports have documented similar adverse effects with other calcium channel blockers, but clear data on amlodipine's specific impact have been limited.
The Link Between Gingival Inflammation and Drug Dosage
The study found a prevalence rate of 3.4% for amlodipine-induced gingival hyperplasia, with no occurrences among the control group using alternative antihypertensive medications. Examination revealed that gingival overgrowth typically appeared as lobular or nodular enlargements in the anterior interproximal regions of the mouth. Notably, the presence of gingival inflammation, often due to plaque accumulation, was found to correlate significantly with the severity of hyperplasia. This relationship highlights how dental hygiene practices could potentially mitigate the risk of developing gingival overgrowth when using amlodipine, emphasizing the importance of maintaining oral health alongside medication.
Conclusion
In conclusion, while the incidence of gingival overgrowth associated with long-term amlodipine use is relatively low, certain factors, including drug dosage and the presence of gingival inflammation, significantly contribute to the condition. The study suggests that males may be more susceptible to this side effect, and it calls for further research into individual biological variances that may affect patient responses to medication. This underscores the need for careful monitoring of oral health in patients prescribed amlodipine and awareness of the potential for gingival hyperplasia as a side effect.
FAQ section (important questions/answers):
What was the aim of the study on amlodipine?
The study aimed to determine the incidence of gingival overgrowth induced by amlodipine, which has been poorly defined in existing literature.
How many patients were involved in the amlodipine study?
The study surveyed 115 dental patients who had taken amlodipine for over three months to determine the occurrence of drug-induced gingival overgrowth.
What was the prevalence of gingival overgrowth among study patients?
The prevalence of amlodipine-induced gingival hyperplasia in the study group was found to be 3.4%, whereas it was not observed at all in the control group.
What factors contributed to gingival overgrowth in the study?
The study found a significant association between gingival inflammation due to dental plaque and drug dosage, indicating that bacterial inflammation is essential for the development of gingival hyperplasia.
What is the relationship between amlodipine and gingival hyperplasia?
Amlodipine use may lead to gingival hyperplasia, especially in males with poor oral hygiene, highlighting the importance of maintaining good oral care.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Amlodipine-induced gingival overgrowth in Loni's rural population”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
A 'Table' in the context of medical research typically summarizes data, findings, or characteristics in a structured format, facilitating easier comparisons and understanding of various results across different groups. In this study, tables present critical statistical evidence regarding gingival indices, plaque scores, and the rates of drug-induced gingival overgrowth, thereby aiding in the interpretation of the study’s findings.
2) Study (Studying):
'Study' refers to the scientific investigation carried out to determine the incidence of gingival overgrowth associated with amlodipine. The term encompasses the research design, methodology, participant selection, data collection, and analysis employed to derive conclusions about the relationship between medication usage and gingival health, contributing to broader medical knowledge.
3) Drug:
The term 'Drug' signifies amlodipine, a calcium channel blocker utilized for treating hypertension and angina. In this study, it is critical as the focal point of investigation, particularly regarding its adverse effects. This term emphasizes the need to explore and document potential side effects of widely used medications on oral health.
4) Inflammation:
Inflammation indicates the body's response to irritation or injury, often involving immune cells and chemicals. In this study, inflammation plays a crucial role as a contributing factor to gingival hyperplasia, highlighting how dental plaque-related inflammation can exacerbate the side effects of amlodipine, thus necessitating consistent oral hygiene practices for management.
5) Channel:
'Channel' pertains to calcium channels in cellular membranes that regulate calcium ion movement. Amlodipine targets these channels, affecting smooth muscle contraction and vascular function. Understanding this mechanism is essential for discussing how calcium channel blockers like amlodipine contribute to gingival overgrowth by altering normal biological processes within oral tissues.
6) Hygiene (Hygienic):
The term 'Hygiene' is crucial as it refers to oral hygiene practices that influence dental health. The study discusses how poor oral hygiene can exacerbate gingival overgrowth induced by amlodipine, suggesting that maintaining good dental hygiene is vital to mitigate adverse effects and preserve oral health in patients taking this medication.
7) Male:
'Male' is used to denote one of the demographic groups studied. This study noted a higher incidence of gingival overgrowth in males compared to females, prompting further inquiry into potential biological or behavioral differences that may predispose men to such side effects, thus informing targeted patient care strategies and preventive measures.
8) Accumulation (Accumulating, Accumulate):
'Accumulated' describes the gradual buildup of plaque and collagen in the gingival tissues as a result of prolonged medication use. The term emphasizes the pathological process leading to gingival hyperplasia, underscoring the importance of regular dental check-ups and personalized oral care to manage these accumulative effects efficiently during treatment.
9) Observation:
The term 'Observation' pertains to the clinical findings noted during the study regarding changes in gingival appearance and condition. It underscores the importance of systematically observing patient responses to amlodipine, and documenting physiological changes, which are crucial for understanding the drug’s side effects and guiding patient management strategies.
10) Discussion:
'Discussion' in the study provides a critical analysis of findings, linking results to existing literature, and interpreting the implications of the results. It allows researchers to contextualize their findings within the broader field of dentistry and pharmacology, offering insights and hypotheses regarding mechanisms of drug-induced gingival overgrowth.
11) Surface:
'Surface' refers to the exterior of the gingiva that is affected by changes due to conditions like overgrowth. In this study, it highlights the significance of the clinical appearance of gingival tissue, emphasizing the manifestation of hypertrophy and the visible effects on oral health, which are critical for diagnosis and assessment.
12) Mast:
'Mast' relates to mast cells, a type of immune cell involved in inflammatory responses within the gingiva. The study highlights the involvement of these cells in the inflammatory process associated with gingival hyperplasia, implicating their activity in the pathogenesis of changes seen in patients taking amlodipine, enhancing understanding of local immunology.
13) Pur:
'Poor' characterizes dental hygiene practices that may lead to increased plaque accumulation and, consequently, greater risk of gingival overgrowth in patients taking amlodipine. This term stresses the importance of proactive oral health measures, encouraging patients and healthcare providers to prioritize effective hygiene and maintenance routines for optimal dental health outcomes.
14) Life:
'Life' typically refers to the overall well-being and health of individuals affected by conditions like hypertension who may be prescribed amlodipine. The application of this term stresses the influence of drug effects on quality of life, oral health, and the long-term implications of managing chronic conditions linked to medication-induced side effects.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Amlodipine-induced gingival overgrowth in Loni's rural population’. Further sources in the context of Science might help you critically compare this page with similair documents:
Long-term consumption, Clinical diagnosis, Significant relationship, Study group, Gingival inflammation, Prevalence rate, Dental plaque, Patient characteristics, Medication history, Gingival hyperplasia, Control subjects, Calcium channel blocker, Biological differences, Interdental papilla, Anti-hypertensive treatment, Gingival fibroblast.