IL-1β in crevicular fluid: correlation with clinical and radiographic data.
Journal name: Journal of Indian Society of Periodontology
Original article title: Interleukin-1β level in peri-implant crevicular fluid and its correlation with the clinical and radiographic parameters
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Aniruddha M. Kajale, Dhoom S. Mehta
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Interleukin-1β level in peri-implant crevicular fluid and its correlation with the clinical and radiographic parameters
Year: 2014 | Doi: 10.4103/0972-124X.131331
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
The use of endosseous dental implants has become a standard treatment option for edentulous patients. Despite their popularity, many implants face complications due to peri-implantitis, a condition characterized by inflammation of the soft and hard tissues surrounding the implant. Traditional evaluation methods, primarily relying on clinical and radiographic data, may not accurately reflect early stages of disease activity. This case series aimed to explore the assessment of peri-implant health by including clinical, radiographic, and biochemical parameters, specifically focusing on the analysis of peri-implant crevicular fluid (PICF) to measure inflammatory activity through interleukin-1β (IL-1β) levels.
The Role of IL-1β in Assessment of Peri-Implant Health
One of the crucial findings from this study is the significant variation in IL-1β levels in PICF over time, highlighting its potential as a valuable biomarker for early detection of inflammation around dental implants. In the analysis, the IL-1β levels showed notable differences between the 6th month (31.79 ± 12.26 pg/μl) and the 12th month (113.09 ± 51.11 pg/μl) after implant placement. Although the overall clinical and radiographic assessments indicated healthy peri-implant conditions, the increase in IL-1β suggests ongoing subclinical inflammation that might not be visible through traditional evaluation techniques. This underscores the complexity of peri-implant health and the need for comprehensive assessment methods that include biochemical markers for more informed diagnosis and monitoring.
Conclusion
In conclusion, the evaluation of parameters in this case series affirmed that the investigated implants maintained a healthy peri-implant status over the course of a year. The increase in IL-1β levels at the 12th month was still within the accepted healthy range, demonstrating the biomarker's utility as an adjunct in assessing early inflammatory changes around dental implants. This research emphasizes the importance of integrating biochemical analysis alongside traditional methods to improve the monitoring and management of implant health, especially as the dental field continues to evolve toward more objective clinical assessments. Further studies with larger sample sizes and diverse comparative groups may enhance understanding of this relationship and its implications for implant dentistry.
FAQ section (important questions/answers):
What is the purpose of assessing peri-implant crevicular fluid (PICF)?
The study investigates whether IL-1β levels in PICF can provide objective measures of disease activity around dental implants, offering insights into early inflammatory changes compared to clinical and radiographic parameters.
How were the clinical and radiographic parameters evaluated in the study?
Thirteen patients underwent dental implant surgeries with evaluations at baseline, 6 months, and 12 months, using indices for plaque, gingival health, bleeding, probing depth, and radiographic imaging to assess implant health.
What were the findings regarding IL-1β levels in PICF?
IL-1β levels increased significantly from the 6th month to the 12th month, showing values of 31.79 pg/μl and 113.09 pg/μl, respectively, indicating potential early inflammatory changes despite implants being classified as healthy.
Was there any correlation found between clinical and biochemical parameters?
Spearman's correlation coefficient revealed no significant correlation between clinical, radiographic, and biochemical parameters at both 6 and 12 months, likely due to all values being within a healthy range.
What conclusions were drawn regarding peri-implant health from the study?
The study concluded that all implants maintained healthy peri-implant status over one year, with IL-1β levels suggesting it can serve as an adjunctive tool for assessing early inflammatory changes around dental implants.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “IL-1β in crevicular fluid: correlation with clinical and radiographic data.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
Table refers to a structured format used to present data or information systematically. In research, it serves to organize findings for clarity, allowing readers to easily digest numerical values, comparisons, or summaries. This facilitates data interpretation and allows quick reference during discussions or analyses of results.
2) Inflammation:
Inflammation is the body's response to injury or infection, characterized by redness, swelling, heat, and pain. In the context of dental health, it reflects the body's attempt to heal following dental procedures or the presence of disease. Monitoring inflammation is crucial in assessing the health of dental implants.
3) Study (Studying):
A study is a systematic investigation designed to discover new information or validate existing knowledge. In research, a study outlines methodology, data collection, and analysis to derive conclusions. It is essential for advancing science and informing practice, particularly in fields requiring evidence-based decision-making.
4) Hygiene (Hygienic):
Hygiene involves practices that maintain health and prevent disease, with a focus on cleanliness. In dentistry, good oral hygiene is vital for implant success, reducing infection risks and improving outcomes. Maintaining proper hygiene protocols can significantly impact the health status of both natural teeth and implants.
5) Activity:
Activity refers to a state of action or a process of engaging in behaviors or functions. In medical terms, it often relates to biological processes, such as disease activity in tissues. Evaluating activity helps determine the severity of conditions, guiding treatment plans and interventions.
6) Bleeding:
Bleeding indicates the loss of blood from the circulatory system, often a sign of injury or disease. In dental health, it can suggest inflammation or infection around implants. Monitoring bleeding helps assess tissue health and the presence of complications like peri-implantitis, guiding clinical decisions.
7) Relative:
Relative refers to the comparison between two or more entities in terms of their properties or status. In health studies, relative measures help determine the significance of findings or risk factors compared to a standard or baseline, such as the health status of patients or the effectiveness of treatments.
8) Disease:
Disease signifies a pathological condition characterized by specific clinical signs and symptoms. In dentistry, diseases can affect teeth and surrounding tissues, including peri-implant diseases like peri-implantitis. Early detection and treatment are essential to prevent severe complications, including loss of the implant or surrounding bone.
9) Incision:
An incision is a surgical cut made by a scapel or blade to facilitate procedures or access the tissues underneath. In dental implant surgery, precise incisions are crucial for successful placement and healing, impacting overall outcomes. Proper technique minimizes trauma and supports recovery and long-term health.
10) Surface:
Surface refers to the outermost layer of an object or tissue. In dental implantology, surface characteristics of implants, such as texture, affect osseointegration and tissue response. Understanding surface properties is vital for implant design, influencing healing, attachment, and overall implant stability in the jaw.
11) Sign:
A sign denotes an observable indication of a condition or disease. In medical practice, signs can help diagnose or monitor health status. Recognizing clinical signs, like swelling around an implant, is essential for timely intervention, guiding practitioners in the evaluation and management of peri-implant health.
12) Performance:
Performance assesses how well a procedure or entity functions. In the context of dental implants, performance metrics would include stability, integration with bone, and overall longevity. Evaluating performance is crucial for determining the effectiveness of various implant types, surgical techniques, and post-operative care.
13) Surrounding:
Surrounding pertains to the area or structures in proximity to a specific entity. In dental contexts, surrounding tissues, such as gums and alveolar bone, play critical roles in implant health and function. Evaluating these structures helps identify risks and supports effective treatment planning.
14) Discussion:
Discussion facilitates the exploration of findings, interpretations, and implications of study results. It contextualizes the research within existing literature, helping to validate or challenge previous understandings. A thorough discussion enhances the value of research by connecting results to practical applications and future directions.
15) Collecting:
Collecting refers to the process of gathering samples or information for analysis. In clinical studies, collecting data is crucial for drawing valid conclusions. Methods of collecting include patient interviews, physical examinations, and biofluid sampling, which ensure researchers have the necessary data to support their findings.
16) Irritation:
Irritation signifies a state of discomfort or inflammation in response to stimuli. In dental health, irritation can arise from procedural techniques or materials, leading to inflammation of surrounding tissues. Recognizing signs of irritation early can prompt adjustments in treatment strategies to enhance patient comfort and outcomes.
17) Quality:
Quality refers to the standard or level of excellence of an entity or process. In dental implantology, quality assessments evaluate implant materials, surgical techniques, and patient outcomes. High-quality practices ensure better health results and longer-lasting implants, contributing to overall patient satisfaction.
18) Nature:
Nature pertains to the inherent characteristics of objects or phenomena. In a clinical setting, understanding the nature of problems, such as inflammation or infection, is critical for diagnosis and treatment. A thorough grasp of the nature of conditions informs practitioners' approaches to interventions.
19) Reason:
Reason indicates the rationale or justification behind an action or observation. In medical research, understanding the reason for study design, findings, or treatment choices enhances comprehension. Identifying reasons helps explain methodologies and supports the validity of conclusions drawn from results.
20) Cotton:
Cotton is a soft, fibrous material widely used in medical settings for its absorbent properties. In dentistry, cotton rolls are employed to isolate areas during procedures, manage moisture, and facilitate the collection of substances such as periapical fluid or debris, ensuring a clean working environment.
21) Blood:
Blood is the fluid that circulates in the vascular system, carrying oxygen and nutrients to cells. In dental research, the presence or analysis of blood can inform diagnoses, as bleeding may indicate underlying conditions or complications related to dental implants, necessitating careful monitoring and management.
22) Pain:
Pain is the body's signal of discomfort or distress, often indicating injury, inflammation, or disease. In dental contexts, managing pain effectively is essential for patient comfort pre-, peri-, and post-surgery. Pain levels can influence treatment choices and overall satisfaction with dental procedures.
23) Post:
Post refers to the period following an event, particularly after procedures such as surgery. In dental studies, post-operative monitoring is vital to assess healing, detect complications, and ensure patient well-being. Post-operative care influences outcomes and enables timely interventions when issues arise.
24) Male:
Male indicates a gender classification, often relevant in medical research demographics. In studies, understanding gender differences in responses to treatment or disease processes can inform tailored approaches to care. Collecting accurate gender data contributes to comprehensive analyses and enhances the relevance of findings.
Other Science Concepts:
Discover the significance of concepts within the article: ‘IL-1β in crevicular fluid: correlation with clinical and radiographic data.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Statistical analysis, Biochemical analysis, Oral hygiene maintenance, Negative correlation, Peri-implantitis, Clinical parameter, Radiographic parameter.