Nanocrystalline vs. synthetic hydroxyapatite for intrabony defects

| Posted in: Science

Journal name: Journal of Indian Society of Periodontology
Original article title: Comparison of nanocrystalline hydroxyapatite and synthetic resorbable hydroxyapatite graft in the treatment of intrabony defects: A clinical and radiographic study
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
This page presents a generated summary with additional references; See source (below) for actual content.

Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

Mansi Bansal, Mayur Kaushik, Brig B. P. Khattak, Anamika Sharma


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: Comparison of nanocrystalline hydroxyapatite and synthetic resorbable hydroxyapatite graft in the treatment of intrabony defects: A clinical and radiographic study

Year: 2014 | Doi: 10.4103/0972-124X.131329

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

The study aimed to compare the effectiveness of nanocrystalline hydroxyapatite (NHA) and synthetic resorbable hydroxyapatite (HA) in treating intrabony defects associated with chronic periodontitis. Ten subjects with bilateral defects were included, each having probing depths ranging from 6 to 9 mm. The study recorded various clinical parameters such as plaque index, gingival index, probing depth (PD), and relative attachment level (RAL) at baseline, 3 months, and 6 months post-surgery to evaluate treatment outcomes.

Efficacy of Nanocrystalline Hydroxyapatite

One of the important concepts examined is the effectiveness of NHA compared to conventional HA. At the 6-month follow-up, both NHA and HA treatment groups demonstrated clinical improvements, including reduced PD and increased RAL. However, the study found no statistically significant differences between the two groups regarding probing depth or attachment level, indicating that while both materials contributed to improved clinical parameters, NHA did not provide a superior outcome compared to HA. Both treatments proved to be well-tolerated, with no significant adverse effects recorded during the follow-up period.

Conclusion

Despite the differences in material properties, the study concluded that NHA did not exhibit statistically significant advantages over conventional HA in the treatment of intrabony defects. Both materials improved clinical outcomes, suggesting a potential role for NHA in periodontal therapy; however, more extensive studies, including histological analyses and a longer follow-up duration, are necessary to fully understand the benefits of NHA. The results underline the ongoing need for research to evaluate new synthetic bone graft materials in clinical applications effectively.

FAQ section (important questions/answers):

What was the aim of the study comparing NHA and HA?

The study aimed to clinically and radiographically compare the effectiveness of nanocrystalline hydroxyapatite (NHA) and synthetic resorbable hydroxyapatite (HA) in treating intrabony defects in patients with chronic periodontitis.

How many subjects participated in the study, and what were their characteristics?

Ten subjects with bilateral intrabony defects, aged between 20 and 50 years, having probing depths of 6-9 mm and intraosseous components of at least 4 mm were recruited for this study.

What clinical parameters were measured during the study?

Probing depth, relative attachment level, plaque index, and gingival index were recorded at baseline, 3 months, and 6 months after surgery to assess the treatment effectiveness.

What were the main findings regarding NHA and HA treatment outcomes?

Both NHA and HA showed improvements in clinical and radiographic parameters, but no statistically significant differences were found between the two groups after treatment.

What recommendations were made for future studies based on this research?

Future studies should include larger sample sizes, longer follow-up periods, and histological analysis to better understand the benefits of NHA compared to HA in clinical settings.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Nanocrystalline vs. synthetic hydroxyapatite for intrabony defects”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Study (Studying):
This refers to the systematic investigation into the effectiveness of nanocrystalline hydroxyapatite (NHA) versus synthetic resorbable hydroxyapatite (HA) in treating dental intrabony defects. The study is significant for advancing periodontal treatments and understanding the potential advantages of utilizing nanomaterials in clinical applications.

2) Table:
In the context of the study, tables present the summarized data, including statistical results of clinical and radiographic parameters. They are critical in conveying clear information and findings, allowing researchers and practitioners to quickly comprehend and compare results across the different treatment groups.

3) Relative:
This term pertains to clinical parameters like relative attachment level (RAL), which measures the change in periodontal support. Understanding relative changes between groups aids in evaluating treatment outcomes, thereby determining the effectiveness of NHA compared to HA in restoring periodontal health in patients.

4) Observation:
This indicates the careful monitoring and assessment of clinical outcomes post-treatment. Observations form the basis for identifying improvements in periodontal health and changes in defect sizes, crucial for drawing conclusions about the efficacy of the various materials used for treatment.

5) Hygiene (Hygienic):
Oral hygiene is essential in managing periodontal diseases. The study emphasizes maintaining good hygiene during the investigation as it impacts clinical outcomes. Poor hygiene can skew results, thereby affecting the perceived effectiveness of the treatments under investigation.

6) Blood:
Blood is significant in the study as it is used to moisten the graft material before implantation. This aids in establishing a favorable environment for healing and optimal integration of the graft with the existing periodontal tissues during the regeneration process.

7) Surface:
Surface properties of graft materials like NHA directly influence osteoconductivity and biocompatibility. The study involves assessing how these surface characteristics impact tissue integration and cell behavior, highlighting the importance of material properties in regenerative medicine for periodontal therapy.

8) Powder:
The term powder refers specifically to the form of NHA utilized in the study. Its nanoscale size is crucial since it enhances the material’s surface area, potentially improving cell interaction and regeneration properties, making it a promising option for dental applications.

9) Post:
Post refers to the follow-up period after treatment, emphasizing the evaluation of recovery and success of the grafting material over time. The longitudinal assessment is essential for understanding the long-term effectiveness and stability of the clinical outcomes achieved.

10) Measurement:
Measurements of clinical parameters such as probing depth and attachment level are pivotal for assessing the effectiveness of the treatments. Accurate measurements ensure that the study's findings are reliable and valid, helping to substantiate the claims made about the materials used.

11) Nature:
The nature of the graft material and its interaction with biological tissues is examined in the study. Understanding the properties of NHA and HA allows for determining their effectiveness and compatibility with human tissues, crucial for successful clinical outcomes.

12) Surrounding:
Surrounding tissues play a key role in the healing process. The integration of graft materials with surrounding periodontal tissues is essential for successful regeneration, underscoring the significance of material selection in promoting tissue health and optimal clinical results.

13) Bleeding:
Bleeding serves as an indicator of the health of periodontal tissues and is a critical parameter monitored during clinical evaluation. The presence or absence of bleeding on probing provides insight into the effectiveness of treatment and the healing status of the site.

14) Disease:
Referring to periodontal disease, this term is central to the study, as the aim is to treat such conditions through regeneration. Understanding disease pathology is fundamental in assessing how new materials can improve patient outcomes and restore periodontal health.

15) Inflammation:
Inflammation is a response to tissue injury and plays a significant role in periodontal diseases. The study's outcome depends on how well the graft materials mitigate inflammation and promote healing, which is vital for achieving lasting clinical improvements.

16) Arrangement:
Arrangement pertains to the structural organization of materials and tissues during the healing process. Proper arrangement is crucial for effective tissue integration and functionality in grafting procedures, influencing the overall success of periodontal interventions.

17) Performance:
Performance of the graft materials is evaluated through their effectiveness in clinical outcomes. This relates to how well NHA and HA materials support tissue regeneration and restoration of periodontal function, influencing treatment choices for clinicians.

18) Reliability:
Reliability refers to the consistency and trustworthiness of the study's results. Ensuring that findings are reproducible is essential for validating the effectiveness of the materials used and for establishing best practices in periodontal regenerative treatments.

19) Discussion:
The discussion section synthesizes the study's findings, evaluations, and implications. It provides context, compares results with existing literature, and explores the potential impact on dental practices, offering insights for future research and treatment methodologies.

20) Developing:
Developing refers to the ongoing process of advancing periodontal treatments and materials, specifically in the context of using NHA for regeneration. Continuous improvement in techniques and materials is essential for enhancing patient outcomes and clinical success.

21) Similarity:
Similarity highlights the comparative aspects of the study, particularly between NHA and HA. Identifying similarities in outcomes allows for better understanding of their comparative effectiveness, guiding future clinical decisions and developing more efficient treatment modalities.

22) Composite:
Composite materials may reference multi-component grafting options that integrate various materials for improved healing. Understanding how composite applications can enhance regenerative processes aids clinicians in optimizing treatment approaches for periodontal diseases.

23) Activity:
Activity pertains to osteogenic or biological activity of materials within the periodontal environment. The degree of biological activity directly influences the efficacy of graft materials, thereby playing a significant role in regenerative success within periodontal therapy.

24) Incision:
Incision refers to the surgical cut made during the grafting procedure. Proper incision techniques are crucial to ensure adequate access and visibility during surgery, ultimately impacting the effectiveness of the graft and the healing process.

25) Grafting:
Grafting is the core procedure involving the transplantation of NHA or HA materials into periodontal defects. Understanding the principles of grafting is key to enhancing treatment outcomes and advancing surgical techniques in periodontal therapy.

26) Quality:
Quality focuses on assessing the characteristics of the biomaterials used, such as their biocompatibility and effectiveness. High-quality materials lead to better integration with host tissues, which is essential for successful periodontal regenerative therapies.

27) Repair:
Repair involves the restoration of periodontal health and structure post-treatment. Evaluating the extent of repair helps assess the success of the grafting materials in regaining lost periodontal tissues, crucial for measuring treatment effectiveness.

28) Liquor:
Liquor may refer to a fluid medium used in the synthesis of NHA, impacting its formation and properties. Analyzing the role of various liquids in material synthesis is important for optimizing clinical applications of bioactive materials.

29) Filling (Filled):
Filled denotes the process of placing graft materials into bone defects. Accurate filling is essential for achieving desired outcomes in tissue regeneration, influencing healing dynamics and the effectiveness of the graft material in promoting repair.

30) India:
In this context, India may refer to the location where the study was conducted, highlighting the cultural and geographical relevance of the findings. It emphasizes the need for localized research in understanding variations in periodontal disease and treatment efficacy.

31) Water:
Water is a vital component in the synthesis of NHA, influencing its chemical properties and effectiveness. The role of water in the biochemical environment is critical, impacting material behavior and interaction with biological systems during healing.

32) Rules:
Rules may pertain to research protocols and clinical guidelines governing the study. Adhering to established rules ensures the reliability of results and ethical conduct in research, reinforcing the importance of scientific rigor in clinical investigations.

33) Field:
Field refers to the area of periodontal research and clinical practice. Advances in the field are essential for improving treatment modalities and ultimately enhancing patient outcomes in periodontal disease management and regeneration.

34) Line:
Line may refer to a reference point or guideline for performing measurements during the study. Accurate lines of measurement are crucial for consistency and reliability in assessing clinical outcomes in periodontal treatments.

35) Hand:
Hand typically refers to surgical techniques employed during the grafting procedure. The skill and dexterity of the clinician’s hand are vital for ensuring precision and effectiveness, ultimately impacting the success of graft placement and patient outcomes.

36) Male:
Male refers to the demographic characteristics of study participants. Understanding gender-related differences in periodontal disease prevalence, treatment responses, and outcomes is important for tailoring appropriate treatment strategies and improving overall clinical effectiveness.

Other Science Concepts:

[back to top]

Discover the significance of concepts within the article: ‘Nanocrystalline vs. synthetic hydroxyapatite for intrabony defects’. Further sources in the context of Science might help you critically compare this page with similair documents:

Patient consent, Biocompatibility, Surgical Procedure, Angiogenesis, Oral Hygiene Index, Statistically non-significant, Probing depth, Clinical parameter, Self-assembly, Periodontal tissue, Bone regeneration, Experimental material, Relative attachment level, Intrabony defect, Long-term results, Nanomaterial.

Let's grow together!

I humbly request your help to keep doing what I do best: provide the world with unbiased sources, definitions and images. Your donation direclty influences the quality and quantity of knowledge, wisdom and spiritual insight the world is exposed to.

Let's make the world a better place together!

Like what you read? Help to become even better: