Aggressive periodontitis: A clinico-hematological appraisal
Journal name: Journal of Indian Society of Periodontology
Original article title: Aggressive periodontitis: A clinico-hematological appraisal
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
This page presents a generated summary with additional references; See source (below) for actual content.
Original source:
This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.
Debabrata Kundu, Prasanta Bandyopadhyay, Vineet Nair, Mona Chowdhury, Saswati Mukherjee, Moumita Nayek
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Aggressive periodontitis: A clinico-hematological appraisal
Year: 2014 | Doi: 10.4103/0972-124X.131317
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Aggressive periodontitis (AP) has been linked to genetic factors such as human leukocyte antigens (HLA) and environmental influences. The present study investigates the potential associations between genetic markers, specifically ABO blood groups and HLA types, and functional abnormalities in leukocytes, particularly concerning polymorphonuclear leukocyte (PMN) adhesion and migration. The study compares these parameters in subjects with AP, chronic periodontitis (CP), and healthy controls to elucidate the role of monocyte subsets and PMN dysfunction in periodontal diseases.
Leukocytic Functional Abnormalities in AP
The study revealed that subjects with AP exhibited significant leukocytic functional defects compared to healthy controls. Specifically, AP subjects displayed lower levels of β2-integrin expression and actin polymerization, which are critical for neutrophil adhesion and migration, respectively. The finding suggests that the impaired adhesion and migration of neutrophils in AP may contribute to the pathogenesis of the disease. Furthermore, there was a notable increase in CD14+ CD16+ and CD45RA monocytes in AP subjects. This correlation indicates that the inflammatory response in AP is distinct from that observed in CP, emphasizing the complexity of immune system involvement in periodontal disease.
Conclusion
The results of the study indicate that while there are observable differences in blood types and HLA phenotypes among the groups, a definitive association between these genetic markers and periodontal diseases has yet to be established. The findings highlight significant leukocytic functional abnormalities in AP subjects, reinforcing the notion that impaired immune response may be a contributing factor to the disease's aggressiveness. As this study is a pioneering effort in Eastern India, further research with larger sample sizes is essential to solidify these findings and enhance the understanding of genetic and immunological factors in periodontal diseases.
FAQ section (important questions/answers):
What is the focus of the study on aggressive periodontitis?
The study assesses the association of genetic risk markers, defective PMN adhesion, neutrophil migration, actin polymerization, and monocyte subsets in aggressive periodontitis compared to chronic periodontitis and healthy controls.
How were the subjects grouped in the study?
A total of 45 subjects aged 20-50 were divided into three groups: Group I (healthy control), Group II (chronic periodontitis), and Group III (aggressive periodontitis), with 15 subjects in each group.
What significant findings were reported for the AP group?
In the AP group, a higher frequency of blood group AB, low β2-integrin expression, and reduced actin polymerization were observed, indicating a potential defect in neutrophil function.
What conclusions were drawn from the study's findings?
The study concluded that no definite association between ABO blood groups and HLA phenotypes with periodontal diseases could be established, but noted significant leukocytic functional defects in aggressive periodontitis subjects.
What methods were used for blood analysis in the study?
Blood analysis included ABO grouping, HLA typing, β2-integrin expression measurement, and FACS analysis to assess monocyte percentages and leukocyte functional characteristics.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Aggressive periodontitis: A clinico-hematological appraisal”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
In clinical research, tables are essential for organizing and presenting data clearly. They allow for easy comparison and interpretation of results, showcasing statistical findings like patient demographics, test results, and group distributions. The inclusion of tables enhances the accessibility of information for readers, facilitating better understanding and decision-making based on the research outcomes.
2) Blood:
Blood plays a crucial role in medical and biological research, particularly in studies related to hematology, immunology, and systemic diseases. Analyzing blood samples provides insights into various health conditions, including leukocyte functionality, blood group associations, and the immune response in diseases like aggressive periodontitis, as discussed in the study.
3) Study (Studying):
A study represents a systematic investigation of a particular phenomenon, often involving structured methodologies to gather and analyze data. In the context of this abstract, the study examines the relationship between genetic markers, immune responses, and periodontal diseases, aiming to contribute valuable insights to the understanding of oral health and disease pathology.
4) Disease:
Disease refers to a pathological condition that disrupts normal bodily functions, often requiring medical intervention. In this research, aggressive periodontitis is investigated for its potential genetic associations and immune dysfunction, highlighting the importance of understanding diseases for effective diagnosis, treatment, and prevention strategies in oral health.
5) Relative:
The term 'relative' denotes a relationship or comparison between different entities, often indicating how one factor influences another. This concept is significant in statistical analyses within the study, where relative frequencies of blood groups and HLA phenotypes are examined to determine their associations with aggressive periodontitis and chronic periodontitis.
6) Observation:
Observation is the process of systematically examining phenomena to gather empirical data. In clinical studies like this one, careful observation leads to insights about patient characteristics, immune responses, and disease markers, enabling researchers to draw valid conclusions and improve therapeutic approaches based on the findings from the observations made.
7) Surface:
In the context of immunology, the term 'surface' often relates to cell membranes and receptors. The study evaluates surface expressions, such as β2-integrin on neutrophils, which is critical for understanding leukocyte adhesion and migration in periodontal disease. This knowledge helps decipher immune responses in health and disease contexts.
8) Sign:
Sign refers to an indicator or representation of an underlying condition or process. In medical studies, signs include observable symptoms or measurable data that provide insights into a patient's health status. The presence of specific HLAs or leukocytic functional defects serves as significant signs in identifying aggressive periodontitis.
9) Eastern India:
Eastern India represents a geographical region pertinent to the study, providing a cultural and demographic context. Investigating health conditions in specific populations helps understand regional variations in disease prevalence, genetic markers, and environmental influences on health, facilitating localized medical insights and improved healthcare interventions for affected groups.
10) Inflammation:
Inflammation is a biological response to harmful stimuli or injury, crucial in the context of periodontal diseases. Understanding inflammation helps researchers and clinicians recognize its role in the progression of diseases like aggressive periodontitis, where inflammatory responses impact tissue destruction and immune functions affecting overall oral health.
11) Discussion:
The discussion segment of a study interprets results, contextualizes findings within existing research, and explores implications. It allows researchers to articulate their interpretations of data related to aggressive periodontitis, analyzing relationships between immune markers and genetic predispositions, which aids in deriving meaningful conclusions and future research directions.
12) Antibiotic (Antibacterial):
Antibiotics are substances used to treat bacterial infections and are significant in medical contexts. Recognizing antibiotic use and its impact on immune responses is crucial in periodontal research, as prior antibiotic exposure may alter leukocyte function and influence disease outcomes, hence addressing their role in patient histories is vital to accurate assessments.
13) Knowledge:
Knowledge refers to the body of information acquired through investigation, experience, and study; it fuels scientific advancements. In research, expanding knowledge about the associations between genetic markers, immune system functions, and periodontal diseases can improve diagnostic methods, treatment protocols, and preventive healthcare practices in dental medicine.
14) Container:
A container in laboratory settings, such as a vaccutainer, is essential for the safe collection and storage of biological samples. Proper containment ensures that blood and other samples remain uncontaminated, preserving their integrity for accurate analysis in research studies, including those investigating immunological parameters in periodontal diseases.
15) Activity:
Activity often denotes various biochemical, immunological, or cellular processes within the body. In this study, 'activity' may relate to the functional responses of leukocytes in aggressive periodontitis, where understanding immune activity is critical for assessing proper immune responses and the relationship between inflammation and periodontal health outcomes.
16) Pradhan:
Pradhan refers to a researcher or author whose work may contribute to the existing literature on the topic. Recognizing past research by individuals such as Pradhan provides contextual references within the study, indicating the evolution of knowledge concerning the associations between periodontal diseases and immunological factors or genetic predispositions.
17) Account:
In a research context, account refers to a detailed report or description of observations, methodologies, and findings. Providing an account of the study's results analyzes associations among immune markers and disease states, offering transparency and reproducibility, crucial components for scientific legitimacy and progression in medical understanding.
18) Cancer:
Cancer signifies a broad category of diseases characterized by uncontrolled cell growth, posing significant health concerns. Although not the focus of the study, understanding immune responses related to cancer can offer parallels concerning leukocyte functionality, inflammation, and potential therapeutic targets, reinforcing the relevance of immune studies across various diseases.
19) India:
India represents the geographic and sociocultural context of the study. Conducting research in specific regions like India allows for investigations into how genetic, environmental, and lifestyle factors interrelate in diverse populations, influencing health outcomes, and facilitating targeted healthcare solutions within the Indian demographic and beyond.
20) Water:
Water is a critical component of biological systems, essential for life, hydration, and physiological processes. In the context of health studies, ensuring access to clean water and understanding its role in systemic health can tie back into research focusing on immune function, oral health, and the prevention of diseases such as periodontitis.
21) Field:
Field signifies a specialized branch of study or area of research. In this study, the field pertains to periodontal health and immunology, focusing on how host factors, like genetic markers and immune responses, influence disease progression. Defining the research field helps contextualize findings within broader scientific conversations and health disciplines.
22) Death:
Death is the irreversible cessation of biological functions that sustain life. In medical research, understanding mortality associated with diseases, including aggressive periodontitis, provides insights into the severity and impacts of health conditions. Studies that address preventable diseases help reduce mortality rates and improve public health overall.
23) Drug:
Drug pertains to any substance used to diagnose, cure, treat, or prevent disease. Understanding pharmacological implications, especially regarding antibiotics, is essential in periodontitis studies, as they impact immune responses and therapeutic outcomes. The role of drugs emphasizes the importance of pharmacotherapy in managing chronic diseases and enhancing patient care.
Other Health Sciences Concepts:
Discover the significance of concepts within the article: ‘Aggressive periodontitis: A clinico-hematological appraisal’. Further sources in the context of Health Sciences might help you critically compare this page with similair documents:
Chronic periodontitis, Inflammatory response, Statistical software, Healthy control, ABO blood group, Human leukocyte antigen, Helsinki Declaration, Peripheral blood samples, Aggressive periodontitis, HLA typing, Polymorphonuclear leukocyte dysfunction, Monocyte subsets, CD45RA monocytes, Actin polymerization level, Fluorescence-activated cell sorter analysis, Neutrophil migration, Bourbon sampling method.