Evaluation of plasma ROM in periodontitis pre- and post-treatment.
Journal name: Journal of Indian Society of Periodontology
Original article title: Comparative evaluation of plasma ROM levels in chronic periodontitis patients before and after non-surgical and surgical periodontal therapy: A clinical trial
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:
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Sohini Chaudhary, Triveni M. Gowda, Dhoom S. Mehta, Tarun A. B. Kumar
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Comparative evaluation of plasma ROM levels in chronic periodontitis patients before and after non-surgical and surgical periodontal therapy: A clinical trial
Year: 2014 | Doi: 10.4103/0972-124X.131303
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Chronic periodontitis (CP) is a common inflammatory disease that leads to the deterioration of connective tissue and alveolar bone due to an inappropriate host response to periodontal pathogens. This condition is associated with increased levels of reactive oxygen species (ROS), suggesting a correlation between periodontal disease and systemic oxidative stress. Increased production of ROS may lead to significant health issues. Recent studies have identified reactive oxygen metabolites (ROMs) as reliable indicators of blood ROS levels, yet limited research exists comparing the effects of non-surgical versus surgical periodontal treatments on blood ROS levels. This study investigates the impact of periodontal therapy on plasma ROM levels in patients with chronic periodontitis.
Importance of Surgical Versus Non-Surgical Treatment
The study involved 30 chronic periodontitis patients who were randomly assigned to either non-surgical treatment (scaling and root planing) or surgical periodontal intervention. Results showed that both treatments led to significant reductions in clinical parameters and plasma ROM levels over two months. Notably, patients undergoing surgical therapy exhibited a more substantial decrease in plasma ROM levels compared to those receiving non-surgical treatment, indicating its effectiveness in reducing systemic oxidative stress. The surgical approach enhanced accessibility for thorough debridement, thereby improving outcomes and suggesting that surgical intervention may be more beneficial for patients at advanced stages of periodontitis.
Conclusion
This study establishes a significant association between chronic periodontitis and elevated plasma ROM levels, with increased oxidative stress correlating with the severity of periodontal disease. The findings highlight that surgical periodontal therapy is more effective than non-surgical treatment in decreasing both local inflammation and systemic oxidative stress, which could potentially reduce the risk of future systemic diseases. However, further longitudinal studies with larger populations are needed to validate these findings and improve the understanding of the relationship between periodontal disease treatment and systemic oxidative stress.
FAQ section (important questions/answers):
What is the objective of the study on chronic periodontitis?
The study aims to investigate the effect of surgical and non-surgical periodontal treatment on plasma reactive oxygen metabolites (ROM) levels in patients with chronic periodontitis (CP), as CP is associated with high blood reactive oxygen species (ROS) levels.
How were the patients grouped for the study?
Thirty patients with chronic periodontitis were randomly divided into two groups: Group II received scaling and root planing (non-surgical treatment), while Group III underwent periodontal flap surgery (surgical treatment) to compare their effects on clinical parameters and plasma ROM levels.
What were the key findings regarding plasma ROM levels?
The study found that plasma ROM levels significantly decreased after both treatments, with surgical therapy resulting in a more substantial reduction compared to non-surgical treatment. Surgical treatment lowered ROM levels effectively, indicating its superiority in managing systemic oxidative stress.
Did the study find a correlation between ROM and clinical parameters?
Yes, the study found a positive correlation between plasma ROM levels and clinical parameters like probing depth, clinical attachment level, and sulcus bleeding index. Higher ROM levels indicated increased periodontal tissue destruction in chronic periodontitis patients.
What conclusions can be drawn from the study's results?
The study concluded that chronic periodontitis leads to elevated plasma ROM levels, and surgical periodontal treatment is more effective in reducing both periodontal inflammation and systemic oxidative stress than non-surgical treatment, warranting further research in larger populations.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Evaluation of plasma ROM in periodontitis pre- and post-treatment.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
In research, a table is a systematic arrangement of data in rows and columns to present information clearly and concisely. It allows for easy comparison and analysis of results, making it essential for effectively conveying findings in scientific studies, such as comparison of clinical parameters or treatment outcomes.
2) Disease:
A disease is a pathological condition of a bodily part, an organism, or system resulting from various causes, including infection, genetic defect, or environmental stress, and characterized by an identifiable group of signs or symptoms. Understanding diseases, like chronic periodontitis, is crucial for developing effective treatments to improve patient health.
3) Blood:
Blood is a vital fluid in the human body that transports oxygen, nutrients, hormones, and waste products. Studies often measure blood components, including reactive oxygen species (ROS), to understand physiological conditions, disease states, or treatment outcomes, such as assessing oxidative stress in periodontal health and systemic diseases.
4) Inflammation:
Inflammation is the body's response to harmful stimuli, such as pathogens or injury, characterized by redness, heat, swelling, and pain. Chronic inflammation is linked to various diseases, including periodontal disease, and can lead to systemic health issues. Understanding its role facilitates the development of therapeutic interventions to mitigate these effects.
5) Study (Studying):
A study is a systematic investigation aimed at discovering and analyzing information regarding a phenomenon. In clinical research, studies assess the effectiveness of treatments, analyze data, and provide new insights into health outcomes, helping improve patient care, understand disease mechanisms, and inform clinical practices based on evidence.
6) Measurement:
Measurement is the process of obtaining the magnitude or quantity of a subject's characteristics, such as clinical parameters or biomarkers like plasma reactive oxygen metabolites (ROMs). Accurate measurement is vital in research to ensure valid results that contribute to understanding health conditions and guiding subsequent therapeutic decisions.
7) Relative:
Relative refers to the comparative relationship between two elements, often used in research to gauge the impact or effectiveness of treatments against a control group. Understanding the relative efficacy of surgical versus non-surgical treatments, for example, helps determine optimal therapeutic approaches in managing conditions like chronic periodontitis.
8) Hygiene (Hygienic):
Hygiene encompasses practices aimed at maintaining health and preventing disease, especially through cleanliness. In periodontal health, good oral hygiene is crucial to prevent plaque accumulation and inflammatory responses. Hygiene practices can impact treatment outcomes in chronic periodontitis and overall systemic health, making patient education essential in clinical settings.
9) Bleeding:
Bleeding, particularly in the context of gingival bleeding on probing (BOP), indicates inflammation and the presence of periodontal disease. Monitoring bleeding is vital in clinical assessments of periodontal health, as it reflects tissue health and response to treatment over time, providing insight into disease activity and treatment effectiveness.
10) Species:
Species refer to distinct groups of organisms sharing common characteristics. In medical research, the study of different bacterial species in the oral microbiome can elucidate their roles in periodontal disease. Understanding species interactions aids in developing targeted therapies for periodontal treatment and managing associated systemic conditions.
11) Activity:
Activity, in a clinical context, often refers to the current state of a disease or condition, such as the active nature of periodontal disease indicated by clinical signs. Monitoring disease activity is crucial for effective treatment planning and assessing the efficacy of therapeutic interventions over time.
12) Surface:
Surface refers to the outermost layer of an object, including biological tissues. In periodontal therapy, the root surface's condition significantly influences treatment outcomes. Effective cleaning and debridement of tooth surfaces can enhance healing and reduce bacteria, playing a key role in managing periodontal diseases and restoring health.
13) Sign:
A sign indicates the presence of a disease or condition, observable by a clinician. In periodontal disease management, signs such as probing depths, bleeding, or inflammation help diagnose and monitor disease status. Understanding these signs is crucial for informing treatment decisions and improving patient outcomes.
14) Post:
Post refers to the period following an event, such as surgery or treatment. Monitoring post-treatment outcomes is essential to evaluate the efficacy and effectiveness of interventions, including surgical and non-surgical therapies for periodontal conditions, helping determine long-term remission and prevention strategies for systemic effects.
15) Accumulation (Accumulating, Accumulate):
Accumulation refers to the gradual gathering of substances, such as bacteria or inflammatory mediators, at a site. In periodontal disease, the accumulation of plaque leads to bacterial biofilm formation, which can instigate inflammation and tissue destruction. Addressing accumulation through effective treatment is critical for maintaining oral and systemic health.
16) Calculation:
Calculation in research involves systematic methods to determine values or outcomes based on data analysis. In clinical studies like those evaluating periodontal treatment, calculations help assess mean differences in clinical parameters and biomarker levels, guiding evidence-based treatment decisions and enhancing the reliability of findings.
17) Discussion:
Discussion sections of research papers are where findings are analyzed concerning existing literature, implications of results, or limitations. This critical analysis provides context, showcasing how study results relate to broader scientific knowledge and suggesting avenues for future research or changes in clinical practice.
18) Alcoholism:
Alcoholism is a chronic disease characterized by an inability to control drinking due to physical and emotional dependence on alcohol. Research has established connections between alcoholism and various health conditions, including periodontal disease, due to shared risk factors and the systemic effects of alcohol on health and immune response.
19) Antibiotic (Antibacterial):
An antibiotic is a substance used to kill or inhibit the growth of bacteria. In chronic periodontitis management, antibiotics may be utilized alongside other treatments to control bacterial infections and inflammation. Understanding their application and effectiveness is essential for enhancing treatment outcomes and preventing adverse effects.
20) Knowledge:
Knowledge in a clinical context refers to the understanding gained through education, experience, and research. It underpins clinical decisions and practices, enabling healthcare professionals to apply evidence-based strategies effectively. Continuous knowledge acquisition is essential for optimizing patient care and treatment outcomes in dentistry and other medical fields.
21) Swelling:
Swelling is an inflammation response characterized by an increase in tissue volume often indicating disease. In periodontitis, gingival tissue swelling signifies active infection and inflammation. Monitoring swelling during treatment provides insight into the effectiveness of interventions and the patient's recovery, guiding further therapeutic decisions.
22) Raising:
Raising, particularly in the context of periodontal therapy, refers to the surgical technique of elevating a flap of tissue to allow access to the underlying tooth roots and alveolar bone. This procedure enhances cleaning and treatment effectiveness, especially in cases of extensive periodontal disease.
23) Nature:
Nature refers to the intrinsic qualities or characteristics of phenomena. In the context of periodontal disease, understanding the nature of its pathogenesis, including the role of microbial factors and host responses, is crucial for developing effective treatment protocols and improving overall management strategies for patients.
24) Animal:
Animal studies provide essential insights into human health by modeling disease processes and treatment responses. In periodontal research, animal models allow for the exploration of disease mechanisms, efficacy of therapeutic interventions, and understanding systemic implications of periodontal disease, advancing translational research and clinical applications.
25) Kappa:
Kappa refers to the kappa statistic, a measure of agreement or reliability for categorical items. In clinical research, calculating kappa helps assess the consistency of diagnoses or measurements, enhancing the validity and reliability of data collected in studies on periodontal disease or treatment outcomes.
26) India:
India, as the location of the study mentioned, brings attention to the regional context of periodontal health and disease management. Geographic and cultural factors influence healthcare access, oral hygiene practices, and dietary habits, which are essential considerations in assessing the prevalence and treatment of periodontal diseases in diverse populations.
27) Visit:
Visit refers to patient appointments for clinical assessments or treatment. Regular visits allow for monitoring of periodontal health, assessment of treatment outcomes, and patient education. Ensuring adherence to scheduled visits is vital for effective management of periodontal disease and improving overall oral health outcomes.
28) Diet:
Diet encompasses the foods and beverages consumed regularly, influencing overall health and disease management. A balanced diet supports immune function and oral health. Research demonstrates that dietary choices can impact inflammation, oxidative stress, and, consequently, periodontal health, necessitating dietary considerations in patient education and treatment planning.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Evaluation of plasma ROM in periodontitis pre- and post-treatment.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Chronic inflammation, Significant difference, Oxidative stress, Study design, Gingival inflammation, Treatment effect, Out Patient Department, Sample size calculation, Subject Recruitment, Chronic periodontitis, Clinical parameter, Polymorphonuclear leukocyte, Systemic Oxidative Stress, Excessive production.