Exploring the role of cranberry polyphenols in periodontits: A brief review

| Posted in: Science

Journal name: Journal of Indian Society of Periodontology
Original article title: Exploring the role of cranberry polyphenols in periodontits: A brief review
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Author:

Malancha Mukherjee, Prasanta Bandyopadhyay, Debabrata Kundu


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: Exploring the role of cranberry polyphenols in periodontits: A brief review

Year: 2014 | Doi: 10.4103/0972-124X.131301

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

Cranberry juice polyphenols, particularly proanthocyanidins, have garnered attention for their health benefits over the past decade. While much research has focused on their role in urinary tract infections and systemic diseases, their effects on oral health remain underexplored. This paper aims to review the impact of high molecular weight cranberry fractions on oral tissues and periodontal diseases, consolidating findings from a comprehensive search in scientific literature.

Bioactive Components and Oral Health

One significant aspect of cranberry's health benefits lies in its bioactive component, proanthocyanidins. These compounds possess various therapeutic effects, particularly in dental health. Research has shown that high molecular weight cranberry constituents exhibit anti-adhesive properties that can disrupt the coaggregation of harmful bacterial species associated with periodontal diseases. Additionally, studies suggest that cranberry polyphenols can inhibit enzymes critical to the formation of dental plaque, thereby reducing the risk of caries. The ability of cranberries to hinder bacterial colonization and modulate inflammatory responses highlights their potential for supporting oral health.

Conclusion

Despite the promising findings regarding cranberries as a natural remedy for dental issues, they should not be considered a substitute for traditional medical treatments. More extensive clinical studies are essential to confirm the efficacy and practical applications of cranberry polyphenols in oral care. Although current evidence suggests that these compounds can inhibit pathogenic bacteria and inflammation, their acidic nature may also pose risks, such as contributing to tooth demineralization. Future research should explore the development of concentrated cranberry formulations suitable for incorporation into oral hygiene products to maximize their health benefits while minimizing potential drawbacks.

FAQ section (important questions/answers):

What are the health benefits of cranberry juice polyphenols?

Cranberry juice polyphenols, especially proanthocyanidins, are known for their health benefits, including potential protection against urinary tract infections, antimicrobial effects, and possible oral health benefits through their anti-adhesion properties.

How do proanthocyanidins affect periodontal diseases?

Proanthocyanidins from cranberries may reduce bacterial colonization in the gums, inhibit harmful bacterial enzymes, and modulate inflammatory responses, potentially helping to manage periodontal diseases and promote oral health.

Are cranberries effective for preventing urinary tract infections (UTIs)?

Yes, cranberry extract can inhibit the adherence of E. coli to urinary tract walls, which may help prevent infections, but drinking large quantities of juice is often required for noticeable effects.

What are the recommended dosages for cranberry supplements?

Common recommendations suggest taking 300 to 400 mg of concentrated cranberry extract twice daily or 8 oz of unsweetened cranberry juice three times daily for effective anti-adhesion and antimicrobial benefits.

Are there any side effects or contraindications associated with cranberry consumption?

Cranberry is generally safe, but it may increase urinary oxalate levels, so caution is advised for individuals with a history of kidney stones or those on certain medications.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Exploring the role of cranberry polyphenols in periodontits: A brief review”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Activity:
Activity refers to the functional aspects and biochemical processes occurring within living organisms, particularly those that indicate health or disease. In the context of cranberry research, activity signifies the various effects that cranberry polyphenols exert, such as antimicrobial and anti-inflammatory actions, particularly in oral and systemic health.

2) Disease:
Disease indicates an abnormal condition affecting a living organism, recognized by particular signs and symptoms. The text mentions conditions like periodontitis and urinary tract infections, highlighting how cranberry polyphenols may contribute to prevention and management, revealing the fruit's therapeutic potential against prevalent health issues.

3) Study (Studying):
Study denotes the systematic investigation of phenomena, focusing on understanding mechanisms and effects. The text discusses various studies investigating the role of cranberry polyanthocyanins in oral health, elaborating on the need for clinical trials to validate the claims regarding their effectiveness in preventing dental diseases.

4) Drug:
Drug refers to any substance used in medical therapy to prevent, diagnose, or treat disease. While cranberry is not classified as a conventional drug, its polyphenolic compounds exhibit bioactive properties that suggest potential as natural agents in dental and general health, emphasizing the importance of holistic approaches in treatment.

5) Sugar:
Sugar signifies simple carbohydrates that can contribute to energy but may also cause negative health effects, particularly in excessive amounts. The text mentions the acidity of cranberry juice requiring sweeteners, raising concerns about sugar contributing to dental caries, thus necessitating careful consumption for oral health preservation.

6) Ulcer:
Ulcer denotes a sore or lesion caused by tissue breakdown, often associated with inflammation or infection. Cranberry is mentioned as a beneficial agent against gastric ulcers by preventing the adhesion of Helicobacter pylori, suggesting its potential role in managing digestive health issues through dietary means.

7) Food:
Food captures the necessary substances consumed to sustain life, providing essential nutrients. The text emphasizes cranberries as a superfruit with antioxidant benefits, promoting a wider understanding of food's role not only in nutrition but also in preventive health strategies, especially regarding oral care and systemic health.

8) Rich (Rch):
Rich in a nutritional context means containing a high concentration of beneficial components such as vitamins, minerals, or bioactive substances. Cranberries are described as rich in flavonoids and proanthocyanidins, marking their significance in dietary choices for improved health outcomes, particularly in combating oral diseases.

9) Human body:
Human body refers to the complex system of bones, muscles, organs, and tissues that works in cohesion to maintain life. The text highlights how cranberry polyphenols interact within the human body to bolster health defenses, emphasizing their importance in disease prevention and overall maintenance of wellbeing.

10) Antibiotic (Antibacterial):
Antibacterial describes substances that inhibit bacterial growth or kill bacteria. The discussion of cranberry's antibacterial properties suggests its potential in preventing infections, especially in the oral cavity and urinary tract, underscoring the relevance of natural compounds in enhancing health and addressing bacterial-related diseases.

11) Accumulation (Accumulating, Accumulate):
Accumulation pertains to the gradual gathering or increase of substances within the body. In the context of periodontal disease, the text mentions the accumulation of inflammatory mediators, which can lead to tissue destruction, thereby emphasizing the need for compounds like cranberry to regulate such processes and enhance oral health.

12) Inflammation:
Inflammation refers to the biological response to harmful stimuli, often causing redness, swelling, and pain. The text connects inflammation with periodontal diseases and the role of cranberry polyphenols in mitigating inflammatory responses, thus revealing the potential benefits of natural compounds in managing inflammatory conditions.

13) Flavonoid:
Flavonoid is a category of bioactive compounds known for their antioxidant and anti-inflammatory properties. Cranberries are highlighted as a rich source of flavonoids, establishing their importance in diet and health as protective agents against various diseases, including those affecting the oral cavity.

14) Hygiene (Hygienic):
Hygiene captures the practices and conditions conducive to maintaining health and preventing disease. The text suggests that incorporating cranberry polyphenols into oral hygiene products could enhance their effectiveness, underlining the significance of combining dietary choices with proper hygiene practices for improved overall health.

15) Surface:
Surface refers to the outermost layer of an object or material. In dental health, the term often denotes the tooth or oral mucosa surfaces, which are affected by bacteria. The text discusses how cranberry polyphenols can impact bacterial adhesion to surface proteins, emphasizing their potential role in oral disease prevention.

16) Cancer:
Cancer signifies a group of diseases characterized by uncontrolled cell growth. Cranberry polyphenols are reported to have deterrent effects on cancer cell line proliferation in various tissues, marking their significance as functional food constituents in promoting health and potentially lowering cancer risks through dietary interventions.

17) Powder:
Powder refers to finely ground solid substances. The text mentions cranberry being available in encapsulated powder forms, presenting a dietary supplement option that can deliver concentrated health benefits while suggesting the versatility of cranberry products in enhancing nutritional intake and health management.

18) India:
India is a country recognized for its rich diversity in culture and food. The mention of cranberries being marketed to India illustrates the globalization of health foods and the increasing awareness of the health benefits associated with cranberries, promoting their integration into diverse diets across various regions.

19) Glass:
Glass in this context likely refers to measurement, specifically a standard-sized drinking vessel. The text discusses the quantity of cranberry juice necessary to achieve health benefits, illustrating how practical recommendations involve measured serving sizes, highlighting the importance of proper consumption levels in maximizing health outcomes.

20) Pine (Pimte):
Pine represents a type of tree from which proanthocyanidins were first extracted. The mention of pine highlights the historical context of flavonoids and their extraction techniques, emphasizing the evolution of natural compounds in health science and the importance of exploring various sources of bioactive materials.

21) Line:
Line in this context may refer to the conceptual lineage of compounds or research findings leading to cranberries. It implies the continuity of scientific understanding from origins to applications, illustrating the ongoing research trajectory in exploring natural compounds' potential in health and disease prevention.

22) Viru:
Viru seems to be an incomplete term but might relate to viruses in the context of diseases. The text touches on cranberry's potential in combating the adherence and infectious capacity of the influenza virus, highlighting its significance as a natural preventive agent against viral infections and related health issues.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Exploring the role of cranberry polyphenols in periodontits: A brief review’. Further sources in the context of Science might help you critically compare this page with similair documents:

Systemic disease, Periodontal disease, Clinical application, Urinary tract infection, Acid resistance, Proanthocyanidins, Anti adhesive properties, Pro-inflammatory cytokine, Matrix metalloproteinase, Host immune system, Proteolytic Enzyme, Bioactive flavonoids, Human cancer cell.

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