Salivary TNF-alpha: A potential marker of periodontal destruction
Journal name: Journal of Indian Society of Periodontology
Original article title: Salivary TNF-alpha: A potential marker of periodontal destruction
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:
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Pritma Singh, Narender Dev Gupta, Afshan Bey, Saif Khan
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Salivary TNF-alpha: A potential marker of periodontal destruction
Year: 2014 | Doi: 10.4103/0972-124X.134566
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
The study investigates the effects of type 2 diabetes mellitus and smoking on salivary levels of tumor necrosis factor-alpha (TNF-α) in individuals with chronic periodontitis. Chronic periodontitis is a prevalent oral disease characterized by the loss of connective tissue and bone supporting the teeth, caused by both bacterial infection and host immune response. The research emphasizes how diabetes affects this immune response, leading to increased tissue destruction in periodontal disease, and highlights the role of smoking in exacerbating periodontal problems by impairing immune functions.
The Impact of Diabetes and Smoking on Salivary TNF-α Levels
The findings reveal that diabetic subjects (group III) exhibited a significantly higher mean salivary TNF-α level compared to both systemically and periodontally healthy individuals (group I) and those with chronic periodontitis alone (group II), indicating a profound impact of diabetes on inflammatory responses in periodontal disease. Additionally, smoking (group IV) also led to elevated TNF-α levels but to a lesser extent compared to the diabetic group, highlighting diabetes as a more potent factor in elevating this proinflammatory cytokine. These results underscore the importance of TNF-α as a biomarker for identifying chronic periodontitis and assessing the systemic influences of diabetes and smoking on oral health.
Conclusion
Overall, the study concludes that increased levels of salivary TNF-α are associated with both type 2 diabetes and smoking in individuals with chronic periodontitis. The data suggest that diabetes significantly enhances TNF-α levels beyond the contributions made by smoking, indicating a need for targeted management strategies for diabetic patients at risk of periodontal disease. These findings reinforce the potential of TNF-α as a non-invasive biomarker for assessing disease risk and susceptibility in periodontitis, advocating for further research into its utility in personalized dental care and broader health assessments.
FAQ section (important questions/answers):
What was the aim of the study on TNF-α levels?
The study aimed to evaluate the effect of type 2 diabetes mellitus and smoking on salivary TNF-α levels in patients with chronic periodontitis and to compare these levels with healthy individuals.
What methods were used to assess salivary TNF-α levels?
The study collected 3 ml of unstimulated saliva from participants. Salivary TNF-α was then determined using the ELISA technique, specifically utilizing the Quantikine Human total TNF-α immunoassay kit.
What were the main findings regarding TNF-α levels?
Results indicated that diabetic subjects had the highest salivary TNF-α levels, significantly higher than healthy individuals and smokers, showing diabetes has a profound impact on TNF-α in chronic periodontitis.
How does smoking affect periodontal disease according to the study?
The study found that smokers with chronic periodontitis exhibited elevated salivary TNF-α levels, indicating that smoking adversely affects host defense mechanisms and exacerbates tissue destruction in periodontal disease.
What conclusion did the research reach regarding TNF-α as a biomarker?
The study concluded that elevated salivary TNF-α serves as a significant biomarker for chronic periodontitis, particularly reflecting the proinflammatory conditions associated with diabetes and smoking.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Salivary TNF-alpha: A potential marker of periodontal destruction”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Study (Studying):
The 'Study' refers to the investigation conducted to evaluate the effects of type 2 diabetes mellitus and smoking on salivary TNF-α levels in chronic periodontitis patients. This research is critical for understanding the relationship between these diseases and biomarkers that could inform treatment strategies.
2) Table:
In the 'Table' format, results such as mean values and statistical significance of TNF-α levels across different groups are presented. It helps in visualizing the differences and comparisons needed to interpret the 'Study' findings clearly.
3) Disease:
The term 'Disease' refers to conditions like chronic periodontitis and diabetes mellitus, which significantly impact oral health and inflammation in the body. Understanding the mechanisms of these 'Diseases' is essential for developing effective treatment protocols.
4) Inflammation:
The term 'Inflammation' is crucial as it underscores the body’s response to infection, especially in conditions like chronic periodontitis. Increased inflammatory markers like salivary TNF-α illustrate the state of 'Inflammation' present in patients suffering from these conditions.
5) Bleeding:
The term 'Bleeding' frequently occurs in relation to gum disease. In the context of the 'Study', variations in bleeding observed in periodontal assessments are essential for determining the severity of 'Disease' and the effect of smoking on periodontal health.
6) Account:
In the analysis, TNF-α levels are shown to 'Account' for significant variations in periodontal health parameters. This understanding is key for researchers and practitioners in determining the relative impact of diabetes and smoking on gum health.
7) Measurement:
'Measurement' in this context refers to the assessment of TNF-α levels in saliva, which serves as a crucial biomarker. Accurate 'Measurement' ensures that the findings are reliable and can guide future clinical applications in medicine.
8) Blood:
While the primary focus is on salivary TNF-α levels, the role of 'Blood' in systemic inflammation cannot be ignored. Elevated inflammatory markers may also be found in 'Blood', linking oral health to overall systemic conditions.
9) Rheumatoid arthritis:
[see source text or glossary: Rheumatoid arthritis]
10) Discussion:
In the 'Discussion' section, the implications of the findings are elaborated on. Researchers highlight how diabetes and smoking influence TNF-α levels, igniting further inquiry into potential treatments and preventative strategies for chronic diseases.
11) Collecting:
'Collecting' refers to the method of obtaining saliva samples for the study. Proper 'Collecting' protocols ensure that the data will be valid and can accurately reflect the underlying health conditions being examined.
12) Developing:
The process of 'Developing' new treatments for chronic periodontitis is highlighted in the context of understanding TNF-α and its role as a biomarker. The findings point towards changes needed in strategies focused on managing oral diseases.
13) Suffering:
Patients 'Suffering' from chronic conditions like diabetes and smoking-related issues are at greater risk for periodontal diseases. This emphasizes the importance of recognizing and treating these health matters early.
14) Medicine:
'Medicine' is the broader field under which the study of chronic periodontitis and related health effects falls. Insights gained from the study can lead to improved practices in 'Medicine' aimed at alleviating patient suffering.
15) Relative:
'Relative' comparisons between different subjects in the study demonstrate how factors like diabetes can elevate TNF-α levels compared to healthy individuals. Understanding these 'Relative' differences is crucial for effective disease management.
16) Pregnant:
[see source text or glossary: Pregnant]
17) Hygiene (Hygienic):
'Hygiene' plays a critical role in preventing chronic periodontitis. Maintaining good oral 'Hygiene' can mitigate some negative effects caused by systemic diseases like diabetes and smoking.
18) Edema (Oedema):
[see source text or glossary: Edema]
19) Field:
'Field' refers to the area of inquiry concerned with periodontics and systemic diseases. Advancements in this 'Field' could potentially lead to improved patient outcomes and more comprehensive approaches to treatment.
20) Visit:
In the context of the study, a 'Visit' to healthcare professionals is important for regular assessments of gum health. Ensuring that all parameters are evaluated during a 'Visit' can lead to better disease management.
21) Sign:
'Sign' is often associated with clinical indicators that correlate with inflammation and disease severity. Recognizing these 'Signs' is essential for timely diagnosis and intervention.
22) Post:
[see source text or glossary: Post]
23) Pur:
'Poor' management of diabetes can exacerbate periodontal disease, thus making patients vulnerable to worse health outcomes. The study indicates a significant link between 'Poor' chronic disease control and increased TNF-α levels.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Salivary TNF-alpha: A potential marker of periodontal destruction’. Further sources in the context of Science might help you critically compare this page with similair documents:
Statistical analysis, Plaque index, Gingival index, Type 2 Diabetes Mellitus, Chronic periodontitis, Oral disease, Systemic inflammation, Proinflammatory cytokine, Immune function, ELISA technique, Smoking status, Clinical parameter, Diabetic subjects, Clinical attachment loss, Pocket probing depth, Systemically healthy individuals.