Tissue inhibitor of MMP-1 in gingival fluid: health, disease, treatment.
Journal name: Journal of Indian Society of Periodontology
Original article title: Estimation of tissue inhibitor of matrix metalloproteinase-1 levels in gingival crevicular fluid in periodontal health, disease and after treatment
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Nagireddy Ravindra Reddy, Anumala Deepa, Dandu Subramanyam Madhu Babu, Nelapati Sarath Chandra, Chowdawaram Venkat Subba Reddy, Avula Kishore Kumar
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Estimation of tissue inhibitor of matrix metalloproteinase-1 levels in gingival crevicular fluid in periodontal health, disease and after treatment
Year: 2014 | Doi: 10.4103/0972-124X.134565
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Chronic periodontitis (CP) is a dental disease characterized by inflammation leading to the irreversible loss of supporting structures around the teeth, ultimately resulting in tooth loss. This tissue degradation is primarily attributed to the activation of host cells responding to inflammatory mediators, which subsequently lead to the breakdown of the extracellular matrix (ECM). A critical player in this process is the family of matrix metalloproteinases (MMPs), which degrade various components of the ECM. The balance between MMPs and their inhibitors, known as tissue inhibitors of matrix metalloproteinases (TIMPs), is crucial for maintaining tissue integrity. In healthy periodontal tissues, TIMP levels typically exceed those of MMPs, whereas this balance is disrupted in periodontal disease.
TIMP-1 Concentrations in Periodontal Disease
The study investigated the levels of TIMP-1 in gingival crevicular fluid (GCF) across three groups: individuals with periodontal health, those with chronic periodontitis, and patients who underwent scaling and root planning treatment. The findings revealed that mean TIMP-1 levels were highest in healthy individuals, significantly lower in CP patients, and intermediate in those after treatment. This trend suggests a relationship between TIMP-1 concentrations and the severity of periodontal disease, with increased levels post-treatment indicating a potential recovery. Additionally, a negative correlation was identified between TIMP-1 levels and clinical parameters such as probing pocket depth and clinical attachment loss, reinforcing the idea that TIMP-1 may serve as a useful biomarker in understanding periodontal disease progression.
Conclusion
The research suggests that TIMP-1 concentrations in GCF correlate negatively with the severity of periodontal disease, being significantly lower in chronic periodontitis compared to healthy individuals and those after treatment. These results support the hypothesis that TIMP-1 may serve as an indicator of disease progression and recovery following periodontal therapy. However, the authors call for further longitudinal studies to better understand TIMP-1's role in the pathogenesis of periodontitis and to validate its potential as a biomarker in periodontal diseases.
FAQ section (important questions/answers):
What is the aim of the study on TIMP-1 in GCF?
The study aims to estimate TIMP-1 levels in gingival crevicular fluid (GCF) across periodontal health, disease, and the effects of periodontal therapy on these levels.
What were the three groups of subjects in the study?
Subjects were categorized into three groups: healthy (Group I), chronic periodontitis (Group II), and after treatment (Group III) following scaling and root planning.
What was the significant finding regarding TIMP-1 concentrations?
TIMP-1 concentrations were highest in healthy individuals, lower in chronic periodontitis patients, and increased after treatment, indicating a negative correlation with periodontal disease severity.
How was gingival crevicular fluid (GCF) collected in the study?
GCF was collected using calibrated volumetric micro capillary pipettes from the highest scored sites, ensuring minimal contamination during the process.
What is the conclusion regarding TIMP-1 as a biomarker?
The study concludes that TIMP-1 levels could serve as a potential biomarker for periodontal disease progression, necessitating further longitudinal research to confirm this possibility.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Tissue inhibitor of MMP-1 in gingival fluid: health, disease, treatment.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Longitudinal studies, Statistical analysis, Periodontal disease, Scaling and root planning, Chronic periodontitis, Enzyme-linked immunosorbent assay, Probing pocket depth, Negative correlation, Randomly selected subjects, Ethics clearance, Periodontal therapy, Gingival crevicular fluid, Clinical parameter, Matrix metalloproteinase, Clinical attachment loss, Healthy periodontal tissues.