P-selection and platelet aggregation in chronic periodontitis study
Journal name: Journal of Indian Society of Periodontology
Original article title: Modulation of P-selection and platelet aggregation in chronic periodontitis: A clinical study
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Ramesh Perumal, Maheashwari Rajendran, Malathi Krishnamurthy, Kiran Kumar Ganji, Sunil Dattuji Pendor
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Modulation of P-selection and platelet aggregation in chronic periodontitis: A clinical study
Year: 2014 | Doi: 10.4103/0972-124X.134563
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Periodontitis is an inflammatory disease affecting the supportive tissues of the teeth, primarily caused by subgingival infections from Gram-negative bacteria. This condition may lead to systematic elevations in pro-inflammatory mediators and has been associated with increased platelet activation. Key mediators, such as P-selectin, play crucial roles in the dynamics of platelet activation and their potential link to cardiovascular diseases (CVD). Recent studies indicate that chronic periodontitis might not only heighten the risk for periodontal tissue degradation but also be a contributing factor to the development of systemic diseases, particularly cardiovascular complications.
Platelet Activation in Chronic Periodontitis
A primary focus of the study is the evaluation of platelet activation in patients with chronic periodontitis by comparing them with healthy controls. The researchers analyzed serum levels of soluble P-selectin and conducted morphological examinations to assess changes in platelet shape and aggregation patterns. The findings revealed significantly elevated levels of soluble P-selectin in periodontitis patients, alongside notable increases in specific platelet forms that signify activation, such as "spider forms." Additionally, a greater prevalence of pathological platelet aggregation—characterized by irreversible aggregation—was observed in the study group compared to the controls, indicating a clear connection between platelet activation and disease severity.
Conclusion
The study concludes that chronic periodontitis is associated with marked platelet activation as evidenced by increased soluble P-selectin levels and altered platelet morphology. The heightened expression of P-selectin and the presence of dysfunctional platelet aggregates suggest that individuals suffering from periodontitis are at increased risk for cardiovascular disease due to chronic inflammation and platelet activation. These findings underscore the need for further exploration of the mechanistic pathways linking periodontal disease to systemic health, particularly in relation to cardiovascular events, emphasizing the importance of managing periodontal health to potentially mitigate the risk of associated systemic diseases.
FAQ section (important questions/answers):
What is the primary cause of periodontitis?
The primary cause of periodontitis is subgingival infection with Gram-negative pathogens, leading to inflammation and the overproduction of pro-inflammatory mediators in affected individuals.
What was the aim of the study?
The aim of the study was to compare platelet activation levels, soluble P-selectin levels, and morphological changes in platelets between periodontitis patients and healthy controls.
What results were found regarding P-selectin levels?
The study found that serum P-selectin levels were significantly higher in periodontitis patients with a mean value of 13.05 ng/mL compared to 4.97 ng/mL in healthy controls.
How did platelet morphology differ between groups?
Platelets in the study group exhibited a higher percentage of spider forms, indicating activation, while smaller forms were more prevalent in the control group.
What correlation was observed in the study?
A positive correlation was found between P-selectin expression and the severity of chronic periodontitis, suggesting a link between periodontal disease and platelet activation.
Other Science Concepts:
Discover the significance of concepts within the article: ‘P-selection and platelet aggregation in chronic periodontitis study’. Further sources in the context of Science might help you critically compare this page with similair documents:
Statistical Significance, Atherosclerosis, Cardiovascular disease, Chronic periodontitis, Platelet aggregation, ELISA method, Clinical parameter, Transient bacteremia, Proinflammatory mediators, P selectin, Secretory granules, Weibel-Palade bodies.