Insights on fibroblast growth factor for periodontal regeneration.
Journal name: Journal of Indian Society of Periodontology
Original article title: An insight into the possibilities of fibroblast growth factor in periodontal regeneration
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Sameera G. Nath, Ranjith Raveendran
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: An insight into the possibilities of fibroblast growth factor in periodontal regeneration
Year: 2014 | Doi: 10.4103/0972-124X.134560
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Periodontitis, a disease caused by bacterial biofilms, leads to the loss of periodontal tissue, and traditional therapies have proven insufficient for meaningful regeneration. The periodontal ligament, made up of various cell populations, loses these cells during the disease process. Several regenerative therapies, such as bone grafts and guided tissue regeneration, have shown some success, but challenges remain in predictability and outcomes. Recently, the application of recombinant cytokines has gained traction as an effective method to stimulate stem cells for periodontal regeneration, with researchers particularly exploring the role of fibroblast growth factor (FGF) in this context.
The Role of Fibroblast Growth Factor in Regeneration
Fibroblast growth factor (FGF) was initially identified as a protein that stimulates fibroblast proliferation. FGF-2, a specific subtype, has shown significant potential for promoting periodontal tissue regeneration by enhancing the proliferation, migration, and differentiation of periodontal ligament cells. FGF-2 stimulates the production of critical extracellular matrix components, including osteopontin and hyaluronan, which support tissue repair processes. Preclinical studies have indicated that topical application of FGF-2 can lead to substantial periodontal tissue regeneration, improving new cementum and periodontal ligament formation without adverse effects such as epithelial downgrowth or inflammation. This suggests FGF-2’s applicability as a therapeutic agent in periodontal regeneration.
Conclusion
Achieving complete regeneration of periodontal tissue remains a primary goal in periodontal therapy. Advances in understanding stem cells within the periodontal ligament and the potential of cytokine therapy provide optimistic avenues for clinical applications. FGF-2 stands out as a promising candidate for enhancing regenerative outcomes in periodontal treatments, demonstrating efficacy in both in vitro and in vivo settings. However, further clinical trials are necessary to confirm the safety and effectiveness of FGF-2-based therapies, alongside the integration of scaffolds for improved regeneration strategies. Overall, cytokine therapy, particularly with FGF-2, presents a valuable opportunity for addressing periodontal tissue loss and improving treatment options.
FAQ section (important questions/answers):
What is the primary cause of periodontitis?
Periodontitis is primarily caused by bacterial biofilms and is influenced by various risk factors, leading to the destruction of periodontal tissue.
How does fibroblast growth factor aid in periodontal regeneration?
Fibroblast growth factor (FGF) enhances the proliferation and migration of periodontal ligament cells, facilitating the regeneration of periodontal tissues by promoting angiogenesis and extracellular matrix production.
What are some regenerative therapies for periodontal tissue repair?
Regenerative therapies include bone grafts, guided tissue regeneration, and the application of enamel matrix derivatives, which have shown varying success in regenerating periodontal tissues.
What role do cytokines play in periodontal regeneration?
Cytokines, particularly when applied topically, stimulate stem cells and undifferentiated mesenchymal cells, enhancing their conversion into bone-forming cells for effective periodontal tissue regeneration.
What findings support the efficacy of FGF-2 in periodontal healing?
Preclinical studies indicate that topical FGF-2 application significantly enhances periodontal tissue regeneration, demonstrating formation of new cementum, periodontal ligament fibers, and alveolar bone without adverse effects.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Insights on fibroblast growth factor for periodontal regeneration.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Topical application, Extracellular matrix, Periodontal disease, Fibroblast Growth Factor, Clinical application, Osteoblasts, Cell migration, Periodontal tissue regeneration, Cytokine therapy, Periodontal Ligament, Progenitor cells, Bacterial biofilm, Regenerative Therapies.