Antioxidants and SOD in periodontitis patients with type 2 diabetes
Journal name: Journal of Indian Society of Periodontology
Original article title: Serum levels of antioxidants and superoxide dismutase in periodontitis patients with diabetes type 2
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Biju Thomas, Amita Rao, Ballamajalu Rajendra Prasad, Suchetha Kumari
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Serum levels of antioxidants and superoxide dismutase in periodontitis patients with diabetes type 2
Year: 2014 | Doi: 10.4103/0972-124X.138686
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
The study investigates the levels of superoxide dismutase (SOD) and total antioxidant capacity (TAOC) in the serum of Type 2 diabetes mellitus (DM) patients compared to healthy individuals, specifically in the context of periodontal disease. Periodontal tissue destruction is largely attributed to an inappropriate host response to microbial invasion, which leads to an imbalance in reactive oxygen species (ROS) and the body's antioxidant defenses. The aim is to understand the oxidative stress implications in both diabetes and periodontal disease, considering how these conditions interact to influence antioxidant levels and tissue health.
The Role of Superoxide Dismutase and Total Antioxidant Capacity
The results indicate that serum TAOC was significantly higher in healthy individuals without periodontal disease compared to those with chronic periodontitis (CP), while diabetic patients with CP exhibited the highest levels of SOD. The elevated SOD levels in diabetic patients may reflect an adaptive response to counteract oxidative stress, which is prevalent in diabetes due to increased ROS production. In essence, while SOD serves a protective role, its heightened levels in DM patients suggest a pronounced oxidative challenge that the body is attempting to mitigate. Conversely, the lower TAOC observed in CP patients emphasizes the detrimental impact of periodontal inflammation on overall antioxidant capacity.
Conclusion
This study concludes that critical differences in TAOC and SOD levels exist between diabetic patients and healthy individuals, with implications for periodontal health. The findings suggest that chronic inflammation in periodontal disease contributes to oxidative stress, which compromises the antioxidant defenses in affected individuals. The increased SOD levels in diabetes patients may signify a protective adaptation to tissue oxidative damage. Future research with larger sample sizes is warranted to further elucidate the relationship between oxidative stress and chronic diseases like periodontitis and diabetes, potentially guiding therapeutic strategies that incorporate antioxidants to enhance treatment outcomes in affected populations.
FAQ section (important questions/answers):
What was the main aim of the study?
The study aimed to estimate and compare the levels of superoxide dismutase and total antioxidant capacity in the serum of Type 2 diabetes patients and healthy individuals, considering the presence of periodontal disease.
What methods were used to analyze serum samples in the study?
Biochemical analysis was conducted to estimate total antioxidant capacity (TAOC) and superoxide dismutase (SOD) levels. Serum samples were tested using the phosphomolybdenum method for TAOC and the Beauchamp and Fridovich method for SOD.
What were the significant findings regarding antioxidant levels?
The study found serum TAOC levels were highest in systemically healthy individuals without periodontal disease. The SOD levels were highest in diabetic patients with chronic periodontitis, suggesting a protective adaptive mechanism against oxidative stress.
How did the presence of diabetes affect antioxidant levels?
Diabetic patients exhibited higher serum SOD levels compared to healthy individuals with chronic periodontitis, but the total antioxidant capacity was lower than that in healthy participants, indicating a compromised antioxidant defense potentially due to periodontal inflammation.
What conclusions were drawn from the study's results?
The study concluded that total antioxidant capacity and SOD levels vary among different groups. The diabetic group showed an increase in SOD as a potential protective response against oxidative stress associated with periodontal disease.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Antioxidants and SOD in periodontitis patients with type 2 diabetes’. Further sources in the context of Science might help you critically compare this page with similair documents:
ANOVA test, Periodontal disease, Superoxide dismutase, Biochemical analysis, Chronic periodontitis, Case-control study, Total antioxidant capacity, Diabetes mellitus type 2, Serum sample, Statistically analysed.