Platelet-rich fibrin aids healing in combined lesions: Two cases
Journal name: Journal of Indian Society of Periodontology
Original article title: Platelet-rich fibrin, “a faster healing aid” in the treatment of combined lesions: A report of two cases
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Parupalli Karunakar, Jammula Surya Prasanna, Matapathi Jayadev, Guniganti Sushma Shravani
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: Platelet-rich fibrin, “a faster healing aid” in the treatment of combined lesions: A report of two cases
Year: 2014 | Doi: 10.4103/0972-124X.142467
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
The intricate connection between pulp and periodontal tissues through anatomical channels can lead to interrelated diseases affecting both structures. This case report presents two instances of primary periodontal lesions with subsequent endodontic involvement. Both cases were treated using root canal procedures followed by periodontal therapy, incorporating platelet-rich fibrin (PRF) as the primary regenerative material. PRF represents a significant advancement in tissue healing, enabling faster recovery for intrabony defects and demonstrating a positive outcome after nine months, including reduced probing depths, absence of pain, and adequate bone fill on radiographic evaluations.
The Role of Platelet-Rich Fibrin in Regenerative Dentistry
Platelet-rich fibrin (PRF) has emerged as a critical element in the regeneration of periodontal tissues, acting not only as a filler material but also as a membrane to guide tissue healing. Developed in 2001, PRF consists of a fibrin matrix rich in growth factors that promotes natural healing mechanisms. It functions by maintaining a protected environment for grafted materials, facilitating cellular migration essential for new blood vessel formation, and providing a sustained release of cytokines over time to enhance healing. The use of PRF has shown potential advantages over traditional platelet-rich plasma (PRP), with a straightforward preparation process that minimizes risks associated with biochemical handling. This versatility makes PRF an appealing option in combined periodontal-endodontic therapies, effectively addressing complex lesions that may involve both tissue types.
Conclusion
The reported cases demonstrate that utilizing a combined treatment approach—root canal therapy followed by regenerative periodontal therapy with PRF—can yield effective outcomes for patients with intrabony defects and combined perio-endo lesions. While the application of PRF has shown promising results, further research is needed to refine its preparation ratios and assess long-term effectiveness in clinical practices. Such studies could better delineate PRF's role as an adjunctive therapy in endodontic treatments, thereby enhancing patient care in managing intricate dental conditions.
FAQ section (important questions/answers):
What is the relationship between pulp and periodontal tissues?
Pulp and periodontal tissues are anatomically and functionally interconnected. Diseases in one can affect the other due to their embryonic development and anatomical connections, often leading to complications known as combined perio-endo lesions.
How were the cases in the report treated?
Both cases were initially treated with root canal therapy. Following this, periodontal therapy was conducted using platelet-rich fibrin (PRF) as the regenerative material, leading to significant improvement in bone healing and reduction of probing depths.
What is platelet-rich fibrin (PRF) used for?
PRF is utilized as a regenerative material to enhance tissue healing. It provides growth factors in high concentrations, facilitating faster healing of intrabony defects and improving the outcomes of dental surgeries, including periodontal treatments.
What were the follow-up results after treatment?
Nine months post-treatment, both cases showed significant bone fill and reduced probing depths, indicating successful healing. The absence of pain and swelling, along with tooth stability, suggested effective management of the endodontic and periodontal conditions.
What challenges are associated with perio-endo lesions?
Perio-endo lesions pose complex treatment challenges due to their intertwined nature. Successful outcomes depend on addressing both endodontic and periodontal issues simultaneously, often requiring a staged approach to treatment for optimal results.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Platelet-rich fibrin aids healing in combined lesions: Two cases”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Table:
In medical studies, a 'Table' often refers to a structured representation of data, making it easier to compare and analyze various elements within a study. In the context of dental treatments, tables may include results of treatment outcomes, measurements of healing times, or comparative effectiveness of different methods used to address periodontal and endodontic diseases.
2) Disease:
A 'Disease' is a pathological condition that disrupts normal bodily functions. In dentistry, diseases can range from periodontal issues to endodontic lesions. Understanding disease progression is crucial for developing effective treatment plans that address both types of diseases, ensuring a comprehensive approach to patient care.
3) Relative:
In the medical context, 'Relative' can refer to the comparison between different conditions or treatment outcomes. For instance, the relative success of various regenerative techniques like platelet-rich fibrin (PRF) in treating periodontal or endodontic issues can significantly influence treatment choices and patient management.
4) Pain:
Pain is a common symptom resulting from diseases affecting the dental pulp or surrounding periodontium. Effective management of pain is essential in the treatment of both endodontic and periodontal conditions, as it impacts patient comfort and treatment compliance.
5) Filling (Filled):
In dentistry, 'Filling' refers to the material used to restore teeth that have cavities, are damaged, or have undergone root canal treatment. The choice of filling material, including the use of regenerative substances such as PRF, can significantly influence the healing outcomes of dental treatments.
6) Rich (Rch):
The term 'Rich' in the context of dental therapies often pertains to biologically active materials, such as platelet-rich fibrin (PRF). PRF is considered rich in growth factors, which are essential for promoting healing and regeneration in periodontal and endodontic treatments.
7) Inflammation:
Inflammation is a natural response of the body's immune system that can be triggered by various factors, including infection or trauma. In the context of dental diseases, controlling inflammation is crucial for successful treatment outcomes, particularly in combined perio-endo lesions.
8) Repair:
Repair refers to the process of healing tissues affected by disease or injury. In dentistry, various procedures, including grafting techniques and the application of regenerative materials, aim to repair the damaged structures of the periodontal and endodontic systems.
9) Blood:
Blood plays a critical role in various dental therapies, particularly in the use of platelet-rich fibrin (PRF), which is derived from the patient's own blood. The use of blood components in regenerative procedures enhances healing and regeneration in periodontal and endodontic treatments.
10) Transformation (Transform, Transforming):
Transforming growth factors are important proteins that play a role in cellular functions and tissue repair. In dental treatments, transforming growth factors present in PRF assist in promoting healing and regeneration of periodontal tissues.
11) Controversy:
The term 'Controversy' often arises in discussions regarding treatment modalities. In dentistry, controversies exist around the relationship between periodontal and endodontic diseases and the best approaches to treatment, emphasizing the need for ongoing research and clinical evidence.
12) Surrounding:
In the context of dental health, 'Surrounding' tissues, such as the periodontium, play a significant role in the overall health of teeth. Maintaining the health of these surrounding structures is crucial for preventing the onset of diseases affecting the pulp.
13) Discussion:
Discussion refers to the analysis and interpretation of findings in research papers. In dental literature, discussions often provide insights into the efficacy of combined treatment approaches and the biological underpinnings of therapies involving PRF and other regenerative materials.
14) Antibiotic (Antibacterial):
Antibiotics are often prescribed in dental treatments to manage infections associated with periodontal or endodontic diseases. Their effective use can reduce inflammation and assist in the healing process, making them an essential part of patient management.
15) Swelling:
Swelling is a common symptom of inflammation that can occur in dental diseases such as periodontal infections. Addressing swelling is vital for patient comfort and is often a sign that treatment is working as inflammation subsides.
16) Grafting:
Grafting refers to surgical procedures that involve placing new tissue into a site of damage or defect. In periodontal therapy, grafting materials like PRF enhance healing and facilitate tissue regeneration, addressing both periodontal and endodontic issues.
17) Pur:
The term 'Poor' refers to the prognosis of dental treatments affected by extensive disease. A poor prognosis often necessitates novel treatment approaches integrating regenerative therapies to improve outcomes for patients with severe periodontal or endodontic lesions.
18) Male:
In clinical studies, 'Male' may refer to the gender of patients being treated. Gender differences can influence treatment responses and outcomes, particularly in periodontal and endodontic therapies that aim for effective regeneration.
19) Life:
Life, in a clinical context, often relates to the quality of life of patients affected by dental diseases. Effective management of periodontal and endodontic conditions is crucial to restoring patient health and improving their overall quality of life.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Platelet-rich fibrin aids healing in combined lesions: Two cases’. Further sources in the context of Science might help you critically compare this page with similair documents:
Clinical diagnosis, Surgical Procedure, Root canal treatment, Scaling and root planing, Immunologic Response, Periodontal therapy, Growth factor, Apical foramen, Platelet-rich-fibrin, Periodontal Ligament, Bone grafting, Guided tissue regeneration, Intrabony defect, Host defense, Accessory canals, Endo-perio lesion.