Study on hydroxyapatite-bioactive glass for periodontal defects.
Journal name: Journal of Indian Society of Periodontology
Original article title: A clinical study on the efficacy of hydroxyapatite - Bioactive glass composite granules in the management of periodontal bony defects
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Tirthankar Debnath, Abhijit Chakraborty, Tamal Kanti Pal
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: A clinical study on the efficacy of hydroxyapatite - Bioactive glass composite granules in the management of periodontal bony defects
Year: 2014 | Doi: 10.4103/0972-124X.142451
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Periodontal disease is a chronic inflammatory condition that results in the degradation of connective tissue attachment and the surrounding alveolar bone. To effectively manage and regenerate the periodontium, particularly in cases of infrabony defects, various treatment modalities are employed. The study evaluates the efficacy of a hydroxyapatite-bioactive glass (HA:BG) composite, known as BioGraft®-HABG Active, in comparison to traditional hydroxyapatite (HAP) granules and open flap debridement with a biodegradable membrane. The key objective is to determine how these materials can facilitate bone regeneration and promote better clinical outcomes in periodontal therapy.
Efficacy of Hydroxyapatite-Bioactive Glass
The investigation found that the HA:BG composite exhibited superior performance in managing periodontal bony defects compared to the other treatments. Specifically, significant improvements were observed in clinical attachment levels, probing pocket depth, and defect fill across all treatment groups. Notably, the sites treated with HA:BG showed greater defect fill than those treated with HAP or the control group, highlighting the material's effectiveness in enhancing tissue regeneration. These results underscore the potential of alloplastic materials in periodontal applications, as they are biocompatible and capable of supporting the healing process.
Conclusion
The results of the study indicate that the use of BioGraft®-HABG Active leads to marked improvements in clinical outcomes, including higher clinical attachment levels and reduced probing pocket depths six months post-treatment. Radiographic evaluations further confirmed the significant obliteration of infrabony defects. Although this study provides promising insights, it emphasizes the necessity for further long-term clinical trials and histological evaluations to thoroughly understand the biological mechanisms underlying the observed results. Overall, the findings advocate for the integration of advanced bioceramics and bioactive glasses in regenerative periodontal therapy to achieve optimal patient outcomes.
FAQ section (important questions/answers):
What is the focus of the study on periodontal defects?
The study evaluates the efficacy of a hydroxyapatite-bioactive glass composite in managing periodontal bony defects, aiming for better reconstruction of new osseous tissue in infrabony defect sites.
How was the study conducted in terms of patient groups?
A randomized control study involved 30 patients with chronic periodontitis, divided into three groups: one treated with HA:BG, one with HAP, and the control group underwent flap debridement.
What were the significant results observed in the study?
The study found significant improvements in clinical attachment levels and probing pocket depth across all groups, with the HA:BG group showing notably better defect fill compared to HAP and control.
What conclusion was drawn regarding HA:BG compared to HAP?
The study concluded that HA:BG composite granules outperform HAP and flap debridement in reconstructing infrabony defects, with better clinical and radiographic outcomes.
What further research is suggested based on the findings?
The authors recommend further studies with larger populations and histological evaluations to fully assess the potential of Bioglass and hydroxyapatite in periodontal regeneration.