Severe gingival enlargement associated with aggressive periodontitis

| Posted in: Science

Journal name: Journal of Indian Society of Periodontology
Original article title: Severe gingival enlargement associated with aggressive periodontitis
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:

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Author:

Shyam Padmanabhan, C. D. Dwarakanath


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: Severe gingival enlargement associated with aggressive periodontitis

Year: 2013 | Doi: 10.4103/0972-124X.107486

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

Gingival enlargement can result from various causes, primarily inflammatory conditions and drug-induced gingival hyperplasia. Among the rare cases is severe enlargement associated with aggressive periodontitis. This case report details an 18-year-old female patient who exhibited significant gingival enlargement in both the maxillary and mandibular regions, accompanied by generalized loss of attachment and radiographic evidence of bone loss. Notably, the patient also presented with generalized vitiligo but had no relevant systemic symptoms or family history affecting her oral condition.

Idiopathic Gingival Fibromatosis and Aggressive Periodontitis

The patient’s diagnosis was characterized by idiopathic gingival fibromatosis (IGF), which appears to be a genetic disorder leading to fibrous enlargement of the gingiva. The enlargement displaced tooth surfaces and created challenges for proper oral hygiene. Histological analysis revealed features consistent with chronic inflammatory gingival hyperplasia. The treatment involved extensive gingivectomy via electrosection and electro-coagulation. Postoperative evaluations demonstrated improved oral hygiene, reduced probing depths, and no recurrence of gingival enlargement, although some complications, such as localized swelling, were noted.

Conclusion

This case underscores the coexistence of nonsyndromic idiopathic gingival fibromatosis and generalized aggressive periodontitis, emphasizing the complexity in diagnosing and managing such conditions. The successful management with electrosurgery highlights the need for careful postoperative monitoring and emphasizes the importance of further research into the genetic and immunological factors linking these conditions. Enhanced understanding may lead to better classification and treatment protocols for patients exhibiting similar dental pathologies.

FAQ section (important questions/answers):

What are common causes of gingival enlargement?

Gingival enlargement can be caused by various factors, including inflammatory responses, medications, and genetic conditions. The inflammatory type and drug-induced types, such as those from phenytoin and cyclosporine, are the most prevalent causes.

What is the significance of gingival fibromatosis?

Gingival fibromatosis is characterized by fibrous enlargement of the gums, potentially linked to genetic disorders or medication. It can occur as an isolated condition or in conjunction with systemic diseases, impacting oral health and hygiene.

How was the patient's gingival enlargement treated?

The patient underwent full mouth gingivectomy performed through electro-section and electro-coagulation under local anesthesia, followed by scaling and oral hygiene instruction. This approach effectively managed the severe gingival enlargement.

What are the distinct features of aggressive periodontitis?

Aggressive periodontitis is a severe, rapidly progressive periodontal disease often linked to genetic predisposition. It can cause significant loss of periodontal attachment and bone height, leading to tooth mobility and extraction.

Why is genetic testing important for gingival conditions?

Genetic testing can provide insights into the hereditary aspects of conditions like gingival fibromatosis. Understanding specific genetic factors may help in diagnosing, managing, and potentially preventing these periodontal diseases.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Severe gingival enlargement associated with aggressive periodontitis”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Disease:
Disease refers to an abnormal condition affecting the body or its systems, often resulting in dysfunction. In the context of the case, gingival enlargement and aggressive periodontitis are classified as diseases affecting the gingiva and periodontium, leading to significant oral health issues and necessitating medical intervention.

2) Inflammation:
Inflammation is a biological response to harmful stimuli, which may include pathogens, damaged cells, or irritants. In this case, inflammation contributed to the gingival enlargement experienced by the patient. The presence of inflammatory components in the biopsy indicates chronic inflammation as a significant factor in gingival hyperplasia.

3) Blood:
Blood is the fluid that circulates through the heart, arteries, and veins, providing essential nutrients and oxygen to cells. In this patient's case, laboratory tests evaluating blood biochemistry were performed to rule out systemic diseases influencing her oral condition, underscoring the importance of blood analysis in diagnosing conditions.

4) Swelling:
Swelling is the enlargement of soft tissues, often due to inflammation or fluid accumulation. The patient's significant gingival swelling resulted in difficulty closing her mouth and was indicative of the underlying gingival hyperplasia. Swelling is a key clinical sign that helps in diagnosing various medical conditions, including periodontitis.

5) Family:
Family refers to a group of individuals related by blood or marriage. In the case, the patient's family history was explored to determine any genetic predispositions to gingival fibromatosis or aggressive periodontitis. Family history can play a crucial role in understanding inherited conditions and their syndromic associations.

6) Post:
Post refers to something that happens after an event. In this context, 'post-extraction' refers to the time following a dental extraction, during which the patient experienced considerable gingival enlargement. Understanding the timeline of events is important for diagnosing the potential causes and associations of the condition.

7) Transmission:
Transmission is the act of passing something from one entity to another, in this case, relating to genetic information or infectious agents. The report discusses potential hereditary transmission of gingival fibromatosis and aggressive periodontitis, emphasizing the importance of understanding genetic factors in the development of these diseases.

8) Hygiene (Hygienic):
Hygiene refers to practices that promote health and prevent disease, especially through cleanliness. In the case, inadequate personal oral hygiene contributed to the patient's severe gingival enlargement. Proper oral hygiene is essential in preventing gingival inflammation and hyperplasia, highlighting its role in maintaining periodontal health.

9) Genetic disorder:
Genetic disorder refers to conditions caused by abnormalities in an individual's DNA. The patient’s gingival enlargement was termed idiopathic but suggested potential genetic predispositions. Genetic disorders can influence susceptibility to diseases and their severity, signifying the need for genetic studies in understanding such conditions.

10) Deafness:
Deafness is the partial or complete inability to hear. While the patient did not exhibit hearing deficiencies, other syndromes associated with gingival fibromatosis include deafness. This highlights the possibility of syndromic associations, stressing the need for thorough assessment in cases of gingival enlargement.

11) Table:
Table refers to a systematic arrangement of data, typically in rows and columns, allowing for easier interpretation of complex information. In the report, tables contained blood investigations and clinical biochemistry results, serving as essential tools for comparing normal and abnormal laboratory findings in the patient's evaluation.

12) Pain:
Pain is an unpleasant sensory experience often associated with injury or illness. The patient experienced pain prior to her dental extraction, indicating a potential underlying periodontal issue. Pain assessment is crucial in diagnosing oral conditions and guiding therapeutic interventions for individuals with similar presentations.

13) Drug:
Drug refers to any substance used to diagnose, cure, treat, or prevent disease. The report discusses the possible association of drug-induced gingival hyperplasia with medications like phenytoin or nifedipine. Understanding drug effects on gingival tissues is vital for appropriate patient management and counseling.

14) Surrounding:
Surrounding denotes areas around a particular object or entity. In the context of this case, the term may refer to surrounding tissues affected by the patient's gingival enlargement. Assessing surrounding tissues helps in understanding the extent of disease involvement and planning effective surgical interventions.

15) Observation:
Observation involves careful monitoring or examination to gain information. The surgical outcome, particularly regarding the patient’s gingival condition, relied on observation of postoperative changes, adhering to the principle of continuous assessment in medical treatment to gauge effectiveness and detect potential complications.

16) Antibiotic (Antibacterial):
Antibiotic refers to a type of medication used to kill or inhibit the growth of bacteria. In this case, antibiotics were administered post-surgery to prevent infection following gingivectomy. The use of prophylactic antibiotics is common in dental practices to enhance postoperative healing and prevent complications.

17) Knowledge:
Knowledge refers to the information and understanding that individuals gain through experience or education. The report emphasizes that acquiring knowledge about genetic and immunological factors influencing periodontitis and gingival enlargement is essential for developing more effective treatment strategies in clinical practice.

18) Mutation:
Mutation denotes a change in the DNA sequence of an organism. In the context of this case, mutations within specific genes may be implicated in hereditary gingival fibromatosis. Understanding genetic mutations can provide insights into disease pathogenesis, informing more targeted therapies and management approaches.

19) Epilepsy:
Epilepsy is a neurological disorder characterized by recurrent seizures. The report references epilepsy in the context of syndromes associated with gingival fibromatosis. Though not directly related to this case, understanding such associations is crucial for differential diagnosis and recognizing potential overlapping clinical manifestations.

20) Incision:
Incision refers to a surgical cut made in the skin or body tissue. In the treatment of the patient, precise incisions were made during the electrosurgery procedure to excise excess gingival tissue. Skillful incisional techniques are fundamental to achieving successful surgical outcomes in periodontal therapies.

21) Cutting:
Cutting involves the act of slicing through tissue, typically with surgical instruments. In this case, electrosurgery was preferred for cutting the gingival tissue due to its advantages, such as immediate hemostasis. Techniques and instruments used for cutting in oral surgeries significantly impact postoperative healing and patient comfort.

22) Surface:
Surface refers to the outermost layer of an object or tissue. In the case of gingival enlargement, the surface characteristics of the gingiva were examined for signs of inflammation or hyperplasia. Analyzing the surface of tissues contributes to clinical evaluations and diagnosis of various periodontal conditions.

23) Reason:
Reason refers to a justification or explanation for an action or condition. In the report, exploring the reasons behind the patient's gingival enlargement and loss of pigmentation was significant for understanding the underlying etiology of her condition, guiding diagnosis and therapeutic strategies.

24) Water:
Water is a universal solvent essential for life. In dental practices, water is often used in cooling systems during procedures, such as cutting or electrosurgery. The report emphasizes the need for adequate irrigation to prevent overheating of tissues and maintain a clear surgical field during interventions.

25) Field:
Field refers to a specific area of study or context. In this case, the surgical field relates to the area being treated or observed during the gingivectomy procedure. Maintaining a clear surgical field is crucial for effective treatment outcomes and minimizes complications during dental surgeries.

26) Sign:
Sign is an objective indication of a medical condition observable by a clinician. The report emphasizes various clinical signs, including severe gingival enlargement. Recognizing signs is essential for clinicians to make accurate diagnoses, leading to appropriate treatment planning and improved patient outcomes.

27) Hair:
Hair may refer to the protein filament that grows from follicles in the skin. While hair is not directly relevant to the case, the mention of characteristics like hair loss can indicate broader systemic conditions. Observations related to hair can contribute to differential diagnosis in conjunction with other symptoms.

28) Hand:
Hand refers to the human appendage used for manipulation and gripping. The report may refer to instruments used by a hand during surgical procedures. The dexterity and skill of the clinician's hand play a vital role in performing delicate surgeries, ensuring precision and minimizing injury to surrounding tissues.

29) Mud:
Mood refers to the emotional state of an individual. The patient expressed feelings of depression due to her severe oral condition. Understanding a patient’s mood is important in managing chronic conditions, as emotional health can significantly impact treatment adherence and overall outcomes in medical care.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Severe gingival enlargement associated with aggressive periodontitis’. Further sources in the context of Science might help you critically compare this page with similair documents:

Systemic disease, Genetic predisposition, Surgical Procedure, Hypopigmented patches, Radiographic evidence, Gingival hyperplasia, Plasma cell gingivitis, Gingival enlargement, Aggressive periodontitis.

Concepts being referred in other categories, contexts and sources.

Loss of attachment.

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