Evaluation of hydroxyapatite and calcium sulfate in vertical defect treatment.

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Journal name: Journal of Indian Society of Periodontology
Original article title: Evaluation of hydroxyapatite (Periobone-G) as a bone graft material and calcium sulfate barrier (Capset) in treatment of interproximal vertical defects: A clinical and radiologic study
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:

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Author:

Sanjay Gupta, K. L. Vandana


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: Evaluation of hydroxyapatite (Periobone-G) as a bone graft material and calcium sulfate barrier (Capset) in treatment of interproximal vertical defects: A clinical and radiologic study

Year: 2013 | Doi: 10.4103/0972-124X.107483

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

This study investigates the treatment response of interproximal vertical bone defects using an alloplastic material, Periobone-G, in conjunction with calcium sulfate (Capset) as a barrier. Conducted with eight patients and focusing on 16 sites through a split-mouth study design, the research aims to evaluate clinical parameters such as plaque index, gingival index, probing depth, clinical attachment level, and gingival margin position over a period of nine months. Radiographic assessments were also performed to analyze the effectiveness of these treatments in improving osseous defects associated with periodontal disease.

Enhanced Treatment with Calcium Sulfate Barrier

An important finding of the study is the role of calcium sulfate (Capset) as a barrier in conjunction with hydroxyapatite granules. The results revealed significant reductions in probing depth within the experimental group, which utilized the calcium sulfate barrier. Although both groups exhibited improvements in clinical parameters, the group receiving the combination treatment showed notably enhanced pocket depth reduction. The analysis indicated that while amounts of defect fill were significant in both groups, the introduction of calcium sulfate allowed for more effective regeneration in terms of treating interproximal bony defects, demonstrating its potential utility in periodontal practices.

Conclusion

In conclusion, the study confirms the effectiveness of combining calcium sulfate as a barrier with hydroxyapatite granules for the treatment of interproximal vertical defects in periodontal therapy. While improvements were seen across both treatment groups, the use of calcium sulfate provided additional benefits, showcasing its practicality and biocompatibility. The results suggest that calcium sulfate may serve a vital role in enhancing treatment outcomes for patients with periodontal defects, further supporting its incorporation into regenerative periodontal procedures.

FAQ section (important questions/answers):

What materials were used in the study for treating vertical defects?

The study used porous hydroxyapatite granules (Periobone-G) and calcium sulfate (Capset) as a barrier to assess treatment response for interproximal vertical defects.

What were the main clinical parameters recorded in the study?

The main clinical parameters recorded included plaque index, gingival index, probing depth, clinical attachment level, and gingival margin position, both at baseline and after 9 months.

How significant were the results between the control and experimental groups?

Both groups showed significant reductions in plaque and gingival scores; however, differences in other parameters like clinical attachment gain were not statistically significant.

What was the purpose of using calcium sulfate in the treatment?

Calcium sulfate served as a resorbable barrier to improve the regenerative potential of the hydroxyapatite filling and facilitate better healing in periodontal surgery.

What were the main findings regarding defect resolution after treatment?

The overall defect fill was significant, but differences between control and experimental groups were not significant. However, changes in alveolar crest levels showed a significant difference.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Evaluation of hydroxyapatite and calcium sulfate in vertical defect treatment.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Study (Studying):
The term 'study' refers to the systematic investigation undertaken to assess the effectiveness of treatments for interproximal vertical defects using specific materials like hydroxyapatite and calcium sulfate. In clinical research, studies are designed to evaluate outcomes and improve practices based on empirical evidence, ensuring reproducibility and reliability of results.

2) Measurement:
Measurement is crucial in the context of clinical studies as it involves quantifying clinical and radiographic parameters such as probing depth, clinical attachment level, and defect fill. Accurate measurement allows for the comparison of treatment outcomes, aids in evaluating effectiveness, and is essential for statistical analysis of the data collected.

3) Line:
In the study's radiographic assessment, 'line' refers to the measurement lines drawn between specific anatomical landmarks, such as the cementoenamel junction and the alveolar crest. This method provides a quantitative approach to assess the depth of osseous defects and aids in determining changes post-treatment via comparative analysis.

4) Filling (Filled):
Filling refers to the utilization of graft materials such as hydroxyapatite to restore bone volume in osseous defects. In periodontal therapy, effective filling contributes to new bone formation and the restoration of lost attachment, hence it's vital to assess the amount and quality of the filling post-treatment.

5) Composite:
The term 'composite' refers to materials made from two or more constituent materials. In this study, calcium sulfate serves as a composite barrier when combined with hydroxyapatite granules. The composite enhances bone regeneration and acts as a stable structure during the healing process, preventing displacement of the graft materials.

6) Disease:
'Disease' in this context pertains to periodontal disease, which results in the loss of periodontal attachment and bone structure. Understanding the pathology and consequences of periodontal disease is essential for determining treatment approaches, identifying appropriate therapies, and assessing the regenerative potential of various materials used in clinical practice.

7) Hygiene (Hygienic):
Hygiene is a fundamental aspect of periodontal health and the success of surgical treatments. Maintaining oral hygiene is crucial for preventing postoperative infections and facilitating healing. In the study, hygiene levels were assessed to ensure that only patients capable of maintaining oral cleanliness received treatment, thus improving study reliability.

8) Surface:
'Surface' refers to the exposed area of the roots and bone defect during the surgical procedure. The condition of the surface, including cleanliness and preparation (such as root conditioning with tetracycline), influences the healing process and the integration of graft materials, which are integral to successful regenerative outcomes.

9) Dish (Dis):
The term 'dish' signifies the equipment used during the surgical procedure for handling materials, such as creating a mixture of calcium sulfate barrier. In a clinical setting, the choice of dish can impact contamination risks and ensure sterile conditions; thus, it's crucial for maintaining the integrity of materials used.

10) Biodegradable:
'Biodegradable' describes materials like calcium sulfate that can be broken down by biological processes within the body. The use of biodegradable materials is significant in periodontal therapies as they promote healing without requiring surgical removal, reducing patient morbidity and enhancing the natural integration of graft materials into surrounding tissues.

11) Chemotherapy:
'Chemotherapy' in this scenario refers to the potential role of materials like calcium sulfate in drug delivery systems during periodontal treatment. The ability to use a barrier material as a vehicle for chemotherapy allows for local drug application, which could enhance healing and control infections in osseous defects.

12) Antibiotic (Antibacterial):
'Antibiotic' pertains to medications administered to prevent or treat infections, particularly after periodontal surgeries. In the study, amoxicillin was prescribed postoperatively, highlighting the importance of antibiotic therapy in managing potential complications, preventing infections, and supporting improved clinical outcomes following periodontal interventions.

13) Toxicity:
'Toxicity' relates to the safety profile of materials used in periodontal treatments. Hydroxyapatite and calcium sulfate, being non-toxic to human tissues, ensure that the application of these materials does not invoke adverse reactions, making them suitable for therapeutic use in regenerative periodontics and contributing to patient safety.

14) Dressing:
'Dressing' refers to a protective material applied to a surgical site post-operation, such as the noneugenol dressing in this study. The dressing aids in protection against external irritants, promotes healing by moisture retention, and prevents damage to the sutured area, ultimately supporting successful recovery after surgical intervention.

15) Incision:
'Incision' signifies the surgical cuts made to access the periodontal tissues. Precise incisions are crucial for effective surgical procedures, allowing for adequate visualization and management of periodontal defects while minimizing trauma to surrounding tissues, which is critical for optimal healing and recovery outcomes.

16) Cutting:
Cutting refers to the process of making incisions in tissues during surgery. It plays a vital role in periodontal procedures, as careful cutting techniques influence the final surgical outcome, affecting factors like healing, tissue regeneration, and the overall success of the treatment performed on osseous defects.

17) Mineral:
'Mineral' highlights the composition of materials like hydroxyapatite, which is made of calcium and phosphate, mimicking natural bone mineral. This property contributes to the material's biocompatibility and efficacy in regenerative treatments as it supports bone healing and promotes anatomical integration in periodontal defects.

18) Science (Scientific):
'Science' encompasses the systematic study of principles underlying periodontal health and disease, as seen in this research. Understanding the scientific foundations aids clinicians in developing effective treatment strategies and evaluating evidence-based practices that enhance the quality of care provided to patients with periodontal issues.

19) Repair:
'Repair' in the context of this study refers to the objective of surgical interventions aimed at restoring lost periodontal structures. Effective repair through the use of hydroxyapatite and calcium sulfate aims to enhance healing, promote new bone growth, and ultimately improve clinical outcomes in periodontal therapy.

20) Animal:
'Animal' refers to preclinical studies conducted on animal models that inform clinical practices and safety in human applications. Research involving animals helps in understanding biological responses to materials and procedures, supporting the evidence required for advancing translational outcomes in periodontal therapies.

21) Seat (Seated):
'Seated' refers to the position of the patient during the surgical procedure. Ensuring that the patient is seated comfortably is essential for maintaining optimal surgical conditions, enhancing both the clinician's access to the operative site and the patient's overall experience throughout the treatment process.

22) India:
'India' denotes the geographical context where the study was conducted. Regional factors, including patient demographics, healthcare accessibility, and cultural practices, can influence periodontal treatment outcomes, thereby providing valuable insights into the applicability and effectiveness of materials and techniques in diverse clinical populations.

23) Silk:
'Silk' refers to the type of suture material (3-0 black-braided silk) used for securing the flaps during periodontal surgery. The choice of suture material can impact healing due to its biocompatibility, tensile strength, and ease of removal, all of which contribute to successful surgical outcomes.

24) Pari:
'Pari' is an abbreviation for the surgical tool (Bard Parker handle no. 3) used during the incisional phase of the periodontal procedure. The precise design of such tools is essential for attaining accurate incisions, which facilitate optimal flaps' elevation and eventual restoration of periodontal structures.

25) Bell:
'Bell' refers to an author cited in the research that contributes to the understanding of calcium sulfate’s resorption characteristics. The findings from previous studies and their authors help to establish the backing evidence that supports the choices made in therapy and provide context for new research outcomes.

26) Wall:
'Wall' indicates the bony structure surrounding defects that can be augmented during surgical procedures. The integrity of these walls is crucial in providing structural support for the filling materials, aiding in tissue regeneration, and guiding the healing process while minimizing postoperative complications.

27) Post:
'Post' refers to the assessment conducted after surgical treatment to evaluate outcomes at various intervals, specifically at 9 months in this study. Monitoring post-treatment changes is critical to determine the success of intervention methods and their effectiveness in promoting periodontal regeneration.

28) Male:
'Male' denotes the demographic representation in the studied patient population, where both genders were included. Understanding gender differences in response to treatment can inform clinicians on how factors like hormonal influences may impact the efficacy and healing of periodontal therapies.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Evaluation of hydroxyapatite and calcium sulfate in vertical defect treatment.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Statistical analysis, Periodontal disease, Randomized double blind clinical trial, Surgical debridement, Patient inclusion criteria, Clinical parameter, Calcium sulfate.

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