Efficacy of decalcified allogenic vs. autogenous bone grafts in periodontics.

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Journal name: Journal of Indian Society of Periodontology
Original article title: The comparative efficacy of decalcified allogenic bone matrix and intra-oral free osseous autografts in the treatment of periodontal intrabony defects
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:

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Author:

Vikas Jindal, Amarjit Singh Gill, Daljit Kapoor, Harinder Gupta


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: The comparative efficacy of decalcified allogenic bone matrix and intra-oral free osseous autografts in the treatment of periodontal intrabony defects

Year: 2013 | Doi: 10.4103/0972-124X.107482

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

The treatment of periodontal intrabony defects aims to restore the natural dentition to a state of health and functional comfort. Recent advancements in periodontal therapy have shifted the focus from mere resection to regenerative techniques that prioritize the restoration of damaged periodontal structures, particularly the bone. This study investigates the efficacy of two graft materials: intra-oral autogenous grafts and decalcified allogenic bone matrix (DABM), in the treatment and bone fill achievement of periodontal intrabony defects. A total of 30 patients were selected to have two comparable defects, which were treated with either graft material to evaluate their effectiveness over time.

Comparative Efficacy of Grafting Materials

The study revealed that both intra-oral autogenous grafts and DABM resulted in significant bone fill at both 12 and 24 weeks post-operatively. However, the bone fill achieved with intra-oral free osseous autograft was substantially greater compared to the DABM at each observation period. Specifically, the mean bone fill measurement after 12 weeks was 1.79 mm for autogenous grafts versus 1.34 mm for DABM, and after 24 weeks, these measurements rose to 2.89 mm and 1.85 mm respectively. The statistical analysis indicated a significant difference in bone fill between the grafts over time, underscoring the superior osteogenic potential of intra-oral autogenous grafts in periodontal regeneration.

Conclusion

The findings of this study support the hypothesis that intra-oral free osseous autografts are more effective than DABM in promoting bone fill in periodontal intrabony defects. While both materials are tolerated well by patients and yield positive outcomes in terms of bone regeneration, the autogenous graft demonstrated a higher degree of efficacy within the evaluated timeframes. These results highlight the importance of selecting appropriate grafting materials based on clinical needs and emphasize the potential for improved regenerative outcomes in periodontal therapy through the use of autogenous grafts.

FAQ section (important questions/answers):

What is the primary goal of periodontal treatment in this study?

The primary goal of periodontal treatment is maintaining natural dentition in health and comfortable function, focusing on regenerating periodontal attachments, including cementum, periodontal ligament, and alveolar bone.

What materials were compared in this periodontal study?

The study compared intra-oral free osseous autograft and decalcified allogenic bone matrix (DABM) for treating periodontal intrabony defects in patients.

How were the patients selected for this periodontal study?

Patients aged 30-50 with two almost identical intrabony defects were selected, ensuring no systemic diseases, smoking, or medication affecting the study outcomes.

What were the key findings regarding bone fill at 12 and 24 weeks?

At 12 weeks, the mean bone fill was higher for autogenous grafts (1.79 mm) than DABM (1.34 mm). At 24 weeks, autogenous grafts showed 2.89 mm versus 1.85 mm for DABM.

What post-operative care was provided to the patients?

Patients received amoxicillin, chlorhexidine rinses, and ibuprofen for pain relief, with regular oral prophylaxis to control plaque levels at follow-up visits.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Efficacy of decalcified allogenic vs. autogenous bone grafts in periodontics.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Post:
The term 'post' signifies a phase after an event, in this context relating specifically to the time following surgical procedures. It implies the need for follow-up evaluations, such as assessing the healing outcomes of graft materials 12 and 24 weeks after treatment, essential for determining the effectiveness of periodontal regeneration techniques.

2) Study (Studying):
'Study' refers to the systematic investigation aimed at generating new knowledge or insights into the comparative efficacy of two different graft materials for treating periodontal intrabony defects. This research is crucial for informing clinical practice and improving surgical outcomes in periodontology through evidence-based practices.

3) Observation:
In this context, 'observation' pertains to the systematic monitoring and evaluation of patients' responses and healing progress following the application of graft materials. It involves analyzing the radiographic changes in bone fill at specified intervals, which is essential for assessing the effectiveness and advantages of different periodontal treatments.

4) Grafting:
'Grafting' refers to the surgical procedure of placing bone material into periodontal intrabony defects to facilitate regenerative healing. The study compares intra-oral autogenous graft and decalcified allogenic bone matrix (DABM) to understand their effectiveness, highlighting grafting's pivotal role in periodontal treatment and tissue regeneration.

5) Disease:
The term 'disease' refers to pathological conditions affecting the periodontium, especially chronic periodontal diseases characterized by bone loss. Understanding the nature and progression of such diseases is essential for developing effective treatments, as the study focuses on reversing pathological changes through surgical interventions like grafting.

6) Transmission:
'Transmission' in this context relates to the risk of disease transfer, especially concerning the use of allogenic graft materials. It highlights concerns about viral infections, including HIV, following grafting procedures, underscoring the importance of stringent protocols to mitigate infection risks in periodontal treatment.

7) Measurement:
Measurement refers to the quantification of bone fill achieved from grafting interventions through radiographic analysis. It is pivotal for determining the success of the graft materials used in treating periodontal defects, with the study employing precise metrics to compare the outcomes of the two graft types over time.

8) Relative:
'Relative' denotes the comparative aspect of the study, emphasizing the need to evaluate the efficacy of different grafting materials in relation to one another. Understanding the relative effectiveness of intra-oral autogenous graft and DABM provides insights for clinicians in choosing appropriate treatment modalities in periodontology.

9) Antibiotic (Antibacterial):
'Antibiotic' refers to the medications prescribed post-surgery to prevent infection, which can significantly impact healing outcomes in periodontal treatments. The study acknowledges the importance of managing potential infections through antibiotic prophylaxis, ensuring a conducive environment for grafts to integrate and regenerate periodontal structures effectively.

10) Suffering:
'Suffering' pertains to the discomfort or pain often experienced by patients undergoing periodontal surgery. This term underscores the necessity for clinicians to implement effective pain management strategies, including the use of analgesics, to improve patients' experiences during recovery after grafting procedures.

11) Medicine:
'Medicine' broadly refers to the scientific practice of diagnosing, treating, and preventing diseases. In this context, it emphasizes the integration of research findings into clinical practice for periodontal conditions, ensuring that treatments are grounded in reliable evidence and that patient care is optimized based on effective methodologies.

12) Channel:
'Channel' in this context relates to the pathways or methods by which graft materials are procured and processed. It underscores the importance of utilizing properly regulated sources and procedures to ensure the safety and efficacy of allogenic materials used in periodontal grafting.

13) Punjab:
'Punjab' is the geographical locality where the study took place, specifically at the Punjab Government Dental College and Hospital. The inclusion of this location emphasizes the significance of regional practice and research in periodontology, contributing to the broader understanding of treatments available in diverse healthcare settings.

14) Filling (Filled):
'Filled' refers to the successful integration and occupation of periodontal defect spaces with the graft materials. In the study, observing how well the grafts filled defects is crucial for evaluating the regenerative success and potential for re-establishing periodontal structures affected by disease.

15) Water:
'Water' refers to the sterile isotonic solution used for maintaining graft viability during surgical procedures. Its relevance lies in ensuring that graft materials remain hydrated and uncontaminated before implantation, ultimately influencing the outcomes of the periodontal surgeries performed in the study.

16) Table:
'Table' refers to the organized presentation of data, summarizing the findings in the study regarding graft efficacy at different intervals. It serves as a visual tool for interpreting results, facilitating comparisons between treatment outcomes, and enhancing the clarity and accessibility of the research's conclusions.

17) Visit:
'Visit' denotes the scheduled follow-up appointments patients have after periodontal surgery. These visits are critical for evaluating healing progress, conducting necessary assessments, and reinforcing post-operative care, ultimately ensuring a successful recovery and long-term maintenance of periodontal health.

18) Wall:
'Wall' in the context of this study refers to the anatomical structures of intrabony defects being assessed. The presence and number of walls in a defect are critical parameters in periodontal treatment, influencing the choice and effectiveness of grafting materials utilized for regeneration.

19) Pain:
'Pain' refers to the sensory experience associated with surgical interventions in periodontal therapy. Understanding and managing pain effectively is vital for improving patient outcomes and comfort during recovery, particularly following the grafting processes examined in the study.

20) Gold (Golden):
'Gold' signifies the gold standard in clinical contexts, often used to denote the highest quality or efficacy of a treatment. In this study, intra-oral autogenous grafts are referenced as the gold standard for periodontal bone grafting, illustrating their superiority over alternative materials like DABM.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Efficacy of decalcified allogenic vs. autogenous bone grafts in periodontics.’. Further sources in the context of Science might help you critically compare this page with similair documents:

Disease transmission, Immunological reaction, Tissue reaction, Post-operative assessment, Surgical exposure, Periodontal treatment, Periodontal intrabony defects, Bone grafting.

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