Effects of non-surgical therapy on IL-6 and CRP in chronic periodontitis.
Journal name: Journal of Indian Society of Periodontology
Original article title: The short-term effects of non-surgical periodontal therapy on the circulating levels of interleukin-6 and C-reactive protein in patients with chronic periodontitis
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:
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Annie Kitty George, Prasanthila Janam
Journal of Indian Society of Periodontology:
(A bimonthly open-access journal)
Full text available for: The short-term effects of non-surgical periodontal therapy on the circulating levels of interleukin-6 and C-reactive protein in patients with chronic periodontitis
Year: 2013 | Doi: 10.4103/0972-124X.107472
Copyright (license): CC BY-NC-SA
Summary of article contents:
Introduction
Recent studies have highlighted the association between periodontal infections and several systemic diseases, suggesting that chronic infection may lead to an increased systemic inflammatory response. This study aimed to investigate the impact of chronic periodontitis and non-surgical periodontal therapy on serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP) in patients diagnosed with severe chronic generalized periodontitis. Conducted at the Government Dental College in Thiruvananthapuram, the study involved the recruitment of patients and healthy controls to evaluate the relationships between periodontal health and systemic inflammation.
Impact of Periodontal Disease on Systemic Inflammation
One vital finding from the study is the significant elevation of IL-6 and hsCRP levels in patients with chronic periodontitis compared to healthy controls. Following non-surgical periodontal therapy, a noteworthy reduction in both IL-6 and hsCRP levels was observed, with values approaching those of the control group. The statistical analysis indicated that these changes were significant, suggesting that periodontal disease not only affects oral health but also contributes to systemic inflammatory responses. This underscores the relevance of addressing periodontal health as a potential means to mitigate inflammation and associated systemic health risks.
Conclusion
The results of this study demonstrate that chronic periodontitis is linked to elevated systemic inflammatory markers, which can be effectively reduced through non-surgical periodontal treatment. This highlights the importance of periodontal therapy not just for oral health, but also as a therapeutic strategy to lower systemic inflammation in affected individuals. Future research could further explore the connections between periodontal disease and systemic health to develop comprehensive treatment modalities aimed at both local and systemic disease management.
FAQ section (important questions/answers):
What systemic inflammatory markers were studied in this research?
The study focused on interleukin-6 and high-sensitivity C-reactive protein (hsCRP) levels in patients with severe chronic generalized periodontitis before and after non-surgical periodontal therapy.
How did periodontal therapy affect interleukin-6 levels?
Following non-surgical periodontal therapy, interleukin-6 levels showed a statistically significant decrease in patients, approaching the levels observed in healthy control subjects.
What was the composition of the study's participant groups?
The study included 25 patients with severe chronic periodontitis and 20 healthy controls, excluding those with systemic diseases or recent antibiotic treatments.
What treatment was administered to the test group?
The test group underwent scaling, root planing, chlorhexidine irrigation, and were given oral hygiene instructions post-treatment, with follow-ups at two weeks and two months.
What statistical methods were used for data analysis?
Data analysis involved the statistical package SPSS version 10, utilizing Chi-square tests and Student's paired t test for comparison of parameters.
Glossary definitions and references:
Scientific and Ayurvedic Glossary list for “Effects of non-surgical therapy on IL-6 and CRP in chronic periodontitis.”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.
1) Thiruvananthapuram (Thiruvanantha-puram, Tiru-anantapuram, Tiruvanantapuram, Tiruananta-puram):
Thiruvananthapuram is the capital city of Kerala, India, and serves as the location where the study was conducted. The Department of Periodontics and Oral Implantology at the Government Dental College in this city was crucial for studying chronic periodontitis and its systemic implications, attracting local patients for research purposes.
2) Blood:
Blood is a vital biological fluid in the body and is essential for various tests and treatments. In the context of this study, blood samples were collected to analyze serum levels of interleukin-6 and C-reactive protein, which are key markers for inflammation and systemic disease related to periodontal health.
3) Study (Studying):
The study refers to the structured research project aimed at investigating the relationship between chronic periodontitis and systemic inflammatory markers. By measuring interleukin-6 and high-sensitivity C-reactive protein levels, the study aims to ultimately elucidate how periodontal disease may influence overall health, thereby contributing to dental and medical knowledge.
4) Disease:
Disease in this context refers to any pathological condition. Chronic periodontitis, being a significant dental disease, is associated with systemic inflammation that could lead to other health complications. Understanding these links between oral health and systemic diseases like cardiovascular conditions provides insight into the importance of maintaining periodontal health.
5) Hygiene (Hygienic):
Hygiene is the practice of maintaining cleanliness to promote health. In the study, oral hygiene assessment was part of the periodontal examination. Proper oral hygiene practices are essential in preventing periodontal disease, which has been linked to systemic inflammation, thereby influencing the outcomes measured in the study.
6) Inflammation:
Inflammation refers to the body's response to infection or injury. In this study, the focus is on systemic inflammation induced by chronic periodontitis. Elevated levels of inflammatory markers like interleukin-6 and C-reactive protein show how periodontal disease can affect overall health, highlighting the connection between oral and systemic inflammation.
7) Science (Scientific):
Science encompasses the systematic study of the structure and behavior of the physical and natural world. This study employs scientific methods to explore the relationships between periodontal health and systemic inflammation. Through rigorous data collection and analysis, it seeks to offer evidence-based conclusions pertinent to dental science and general health.
8) Cancer:
While not the primary focus of the study, cancer is mentioned in the scope of systemic diseases affected by chronic infections. Understanding the role of inflammatory markers in periodontal disease may offer insights into potential links between chronic inflammation and the increased risk of malignancies, including cancer.
9) Measurement:
Measurement in this study pertains to quantifying levels of specific biomarkers such as interleukin-6 and C-reactive protein. Accurate measurement is essential for understanding the extent of inflammation and evaluating the effectiveness of non-surgical periodontal therapy, establishing a scientific basis for treatment outcomes in patients with chronic periodontitis.
10) Antibiotic (Antibacterial):
Antibiotics are medications used to treat bacterial infections. Patients with chronic periodontitis were excluded if they had received antibiotic treatment in the lead-up to the study to ensure that the data collected on inflammatory markers accurately reflected the effects of periodontal therapy, rather than confounding factors like antibiotic intervention.
11) Pregnant:
Pregnant refers to a state in which a woman is carrying a developing fetus. Individuals in this condition were excluded from the study to avoid potential complications or confounding variables that may arise from hormonal and physiological changes during pregnancy, ensuring that the study results accurately reflect the target population.
12) Visit:
Visit refers to appointments where participants received dental examinations, treatments, and follow-ups. In the study, visits for assessments at baseline and post-treatment were critical for documenting changes in periodontal health and evaluating the impact of non-surgical therapy on serum levels of inflammatory markers.
13) Post:
Post refers to the period following an event or treatment. In this study, 'post' is relevant for the assessment conducted two months after non-surgical periodontal treatment. Evaluating changes in inflammatory marker levels at this stage is essential for determining the effectiveness of the treatment and its impact on systemic health.
Other Science Concepts:
Discover the significance of concepts within the article: ‘Effects of non-surgical therapy on IL-6 and CRP in chronic periodontitis.’. Further sources in the context of Science might help you critically compare this page with similair documents:
Clinical examination, Statistical analysis, Systemic disease, C-Reactive Protein, Systemic infection, Controlled Study, Chronic periodontitis, Interleukin-6, Risk factor, Chronic infection, Serum level, Clinical attachment loss, Periodontal examination, Systemic inflammatory response.