Antioxidant therapy for treating periodontal diseases alone or adjunctively

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Journal name: Journal of Indian Society of Periodontology
Original article title: Antioxidant therapy as monotherapy or as an adjunct to treatment of periodontal diseases
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:

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Author:

Aditi Mathur, Lalit Mathur, Balaji Manohar, Hemant Mathur, Rajesh Shankarapillai, Neema Shetty, Aman Bhatia


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: Antioxidant therapy as monotherapy or as an adjunct to treatment of periodontal diseases

Year: 2013 | Doi: 10.4103/0972-124X.107469

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

Periodontal diseases, primarily caused by gram-negative anaerobic bacteria, are highly prevalent globally. The inflammatory response of periodontal tissues leads to the production of various cytokines and oxidative stress markers. Recent research highlights the role of antioxidants in managing these diseases, as they can scavenge harmful reactive oxygen species. This study aimed to evaluate the efficacy of antioxidant therapy in the treatment of chronic gingival and periodontal diseases as both a standalone and adjunct therapy alongside nonsurgical debridement procedures.

Impact of Antioxidant Therapy on Periodontal Disease

The study demonstrated that patients with increased periodontal attachment loss exhibited significantly lower levels of uric acid, a major antioxidant found in saliva, compared to clinically healthy and gingivitis groups. Patients received 6 mg of antioxidant therapy in three divided doses over two weeks. Following treatment, there was a notable increase in salivary uric acid levels in both gingivitis and periodontitis subgroups, suggesting that antioxidant therapy can enhance periodontal health by mitigating inflammation. Although no significant difference was observed between subgroups receiving scaling and root planing alone and those who also received antioxidants, there was a consistent upward trend in uric acid levels over time, implying a protective role of antioxidants.

Conclusion

The findings suggest that antioxidant therapy can be effectively utilized as an adjunct to nonsurgical periodontal therapy for patients with gingivitis and chronic periodontitis. The observed increase in salivary uric acid levels correlates with reduced periodontal inflammation, supporting the notion that antioxidants play a beneficial role in periodontal disease management. However, further longitudinal studies are warranted to comprehensively evaluate the long-term effects of antioxidant therapy on periodontal health.

FAQ section (important questions/answers):

What is the aim of the study on antioxidant therapy?

The study aimed to investigate the effect of antioxidant therapy on the progression of periodontal disease, both as a standalone treatment and as an adjunct to nonsurgical debridement like scaling and root planing.

How were subjects classified in the study?

Subjects were classified based on their periodontal health using the Community Periodontal Index of Treatment Needs score, resulting in three groups: clinically healthy, gingivitis, and periodontitis, with further subdivisions for specific treatments.

What were the key findings related to uric acid levels?

The study found that uric acid levels were significantly lower in patients with periodontal attachment loss. Additionally, a significant increase in uric acid levels was observed after antioxidant therapy was administered.

How was antioxidant therapy administered in the study?

Antioxidant therapy involved administering 6 mg of an antioxidant, consisting of lycopene, zinc, and selenium, in three divided doses for two weeks to the relevant subgroups suffering from gingivitis and periodontitis.

Can antioxidants be used alongside nonsurgical periodontal therapy?

Yes, the study concluded that antioxidants can be effectively used as an adjunct to nonsurgical periodontal therapy, enhancing the treatment outcome for gingivitis and periodontitis patients.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Antioxidant therapy for treating periodontal diseases alone or adjunctively”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Disease:
The term 'disease' refers to a pathological condition that affects a bodily system or function. In this context, it pertains primarily to periodontal diseases caused by bacterial infections leading to inflammation and tissue destruction, significantly impacting oral health and requiring effective treatment approaches such as nonsurgical debridement and antioxidant therapy.

2) Study (Studying):
The word 'study' signifies a systematic investigation aimed at exploring a specific hypothesis or query within the field of periodontal health. This research involved evaluating the efficacy of antioxidant therapy on periodontal disease, contributing valuable findings to existing medical literature, thereby enhancing understanding and treatment methodologies for gingivitis and periodontitis.

3) Table:
The term 'table' indicates a structured format for presenting data and results in the study. Tables are crucial for summarizing complex information, like comparisons of periodontal indices and uric acid levels across different groups. They facilitate quick reference and analysis of findings, vital for drawing meaningful conclusions from the research.

4) Post:
In this context, 'post' often relates to the statistical testing performed after various treatment phases (e.g., post hoc tests). This analysis is essential for identifying significant differences among groups following the interventions, helping researchers understand how treatments impacted periodontal health across different time points during the study.

5) Species:
The word 'species' typically refers to a group of organisms capable of interbreeding; however, here it may relate indirectly to bacterial species implicated in periodontal disease. Understanding the various bacterial strains contributing to periodontal pathology is crucial for effectively targeting treatments and mitigating their harmful effects on oral health.

6) Inflammation:
Inflammation describes the body's response to infection or injury, characterized by redness, swelling, and pain. In periodontal disease, chronic inflammation occurs due to bacterial presence in the gums, leading to attachment loss and other complications. Managing inflammation is central to effective treatment outcomes in periodontal care as highlighted in the study.

7) Cancer:
Cancer refers to a group of diseases characterized by uncontrolled cell growth. While not directly related to periodontal studies, there is a mention of potential links between periodontal disease and systemic conditions like cancer. Understanding these connections emphasizes the importance of oral health in overall wellness and disease prevention initiatives.

8) Chandra:
Chandra likely refers to a researcher or study author whose work adds credibility to the current study. Their previous findings, regarding antioxidants and periodontal disease, form a basis for comparison, thus underscoring the continuity of research in understanding the role of antioxidants as a treatment adjunct in periodontal therapy.

9) Antibiotic (Antibacterial):
Antibiotics are medications used to treat bacterial infections. The study excludes patients on antibiotics within a specified timeframe, ensuring that the effects observed are solely due to antioxidant therapy and nonsurgical debridement without any interference from antibiotics, which could skew results related to periodontal disease management.

10) Rajasthan:
Rajasthan, where the study was conducted, is significant as it contextualizes the research demographics. Its population may exhibit diverse dietary habits affecting antioxidants in saliva. Insights from this region contribute to broader understanding of periodontal disease's ethnic and geographical variations, highlighting regional health perspectives in dental research.

11) Attending:
The term 'attending' refers to individuals who visit a healthcare facility for treatment. In this study, it indicates the subjects' participation in the research at the dental college. Their attendance is critical for data collection, ultimately influencing the study's validity by ensuring an appropriate representative sample for analysis.

12) Suffering:
The word 'suffering' denotes the experience of pain or distress resulting from periodontal disease in affected individuals. It's a reminder of the clinical significance of the study, as many patients endure the discomfort and complications of diseases like gingivitis and periodontitis, emphasizing the need for effective treatment solutions.

13) Activity:
Here, 'activity' refers to biological processes like oxidative stress and antioxidant responses within the context of periodontal disease. The study addresses how various biochemical activities, particularly the imbalance between reactive oxygen species and antioxidants, contribute to periodontal health status, underlining the importance of monitoring these activities in treatment assessment.

14) Pregnant:
The term 'pregnant' relates to women expecting a child. The study excludes pregnant individuals to avoid potential confounding factors affecting treatment outcomes. Pregnancy can alter systemic physiological responses and affect oral health significantly, thus ensuring clear results in the study focused on non-pregnant participants strengthens the relevance of findings.

15) Udaipur (Udaypur):
Udaipur, a city in Rajasthan, provides geographical context for the study. Its local population's unique characteristics, lifestyle, and dietary habits might influence periodontal health and antioxidant levels. Including subjects from Udaipur helps in assessing the impact of regional factors on periodontal disease, enriching the applicability of study findings.

16) Surface:
In this context, 'surface' references the tooth root surfaces where periodontal bacteria form biofilms. The importance of debridement lies in effectively removing these bacterial colonies from the tooth surface, crucial for treatment success. Understanding the dynamics at the surface level aids in designing more effective periodontal therapies.

17) Water:
Water is significant in this study as participants were instructed to rinse their mouths with water before saliva collection to eliminate extraneous cells and substances. This procedural integrity is vital for ensuring that collected saliva accurately reflects the biochemical status of the oral environment, particularly uric acid levels.

18) Sign:
The term 'sign' often denotes a clinical indication of disease. In this study, it emphasizes the need for identifying signs of periodontal disease as indicated by CPI scores. Recognizing these signs is crucial for categorizing participants and assessing the severity of periodontal conditions, which impacts treatment strategies.

19) Gold (Golden):
'Gold' in this context is metaphorical, referring to nonsurgical debridement as the 'gold standard' treatment for periodontal disease. It signifies that this approach is the benchmark against which other treatments, such as antioxidant therapy, are compared, underscoring its importance and effectiveness in managing periodontal health.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Antioxidant therapy for treating periodontal diseases alone or adjunctively’. Further sources in the context of Science might help you critically compare this page with similair documents:

Chronic disease, Informed consent, Ethical committee, Oxidative stress, Reactive oxygen species, Periodontal disease, Antioxidant, Antioxidant therapy, Scaling and root planing, Uric acid level, Saliva sample, Lycopene, Pro-inflammatory cytokine.

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