Serum ceruloplasmin in aggressive vs. chronic periodontitis patients

| Posted in: Science

Journal name: Journal of Indian Society of Periodontology
Original article title: Evaluation of serum ceruloplasmin in aggressive and chronic periodontitis patients
The Journal of Indian Society of Periodontology (JISP) publishes original scientific articles on periodontology (the study of supporting structures of teeth) and oral implantology. It is a bimonthly open-access journal with special issues for specific occasions.
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Original source:

This page is merely a summary which is automatically generated hence you should visit the source to read the original article which includes the author, publication date, notes and references.

Author:

B. Harshavardhana, S. K. Rath, Manish Mukherjee


Journal of Indian Society of Periodontology:

(A bimonthly open-access journal)

Full text available for: Evaluation of serum ceruloplasmin in aggressive and chronic periodontitis patients

Year: 2013 | Doi: 10.4103/0972-124X.115659

Copyright (license): CC BY-NC-SA


Summary of article contents:

Introduction

Periodontitis is an inflammatory disease affecting the connective tissue and supporting bone around the teeth, resulting from interactions between periodontal microflora and host responses. The two main types are chronic and aggressive periodontitis, with the latter characterized by rapid progression and occurring more frequently in younger individuals. Accurate diagnosis and identification of at-risk patients remain challenging, thus emphasizing the need for biomarkers that can provide objective measures of periodontal disease. Among various pro-inflammatory markers investigated, ceruloplasmin has recently gained attention for its potential role in periodontal disease diagnosis due to its association with inflammatory processes.

Ceruloplasmin: A Potential Biomarker

Ceruloplasmin is a multi-copper binding plasma protein that displays ferroxidase activity, impacting the body's iron state and playing a role in systemic inflammatory responses. This study evaluated serum ceruloplasmin levels across three groups: patients with aggressive periodontitis, those with chronic periodontitis, and periodontally healthy individuals. Findings indicate that ceruloplasmin levels were significantly higher in patients with aggressive periodontitis compared to chronic periodontitis and healthy subjects, suggesting a correlation between ceruloplasmin levels and the severity of periodontal disease. Notably, the levels increased with disease severity as indicated by clinical parameters like bleeding on probing and clinical attachment loss, reinforcing the idea that ceruloplasmin could serve as a reliable biomarker for diagnosing and assessing periodontal diseases.

Conclusion

The research highlights the potential of ceruloplasmin as a diagnostic biomarker for periodontitis, applicable for clinical use in screening and evaluating disease severity. While the findings showed clinically significant results, the statistical significance was inconclusive possibly due to the limited sample size. Future studies with larger cohorts are needed to validate these results and explore the feasibility of using ceruloplasmin in clinical settings, possibly leading to the development of chair-side detection kits. Overall, this study paves the way for further investigation into ceruloplasmin's role in periodontal disease, underscoring its importance in enhancing diagnostic practices.

FAQ section (important questions/answers):

What is the purpose of the study on ceruloplasmin levels?

The study aimed to evaluate serum ceruloplasmin levels in patients with aggressive and chronic periodontitis, investigating its potential as a diagnostic marker for periodontal diseases.

What were the main findings regarding ceruloplasmin levels in patients?

Ceruloplasmin levels were significantly higher in aggressive periodontitis patients compared to chronic periodontitis and healthy individuals, indicating its potential as a biomarker for periodontal disease severity.

How was ceruloplasmin measured in the study participants?

Serum ceruloplasmin levels were assessed using a new kinetic method with norfloxacin-based reagents, measuring ferroxidase activity in the serum samples collected from participants.

What implications does the study have for periodontal disease diagnosis?

The findings suggest that ceruloplasmin could serve as a non-invasive biomarker for diagnosing periodontitis, helping clinicians identify and monitor disease severity in patients.

What factors influenced the increase in ceruloplasmin levels?

Ceruloplasmin levels increased with the severity of periodontal disease, correlating with parameters like bleeding on probing, probing depth, and clinical attachment loss.

Glossary definitions and references:

Scientific and Ayurvedic Glossary list for “Serum ceruloplasmin in aggressive vs. chronic periodontitis patients”. This list explains important keywords that occur in this article and links it to the glossary for a better understanding of that concept in the context of Ayurveda and other topics.

1) Disease:
Disease refers to pathological conditions that impair normal bodily functions. In the context of periodontitis, it signifies the inflammatory conditions affecting the support structures of the teeth, leading to symptoms like gum swelling, bleeding, and ultimately loss of tooth support. Accurate identification and management of disease are crucial for oral health.

2) Study (Studying):
Study denotes a systematic investigation aimed at understanding a particular subject or phenomenon. In this context, it involves evaluating serum ceruloplasmin levels in different types of periodontitis. The study's outcomes contribute to knowledge about biomarkers for periodontal disease and may influence future diagnostic and therapeutic approaches.

3) Table:
Table refers to an organized arrangement of data, often used for presenting key findings from research. In this document, tables summarize clinical parameters, serum ceruloplasmin levels, and other vital statistics, facilitating the comparison and interpretation of results between different groups of patients, thus enhancing data clarity.

4) Activity:
Activity signifies the function or behavior of biological agents or markers in response to physiological or pathological conditions. Here, it relates notably to the ferroxidase activity of ceruloplasmin, which plays a role in iron metabolism and immune responses in the context of inflammation and periodontal disease.

5) Blood:
Blood is a bodily fluid containing red cells, white cells, plasma, and platelets that circulates in the cardiovascular system. In this research, blood samples were integral for isolating serum to assess ceruloplasmin levels, enabling a connection between systemic inflammation and periodontal disease presence and severity.

6) Inflammation:
Inflammation is the body's immune response to injury or infection, characterized by redness, swelling, and pain. In periodontitis, ongoing inflammation affects periodontal tissues, leading to disease progression. Pro-inflammatory markers like ceruloplasmin are critical in understanding inflammation's role in periodontal disease and overall health.

7) Bleeding:
Bleeding, particularly in a periodontal context, usually indicates inflammation and disease progression. Measurement of bleeding on probing (BOP) helps assess periodontal health, as higher bleeding rates correlate with increased disease severity. It serves as an important clinical parameter in evaluating and diagnosing periodontitis.

8) Male:
Male refers to one of the sexes, which is relevant in clinical studies assessing disease prevalence and characteristics across genders. In this study, a notable proportion of male subjects was included, potentially influencing results and interpretations of ceruloplasmin levels and periodontal disease within the male population.

9) Measurement:
Measurement denotes the process of quantifying clinical parameters such as bleeding on probing, probing depth, and ceruloplasmin levels. Precise measurement is vital for accurate diagnosis, evaluation of disease severity, and tracking treatment outcomes in periodontal disease, offering insight into patient management strategies.

10) Antibiotic (Antibacterial):
Antibiotics are medications used to treat bacterial infections. In the context of the study, the exclusion of individuals who had taken antibiotics recently was crucial to ensure that the serum ceruloplasmin levels were reflective of periodontitis-related inflammation rather than influences from antibiotic treatment, maintaining result integrity.

11) Reason:
Reason indicates the rationale behind certain study designs or findings. In this research, understanding the reasons for elevated ceruloplasmin levels in aggressive periodontitis versus chronic forms aids in establishing it as a potential biomarker, influencing diagnostic and therapeutic strategies for periodontal disease management.

12) Pune:
Pune is the location of the study, highlighting the geographical context of the research. The setting impacts the demographic characteristics of the patient population and may reflect regional variations in periodontal disease prevalence, lifestyle factors, and healthcare access, essential for generalizing findings.

13) Dividing:
Dividing refers to the classification of study participants into distinct groups based on their periodontal disease status. This separation of subjects into groups allows for comparative analysis of ceruloplasmin levels and clinical parameters, enhancing the understanding of how disease type influences systemic inflammatory responses.

14) Pregnant:
Pregnant denotes the state of carrying a fetus, indicating an individual condition that can impact health and treatment protocols. In this study, pregnant women were excluded due to potential confounding factors affecting ceruloplasmin levels and periodontal disease progression, ensuring more reliable and valid study outcomes.

15) Species:
Species refers to different categories of living organisms. Although this document primarily discusses human subjects, the concept of species emphasizes biological variability and responsiveness to disease. Understanding host species differences is important in interpreting results and drawing conclusions about periodontal disease mechanisms and treatment.

16) Doubt:
Doubt signifies uncertainty or lack of conviction regarding findings or interpretations. In scientific investigations, addressing doubts through robust data collection and analysis is crucial for establishing credible conclusions. The study aims to reduce doubt about ceruloplasmin's role as a biomarker for periodontitis.

17) Fight:
Fight indicates the body's defense mechanism against infections and diseases. In periodontitis, the immune response includes inflammatory markers like ceruloplasmin, which assist in combating periodontal pathogens. Understanding how ceruloplasmin influences immune responses helps clarify its potential role in managing periodontal disease.

18) Sign:
Sign refers to an indication or evidence of a condition or phenomenon. In the context of this study, the serum levels of ceruloplasmin serve as a sign of systemic inflammation related to periodontal disease. Identifying such signs is essential for diagnosis and monitoring of periodontal health.

Other Science Concepts:

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Discover the significance of concepts within the article: ‘Serum ceruloplasmin in aggressive vs. chronic periodontitis patients’. Further sources in the context of Science might help you critically compare this page with similair documents:

Severe case, Statistical analysis, Cross-sectional study, Natural resistance, Chronic periodontitis, Ceruloplasmin level, Clinical parameter, Serum sample, Pro-inflammatory markers, Hypoxia inducible factor, Aggressive periodontitis, Mild cases, Diagnostic biomarker.

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